LOCUS       NM_001377565            1527 bp    mRNA    linear   INV 22-NOV-2023
DEFINITION  Caenorhabditis elegans Protein kinase domain-containing protein
            (prk-1), partial mRNA.
ACCESSION   NM_001377565
VERSION     NM_001377565.2
DBLINK      BioProject: PRJNA158
KEYWORDS    RefSeq.
SOURCE      Caenorhabditis elegans
  ORGANISM  Caenorhabditis elegans
            Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
            Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
            Caenorhabditis.
REFERENCE   1  (bases 1 to 1527)
  AUTHORS   Sulson,J.E. and Waterston,R.
  CONSRTM   Caenorhabditis elegans Sequencing Consortium
  TITLE     Genome sequence of the nematode C. elegans: a platform for
            investigating biology
  JOURNAL   Science 282 (5396), 2012-2018 (1998)
   PUBMED   9851916
  REMARK    Erratum:[Science 1999 Jan 1;283(5398):35]
REFERENCE   2  (bases 1 to 1527)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (22-NOV-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 1527)
  AUTHORS   WormBase.
  CONSRTM   WormBase Consortium
  TITLE     Direct Submission
  JOURNAL   Submitted (29-OCT-2023) WormBase Group, European Bioinformatics
            Institute, Cambridge, CB10 1SA, UK. Email: help@wormbase.org
REFERENCE   4  (bases 1 to 1527)
  AUTHORS   Sulson,J.E. and Waterston,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAR-2003) Nematode Sequencing Project: Sanger
            Institute, Hinxton, Cambridge CB10 1SA, UK and The Genome Institute
            at Washington University, St. Louis, MO 63110, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by WormBase. This
            record is derived from an annotated genomic sequence (NC_003281).
            
            On May 27, 2020 this sequence version replaced NM_001377565.1.
            COMPLETENESS: incomplete on the 5' end.
FEATURES             Location/Qualifiers
     source          1..1527
                     /organism="Caenorhabditis elegans"
                     /mol_type="mRNA"
                     /strain="Bristol N2"
                     /db_xref="taxon:6239"
                     /chromosome="III"
     gene            <1..1527
                     /gene="prk-1"
                     /locus_tag="CELE_C06E8.3"
                     /db_xref="GeneID:175980"
                     /db_xref="WormBase:WBGene00004182"
     CDS             1..1137
                     /gene="prk-1"
                     /locus_tag="CELE_C06E8.3"
                     /standard_name="C06E8.3c"
                     /note="Confirmed by transcript evidence"
                     /codon_start=1
                     /product="Protein kinase domain-containing protein"
                     /protein_id="NP_001364691.1"
                     /db_xref="EnsemblGenomes-Gn:WBGene00004182"
                     /db_xref="EnsemblGenomes-Tr:C06E8.3c"
                     /db_xref="GeneID:175980"
                     /db_xref="GOA:Q8T3F1"
                     /db_xref="InterPro:IPR000719"
                     /db_xref="InterPro:IPR008271"
                     /db_xref="InterPro:IPR011009"
                     /db_xref="InterPro:IPR017348"
                     /db_xref="InterPro:IPR017441"
                     /db_xref="UniProtKB/TrEMBL:Q8T3F1"
                     /db_xref="WormBase:WBGene00004182"
                     /translation="

MIKRKLQDLAVCCSYQVDFLHEKKHSVKEFKRKYEVLDEIGRGGFGIVYEATTRQDGQQPVAVKFVQHKHVRSWTMTCRQLIPSEVCHLETCEDIPGVIKILDWFANSKGFLIVMERPANCMDLFDMVSVHGPLNEDMGKFIFKQVITTVFNMYSKHGLLHRDIKDENLIVNMNTGEVKLVDFGATAYAEKATKKEFQGTRSYCPPEWFRDQLYLPLEATSWSLGVLLFILLTGKLPFRNEIQICLGNVKFPPDLSKEVCQLVKSCLTTSTSARASLAQIAAHPWMETDKPFFGGDLTFEEALMEIKNPPVVIEDKEAEEEDNDLNDVVILTRSRESRTDLDAESICTMVTAVEDRYEPSIAVKELEQEEIVETAIDS"

