2024-04-27 13:11:38, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS NM_001032607 2732 bp mRNA linear INV 04-MAY-2019 DEFINITION Ciona intestinalis beta-catenin (cibeta-catenin), mRNA. ACCESSION NM_001032607 VERSION NM_001032607.1 KEYWORDS RefSeq. SOURCE Ciona intestinalis (vase tunicate) ORGANISM Ciona intestinalis Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia; Cionidae; Ciona. REFERENCE 1 (bases 1 to 2732) AUTHORS Oda-Ishii I, Kubo A, Kari W, Suzuki N, Rothbacher U and Satou Y. TITLE A Maternal System Initiating the Zygotic Developmental Program through Combinatorial Repression in the Ascidian Embryo JOURNAL PLoS Genet. 12 (5), e1006045 (2016) PUBMED 27152625 REMARK GeneRIF: Third, Gata.a directs specific gene expression in the animal hemisphere domain, because beta-catenin/Tcf7 weakens the Gata.a-binding activity for target sites through a physical interaction in the vegetal cells. Thus, repressive regulation through protein-protein interactions among the maternal transcription factors is essential to establish the first distinct domains of gene expression in the chordate embryo. Erratum:[PLoS Genet. 2016 Oct 14;12 (10 ):e1006392. PMID: 27741234] Publication Status: Online-Only REFERENCE 2 (bases 1 to 2732) AUTHORS Rothbacher U, Bertrand V, Lamy C and Lemaire P. TITLE A combinatorial code of maternal GATA, Ets and beta-catenin-TCF transcription factors specifies and patterns the early ascidian ectoderm JOURNAL Development 134 (22), 4023-4032 (2007) PUBMED 17965050 REMARK GeneRIF: Initially distributed throughout the embryo, Ci-GATAa activity is progressively repressed in vegetal territories by accumulating maternal beta-catenin. REFERENCE 3 (bases 1 to 2732) AUTHORS Satou Y, Kawashima T, Shoguchi E, Nakayama A and Satoh N. TITLE An integrated database of the ascidian, Ciona intestinalis: towards functional genomics JOURNAL Zool. Sci. 22 (8), 837-843 (2005) PUBMED 16141696 REFERENCE 4 (bases 1 to 2732) AUTHORS Imai KS, Hino K, Yagi K, Satoh N and Satou Y. TITLE Gene expression profiles of transcription factors and signaling molecules in the ascidian embryo: towards a comprehensive understanding of gene networks JOURNAL Development 131 (16), 4047-4058 (2004) PUBMED 15269171 REFERENCE 5 (bases 1 to 2732) AUTHORS Satou Y and Satoh N. TITLE Genomewide surveys of developmentally relevant genes in Ciona intestinalis JOURNAL Dev. Genes Evol. 213 (5-6), 211-212 (2003) PUBMED 12736827 REFERENCE 6 (bases 1 to 2732) AUTHORS Satou Y, Yamada L, Mochizuki Y, Takatori N, Kawashima T, Sasaki A, Hamaguchi M, Awazu S, Yagi K, Sasakura Y, Nakayama A, Ishikawa H, Inaba K and Satoh N. TITLE A cDNA resource from the basal chordate Ciona intestinalis JOURNAL Genesis 33 (4), 153-154 (2002) PUBMED 12203911 REFERENCE 7 (bases 1 to 2732) AUTHORS Imai K, Takada N, Satoh N and Satou Y. TITLE (beta)-catenin mediates the specification of endoderm cells in ascidian embryos JOURNAL Development 127 (14), 3009-3020 (2000) PUBMED 10862739 COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB210325.1. ##Evidence-Data-START## Transcript exon combination :: AB210325.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN07436332, SAMN07436333 [ECO:0000348] ##Evidence-Data-END## FEATURES Location/Qualifiers source 1..2732 /organism="Ciona intestinalis" /mol_type="mRNA" /db_xref="taxon:7719" /chromosome="9" /map="9" gene 1..2732 /gene="cibeta-catenin" /gene_synonym="CTNNB1" /note="beta-catenin" /db_xref="GeneID:445806" misc_feature 50..52 /gene="cibeta-catenin" /gene_synonym="CTNNB1" /note="upstream in-frame stop codon" CDS 74..2383 /gene="cibeta-catenin" /gene_synonym="CTNNB1" /codon_start=1 /product="beta-catenin" /protein_id="NP_001027779.1" /db_xref="GeneID:445806" /translation="
