LOCUS       XM_077810777            7762 bp    mRNA    linear   VRT 03-DEC-2025
DEFINITION  PREDICTED: Eretmochelys imbricata ATPase copper transporting beta
            (ATP7B), mRNA.
ACCESSION   XM_077810777
VERSION     XM_077810777.1
DBLINK      BioProject: PRJNA1372753
KEYWORDS    RefSeq.
SOURCE      Eretmochelys imbricata (hawksbill sea turtle)
  ORGANISM  Eretmochelys imbricata
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
            Americhelydia; Chelonioidea; Cheloniidae; Eretmochelys.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_135572) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_965152235.1-RS_2025_12
            Annotation Pipeline         :: NCBI Eukaryotic Genome Annotation
                                           Pipeline (EGAP)
            Annotation Software Version :: 10.5
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/02/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7762
                     /organism="Eretmochelys imbricata"
                     /mol_type="mRNA"
                     /isolate="rEreImb1"
                     /db_xref="taxon:27787"
                     /chromosome="1"
                     /geo_loc_name="USA: Hawai'i Island, Hawai'i"
                     /collection_date="2021-11-04"
     gene            1..7762
                     /gene="ATP7B"
                     /note="ATPase copper transporting beta; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 8 Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments"
                     /db_xref="GeneID:144261338"
     CDS             154..4548
                     /gene="ATP7B"
                     /codon_start=1
                     /product="copper-transporting ATPase 2"
                     /protein_id="XP_077666903.1"
                     /db_xref="GeneID:144261338"
                     /translation="

MALSMSSSPPSCVWEPTMKQNFAFDNIGYEGSTENMPSQDMLPQMSTVTVNILGMTCQSCVQSIEGRISKVKGVVSTKVSLEQSNAVVKHIQSEIGPQEICQEIGDMGFDASIAEGRTTPLSVRSTSLGEALMKLRVEGMTCQSCVNTIEGKIGKLHGVLRIKVSLSNQEAVIAYQPYIIQPEDLKNHIDNIGYESTIKSKLAPLKLGTIDLERLQTTSTKKTPASLNNSNVKPAVGKMNSTTTMTLGVEGMHCRSCVKNIEGNISGLPGVQSIEVSLEYKNAVVQFNPNVITPVSLQQAIEALQPSNFKVSLPNGVEANNGELLSKAAFSSPQLRSTFSGDQLTSTTVLSIDGMTCGSCVQSIEGTMSQRKGVQHISVSLVERTGTIHYNSTVTNSEELRGAIEDMGFDASILTDTTTWKYTDQPLFKDATIHPNAWESASQRTENVSESSHQGYMSDVQPKNSSLDSPKPPSVATTEKCFMQITGMTCASCVSNIERNLQKEDGIVSVLVALMAGKAEIKYKPESIQPLEIVQLIQNLGFDATVIEDHTDTDGNVELIITGMTCASCVHNIESKLTRTNGIFYASVALATSKAHIQFDPEIIGPRDIIQIIEGIGFHASLAKRDPNAHNLDHKKEIKQWRKSFLCSLVFGIPVLILMIYMLIPAGQQHGSMVLERNLIPGLSILNLLFFVLCTLVQFLGGWYFYVQAYKSLKHKTANMDVLIVLATTIAYIYSCVILVVAIAEKAEESPVTFFDTPPMLFVFISLGRWLEHIAKSKTSEALAKLMSLQATEATIVTLGPDHSVIREEQVAVELVQRGDIVKVVPGGKFPVDGKVIEGSSMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLVNATHVGSDTTLAQIVKLVEEAQMSKAPIQQLADKFSGYFVPFIIIISTATLLVWITIGFINFDVVQKYFPHQNKHLSKAEVIVRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITCGVPKVMRMLLLGDTAKLSLKKVLAIVGTAEASSEHPLGVAVTKYCKEELGTESLGYCTDFQAVPGCGISCKVRNVEAILGQSEQSLSEQNAYLSSVSTVSLGHSSSIMVSESDGEAAPLTYSVLIGNREWMKRNGLLISSDVNDAMTGHEMKGQTAILVAIDGALCGMIAIADTVKQEAALAVHTLQNMGIDVVLITGDNRKTAKAIATQVGIKKVFAEVLPSHKVAKVQELQNEGKKVAMVGDGVNDSPALAGADIGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLVLALIYNLLGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPGTERYEAKAQGHMKPLTPSQISVHIGMDDRRRDSPRPTAWDQISQVSLSSLTSNKLHRHGLFREEEGGKWSLLTNDRDEEQYI"

