LOCUS       NM_001276777            2087 bp    mRNA    linear   INV 22-NOV-2023
DEFINITION  Caenorhabditis elegans Protein kinase domain-containing protein
            (prk-1), mRNA.
ACCESSION   NM_001276777
VERSION     NM_001276777.4
DBLINK      BioProject: PRJNA158
KEYWORDS    RefSeq.
SOURCE      Caenorhabditis elegans
  ORGANISM  Caenorhabditis elegans
            Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
            Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
            Caenorhabditis.
REFERENCE   1  (bases 1 to 2087)
  AUTHORS   Sulson,J.E. and Waterston,R.
  CONSRTM   Caenorhabditis elegans Sequencing Consortium
  TITLE     Genome sequence of the nematode C. elegans: a platform for
            investigating biology
  JOURNAL   Science 282 (5396), 2012-2018 (1998)
   PUBMED   9851916
  REMARK    Erratum:[Science 1999 Jan 1;283(5398):35]
REFERENCE   2  (bases 1 to 2087)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (22-NOV-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 2087)
  AUTHORS   WormBase.
  CONSRTM   WormBase Consortium
  TITLE     Direct Submission
  JOURNAL   Submitted (29-OCT-2023) WormBase Group, European Bioinformatics
            Institute, Cambridge, CB10 1SA, UK. Email: help@wormbase.org
REFERENCE   4  (bases 1 to 2087)
  AUTHORS   Sulson,J.E. and Waterston,R.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-MAR-2003) Nematode Sequencing Project: Sanger
            Institute, Hinxton, Cambridge CB10 1SA, UK and The Genome Institute
            at Washington University, St. Louis, MO 63110, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by WormBase. This
            record is derived from an annotated genomic sequence (NC_003281).
            
            On Feb 2, 2021 this sequence version replaced NM_001276777.3.
FEATURES             Location/Qualifiers
     source          1..2087
                     /organism="Caenorhabditis elegans"
                     /mol_type="mRNA"
                     /strain="Bristol N2"
                     /db_xref="taxon:6239"
                     /chromosome="III"
     gene            1..2087
                     /gene="prk-1"
                     /locus_tag="CELE_C06E8.3"
                     /db_xref="GeneID:175980"
                     /db_xref="WormBase:WBGene00004182"
     CDS             189..1958
                     /gene="prk-1"
                     /locus_tag="CELE_C06E8.3"
                     /standard_name="C06E8.3d"
                     /note="Confirmed by transcript evidence"
                     /codon_start=1
                     /product="Protein kinase domain-containing protein"
                     /protein_id="NP_001263706.1"
                     /db_xref="EnsemblGenomes-Gn:WBGene00004182"
                     /db_xref="GeneID:175980"
                     /db_xref="GOA:K8ESD7"
                     /db_xref="InterPro:IPR000719"
                     /db_xref="InterPro:IPR008271"
                     /db_xref="InterPro:IPR011009"
                     /db_xref="InterPro:IPR017441"
                     /db_xref="UniProtKB/TrEMBL:K8ESD7"
                     /db_xref="WormBase:WBGene00004182"
                     /translation="

MTRAPGDAGAVRRQRLWLYESVRMIKRKLQDLAVCCSYQVDFLHEKKHSVKEFKRKYEVLDEIGRGGFGIVYEATTRQDGQQPVAVKFVQHKHVRSWTMTCRQLIPSEVCHLETCEDIPGVIKILDWFANSKGFLIVMERPANCMDLFDMVSVHGPLNEDMGKFIFKQVITTVFNMYSKHGLLHRDIKDENLIVNMNTGEVKLVDFGATAYAEKATKKEFQGTRSYCPPEWFRDQLYLPLEATSWSLGVLLFILLTGKLPFRNEIQICLGNVKFPPDLSKEVCQLVKSCLTTSTSARASLAQIAAHPWMETDKPFFGGDLTFEEALMEIKNPPVVIEDKEAEEEDNDLNDVVILTRSRESRTDLDAESICTMVTAVEDRYEPSIAVKELEQEEIVETGETTNLMRSESRYDNISSSSFCDYVSLVSSSYDDQFTSTSDIYQSACEVFPHTGSSSSLSRSMGAVKSASAYNLVRMRKKSSIFKSFDTELDPVSENDHQPLIPETSSATCQSTYSNDEDVTISEKVVSPAQPLPPPLSPRKGSLQCFESVPRSRDSVIRMSRHRPLQFAIDSSSPPPALAIFQVSPTASVG"

