LOCUS       XM_077752591            6487 bp    mRNA    linear   MAM 26-NOV-2025
DEFINITION  PREDICTED: Crocuta crocuta ATPase copper transporting beta (ATP7B),
            mRNA.
ACCESSION   XM_077752591
VERSION     XM_077752591.1
DBLINK      BioProject: PRJNA1367629
KEYWORDS    RefSeq.
SOURCE      Crocuta crocuta (spotted hyena)
  ORGANISM  Crocuta crocuta
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia;
            Hyaenidae; Crocuta.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_027527955) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_008692635.1-RS_2025_11
            Annotation Pipeline         :: NCBI Eukaryotic Genome Annotation
                                           Pipeline (EGAP)
            Annotation Software Version :: 10.5
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 11/25/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6487
                     /organism="Crocuta crocuta"
                     /mol_type="mRNA"
                     /isolate="KB4526"
                     /db_xref="taxon:9678"
                     /chromosome="Unknown"
                     /sex="male"
                     /tissue_type="muscle"
                     /dev_stage="Adult"
                     /geo_loc_name="USA: Institute for Conservation Research,
                     San Diego Zoo, Escondido, CA"
     gene            1..6487
                     /gene="ATP7B"
                     /note="ATPase copper transporting beta; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 8 Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 2 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:144222075"
     CDS             42..4346
                     /gene="ATP7B"
                     /codon_start=1
                     /product="copper-transporting ATPase 2"
                     /protein_id="XP_077608717.1"
                     /db_xref="GeneID:144222075"
                     /translation="

MKQKQSFAFDNVGYEGGLDSMCPSQTTTGTISISGMTCQSCVKSIEGRISSLKGIASVKVSLEQGSATVSYVPSVLSLPQVCRHIEDMGFEASVTEGKAASWPSRSSSAPEAVVKLRVEGMTCQSCVSSIEGRLGKLQGVVRVRVSLGTQEAVITYQPYLIQPQDLRDHVNDMGFEAVIKNRVAPISLGPIDIGRLQRTGPKMPSVADNQNLNNSESLGSQGSHAVTLQLRVDGMHCKSCVQNIEENVGRLPGVQSIQVSLEDRIAHVQLDPSRVTPGDLQRAIEALPPGNFKVSLPDGAAGSGTDDRPSPRPAPAPAPGARVQGVCSTTVLAIAGMTCASCVQSIEGLLSRREGVWRVSVSLAEGTGVVLYDPSVITPEELRAAVEETGFEASVISENWYSNHAGNLGAGNSAAPSTAGVPVSEQGTAPRAGGLPTNHSPSCSSKSLQDSAAVAPQKCFLQITGMTCASCVSTIERNLQKEAGILSVLVALMAGKAEVKYNPEVIQPLEIAQLIQDLGFEATVMEDYTGSDGDLELIITGMTCASCVHNIESKLTRTNGITYASVALATSKAHVKFDPEIIGPRDIVKIIEEIGFRASPAQRNPNAHHLDHKVEIKQWKKSFLCSLVFGIPVMGLMIYMLVPSSEPHETMVLDHNIVPGLSFLNLIFFILCTFVQLLGGWYFYVQAYRSLRHRAANMDVLIVLATSIAYTYSVVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHVAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDVIKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLINATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIISTLTLVVWIIIGFIDFGVVQKYFPTPNKHVSQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPKVMRVLLLVDMATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTDTLGYCTDFQAVPGCGIGCKVSSVEGILAHGGHQRGKQAALKNGGGGAPEETDATPQTFSVLIGNREWMRRNGLTISNGISDTMTDHEMKGQTAILVAIDGVLCGMIAIADSVKQEAALAVHTLKSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNEGKKVAMVGDGVNDSPALARADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVWRIRLNLVLALIYNLIGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLQRYEAQAQGRMKPLTASQVSVHIGMDDRRWDSPRATAWDQVSYISQVSLSSLKSDRLSRHSAGADDSGDKWSLLLSDRDEEQCI"

