LOCUS       NM_102866               3602 bp    mRNA    linear   PLN 20-OCT-2022
DEFINITION  Arabidopsis thaliana Argonaute family protein (AGO2), mRNA.
ACCESSION   NM_102866
VERSION     NM_102866.3
DBLINK      BioProject: PRJNA116
            BioSample: SAMN03081427
KEYWORDS    RefSeq.
SOURCE      Arabidopsis thaliana (thale cress)
  ORGANISM  Arabidopsis thaliana
            Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
            Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
            Pentapetalae; rosids; malvids; Brassicales; Brassicaceae;
            Camelineae; Arabidopsis.
REFERENCE   1  (bases 1 to 3602)
  AUTHORS   Theologis,A., Ecker,J.R., Palm,C.J., Federspiel,N.A., Kaul,S.,
            White,O., Alonso,J., Altafi,H., Araujo,R., Bowman,C.L.,
            Brooks,S.Y., Buehler,E., Chan,A., Chao,Q., Chen,H., Cheuk,R.F.,
            Chin,C.W., Chung,M.K., Conn,L., Conway,A.B., Conway,A.R.,
            Creasy,T.H., Dewar,K., Dunn,P., Etgu,P., Feldblyum,T.V., Feng,J.,
            Fong,B., Fujii,C.Y., Gill,J.E., Goldsmith,A.D., Haas,B.,
            Hansen,N.F., Hughes,B., Huizar,L., Hunter,J.L., Jenkins,J.,
            Johnson-Hopson,C., Khan,S., Khaykin,E., Kim,C.J., Koo,H.L.,
            Kremenetskaia,I., Kurtz,D.B., Kwan,A., Lam,B., Langin-Hooper,S.,
            Lee,A., Lee,J.M., Lenz,C.A., Li,J.H., Li,Y., Lin,X., Liu,S.X.,
            Liu,Z.A., Luros,J.S., Maiti,R., Marziali,A., Militscher,J.,
            Miranda,M., Nguyen,M., Nierman,W.C., Osborne,B.I., Pai,G.,
            Peterson,J., Pham,P.K., Rizzo,M., Rooney,T., Rowley,D., Sakano,H.,
            Salzberg,S.L., Schwartz,J.R., Shinn,P., Southwick,A.M., Sun,H.,
            Tallon,L.J., Tambunga,G., Toriumi,M.J., Town,C.D., Utterback,T.,
            Van Aken,S., Vaysberg,M., Vysotskaia,V.S., Walker,M., Wu,D., Yu,G.,
            Fraser,C.M., Venter,J.C. and Davis,R.W.
  TITLE     Sequence and analysis of chromosome 1 of the plant Arabidopsis
            thaliana
  JOURNAL   Nature 408 (6814), 816-820 (2000)
   PUBMED   11130712
REFERENCE   2  (bases 1 to 3602)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 3602)
  AUTHORS   Krishnakumar,V., Cheng,C.-Y., Chan,A.P., Schobel,S., Kim,M.,
            Ferlanti,E.S., Belyaeva,I., Rosen,B.D., Micklem,G., Miller,J.R.,
            Vaughn,M. and Town,C.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-JUL-2017) Plant Genomics, J. Craig Venter Institute,
            9704 Medical Center Dr, Rockville, MD 20850, USA
  REMARK    Protein update by submitter
REFERENCE   4  (bases 1 to 3602)
  AUTHORS   Krishnakumar,V., Cheng,C.-Y., Chan,A.P., Schobel,S., Kim,M.,
            Ferlanti,E.S., Belyaeva,I., Rosen,B.D., Micklem,G., Miller,J.R.,
            Vaughn,M. and Town,C.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-MAY-2016) Plant Genomics, J. Craig Venter Institute,
            9704 Medical Center Dr, Rockville, MD 20850, USA
  REMARK    Protein update by submitter
REFERENCE   5  (bases 1 to 3602)
  AUTHORS   Swarbreck,D., Lamesch,P., Wilks,C. and Huala,E.
  CONSRTM   TAIR
  TITLE     Direct Submission
  JOURNAL   Submitted (18-FEB-2011) Department of Plant Biology, Carnegie
            Institution, 260 Panama Street, Stanford, CA, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by TAIR and Araport.
            This record is derived from an annotated genomic sequence
            (NC_003070).
            
            On Sep 12, 2016 this sequence version replaced NM_102866.2.
