LOCUS       NM_059644               3055 bp    mRNA    linear   INV 22-NOV-2023
DEFINITION  Caenorhabditis elegans Argonaute protein wago-1 (wago-1), mRNA.
ACCESSION   NM_059644
VERSION     NM_059644.8
DBLINK      BioProject: PRJNA158
KEYWORDS    RefSeq.
SOURCE      Caenorhabditis elegans
  ORGANISM  Caenorhabditis elegans
            Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
            Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
            Caenorhabditis.
REFERENCE   1  (bases 1 to 3055)
  AUTHORS   Sulson,J.E. and Waterston,R.
  CONSRTM   Caenorhabditis elegans Sequencing Consortium
  TITLE     Genome sequence of the nematode C. elegans: a platform for
            investigating biology
  JOURNAL   Science 282 (5396), 2012-2018 (1998)
   PUBMED   9851916
  REMARK    Erratum:[Science 1999 Jan 1;283(5398):35]
REFERENCE   2  (bases 1 to 3055)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (22-NOV-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 3055)
  AUTHORS   WormBase.
  CONSRTM   WormBase Consortium
  TITLE     Direct Submission
  JOURNAL   Submitted (29-OCT-2023) WormBase Group, European Bioinformatics
            Institute, Cambridge, CB10 1SA, UK. Email: help@wormbase.org
REFERENCE   4  (bases 1 to 3055)
  AUTHORS   Sulson,J.E. and Waterston,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAR-2003) Nematode Sequencing Project: Sanger
            Institute, Hinxton, Cambridge CB10 1SA, UK and The Genome Institute
            at Washington University, St. Louis, MO 63110, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by WormBase. This
            record is derived from an annotated genomic sequence (NC_003279).
            
            On Feb 2, 2021 this sequence version replaced NM_059644.7.
FEATURES             Location/Qualifiers
     source          1..3055
                     /organism="Caenorhabditis elegans"
                     /mol_type="mRNA"
                     /strain="Bristol N2"
                     /db_xref="taxon:6239"
                     /chromosome="I"
     gene            1..3055
                     /gene="wago-1"
                     /locus_tag="CELE_R06C7.1"
                     /db_xref="GeneID:172463"
                     /db_xref="WormBase:WBGene00011061"
     CDS             25..2862
                     /gene="wago-1"
                     /locus_tag="CELE_R06C7.1"
                     /standard_name="R06C7.1"
                     /note="Confirmed by transcript evidence"
                     /codon_start=1
                     /product="Argonaute protein wago-1"
                     /protein_id="NP_492045.1"
                     /db_xref="EnsemblGenomes-Gn:WBGene00011061"
                     /db_xref="EnsemblGenomes-Tr:R06C7.1"
                     /db_xref="GeneID:172463"
                     /db_xref="WormBase:WBGene00011061"
                     /translation="

MSPHPPQPHPPMPPMPPVTAPPGAMTPMPPVPADAQKLHQSTGNDACIKRLQQLNVEDGAKMYMKPTEPGKMGRPVDIQTNVFGIEVTKETTVHRFMVHAKADLTSTKEVTFTKKGKEDFVVQDRRDKCCNIFFLAVEKNPEFFKMKDGNQIVYDGQSTLYTTVNLFSELDANGTKSKVFQINGADTGNDDLKTLPCISLEIYAPRDNSITLSSENLGKRTADQNIEVNNREYTQFLELALNQHCVRETNRFGCFEHGKVYFLNATEEGFDQRDCVDVGDGKQLYPGLKKTIQFIEGPYGRGQNNPSLVIDGMKAAFHKEQTVIQKLFDITGQDPSNGLNNMTREKAAAVIKGLDCYSTYTNRKRHLRIEGIFHESATKTRFELPDGKTCSIAEYYADKYKISLQYPNANLVVCKDRGNNNYFPAELMTVSRNQRVTIPQQTGNQSQKTTKECAVLPDVRQRMIITGKNAVNITLENELLVALGIKVYSEPLMVQARELDGKELVYQRSVMSDMGKWRAPPGWFVKPATVPDLWAAYAVGNPGCRFSIGDVNQLVGMFIDSCKKKGMVIKPPCETGLYSTEKIMTQLEKVAASKCKYVLMITDDAIVHLHKQYKALEQRTMMIVQDMKISKANAVVKDGKRLTLENIINKTNVKLGGLNYTVSDAKKSMTDEQLIIGVGVSAPPAGTKYMMDNKGHLNPQIIGFASNAVANHEFVGDFVLAPSGQDTMASIEDVLQNSIDLFEKNRKALPKRIIIYRSGASEGSHASILAYEIPLARAIIHGYSKEIKLIFIVVTKEHSYRFFRDQLRSGGKATEMNIPPGIVLDNAVTNPACKQFFLNGHTTLQGTAKTPLYTVLADDCKAPMDRLEELTFTLCHHHQIVSLSTSIPTPLYVANEYAKRGRDLWGELTTKGPIEAKESQGERLKELTKEIGYKQTDLNQKRVNA"