     misc_feature    298..489
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(316..324,331..333)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    553..744
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(571..579,586..588)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    889..1065
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(907..915,922..924)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1186..1386
                     /gene="ATP7B"
                     /note="Copper chaperone CopZ [Inorganic ion transport and
                     metabolism]; Region: CopZ; COG2608"
                     /db_xref="CDD:442020"
     misc_feature    1600..1788
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1615..1623,1630..1632)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1825..2016
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1843..1851,1858..1860)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    2080..4221
                     /gene="ATP7B"
                     /note="P-type heavy metal-transporting ATPase, similar to
                     human copper-transporting ATPases, ATP7A and ATP7B;
                     Region: P-type_ATPase_Cu-like; cd02094"
                     /db_xref="CDD:319783"
     misc_feature    order(3073..3075,3079..3081,4150..4152)
                     /gene="ATP7B"
                     /note="putative Cu binding site [ion binding]; other site"
                     /db_xref="CDD:319783"
     misc_feature    order(3205..3213,3415..3417,3601..3609,3697..3699,
                     3817..3825,3883..3885,3892..3894,3901..3903,3958..3960,
                     3967..3969)
                     /gene="ATP7B"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319783"
ORIGIN      

gccgtgctcccgggtttgcacggaggagcagtgaagataaggcaagaggatggtgggtggtgtaccccgggccacagaccacggtgtataacttcacattacttcctacaccactgggcattatttctgcatgtgtctcttcattatggcaaaatggctttgtctatgtctagctcccctcctagttgtgtatgggaaccaaccatgaagcagaattttgcctttgacaacatcggctacgaagggagcactgaaaatatgccctctcaagatatgcttcctcaaatgagcactgtcacggtcaatattttgggtatgacttgccagtcttgtgtgcagtcgatagagggcagaatttccaaggtgaagggcgttgtgagcaccaaggtctcccttgagcagagcaatgctgtagtaaaacatatacagtcagaaataggtccccaagagatttgccaggaaattggagacatgggctttgatgccagcattgcagaaggaagaactacaccattatctgtaagatcgacatccttgggagaagcactaatgaagctgcgggtagaaggtatgacatgccaatcttgtgtcaacaccattgaaggaaagattggaaaactacatggtgtgttgagaatcaaagtctccctcagtaaccaagaagcagtcattgcttaccagccttacatcattcaacctgaagacctcaaaaaccacatagataacattgggtatgaaagcactattaagagcaagctagccccattaaagcttggtacgattgatctagaacgcttgcagactacaagcacaaagaaaactccagccagcctgaacaatagtaatgtgaagccagcggtaggcaaaatgaatagtacaacaactatgacgctgggagtagaagggatgcattgcaggtcttgcgtcaaaaacattgaaggaaatatatccggtcttccaggcgtacaaagtattgaagtgtcattggaatataaaaatgctgtcgtgcaatttaacccaaacgtaattaccccagtatctttgcaacaagccattgaggcccttcaacctagtaactttaaagtatccctccctaatggagtggaagcaaataatggagagcttttatcaaaggcagcattttcatcacctcagcttcgtagcacattctctggggatcagctgacaagcacaactgtacttagtattgatggaatgacctgtggatcctgtgtacagtccatagaaggcacaatgtcccaaagaaaaggggtacaacatatatcagtttcgttagttgaaaggactggaaccatacactacaattcaactgtaactaattcagaagagctaagaggtgctatagaggacatgggatttgatgcttccattcttacagataccaccacttggaaatatacggatcagcctcttttcaaggacgctacaattcaccctaatgcttgggagtcagcttcccagagaacagaaaatgtttctgaatcctctcatcaaggctacatgtctgatgtccagccaaagaattcttcccttgatagtccaaagccacccagtgtagcaacaacagaaaagtgctttatgcagatcacaggcatgacctgtgcatcatgtgtgtcgaacattgaaagaaatctgcaaaaagaagatggtatcgtttcagtgctagtagcactgatggcaggaaaagcggagataaaatacaagccagagagcattcagcctcttgaaatagtacagctgatccaaaacttgggcttcgatgctacagtcatagaagaccatactgatacagatggcaatgtagagcttattattacggggatgacttgtgcttcctgtgttcacaatattgaatccaaactaaccagaactaatggcatcttctatgcctccgtggcacttgctaccagcaaagctcacatccagtttgatcctgaaatcattggacctcgagatattatacaaattattgagggaattggttttcatgcttccttggccaagagagaccctaatgctcataacttggatcacaaaaaggaaataaaacaatggaggaaatctttcctgtgcagcctagtgtttggaatccctgtcttaatcttaatgatatatatgctaatacctgctggccaacagcatggcagtatggtgctggaacgaaatctaattcctggattatctattttaaatcttctcttctttgtcctgtgcactttagttcagttcctcggtggatggtacttttatgtccaagcttacaaatcactgaagcacaaaacagccaatatggatgtactgattgtgctggctacaactattgcttatatatactcttgtgtgatcttggtggtggctatagctgaaaaagcagaggaaagccccgtcacgttctttgacacaccacctatgttattcgtattcatttctcttgggagatggttggaacacatagcaaagagtaaaacatcagaagcacttgctaaactaatgtctctccaagctactgaagctaccatagtgactcttggacctgaccactccgtcatcagggaggagcaggtggctgttgaactggttcagcggggtgacattgtaaaagttgtccctggtgggaagttcccagttgatggaaaagtcattgaaggcagctctatggcagatgaatctctcattactggggaagccatgccagtcactaaaaaacctgggagcacagtgattgcaggttctataaatgcgcatggctcagttctcgttaatgcaactcacgttgggtctgacaccaccctggcacaaattgtgaaattggtagaagaagctcagatgtcaaaggcacccatccagcaattggctgataagtttagtggatattttgttccatttatcatcatcatttcaacagcgacattgctagtgtggatcacaattggttttataaactttgatgttgttcagaaatactttcctcatcagaacaaacacctctcaaaagctgaagtaatagtgaggtttgcatttcaaacctcaatcactgtgttgtgcattgcatgtccctgttccttgggcttggctactccaacagctgtgatggtgggcacaggagttgctgctcagaatggtattctcatcaaaggtggaaaacccctggaaatggcccacaagataaagactgtgatgtttgataaaactgggaccatcacctgtggcgttcctaaagtcatgaggatgctcttgctaggggacacggctaagctgtccctaaagaaggtacttgcaattgtcggcactgcagaagccagcagtgagcatcccttaggagtggctgtcactaaatactgtaaagaggaacttggcaccgagagcctgggatactgcacagattttcaggcagtcccaggctgtggaatcagctgtaaagtgcgcaatgtggaagctatactgggccagagtgagcagagtctgagtgagcagaatgcttacctgagcagtgtcagcacggtttcgctgggacacagttcatcgatcatggtctctgaatctgatggtgaagcagcccctctgacctactcagtgctgattggaaatcgtgaatggatgaaacggaacggcttgcttatatccagtgatgttaatgatgcaatgacaggccatgaaatgaaaggacagacagccatattggtggctatagatggtgcgttgtgtggaatgatcgcgatagcagataccgtcaaacaggaggcagcgctcgctgtgcacactctgcaaaatatgggaatagacgtggtgctaataacaggggacaacagaaaaactgcaaaagcaattgctactcaggttggcatcaaaaaggtctttgctgaggttctgccctctcacaaagtcgcaaaggttcaggaactccagaacgaagggaagaaggttgccatggttggagatggagtcaacgattccccggcattggctggagcagacattggcattgctattggaacaggcacggatgttgccattgaagctgcagacgtcgttcttattcgaaatgacttactggacgtggttgctagtattcatctatcaaagaggacagtaagaagaatacgaataaatctggtccttgccttaatttataatctgcttgggatacctatagcggcaggggtgttcatgcctattggaattgttctgcagccatggatggggtcagctgcaatggcagcttcttcagtatctgtggtgctatcttccctgcaactgaaatgctacaagaagccaggaactgaaaggtatgaagcaaaagctcaaggccacatgaagccactgactccttcccaaatcagtgttcacattgggatggacgacaggagacgggattcacccaggccaactgcctgggatcagattagtcaagtgtctctttcctctctgacttcaaacaagctgcacagacatggtttgtttagagaggaagaaggtggcaagtggtcactgctcactaatgaccgagatgaagaacagtacatttaaatgctgcatcccatcactgaacatgaagtcactgtgattcttcaccattggcagcgatgaccacaagacccacataagtataaatggaaccctgatgttccagtttgcaaagcagctcagaaattcagcattagattgtgtgaattatgattttgtcagttcacaaataattgccagtcattgaaaaagcttgagaccctacaatgaattatgccctttacttcttgcgcagtgggaagttggagtccacaaagcctaacaggacccctacattgtggatcagttactgagaatcaaaaccccagcctgtccagtctcattgactctcttgtgcttctttatggaacttctgtgaaaagatttttaaattaaacgacctagaaaatgaatttggcagaaagtgaaaaccattaaaccggacatcaaatagctctatatttggggatcatatttttacatagaatcaaatctagtcatctcaacatgggaaaattttatatttagggctccgacaacatgtgtgtgtttgattagcacaaaaatatattaattgtatattttgctgtgcataaaaattgtaaaattctgtttcaaagatgaccatgtatcttatagcatcactaattgtattttatgaaacgtctccatttgccaaacttgcttgctgtgtgcaactactcctcttaggttttccagttttctcctgtgtgttctttggagccctttcttcccagtaaagttccacctttagacatttgttatgtcttcagatttttcccatgggatgagatcctacaaggcaccggggaccctgcaattcctgttgaaatccacagagtttgagctcctgtcaaggttccttccccactctgaacgctagggtacagatgtggggacctgcatgaaaacctcctaagcatatctttaccagcttaggtcaaaacttccccaaggtacaaaatattccaccctttgtccttggattggccgctaccaccaccaaacaaatactggttactggggaagagctgtttggaaacgtctttccccccaaatacttcccaaaaccttgcaccccacttcctggacaaggtttggtaaaaagcctcaccaatttgcataggtgaccacagacccaaacccttggatctgagaacaatgaaaaagcattcagttttcttacaagaagacttttaatagaaatagaagtaaagaaatcccctctgtaaaatcaggatggtagataccttacagggtaattagattcaaaacatagagaatccctctaggcaaaaccttaagttacaaaaaagatacacagacagaaatagttattctattcagcacaattcttttctcagccatttaaagaaatcctaatctaacacatacctagctagattacttactaaaagttctaagactccattcctggtctatccccggcaaaagcagcatatagacagacagagaccctttgtttttctccctccttccttttgaaagtatcttgtctcctcattggtcattttggtcaggtgccagcgaggttacctttagcttcttaacgctttacaggtgagaggagttttcctctggccaggagggattttaaaggggtttacccttccctttatatttatgacagctcctctctgggttttactctggttcaggatagctcaccattttgtcgaatcttttgacactcctgataactgcagtgttcagctatttctttgtgcagagtggcataaatgtgccagtgtaagccatcctggtggctcaattattggtacacttatgctaatgcattgacgagatgctttccgacttggagtgttttgttcttggtcctgatgggagctagaatgttagaggtgacatgctcagtctctgtgctgatggattagctaacagtgcttttcaaggactctgtggaagttgtggggacacctcaaaagccaaggttcaacagagaggcagggtttgggaggctgtcctgtgcaaatggcaggtgagaaagaagtagtaggttaaagcccatctgtaactctactcaaaatccctcttgatatcttgtgttagagctgggtgcttaaagtaaagtccatgcctgaaaactctcactatcccctttaaaaattactgcattattacagatcacgttaagctaaaagggactcttacttcatctctgagtttatcttggaccacaaacactacagccaatgcttaaaaattgccactaggaggcaattgtatatataacaataattatactgatgtaacagagaacagagcgtgaccaagtgttcatgggattccagggtggttggagggggtgggggggaaagggtttgagattactgtactgtttaaatagcatcacataacacagcttgttggtcgtttaaaataaaagtgtaaaccgattaaaaatggagataatagtgcatggccaccaggctttcatttattctggtatgaatcatctcagcagtgctagctgtttgtcatttaatcctattctggtttatagcccgtgaagactttggaatttatttaaatggagctttaacatttttgtagtgttttatctccctgcttgggctagtgtaataacaaatcaaggtggaagagaaaagccttctctcatgctgctaaagtatgagcttaatcaccgcaactttgtttccaaattcaccctccaatacttgtctcttagtcagggcatttggagtcaggtgctttcagtgagctgagtgggtgaaatcctggccccattgaagtaaaaaaatctgaagttgggaagtggggcaggattttacccttgtaaaagatcccaaatcattgccctgggcagtggtgaaagcactggtttggtttggtttaaagtctgccagtttccctgcaaagggccaaatcatgtttccactaaagtaaatgtccacactccggcagactctgagggaaagagtgttgtgttcataacattggaaattggttctaatcgtaatgttctatcctttgcatgtcctttttaataatttccttatatttaggttcctgtaaatgacccattcatctctgttgactaatcacaacatttgctaggatgtaatacactgattttttttcacatttccgtttcaaaactataaaaactttttagataatttaaaagtatacaactgtaaaaatatccagtaaa

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