FEATURES             Location/Qualifiers
     source          1..3602
                     /organism="Arabidopsis thaliana"
                     /mol_type="mRNA"
                     /db_xref="taxon:3702"
                     /chromosome="1"
                     /ecotype="Columbia"
     gene            1..3602
                     /gene="AGO2"
                     /locus_tag="AT1G31280"
                     /gene_synonym="argonaute 2; AtAGO2; T19E23.7; T19E23_7"
                     /note="Encodes Argonaute gene that binds viral siRNAs and
                     is involved in antiviral defense response. Regulates
                     innate immunity."
                     /db_xref="Araport:AT1G31280"
                     /db_xref="GeneID:840016"
                     /db_xref="TAIR:AT1G31280"
     CDS             274..3318
                     /gene="AGO2"
                     /locus_tag="AT1G31280"
                     /gene_synonym="argonaute 2; AtAGO2; T19E23.7; T19E23_7"
                     /inference="Similar to RNA sequence,
                     EST:INSD:ES206125.1,INSD:BP817081.1,INSD:ES179532.1,
                     INSD:ES134722.1,INSD:BP648434.1,INSD:AU239324.1,
                     INSD:ES177758.1,INSD:BP808901.2,INSD:AU230620.1,
                     INSD:EH867161.1,INSD:EG498489.1,INSD:ES075865.1,
                     INSD:EH952813.1,INSD:EG457867.1,INSD:BP784895.1,
                     INSD:CD532401.1,INSD:BE526767.1,INSD:CD533470.1,
                     INSD:BU635669.1"
                     /inference="similar to RNA sequence,
                     mRNA:INSD:AK118463.1,INSD:BT005914.1"
                     /note="argonaute 2 (AGO2); FUNCTIONS IN: nucleic acid
                     binding; INVOLVED IN: biological_process unknown; LOCATED
                     IN: cellular_component unknown; EXPRESSED IN: 21 plant
                     structures; EXPRESSED DURING: 12 growth stages; CONTAINS
                     InterPro DOMAIN/s: Domain of unknown function DUF1785
                     (InterPro:IPR014811), Stem cell self-renewal protein Piwi
                     (InterPro:IPR003165), Argonaute/Dicer protein, PAZ
                     (InterPro:IPR003100), Polynucleotidyl transferase,
                     ribonuclease H fold (InterPro:IPR012337); BEST Arabidopsis
                     thaliana protein match is: ARGONAUTE 3 (TAIR:AT1G31290.1);
                     Has 30240 Blast hits to 14140 proteins in 1171 species:
                     Archae - 11; Bacteria - 7749; Metazoa - 10383; Fungi -
                     2602; Plants - 5076; Viruses - 357; Other Eukaryotes -
                     4062 (source: NCBI BLink)."
                     /codon_start=1
                     /product="Argonaute family protein"
                     /protein_id="NP_174413.2"
                     /db_xref="Araport:AT1G31280"
                     /db_xref="GeneID:840016"
                     /db_xref="TAIR:AT1G31280"
                     /translation="