     misc_feature    982..1314
                     /gene="wago-1"
                     /locus_tag="CELE_R06C7.1"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1123..1125,1168..1170,1198..1200,1210..1212,
                     1264..1266,1285..1287,1291..1293)
                     /gene="wago-1"
                     /locus_tag="CELE_R06C7.1"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1816..2739
                     /gene="wago-1"
                     /locus_tag="CELE_R06C7.1"
                     /note="This domain is found in the protein Piwi and its
                     relatives; Region: Piwi; smart00950"
                     /db_xref="CDD:214930"
     misc_feature    order(1852..1854,1864..1866,1897..1908,1921..1923,
                     1951..1953,1960..1962,1972..1974,1984..1986)
                     /gene="wago-1"
                     /locus_tag="CELE_R06C7.1"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:239208"
     misc_feature    order(2059..2061,2065..2067,2296..2298,2707..2709)
                     /gene="wago-1"
                     /locus_tag="CELE_R06C7.1"
                     /note="active site"
                     /db_xref="CDD:239208"
ORIGIN      

aactaatattgcaatagtaataagatgtctcctcatccaccacaaccgcatccaccgatgcctccaatgccaccagtcactgctccaccaggagctatgactccaatgcctccagttccagccgatgctcaaaagcttcaccaaagcactggcaacgacgcatgcatcaagcgtttacaacagttaaacgttgaggatggtgcgaaaatgtacatgaagccaaccgaacctggaaaaatgggcagaccagtggacatccaaaccaatgtcttcggaattgaagtcacaaaggaaaccacagttcatcgttttatggttcacgcaaaggccgatttgacttcaacaaaggaagtgactttcactaaaaaaggaaaggaggacttcgtcgttcaggatcgtcgcgataagtgttgcaacatctttttccttgcggttgagaagaacccggaattcttcaaaatgaaggatgggaatcagattgtatatgacggtcaatcaactctctacacgacggtcaacttgttctcagaactggatgccaacggtacgaagtccaaagtcttccaaatcaacggagctgataccggcaatgacgaccttaagaccctgccttgcatttctctcgagatttatgccccaagggacaactctatcacgctctcttctgaaaatctgggcaagcgtactgcggatcaaaacattgaagtaaacaatcgagaatacactcaattcttggaacttgctctgaatcaacattgcgtgagagaaacaaatcgtttcggatgcttcgagcacggaaaagtatatttcctcaacgccaccgaagaaggattcgatcaacgagactgtgtcgacgtaggagacggaaaacaactttatcctggcctcaagaagacgattcaattcatcgagggtccttatggtcgcggacagaacaatccatctctcgtgattgatggtatgaaagctgctttccacaaagagcaaactgtgatccaaaaactgttcgacatcacgggacaagatccttcaaatggactcaataatatgacccgtgagaaggctgcggcagtgattaaaggacttgattgctattcgacttataccaacagaaagcgccatctaagaatcgaaggtatctttcacgaaagtgccacaaagaccagatttgagttgcccgatggaaaaacttgttcaatcgccgagtactatgcggacaaatacaagatcagtctacagtatccgaacgccaatttggtggtttgtaaggatcgaggcaacaacaattacttcccggctgaactgatgactgtgtccagaaatcaacgtgtcaccattcctcagcaaacgggaaatcaatctcaaaagacaacgaaggagtgcgcggttcttccggatgtccgtcagcgaatgatcatcactggtaaaaatgctgtcaacattacactcgaaaacgagttgctcgtcgctcttggaatcaaggtttactcggagcctctgatggtccaagcacgtgagcttgatggaaaagaacttgtataccagagatcggtaatgtcggatatgggaaaatggcgtgcgcctccaggatggtttgtgaagcctgcgactgttcctgatttgtgggctgcttacgctgttggaaatccaggttgcagattctccattggagatgtcaaccaactcgtcggaatgttcattgattcttgcaagaagaaaggcatggtgatcaagccaccatgtgaaacaggactttacagtacggaaaaaattatgactcagctggaaaaagtggctgcgagtaagtgcaagtatgtcttgatgatcactgatgacgcaatcgttcacctccacaagcagtacaaagccttggaacagagaacaatgatgatcgtccaggatatgaaaatttccaaagccaatgccgttgtcaaagatgggaagagattgacgttggagaacatcatcaacaaaactaacgtgaagttaggtggtcttaactacactgtttcggatgcaaagaagagcatgaccgacgaacaattgatcatcggagttggcgtttccgcaccaccggctggaacgaagtacatgatggataacaagggacatcttaatccacaaatcattggcttcgcttcaaatgctgttgcaaatcacgagtttgtcggcgatttcgttttggctccctccggacaggacacaatggcatcaattgaagacgtgttgcaaaattcaatcgatttgttcgaaaagaaccgcaaagcgttgccaaaaagaatcatcatttatagaagtggtgcatcggagggttctcacgcttctattctggcttatgaaatcccattagcccgagctattatccatggttactcgaaagaaatcaaattgattttcatcgtcgtcactaaggagcacagttaccgattcttccgtgatcagcttcgttcgggcggcaaagccactgaaatgaatattcctccgggcattgtcttggataacgctgtcacgaatccggcatgtaagcagttcttcctgaacggtcacacgactcttcaaggaacagcaaagacaccattgtacactgttcttgctgacgactgcaaagctccaatggaccgcctggaggagctgaccttcactttgtgtcatcatcaccaaattgtttccctgagcacgtcgattcccactccactttatgtggcaaatgagtatgcaaagcgtggaagagatctctggggtgaactaacgactaaaggaccaattgaagcaaaggagtcgcaaggcgagcgcctcaaggaacttacaaaggaaatcggctacaaacaaaccgatctcaatcagaagcgcgtcaatgcatagatttggagctatgccacatacacttgatgttttacctaggataataattttacggtcacctaggataataattttacggtttttccgctagttttattgtaattttttagtcaaatgttttatatttttgtaatgtggttctgtgtgacccgtagtaattaaactcggtatgataaaagttttaggctgataa

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