LOCUS       NM_128262               3236 bp    mRNA    linear   PLN 20-OCT-2022
DEFINITION  Arabidopsis thaliana Argonaute family protein (AGO4), mRNA.
ACCESSION   NM_128262
VERSION     NM_128262.4
DBLINK      BioProject: PRJNA116
            BioSample: SAMN03081427
KEYWORDS    RefSeq.
SOURCE      Arabidopsis thaliana (thale cress)
  ORGANISM  Arabidopsis thaliana
            Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
            Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
            Pentapetalae; rosids; malvids; Brassicales; Brassicaceae;
            Camelineae; Arabidopsis.
REFERENCE   1  (bases 1 to 3236)
  AUTHORS   Lin,X., Kaul,S., Rounsley,S., Shea,T.P., Benito,M.I., Town,C.D.,
            Fujii,C.Y., Mason,T., Bowman,C.L., Barnstead,M., Feldblyum,T.V.,
            Buell,C.R., Ketchum,K.A., Lee,J., Ronning,C.M., Koo,H.L.,
            Moffat,K.S., Cronin,L.A., Shen,M., Pai,G., Van Aken,S., Umayam,L.,
            Tallon,L.J., Gill,J.E., Adams,M.D., Carrera,A.J., Creasy,T.H.,
            Goodman,H.M., Somerville,C.R., Copenhaver,G.P., Preuss,D.,
            Nierman,W.C., White,O., Eisen,J.A., Salzberg,S.L., Fraser,C.M. and
            Venter,J.C.
  TITLE     Sequence and analysis of chromosome 2 of the plant Arabidopsis
            thaliana
  JOURNAL   Nature 402 (6763), 761-768 (1999)
   PUBMED   10617197
REFERENCE   2  (bases 1 to 3236)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 3236)
  AUTHORS   Krishnakumar,V., Cheng,C.-Y., Chan,A.P., Schobel,S., Kim,M.,
            Ferlanti,E.S., Belyaeva,I., Rosen,B.D., Micklem,G., Miller,J.R.,
            Vaughn,M. and Town,C.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-MAY-2016) Plant Genomics, J. Craig Venter Institute,
            9704 Medical Center Dr, Rockville, MD 20850, USA
  REMARK    Protein update by submitter
REFERENCE   4  (bases 1 to 3236)
  AUTHORS   Swarbreck,D., Lamesch,P., Wilks,C. and Huala,E.
  CONSRTM   TAIR
  TITLE     Direct Submission
  JOURNAL   Submitted (18-FEB-2011) Department of Plant Biology, Carnegie
            Institution, 260 Panama Street, Stanford, CA, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by TAIR and Araport.
            This record is derived from an annotated genomic sequence
            (NC_003071).
            
            On Sep 12, 2016 this sequence version replaced NM_128262.3.
FEATURES             Location/Qualifiers
     source          1..3236
                     /organism="Arabidopsis thaliana"
                     /mol_type="mRNA"
                     /db_xref="taxon:3702"
                     /chromosome="2"
                     /ecotype="Columbia"
     gene            1..3236
                     /gene="AGO4"
                     /locus_tag="AT2G27040"
                     /gene_synonym="ARGONAUTE 4; OCP11; OVEREXPRESSOR OF
                     CATIONIC PEROXIDASE 11; T20P8.9; T20P8_9"
                     /note="AGO4 is a member of a class of PAZ/PIWI domain
                     containing proteins involved in siRNA mediated gene
                     silencing.Loss of function mutations have reduced site
                     specific CpNpG and CpHpH methylation and increased
                     susceptibility to bacterial pathogens."