MERGGYRGGRGDGRGRGGRGYGGGGGGGEQGRDRGYGGGEQGRGRGSERGGGNRGQGRGEQQDFRSQSQRGPPPGHGGRGTTQFQQPRPQVAPQPSQAPASYAGSVGGVAGRGAWGRKPQVPSDSASPSTSTTVVSEPVRVAEVMNLKPSVQVATSDRKEPMKRPDRGGVVAVRRVNLYVNHYKVNFNPESVIRHYDVEIKGEIPTKKVSRFELAMVRDKVFTDNPDEFPLAMTAYDGQKNIFSAVELPTGSYKVEYPKTEEMRGRSYTFTIKQVNVLKLGDLKEYMTGRSSFNPRDVLQGMDVVMKEHPSKCMITVGKSFFTRETEPDEDFRFGVIAAKGYRHTLKPTAQGLSLCLDYSVLAFRKAMSVIEYLKLYFNWSDMRQFRRRDVEEELIGLKVTVNHRKNKQKLTIVGLSMQNTKDIKFDLIDQEGNEPPRKTSIVEYFRIKYGRHIVHKDIPCLDLGKNGRQNFVPMEFCDLVEGQIYPKDNLDKDSALWLKKLSLVNPQQRQRNIDKMIKARNGPSGGEIIGNFGLKVDTNMTPVEGRVLKAPSLKLAERGRVVREEPNPRQNNQWNLMKKGVTRGSIVKHWAVLDFTASERFNKMPNDFVDNLIDRCWRLGMQMEAPIVYKTSRMETLSNGNAIEELLRSVIDEASRKHGGARPTLVLCAMSRKDDGYKTLKWIAETKLGLVTQCFLTGPATKGGDQYRANLALKMNAKVGGSNVELMDTFSFFKKEDEVMFIGADVNHPAARDKMSPSIVAVVGTLNWPEANRYAARVIAQPHRKEEIQGFGDACLELVKAHVQATGKRPNKIVIFRDGVSDAQFDMVLNVELLDVKLTFEKNGYNPKITVIVAQKRHQTRFFPATNNDGSDKGNVPSGTVVDTKVIHPYEYDFYLCSHHGGIGTSKPTHYYTLWDELGFTSDQVQKLIFEMCFTFTRCTKPVSLVPPVYYADMVAFRGRMYHEASSREKNFKQPRGASTSAASLASSLSSLTIEDKAIFKLHAELENVMFFV"

     misc_feature    982..1191
                     /gene="AGO2"
                     /locus_tag="AT1G31280"
                     /gene_synonym="argonaute 2; AtAGO2; T19E23.7; T19E23_7"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:435368"
     misc_feature    1219..1371
                     /gene="AGO2"
                     /locus_tag="AT1G31280"
                     /gene_synonym="argonaute 2; AtAGO2; T19E23.7; T19E23_7"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    1417..1737
                     /gene="AGO2"
                     /locus_tag="AT1G31280"
                     /gene_synonym="argonaute 2; AtAGO2; T19E23.7; T19E23_7"
                     /note="PAZ domain; Region: PAZ; pfam02170"
                     /db_xref="CDD:426635"
     misc_feature    order(1504..1506,1549..1551,1597..1599,1609..1611,
                     1663..1665,1684..1686,1690..1692)
                     /gene="AGO2"
                     /locus_tag="AT1G31280"
                     /gene_synonym="argonaute 2; AtAGO2; T19E23.7; T19E23_7"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1855..3162
                     /gene="AGO2"
                     /locus_tag="AT1G31280"
                     /gene_synonym="argonaute 2; AtAGO2; T19E23.7; T19E23_7"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(2305..2307,2317..2319,2353..2364,2371..2373,
                     2395..2397,2404..2406,2416..2418,2428..2430)
                     /gene="AGO2"
                     /locus_tag="AT1G31280"
                     /gene_synonym="argonaute 2; AtAGO2; T19E23.7; T19E23_7"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(2509..2511,2515..2517,2728..2730,3133..3135)
                     /gene="AGO2"
                     /locus_tag="AT1G31280"
                     /gene_synonym="argonaute 2; AtAGO2; T19E23.7; T19E23_7"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

