LOCUS       NM_070961               3655 bp    mRNA    linear   INV 22-NOV-2023
DEFINITION  Caenorhabditis elegans Piwi-like protein ergo-1 (ergo-1), mRNA.
ACCESSION   NM_070961
VERSION     NM_070961.10
DBLINK      BioProject: PRJNA158
KEYWORDS    RefSeq.
SOURCE      Caenorhabditis elegans
  ORGANISM  Caenorhabditis elegans
            Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
            Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
            Caenorhabditis.
REFERENCE   1  (bases 1 to 3655)
  AUTHORS   Sulson,J.E. and Waterston,R.
  CONSRTM   Caenorhabditis elegans Sequencing Consortium
  TITLE     Genome sequence of the nematode C. elegans: a platform for
            investigating biology
  JOURNAL   Science 282 (5396), 2012-2018 (1998)
   PUBMED   9851916
  REMARK    Erratum:[Science 1999 Jan 1;283(5398):35]
REFERENCE   2  (bases 1 to 3655)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (22-NOV-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 3655)
  AUTHORS   WormBase.
  CONSRTM   WormBase Consortium
  TITLE     Direct Submission
  JOURNAL   Submitted (29-OCT-2023) WormBase Group, European Bioinformatics
            Institute, Cambridge, CB10 1SA, UK. Email: help@wormbase.org
REFERENCE   4  (bases 1 to 3655)
  AUTHORS   Sulson,J.E. and Waterston,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAR-2003) Nematode Sequencing Project: Sanger
            Institute, Hinxton, Cambridge CB10 1SA, UK and The Genome Institute
            at Washington University, St. Louis, MO 63110, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by WormBase. This
            record is derived from an annotated genomic sequence (NC_003283).
            
            On Feb 2, 2021 this sequence version replaced NM_070961.9.
FEATURES             Location/Qualifiers
     source          1..3655
                     /organism="Caenorhabditis elegans"
                     /mol_type="mRNA"
                     /strain="Bristol N2"
                     /db_xref="taxon:6239"
                     /chromosome="V"
     gene            1..3655
                     /gene="ergo-1"
                     /locus_tag="CELE_R09A1.1"
                     /db_xref="GeneID:178602"
                     /db_xref="WormBase:WBGene00019971"
     CDS             11..3376
                     /gene="ergo-1"
                     /locus_tag="CELE_R09A1.1"
                     /standard_name="R09A1.1a"
                     /note="Confirmed by transcript evidence"
                     /codon_start=1
                     /product="Piwi-like protein ergo-1"
                     /protein_id="NP_503362.2"
                     /db_xref="EnsemblGenomes-Gn:WBGene00019971"
                     /db_xref="EnsemblGenomes-Tr:R09A1.1a"
                     /db_xref="GeneID:178602"
                     /db_xref="GOA:O61931"
                     /db_xref="InterPro:IPR003100"
                     /db_xref="InterPro:IPR003165"
                     /db_xref="InterPro:IPR012337"
                     /db_xref="InterPro:IPR036085"
                     /db_xref="InterPro:IPR036397"
                     /db_xref="UniProtKB/Swiss-Prot:O61931"
                     /db_xref="WormBase:WBGene00019971"
                     /translation="