                     /db_xref="Araport:AT2G27040"
                     /db_xref="GeneID:817246"
                     /db_xref="TAIR:AT2G27040"
     CDS             169..2943
                     /gene="AGO4"
                     /locus_tag="AT2G27040"
                     /gene_synonym="ARGONAUTE 4; OCP11; OVEREXPRESSOR OF
                     CATIONIC PEROXIDASE 11; T20P8.9; T20P8_9"
                     /inference="Similar to RNA sequence,
                     EST:INSD:AV524024.1,INSD:ES152697.1,INSD:ES165255.1,
                     INSD:ES133755.1,INSD:BP836492.1,INSD:ES128005.1,
                     INSD:EG496003.1,INSD:ES028114.1,INSD:ES105851.1,
                     INSD:AV803019.1,INSD:BP641212.1,INSD:ES195973.1,
                     INSD:AV827605.1,INSD:ES139270.1,INSD:ES029852.1,
                     INSD:BP822027.1,INSD:ES026264.1,INSD:ES167458.1,
                     INSD:ES135001.1,INSD:EL975056.1,INSD:ES003174.1,
                     INSD:EL972164.1,INSD:BP823321.1,INSD:BE525238.1,
                     INSD:ES065981.1,INSD:DR368741.1,INSD:ES021852.1,
                     INSD:AV523023.1,INSD:ES048233.1,INSD:BP793913.1,
                     INSD:ES017896.1,INSD:EL188648.1,INSD:ES048628.1,
                     INSD:AV523440.1,INSD:BP789382.1,INSD:ES201121.1,
                     INSD:AV814348.1,INSD:ES187902.1,INSD:ES131706.1,
                     INSD:ES170037.1,INSD:BP784806.1,INSD:ES200647.1,
                     INSD:ES077186.1,INSD:BP779380.1,INSD:AV546094.1,
                     INSD:EL983819.1,INSD:ES169316.1,INSD:BP859416.1,
                     INSD:ES080130.1,INSD:AV529826.1,INSD:AV529113.1,
                     INSD:ES084670.1,INSD:EL969377.1,INSD:ES105771.1,
                     INSD:ES008762.1,INSD:AV523915.1,INSD:EL983340.1,
                     INSD:BE529725.1,INSD:ES199854.1,INSD:BP862456.1,
                     INSD:CB255015.1,INSD:AV543687.1,INSD:ES203279.1,
                     INSD:T21581.1,INSD:BP831223.2,INSD:ES141314.1,
                     INSD:ES085388.1,INSD:EH894144.1,INSD:ES111514.1,
                     INSD:AV529680.1,INSD:BE528457.1,INSD:ES081488.1,
                     INSD:ES158232.1,INSD:ES116988.1,INSD:ES035121.1,
                     INSD:ES018335.1,INSD:ES128331.1,INSD:BP793414.1,
                     INSD:ES141653.1,INSD:ES158151.1,INSD:EL997924.1,
                     INSD:EL216941.1,INSD:ES073692.1,INSD:EL210667.1,
                     INSD:ES188195.1,INSD:BP790393.1,INSD:ES059089.1,
                     INSD:BP821303.1,INSD:EG496009.1,INSD:ES205510.1,
                     INSD:AV547418.1,INSD:ES001141.1,INSD:EL170323.1,
                     INSD:ES166352.1,INSD:ES009496.1,INSD:EL095981.1"
                     /inference="similar to RNA sequence,
                     mRNA:INSD:AY051033.1,INSD:BX820023.1,INSD:AY035081.1"
                     /note="ARGONAUTE 4 (AGO4); FUNCTIONS IN: siRNA binding;
                     INVOLVED IN: in 6 processes; LOCATED IN: nuclear
                     euchromatin, nucleolus, Cajal body; EXPRESSED IN: 24 plant
                     structures; EXPRESSED DURING: 13 growth stages; CONTAINS
                     InterPro DOMAIN/s: Domain of unknown function DUF1785
                     (InterPro:IPR014811), Stem cell self-renewal protein Piwi
                     (InterPro:IPR003165), Argonaute/Dicer protein, PAZ
                     (InterPro:IPR003100), Polynucleotidyl transferase,
                     ribonuclease H fold (InterPro:IPR012337); BEST Arabidopsis
                     thaliana protein match is: Argonaute family protein
                     (TAIR:AT5G21150.1); Has 1929 Blast hits to 1875 proteins
                     in 205 species: Archae - 0; Bacteria - 0; Metazoa - 1009;
                     Fungi - 290; Plants - 478; Viruses - 0; Other Eukaryotes -
                     152 (source: NCBI BLink)."