     misc_feature    354..1115
                     /gene="prk-1"
                     /locus_tag="CELE_C06E8.3"
                     /note="Catalytic domain of the Serine/Threonine kinase,
                     Proviral Integration Moloney virus (PIM) kinase; Region:
                     STKc_PIM; cd14005"
                     /db_xref="CDD:270907"
     misc_feature    order(375..389,399..401,441..443,447..449,552..554,
                     600..611,624..626,630..635,639..644,744..746,750..761,
                     765..767,801..803,849..857,861..863,945..947,957..965,
                     972..974)
                     /gene="prk-1"
                     /locus_tag="CELE_C06E8.3"
                     /note="active site"
                     /db_xref="CDD:270907"
     misc_feature    order(375..389,399..401,441..443,447..449,552..554,
                     600..611,624..626,744..746,750..752,756..761,765..767,
                     801..803)
                     /gene="prk-1"
                     /locus_tag="CELE_C06E8.3"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270907"
     misc_feature    order(624..626,630..635,639..644,744..746,750..758,
                     849..857,861..863,945..947,957..965,972..974)
                     /gene="prk-1"
                     /locus_tag="CELE_C06E8.3"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270907"
     misc_feature    order(798..830,837..863)
                     /gene="prk-1"
                     /locus_tag="CELE_C06E8.3"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270907"
ORIGIN      

catttttcaataaggaacacactaaaaactcttaaatctctgaaactttttatttctggaataccaccacaattcctgaattgtgctagaaaacaattgccatcagaggtacacaaaagtgttttccattttcttatttcattaaatcctggctactgttgcttaattttaattaaaactattccaatatgacacgagcaccaggagacgctggagctgttagaaggcaaagattgtggctttacgagtccgtcagaatgatcaaacgaaaattacaagatttagccgtatgctgctcgtaccaagtggatttcctacacgagaaaaaacattcggtaaaagagttcaaacggaaatacgaagtattagatgaaattggacgtggtggattcggaatagtgtatgaagcaacaactcgacaggatggacaacagccagttgccgttaaatttgtgcaacataaacatgtcagaagctggacaatgacatgccggcaactaattccttcagaagtatgtcatttggagacgtgcgaagacattccaggtgtgataaaaatcctcgattggtttgcaaattcaaaaggttttctaatcgtgatggagcgaccggccaattgtatggatctgttcgatatggtttctgtacatggtccactcaacgaggatatggggaaatttatatttaagcaggtaatcacaacggttttcaatatgtacagtaagcacggacttctgcatcgagatattaaagatgagaatttgattgtgaatatgaatacaggagaagtgaaattggtcgatttcggagcaacagcatacgcggaaaaggccacgaaaaaagaatttcagggcactcggtcatactgccctccagaatggttccgtgatcaactttatcttccactcgaagccacatcctggtctctcggagttctactcttcatccttctaaccggaaaactcccattccgcaacgagattcaaatctgtcttggaaatgtcaaatttccacctgatctctcaaaagaagtgtgtcaactcgtcaaaagttgcctgacaacttctacgtctgcacgtgcatctttagcacagatagctgctcatccatggatggagactgataaaccattttttggtggagacttgacttttgaggaagctcttatggaaatcaaaaatcctcctgtagtgatcgaagacaaagaagctgaggaagaggataatgatctcaacgatgtagtgattctgacgagaagccgtgaaagtcgaactgatttggatgcagaaagtatttgtacaatggtcactgctgttgaagatcgatatgagccatcgattgctgtcaaagagttggagcaagaagagattgttgagacaggcgaaacgacgaatcttatgcgtagcgaatctcgttacgacaatatttcatcgtcctctttctgcgattatgtctcattggtctcctcatcatacgacgatcaattcacttcgacttctgatatctaccaatcggcttgtgaagtgttcccacacacaggctcgtcatcctcactgagcagaagcatgggagcagtcaaatcagcatccgcctataatttagttcggatgcgaaagaaatcgagtattttcaaatcatttgacacagaactcgatccagtttctgaaaacgatcatcaaccattgattcctgagacgtcgtcagcaacgtgtcagtcaacatacagtaatgatgaagatgtgacaatatcggaaaaagttgtatcaccagctcagccactgccaccacctctgtcccctcggaaaggaagccttcaatgcttcgaatcagtaccaagatctcgagattctgttatcagaatgtcacgtcatcgtccacttcaatttgcaattgattcatcatcaccaccgccagctcttgccatttttcaagtcagcccaacagcatctgttggttgattttcgacatttttctttgtgaatttttcttatatagaagggtaaaatcgggtcaatcatttccacttgtacagcacctcttctatgggttttaaaagtttcgtttccttcttgaaaaatgaattgttt

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