MAEMMMNRNEMVPDAKSQVRMWGWDSGIQSGATTASPSISGASHHDGNFPDTNQVLGEWQREFTMEEANQIHDQFVRTRADRVRDVLFPETMMEESGPVPSTQYESNTATSVQRLAEPSQQLKKAVVNLINYQDDADLATKAIPELTGLLNDDDQVVVQQAAQMVHMLSKKVASRQAIMNSPAMVSALVRAMQNATDPETQRYCTGALHNLSHHKQGLLSIFKSGGIPALVKMLSSPIESVVFYAITTLHNLLLHQEGAKEAVRLAGGLQKMVYLLSRDNVKFLAIDTDCLQILAYGNQESKLIILASNGPQELVRIMRTYDYEKLLWTTSRVIKVLSVCSSNKPAIVEAGGMQALGMHLGSPSQRLLQNCLWSLRNLSDAGTKQDHVENLLQMLVQLLSSNDINVVTCAAGILSNLTCNNMSNKTRVCQVGGIEALVRTVLQAGDREDITEPTVCALRHLTSRHPDAEMAQNAVRLHYGLPVLVKLLHPPSRWPLIKAVVGLIRNLALCAANHAALREHGAIPRLVQLLMRAHQDTQRRTSMASSHSQMSAAYVDGVRMEEIVEGTTGTLHILAREPHSRSVIRGLNTIPLFVQLLYSQVENIQRVAAGVLCELAQDKESADLIENEGASAPLTELLHSKNEGVATYAAAALFRMSEDKSQDYKKRLSVELTSSLFKDDGALYNGADLMDPCMQGYQHQMTPPMSHQSSVSSVHNSHHSGFPQAEGQQPMDFQQHLVPPADYPLPDLSNDLDLEPMIGVQQPWLDTDL"
misc_feature 284..496 /gene="cibeta-catenin" /gene_synonym="CTNNB1" /note="alpha-catenin binding domain found in catenin beta-1 (CTNNB1), catenin gamma (CTNNG) and similar proteins; Region: CTNNAbd_CTNNB1-like; cd21719" /db_xref="CDD:439240" misc_feature order(287..298,308..313,317..325,332..337,344..346, 401..409,413..418,425..430,437..439,446..472) /gene="cibeta-catenin" /gene_synonym="CTNNB1" /note="CNTTA binding site [polypeptide binding]; other site" /db_xref="CDD:439240" misc_feature 500..>2038 /gene="cibeta-catenin" /gene_synonym="CTNNB1" /note="cellulose synthase-interactive protein; Provisional; Region: PLN03200" /db_xref="CDD:215629" misc_feature 500..577 /gene="cibeta-catenin" /gene_synonym="CTNNB1" /note="armadillo repeat [structural motif]; Region: armadillo repeat" /db_xref="CDD:293788" misc_feature 596..712 /gene="cibeta-catenin" /gene_synonym="CTNNB1" /note="armadillo repeat [structural motif]; Region: armadillo repeat" /db_xref="CDD:293788" misc_feature 734..829 /gene="cibeta-catenin" /gene_synonym="CTNNB1" /note="armadillo repeat [structural motif]; Region: armadillo repeat" /db_xref="CDD:293788" misc_feature order(800..802,812..814,824..826,926..928,938..940, 950..952,1055..1057,1067..1069,1079..1081) /gene="cibeta-catenin" /gene_synonym="CTNNB1" /note="putative peptide binding site [polypeptide binding]; other site" /db_xref="CDD:293788" misc_feature 851..961 /gene="cibeta-catenin" /gene_synonym="CTNNB1" /note="armadillo repeat [structural motif]; Region: armadillo repeat" /db_xref="CDD:293788" misc_feature 977..1084 /gene="cibeta-catenin" /gene_synonym="CTNNB1" /note="armadillo repeat [structural motif]; Region: armadillo repeat" /db_xref="CDD:293788" misc_feature 1103..1213 /gene="cibeta-catenin" /gene_synonym="CTNNB1" /note="armadillo repeat [structural motif]; Region: armadillo repeat" /db_xref="CDD:293788" misc_feature 1247..1324 /gene="cibeta-catenin" /gene_synonym="CTNNB1" /note="armadillo repeat [structural motif]; Region: armadillo repeat" /db_xref="CDD:293788" misc_feature order(1295..1297,1307..1309,1319..1321,1427..1429, 1439..1441,1451..1453,1565..1567,1577..1579,1589..1591) /gene="cibeta-catenin" /gene_synonym="CTNNB1" /note="putative peptide binding site [polypeptide binding]; other site" /db_xref="CDD:293788" misc_feature 1346..1462 /gene="cibeta-catenin" /gene_synonym="CTNNB1" /note="armadillo repeat [structural motif]; Region: armadillo repeat" /db_xref="CDD:293788" misc_feature 1487..1594 /gene="cibeta-catenin" /gene_synonym="CTNNB1" /note="armadillo repeat [structural motif]; Region: armadillo repeat" /db_xref="CDD:293788" misc_feature 1613..1798 /gene="cibeta-catenin" /gene_synonym="CTNNB1" /note="armadillo repeat [structural motif]; Region: armadillo repeat" /db_xref="CDD:293788" misc_feature 1814..1918 /gene="cibeta-catenin" /gene_synonym="CTNNB1" /note="armadillo repeat [structural motif]; Region: armadillo repeat" /db_xref="CDD:293788" misc_feature 1937..2041 /gene="cibeta-catenin" /gene_synonym="CTNNB1" /note="armadillo repeat [structural motif]; Region: armadillo repeat" /db_xref="CDD:293788" ORIGIN
ataagtttttatttttattgttaaaaccttttatcctgcgttaaactgttgagactcaccactgcatatcagcatggctgaaatgatgatgaacagaaatgaaatggtgccggacgccaagtcccaggtccggatgtggggttgggattctggcattcagtcaggggcaaccacagcctccccatcaataagtggggcaagccaccacgatgggaacttccccgatacaaaccaagtactcggggaatggcaacgagagtttacaatggaagaagcaaaccaaatccatgatcagtttgtgcgcacacgtgccgatcgtgtccgcgacgtgctgttccctgaaaccatgatggaggaaagtgggcccgtcccaagcacacaatacgagtcgaacacggcaacatccgtgcagagattggcagaaccatcgcaacaacttaagaaggcagtggtaaacttgatcaattatcaggacgatgccgacctcgccacgaaagcgatccccgagttgactggtcttctcaatgatgacgaccaagtggttgttcaacaagcagcacaaatggtgcacatgttgtccaagaaagttgcgagtagacaagcgataatgaatagcccggccatggtgtcggctctcgttagagccatgcagaacgccaccgaccccgagacccagcgttattgtaccggcgccctacacaacttgtcgcatcacaaacaaggattgttgtcaatattcaaatccgggggaattcctgctcttgtcaaaatgctcagttccccaattgagtcggttgtgttctacgcgatcaccaccctgcataacctacttttgcaccaagagggagctaaagaggccgtgagattggcaggggggttgcagaaaatggtgtatctattgtcgcgtgacaacgtaaagtttctggcaattgacaccgattgtttacaaatcctagcttatggaaatcaagagagcaagttgatcattcttgcgagcaacggaccccaggaattggtccgcatcatgaggacttacgattatgagaagttattatggacgactagtcgcgtgatcaaggtgctgtcggtttgttcgagtaacaaaccagccatcgtagaagcaggtggaatgcaagcacttggcatgcaccttgggtcaccctcacaaaggctgttacaaaactgtttgtggagtcttcgaaacttatctgatgctggaaccaaacaagatcatgtggagaacttgctacagatgcttgtccagcttctatcatcgaatgacatcaacgtggttacatgcgctgcggggattctaagcaaccttacttgcaacaacatgagtaataagaccagagtgtgtcaggttggaggaatcgaagctttggtgcgcactgtgttgcaagctggtgatcgtgaggatatcacggaacccacagtgtgtgcgttgcgtcatcttacttcgcgtcacccagacgctgagatggcacaaaatgctgttcggttgcattacggcctcccagtgttggtcaaactgcttcacccaccttcaagatggccgctcattaaggctgttgttggtttgattagaaacttggctttgtgcgctgccaaccacgcggcacttcgtgagcatggggcgataccacggcttgtgcaactactaatgcgtgcccaccaagacacacagcgtaggacaagcatggcgtcgagtcatagccagatgtctgctgcttatgtggacggagtacgaatggaggaaatagtggaaggaacaactggaacactccatatattggctcgtgaacctcacagtagatcggtcatccgaggacttaacacaatccctctgtttgtgcaacttctttattcacaggttgagaacatccagcgggtggcagcaggcgtgttgtgcgaattagcgcaagacaaggaaagtgccgacctcatcgagaacgagggggcgagcgctccattgaccgagttgttgcattccaaaaatgaaggagttgccacgtacgcggctgctgcattattccgcatgtccgaggataaatcgcaagattacaagaagagattgtctgttgagttgacgagctccttgttcaaggatgatggagctttatataatggtgcggacctaatggacccctgcatgcaaggttaccaacaccagatgacccccccgatgtctcatcaaagctccgtcagttcagttcataactcgcaccattctgggttcccacaagcagaaggccaacaacccatggactttcaacaacacctcgtccccccggcagattacccgctaccagacctttcaaacgacttggaccttgaaccaatgattggtgttcaacaaccatggctcgatactgacctctaagggattggatgagggatgacgactttgtaaagactctacaatcatgaacattattgaaaccccggataatttttacttgtacagaacttttataatttgctgaatcatcattgaaggttttgctgaatcatgttggaagtgaatttcttaaaaagaaattttgttaaaattgttttcggaaaaatgttagtgaatgatttatggtgcttccatggtgattatgacatcacagccagttcgttttatattgtttttatgacgtagccttaaacctggtaaccatagcaactctgtagcttcgtgtgaataaaataaaatgtacagaaaataaaaaaaaaaaaaaaaaaaa
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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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