                     /codon_start=1
                     /product="Argonaute family protein"
                     /protein_id="NP_565633.1"
                     /db_xref="Araport:AT2G27040"
                     /db_xref="GeneID:817246"
                     /db_xref="TAIR:AT2G27040"
                     /translation="

MDSTNGNGADLESANGANGSGVTEALPPPPPVIPPNVEPVRVKTELAEKKGPVRVPMARKGFGTRGQKIPLLTNHFKVDVANLQGHFFHYSVALFYDDGRPVEQKGVGRKILDKVHQTYHSDLDGKEFAYDGEKTLFTYGALPSNKMDFSVVLEEVSATRANGNGSPNGNESPSDGDRKRLRRPNRSKNFRVEISYAAKIPLQALANAMRGQESENSQEAIRVLDIILRQHAARQGCLLVRQSFFHNDPTNCEPVGGNILGCRGFHSSFRTTQGGMSLNMDVTTTMIIKPGPVVDFLIANQNARDPYSIDWSKAKRTLKNLRVKVSPSGQEFKITGLSDKPCREQTFELKKRNPNENGEFETTEVTVADYFRDTRHIDLQYSADLPCINVGKPKRPTYIPLELCALVPLQRYTKALTTFQRSALVEKSRQKPQERMTVLSKALKVSNYDAEPLLRSCGISISSNFTQVEGRVLPAPKLKMGCGSETFPRNGRWNFNNKEFVEPTKIQRWVVVNFSARCNVRQVVDDLIKIGGSKGIEIASPFQVFEEGNQFRRAPPMIRVENMFKDIQSKLPGVPQFILCVLPDKKNSDLYGPWKKKNLTEFGIVTQCMAPTRQPNDQYLTNLLLKINAKLGGLNSMLSVERTPAFTVISKVPTIILGMDVSHGSPGQSDVPSIAAVVSSREWPLISKYRASVRTQPSKAEMIESLVKKNGTEDDGIIKELLVDFYTSSNKRKPEHIIIFRDGVSESQFNQVLNIELDQIIEACKLLDANWNPKFLLLVAQKNHHTKFFQPTSPENVPPGTIIDNKICHPKNNDFYLCAHAGMIGTTRPTHYHVLYDEIGFSADELQELVHSLSYVYQRSTSAISVVAPICYAHLAAAQLGTFMKFEDQSETSSSHGGITAPGPISVAQLPRLKDNVANSMFFC"

     misc_feature    301..2940
                     /gene="AGO4"
                     /locus_tag="AT2G27040"
                     /gene_synonym="ARGONAUTE 4; OCP11; OVEREXPRESSOR OF
                     CATIONIC PEROXIDASE 11; T20P8.9; T20P8_9"
                     /note="protein argonaute; Provisional; Region: PLN03202"
                     /db_xref="CDD:215631"
ORIGIN      

ctcgatttatgctactgtcactgaaccattttcctctcaggtcggagctaaattttgagagtaaaataaaaaagcaaaagagagaaattgaaaaaaaaagaaagaaaaataatcctctcttgtttcggctagggtttcgtttttgtttcatcgataaactcaaaggagatggattcaacaaatggtaacggagctgatcttgaatcagcaaatggggcaaacgggagtggggttactgaggcattaccacctcctccaccagttatacctccaaatgtggaaccagttcgtgttaaaactgaacttgctgagaagaaggggccagttcgagttcctatggctcgaaaaggatttggaacaaggggccaaaagatccccttgttaacaaatcatttcaaagtcgatgtggctaatcttcagggtcatttcttccactacagtgtggctctattctatgatgatggtcgtcctgttgaacaaaagggtgttggaagaaaaatccttgacaaggtgcatcagacttaccattctgatctggatggtaaagagtttgcttatgacggtgagaagacgttgtttacatatggagctttgcctagtaacaagatggatttttctgtggtgcttgaggaagtatctgctacaagggctaatggaaacggaagccccaatgggaatgaaagtccaagtgatggtgataggaaaagactgcgtaggcctaaccggtccaaaaactttagagtggagatcagctatgcggccaaaattcctcttcaagctcttgctaatgcaatgcggggacaagaatcagagaattcccaggaggcaatacgggttcttgatatcatattgaggcaacatgctgctagacaaggttgcttgcttgttcgacagtcttttttccacaatgatccaaccaactgtgaaccagttggtggtaacatcttaggatgtaggggatttcactccagtttcagaacaacgcagggtggcatgtcacttaatatggatgttacaaccaccatgatcatcaagcctggtccagtggttgatttcctaattgctaaccaaaatgctagggacccttattcgattgactggtctaaggctaaacgaacccttaagaacctaagggtaaaggtcagcccctcaggccaagaattcaagataaccggattgagtgacaagccttgcagggaacaaacgtttgaattgaagaaaaggaacccaaatgaaaatggagagttcgaaactactgaagttacagttgctgactacttccgcgatacaaggcatattgatttgcaatattctgcggatttgccttgcatcaatgttgggaagccaaagcgacccacttacattcctctcgagctctgcgcgttggttccacttcagaggtacacaaaagcacttaccacgttccaaagatctgcccttgttgagaaatccagacagaaaccccaagagaggatgactgttctgtccaaagctctgaaagttagcaactatgatgcggaaccactcctgcgatcctgtggcatttcgatcagctccaactttactcaggtggagggtcgtgttctaccagctcccaagctgaaaatgggatgtggatctgaaacctttcccagaaatggtcgctggaacttcaacaacaaggaatttgttgagcccaccaaaattcaacgatgggttgttgtcaatttctctgctcgctgtaatgtacgtcaagttgttgatgatctgataaaaattggaggatcaaaaggaattgaaattgcttctccctttcaagtgtttgaggagggtaatcaattccgccgtgctcctcctatgattcgtgttgagaacatgtttaaggacatccaatcgaaactccctggtgtcccacaattcatactatgtgtgctccctgacaaaaagaacagtgatctctatggtccatggaagaaaaaaaacttaactgaatttggcattgttactcaatgcatggctccaacgcggcaacctaatgatcagtatcttactaacttacttctgaagattaatgcaaagcttggaggcctgaactcaatgttaagtgtagagcgtacacctgcgttcactgtgatttctaaggttccaaccattatccttgggatggatgtttcacatggatctcctggacagtctgatgtcccgtccatcgctgctgtggtgagttctagggagtggccactgatatccaaatatagagcatctgttcggacacagccttctaaggctgagatgattgagtcccttgtcaagaaaaatggaactgaagacgatggcattatcaaggagttgctggtagatttctacaccagctcgaataagagaaaaccagagcatatcataattttcagggatggtgtgagtgaatctcaattcaatcaggttctgaatattgaacttgatcagatcatcgaggcttgcaagctcttagacgcaaattggaacccaaagttccttttgttggtggctcaaaagaatcatcataccaagttcttccagccaacgtctcctgaaaatgttcctccagggacaatcattgacaacaaaatatgtcacccaaagaacaatgatttctacctctgtgctcacgctggaatgattggaactacccgcccaactcactaccacgtcctgtatgatgagattggtttttcagctgacgaacttcaggaacttgtccactcgctctcctatgtgtaccaaagaagcaccagtgccatttctgttgttgcgccgatctgctatgctcacttggcagctgctcagcttgggacgttcatgaagtttgaagatcagtctgagacatcatcaagccatggtggtatcacagctccaggaccaatctctgttgcacagctcccaagactcaaagacaacgtcgccaactccatgttcttctgttaaatgagcagccctacttggctcagtaagtaagtagtagttcaataggctatctgactttcagcttaggatctctctcggccttgaagccaggcatcgacactaaggcttggaatgttttttgtgactattatcgccagccttgtttgcctgttggggtttgaatatgcttttgtcccccttaacaattcggttgtttaattaaagacttattgtagtgaatatctaagttcaggaagttacccttttgtctaaatcgttcttgcattggaaacagactacatacataacctaga

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