MSYNNGGGGGGGGYRNDRDDRYHNNDRQNYRSSDQGRSGYNDDRRDNRYDDRRGSNNDRGCYDQHDRRGSSNDDRRGYRGYNQGGGGYQQQYSQDARYGSNQRNDNYGNNRGSHGGANMYSQNGGNRGGGGGRVGGGRTAAGMSNPGDLVGGADQPIHSVSKKSLRHNAQEFAVRPKTMVQDKGLGQKTTLLTNHTLVQLPQEPITLHVFNIEVFINGKSSNKRELCGPRFWEILKENKPTFGMPNQYIFNDVNMMWSTNKLRQSEGRTNNRRMNFVWKYVKQIKFGGNIEDEETMQLLSTLIDAIATQRARLPLAPPKYTVFKRLTYLICEEAYEPELPDVSLCHKLRIGTDARVGVSIAIRTNLRAGITACFDLGHTLFTRPAYPLVRLLCDIIEHSVVLDEAFEMKYDAALRACNVSDENLRVMTQILTKMTLQLSTETGDYVGEDGEVIVRPAPTIRNPGRNFKFVGLGAPADRYYFTSDGVELTVADYYLQKYNIRLRYPNLPCVLKKAPEQCGNKHSAMPLELVSYIVVPTRYGGFTMPDMRADMINKTTYTAQQRGKLLQHIIAQKSLSGIEPPVSNNDDYMKKHKLVMKREPIRVKATILPPPTLVYGDSVFHDEHHIGEWEAVTHDPPRQVLDGAVFRRKLYKSSEQPLMKRLMGSILLIQSPRQCRDFDYNQQGYHAIMRAIEDSGQPVLWADENKHSAVIQGELQFNQNQHGIEVIEQFLQNIKSTIGEYERDGEVIVPIVFAVFQARATVYSGNNNEYNDYNVLKYLADNKYGIHTQGILEKSLGVVGPSPKNCALTRLMVEKVLGKVGTTHRKLERGGAHKTWTIFTDPAKPTLVLGIDVSHPSTRDRETGNVLQKMSAATVVGNIDLDVTEFRASSRIQDTGVECLIDFSKEIDERIGEFIDHTGKRPAHIVVYRDGLSEGDFQKYLFEERVCIEERCLKIDTSFQPSITYIVVTKRHHTQFFLEDPSQGYESQGYNVLPGTLIEDAVTTNKYYDFFLSTQIGNEGCFRPTHYYVLHDTWTGKPDSFWPTVTHALTYNFCRSTTTVALPAPVLYAHLAAKRAKETLDGINTYKSVNNIYCDLESFGDLCEVNKDMNVNEKLEGMTFV"

     misc_feature    1271..1681
                     /gene="ergo-1"
                     /locus_tag="CELE_R09A1.1"
                     /note="This domain is named PAZ after the proteins Piwi
                     Argonaut and Zwille; Region: PAZ; smart00949"
                     /db_xref="CDD:198017"
     misc_feature    order(1409..1411,1451..1453,1478..1480,1490..1492,
                     1544..1546,1577..1579,1583..1585)
                     /gene="ergo-1"
                     /locus_tag="CELE_R09A1.1"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1772..3250
                     /gene="ergo-1"
                     /locus_tag="CELE_R09A1.1"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(2327..2329,2339..2341,2375..2386,2393..2395,
                     2432..2434,2441..2443,2453..2455,2465..2467)
                     /gene="ergo-1"
                     /locus_tag="CELE_R09A1.1"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(2564..2566,2570..2572,2798..2800,3218..3220)
                     /gene="ergo-1"
                     /locus_tag="CELE_R09A1.1"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