tatttggaagttatttttctcaagtagaatactgtgaaagacgattcaacatcccttattttacggttgtgtcaaggaacattcgagaactttttttaataactccttaagggacaagttctctctgtttttcttttttcaatagcttctctgacactttattctttctttctgatattataaacctccgatttggtttagttcaaaactagaagcagcaaaattctgaacacgtaaagctttgtttcactcagtgtttcccgatcagatccaatggagagaggtggttatcgaggaggtcgtggtgatggccgtggtagaggtggccgtggttatggcggaggcggaggaggaggagaacaaggtcgtgatcgtggctacggcggcggagaacaaggtcgtggtcgtggctcagagcgaggcggcggaaatcgtggtcaaggtcgtggtgaacaacaggattttcgaagccagagtcagcggggacctccgccaggtcacggtggccgtgggacgacgcagttccaacagcctcgaccacaggtggctccgcagccgtcgcaggctccggcgagttatgccggttcagtaggaggagtcgctggtagaggcgcgtggggtcgtaagccacaggttccgtctgattcggcttctccgtccaccagcaccaccgtggtttctgaacccgttcgtgtagctgaagttatgaatctgaagccatcggtgcaagttgcgacttctgataggaaagaaccaatgaagcgacctgatagaggcggagttgtggctgtgcggcgtgttaatctatatgtgaatcattataaagtgaatttcaatcctgaaagtgttataagacattatgatgttgaaatcaaaggagaaattcctaccaagaaggtttcgaggtttgagctagctatggttagggacaaggtgttcactgacaatcccgatgagtttcccttagctatgacagcttatgatggtcagaagaacattttcagtgcggttgagttacctacggggtcatacaaggtggagtatcctaaaactgaagagatgagaggtcgaagctatacgttcactatcaaacaggtgaatgtgctgaagctaggtgacttgaaagagtacatgacagggagatcgtctttcaatccgcgtgatgtgttgcaaggaatggatgttgtgatgaaggagcatccttccaagtgtatgatcactgttggtaaaagctttttcactcgtgaaactgagccagatgaagattttcgtttcggggttatagctgcgaaagggtatcgccacactctgaagcccacagcacaaggtttgtctttgtgtttggattactcggtgttggcgttccgcaaagcaatgtcggtcattgaatacctgaagttgtactttaactggtctgatatgcgtcagtttaggaggcgtgatgtggaagaggaattgattggtttgaaagtcactgtcaatcatcggaagaacaagcagaaactcaccattgtagggctgagtatgcaaaacacaaaagacatcaaatttgatcttattgatcaagagggaaacgagccgccaaggaagacgtccattgttgagtatttcaggataaagtatggaagacacattgttcacaaggatataccttgcttggatttgggaaaaaacggtaggcaaaattttgtgcccatggaattctgtgacttggttgagggacagatatatccaaaggataacttggataaagattcagctttgtggctaaaaaagttgtcactggtcaatccacaacaaaggcagaggaatatagataagatgataaaggctcgtaatggaccgagcggtggtgaaatcattggaaactttggattgaaagtggatacaaacatgacaccggtggaaggtcgtgtactcaaggctccatcattgaagttggcagagagagggagagttgtgcgtgaggaacccaacccgagacagaacaaccaatggaaccttatgaagaagggagtcacaaggggatctatagtcaagcattgggctgtacttgacttcactgcatccgagagatttaacaagatgcctaatgactttgtggataaccttattgatcgttgttggagacttgggatgcagatggaggctcctatcgtttacaaaacatcgagaatggaaacactttctaatggtaatgctattgaggaattgcttcgatccgtgatagatgaagcttctcgtaagcatggtggggctcgtccaactcttgttctgtgtgctatgtctcggaaagacgatggctataagactctgaaatggatagccgagaccaaacttggtctggtgactcagtgtttcttgactggtcctgccactaaaggaggtgatcagtaccgggcaaatcttgccctcaagatgaacgcaaaggttggtggaagcaatgtcgagcttatggatactttctctttcttcaaaaaagaggatgaggtcatgttcattggtgctgatgtcaatcatcccgctgctcgggacaagatgagcccgtccattgttgctgttgtgggaactcttaactggcctgaagcaaatcgctatgcagctagagtcattgcccagcctcaccgcaaagaggaaatacaaggatttggcgacgcttgtttggagcttgtcaaagctcatgttcaggccacagggaaacggcctaacaagattgtgatattccgtgatggtgtcagcgatgctcagttcgatatggttctcaatgtggagttgcttgatgttaagctaacttttgagaagaatggttacaatccaaagataacggtaatcgtagcccagaaacgtcatcaaacccgtttcttcccagccacaaataatgatggaagtgataagggcaatgtgccttcaggtacggttgttgatactaaagttattcacccgtatgagtatgatttctacctctgcagtcaccacggagggatagggacaagcaaaccgactcattactacactctttgggacgaacttggattcacttcggatcaggtgcagaagctcatcttcgagatgtgcttcactttcactcgctgcaccaaacccgtctctcttgttccgccggtgtattatgctgacatggttgcttttagaggaaggatgtaccacgaggcaagctctcgtgagaagaactttaagcagccgcggggagcgtcaacctctgctgcttcgcttgcctcttcattatcttctcttacaattgaggacaaagcgattttcaagctgcatgcagagcttgagaatgttatgttcttcgtctgaagaagagagtgagtttcttttgtgttttgggtctcaagctgaacttaaacctatattcgaaatcggaacgccccaataacgcagttttaactccttttttctggtagaaaggagtttgtgcgtgaatctaattgggtttttcgtagtgtgtttctttctttttggttttggtgtgttgaaacgaatttgtaatctcttttgagcaaaaactacgtcttcttctttttttggtattattgtatttcagactctgcattcagtaattatttcatattttgctaatt

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