     misc_feature    97..858
                     /gene="prk-1"
                     /locus_tag="CELE_C06E8.3"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Proviral Integration Moloney virus (PIM) kinase; Region:
                     STKc_PIM; cd14005"
                     /db_xref="CDD:270907"
     misc_feature    order(118..132,142..144,184..186,190..192,295..297,
                     343..354,367..369,373..378,382..387,487..489,493..504,
                     508..510,544..546,592..600,604..606,688..690,700..708,
                     715..717)
                     /gene="prk-1"
                     /locus_tag="CELE_C06E8.3"
                     /note="active site"
                     /db_xref="CDD:270907"
     misc_feature    order(118..132,142..144,184..186,190..192,295..297,
                     343..354,367..369,487..489,493..495,499..504,508..510,
                     544..546)
                     /gene="prk-1"
                     /locus_tag="CELE_C06E8.3"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270907"
     misc_feature    order(367..369,373..378,382..387,487..489,493..501,
                     592..600,604..606,688..690,700..708,715..717)
                     /gene="prk-1"
                     /locus_tag="CELE_C06E8.3"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270907"
     misc_feature    order(541..573,580..606)
                     /gene="prk-1"
                     /locus_tag="CELE_C06E8.3"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270907"
ORIGIN      

atgatcaaacgaaaattacaagatttagccgtatgctgctcgtaccaagtggatttcctacacgagaaaaaacattcggtaaaagagttcaaacggaaatacgaagtattagatgaaattggacgtggtggattcggaatagtgtatgaagcaacaactcgacaggatggacaacagccagttgccgttaaatttgtgcaacataaacatgtcagaagctggacaatgacatgccggcaactaattccttcagaagtatgtcatttggagacgtgcgaagacattccaggtgtgataaaaatcctcgattggtttgcaaattcaaaaggttttctaatcgtgatggagcgaccggccaattgtatggatctgttcgatatggtttctgtacatggtccactcaacgaggatatggggaaatttatatttaagcaggtaatcacaacggttttcaatatgtacagtaagcacggacttctgcatcgagatattaaagatgagaatttgattgtgaatatgaatacaggagaagtgaaattggtcgatttcggagcaacagcatacgcggaaaaggccacgaaaaaagaatttcagggcactcggtcatactgccctccagaatggttccgtgatcaactttatcttccactcgaagccacatcctggtctctcggagttctactcttcatccttctaaccggaaaactcccattccgcaacgagattcaaatctgtcttggaaatgtcaaatttccacctgatctctcaaaagaagtgtgtcaactcgtcaaaagttgcctgacaacttctacgtctgcacgtgcatctttagcacagatagctgctcatccatggatggagactgataaaccattttttggtggagacttgacttttgaggaagctcttatggaaatcaaaaatcctcctgtagtgatcgaagacaaagaagctgaggaagaggataatgatctcaacgatgtagtgattctgacgagaagccgtgaaagtcgaactgatttggatgcagaaagtatttgtacaatggtcactgctgttgaagatcgatatgagccatcgattgctgtcaaagagttggagcaagaagagattgttgagacagccattgattcctgagacgtcgtcagcaacgtgtcagtcaacatacagtaatgatgaagatgtgacaatatcggaaaaagttgtatcaccagctcagccactgccaccacctctgtcccctcggaaaggaagccttcaatgcttcgaatcagtaccaagatctcgagattctgttatcagaatgtcacgtcatcgtccacttcaatttgcaattgattcatcatcaccaccgccagctcttgccatttttcaagtcagcccaacagcatctgttggttgattttcgacatttttctttgtgaatttttcttatatagaagggtaaaatcgggtcaatcatttccacttgtacagcacctcttctatgggttttaaaagtttcgtttccttcttgaaaaatgaatt

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