actaacaaaaatgagctataacaacggcggcggcggcggtggtggtggctatcgaaacgatcgtgacgatcgctaccataacaacgatcggcaaaattaccgcagcagtgaccaaggtcgctccggatacaacgacgatcgtcgggacaatcgctacgatgatcgtcgcggctccaacaacgatcgtggctgctacgatcaacatgatcgtcgtggatcctccaacgatgatcgtagaggttatcgtggatacaaccagggtggtggaggatatcaacagcaatacagtcaggatgccagatatggatccaatcagagaaatgacaattatggaaataatcgtggaagtcacggcggcgcgaacatgtacagccaaaacggtggaaaccgcggaggaggaggaggacgtgtcggtggtggccgaaccgctgccggtatgtcgaatcctggagatctcgtcggaggtgccgaccagccgatccattcagtttcgaaaaagtcgctcagacacaacgcccaggagtttgcagtccggccgaaaacaatggtccaggataagggtctcggccagaagacgacacttttgacgaatcacacgttggtgcaactcccgcaggagcccatcacgcttcacgtcttcaatattgaagtatttattaatggaaagtctagcaataagcgagaactttgtgggccacgattttgggaaattttgaaggagaataagcccacttttggcatgccaaatcagtacatcttcaatgatgtgaatatgatgtggtcgacgaataagctgagacaatccgagggaagaactaataaccggagaatgaatttcgtttggaaatatgtgaaacaaatcaagtttggaggaaatattgaggatgaggagaccatgcagcttttgtcaacacttattgatgcgattgcaacgcagagagctcgcttgccacttgccccaccaaagtacactgtgttcaaaagattaacatatctaatttgcgaagaagcgtacgaacccgagcttccggatgtgtcactgtgtcataaactgagaattggtacagacgcgagagttggagtttcgattgctattcgcacaaatctgagagccggaatcactgcatgctttgatcttggtcacacactgttcacacgtccagcctacccactggttcgtctcctctgcgacatcatcgagcacagtgttgtcctcgatgaagcctttgagatgaagtatgatgctgctctcagagcatgtaatgtttccgacgagaatcttcgagtcatgactcaaatcttgacaaaaatgacgctccagctgtcaactgaaactggcgactatgtcggtgaggacggagaagtgattgttcgtccggctccaacaatccgtaatcctggacggaatttcaagtttgtcgggctcggagctccggccgatcgatattacttcacttctgatggagttgagttgaccgtcgccgactactacctccaaaagtataacattcggcttcgctatccaaatttaccgtgtgtcctgaaaaaagcgccggaacagtgtggaaataagcattcggcgatgccgttggaactcgtcagctacatagtcgttccgacgagatacggaggatttacgatgcccgatatgagggcagatatgatcaataagactacgtatacagctcagcaacgtggaaagcttcttcaacatatcattgctcagaagtcgctgtcgggaatcgaaccgcccgtgtcgaacaacgatgattacatgaaaaagcataaacttgtcatgaaaagggagccgatcagagttaaagccacaatcctaccacctccaactctggtttatggtgattctgtattccacgatgagcatcatatcggagaatgggaagctgttactcatgatccaccgagacaagttttggatggtgctgtgtttcggagaaaactctataagtcttctgagcagccgctcatgaagcgtctcatgggctcgattcttctgattcaatcgccgagacaatgtagagatttcgattacaatcagcaaggatatcacgcaatcatgagagccatcgaagacagtggtcaaccagtgttgtgggctgacgagaataagcattcggccgtgatccagggagagctccaatttaatcaaaatcagcatggaatcgaagtaattgagcaattcctccaaaatatcaaatcgacaattggcgagtacgaacgagacggcgaagtcatcgttccgattgtttttgccgttttccaggcgagagccactgtgtattctggcaacaataatgagtataatgattataatgttctcaagtatcttgccgataacaagtatggaatccacactcaaggaattctcgagaaaagtctcggagttgttgggccttcaccaaagaattgcgccctaacccgattgatggtggaaaaagtgctcggaaaagtcggaaccactcatcgcaagcttgaacgcggcggagctcacaagacatggacaattttcacagatcccgccaagccaacgctagttctcggaatcgacgtttctcatccatcgactcgtgatcgtgagactggtaatgtacttcagaaaatgtctgcagcgaccgtcgtcggaaatattgatctagatgtcaccgaattccgagcatcttcaagaattcaggatacaggtgtcgagtgtctgatcgatttctcgaaagagatcgatgaacgaatcggagagttcatagatcacactgggaaacgtccagcacatattgttgtctatcgtgacgggctatcagagggagatttccaaaagtacctgttcgaggagcgcgtttgcattgaggaacgatgccttaaaatcgacacctcattccaaccatcaataacgtatatcgtagttaccaagcgacatcatactcaattcttcctagaagatccgagtcaaggatacgaatcacagggttacaatgtcctaccgggaactttaatcgaagacgctgttaccaccaacaagtactacgatttcttcctctccacacagatcggcaatgaaggatgtttccgtccaactcattactatgtgcttcacgatacgtggaccgggaagcccgactcgttctggccgactgtcacgcatgcgttgacctataatttctgtagatcaacgaccactgtcgcgttgccagcgccggtgttgtatgctcatttggcggcgaaacgtgccaaggagacgctggatggaatcaatacgtacaagtcagtaaataatatctactgcgacctcgaatcattcggagacctctgcgaagtcaacaaggacatgaatgtcaacgaaaagctcgaaggaatgacatttgtctaatatgtttcttaatgatttcaatcaactgttccatttttcacgttctttattatatttaccctaacaaccaacctttaatcaactaaaatgtacaagtatttcgacatcattttcccaattttctcaactattcctttacttttacactttaaattgccccgaaattgcttatttcttgttccatatttcaaatttcaaattctcggattctcacttgcccctaatcccacaaaagttttaaaatttgccacaacaataataataaacccccaagcagtt

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