     misc_feature    129..320
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(147..155,162..164)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    384..572
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(402..410,417..419)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    726..902
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(744..752,759..761)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1026..1232
                     /gene="ATP7B"
                     /note="Copper chaperone CopZ [Inorganic ion transport and
                     metabolism]; Region: CopZ; COG2608"
                     /db_xref="CDD:442020"
     misc_feature    1422..1610
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1437..1445,1452..1454)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1647..1838
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1665..1673,1680..1682)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1902..4010
                     /gene="ATP7B"
                     /note="P-type heavy metal-transporting ATPase, similar to
                     human copper-transporting ATPases, ATP7A and ATP7B;
                     Region: P-type_ATPase_Cu-like; cd02094"
                     /db_xref="CDD:319783"
     misc_feature    order(2895..2897,2901..2903,3939..3941)
                     /gene="ATP7B"
                     /note="putative Cu binding site [ion binding]; other site"
                     /db_xref="CDD:319783"
     misc_feature    order(3027..3035,3237..3239,3390..3398,3486..3488,
                     3606..3614,3672..3674,3681..3683,3690..3692,3747..3749,
                     3756..3758)
                     /gene="ATP7B"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319783"
ORIGIN      

tatctaaacgttctttgcccgcccgtgtctgggaaccagcaatgaagcagaagcagagtttcgccttcgacaacgttggctacgagggggggctggacagcatgtgcccttctcagacgaccaccggcaccatcagcatttcaggcatgacctgccagtcatgtgtaaagtctatcgagggcaggatttcgagtttgaaaggcatcgcgagcgttaaggtttccctggagcaaggcagcgcgactgtgagctacgtgccgtcggtcctgagcctgccgcaggtgtgccgtcacatcgaggacatgggcttcgaggccagcgtcacagaaggaaaggccgcctcctggccttcgagatcctcgtctgccccagaggccgtggtcaagcttcgggtggagggcatgacctgccagtcctgtgtcagctccatcgagggcaggctggggaagctgcagggggtggtgagagtccgcgtgtcccttggcacccaggaggccgtcattacttaccagccttatctcattcagccccaggacctcagggaccacgtaaacgacatgggatttgaagctgtcatcaagaacagagtggcgcccataagcctgggaccaattgatattgggcggttacagaggaccggcccgaagatgccttcggtggctgataaccagaatctcaataactctgagtccttggggtcccaagggagccatgcggtcaccctgcaactgagagtcgatgggatgcactgtaaatcctgcgtccagaatattgaagaaaatgtaggccggctcccaggggtccagagtattcaagtgtccttggaggacagaattgcccacgtacagcttgacccttctcgtgtcacccccggggacctgcagagggccattgaggctcttcctcctgggaactttaaagtgtctcttccggatggagccgcggggagtgggacggatgacaggccttccccacgccccgcccccgcccccgccccgggagcccgggtccagggcgtgtgcagcaccacggtgctcgccattgccggcatgacctgtgcatcctgcgtccagtccatcgaaggcctgctctcccgcagggagggcgtgtggcgcgtatccgtctccctggctgaagggactggagtggtgctctatgatccctctgtaattaccccagaagagctccgagctgctgtcgaagaaacgggattcgaggcttcagtcatttctgaaaactggtatagcaaccatgctggaaacctcggcgcggggaattccgcggcgcccagcacagccggcgtgcctgtgtctgagcagggaacggctccccgtgccggggggctccctacaaaccacagccccagctgctcgtcaaagtccctgcaggactctgcggcagtggcaccacagaagtgctttctacagatcacaggcatgacctgtgcgtcctgcgtgtccaccatagagagaaacctgcagaaagaggcaggtattctctcggtgctggtcgccttgatggccggaaaggcagaggtgaagtacaatccggaagtcatccagccgctggagatagctcagctcatccaggacttgggctttgaggccacagtaatggaagactacacaggctcagacggtgacctcgagctgatcatcacgggcatgacctgcgcatcctgtgttcacaacatagaatccaaactcacgaggacgaatggcatcacctacgcctctgtggcccttgccaccagcaaagcccacgtgaagttcgatcccgaaatcattggtccgcgggatattgtcaaaattatcgaggaaatcggctttcgtgcttccccggcccagagaaaccccaacgcgcatcacttggaccacaaggtggaaataaagcagtggaagaagtcttttctgtgcagcctggtgttcggcatccctgttatgggtttaatgatctatatgctggtgcccagcagcgagccccacgagactatggtcctggaccacaacatcgttccgggactgtcctttctaaatctcatcttctttatcctgtgtacctttgtccagctcctgggcggctggtacttctacgtccaggcctacaggtctctgcggcacagggcggccaacatggacgtgctcattgtgctggccacgagcatcgcctacacctactcagtcgtcatcctggtggtggccgtggctgagaaggcggagaggagccccgtgaccttcttcgacaccccccctatgctctttgtgttcattgccctgggccggtggctggagcacgtggcgaagagtaaaacttcagaagcccttgccaagctcatgtctctccaagccacggaagccaccgtcgtgaccctcggcgaggacaacttgatcatcagagaggaacaggtacccatggagctggtgcagcggggcgacgtcatcaaggtcgtgcccgggggaaagttcccggtggatgggaaagtcctggaaggcaataccatggccgacgagtccctcatcacaggagaagccatgccggtcactaagaaacccggaagcacagtgattgctgggtctataaatgcacatggctctgtgctcattaatgccacccatgtgggcaatgacaccactttggctcagattgtgaaattggtagaagaggctcagatgtcaaaggcacccattcagcaactggctgaccggtttagtggatattttgtcccatttatcatcatcatttcaacgttgacgttggtggtatggattataatcggttttatcgattttggtgttgttcagaaatactttcctacccccaacaagcatgtctcccagacagaggtgatcatccgctttgcgttccagacgtccatcacggtgctctgcatcgcctgcccctgctccctgggcttggccacgcccacggccgtcatggtgggcaccggggtggccgcccagaatggcatcctcatcaagggaggcaagcctctggagatggcccacaagataaagactgtgatgtttgacaaaacgggcaccattacccacggggtccccaaagtcatgagggtcctcctgctcgtggacatggccacgctgcccctcaggaaggtcctcgctgtggtggggactgcggaggccagcagcgagcacccgctgggcgtggcagtcaccaagtactgtaaagaggaactgggaacagacaccttggggtactgcacagacttccaggcggtgccaggctgtggaattggctgcaaagtcagcagcgtggagggcatcctggcccacggcgggcaccagcggggcaagcaggctgctctcaagaatggcggcggcggcgctcctgaggagacagatgcgaccccccagaccttctctgtgctgattgggaaccgcgagtggatgagacgcaacggcttaaccatttccaatggcatcagtgacaccatgaccgatcatgagatgaaaggccagacagccatcctggtggccattgatggggtgctctgcgggatgatcgccatcgcggactcggtcaagcaggaggccgccctggccgtgcacacgctgaagagcatgggtgtggacgtggttctgatcaccggggacaaccggaaaacggccagagccattgccacccaggttggcatcaacaaagtctttgcagaggtgctgccttctcacaaggtggccaaggtccaggagctccagaatgaagggaagaaagtcgccatggtgggagacggggtcaacgactcgccggccttggcccgggccgacgtgggcattgccatcgggacaggcacagacgtcgccattgaggctgccgatgtggtcctcatcagaaacgacttgctcgacgtggtggccagcattcacctctccaagaggaccgtctggagaatacgactcaatctggtgctggcgttgatctacaacctgattgggatacccatcgcagcaggggtcttcatgcccatcggcatcgtgctacagccgtggatgggctcagcggccatggcggcctcctctgtgtctgtggttctctcgtcgctgcagctcaagtgctataagaagcctgacctgcagaggtacgaggcgcaggcgcagggccgcatgaagcccctgaccgcgtcccaggttagtgtgcacatcggcatggatgaccggcgctgggactcgccgagggccacggcctgggaccaggtcagctacatcagccaggtgtctctgtcctcactgaagtcggacaggctgtctcggcacagtgctggggctgacgacagtggggacaaatggtccctgctcctgagtgacagggatgaggaacagtgcatctgaacagtcccagggctcggtcccccggctgagtagccggcccggctttcctggtagacgaggtgcaggccggtcaggtgcggcaccagcagcaagatggacgaagctcctgtctggccttggggcccttcactccctggacgttcctggccgtctctgctggcgcgtgccgcatcccgatgtggcccctggctaggcccgtcctgcctgggtcccactggcacggcggccgggcttcctggccagaccctgccgctggcacgggcttgtcgggacctgggctggactctagcagaggaagggacagccagccctgtgctcggacctctgcttgcatgtttgggatgaccacttgtaaaatgaggaacagctcatcaggaccaaaaccttctctgggcctttccttaaaacccgtgagaagccttggtgttgggttcttttggacgacacccacacgcacgggtatctgagaccgcggtttacctcaaatgcaccccattgatttctgccggcacagtctcttccttttctgttcctaacactggggatgtgccccccaccccccacccctgcccgctctctgagggcagcactgacgccgtagcgatccctgtggctgctctcggcacttctgcccgaatctgcatgctcacacgcctggccggagggccagctgtgcctcgcagcttgaggagagttctttctcgcttaatgtgccgcatgaccacggggtcctggccacgtgctcggctgccgtggtggcctctgtttctgtggttctcttgtcgctgcagctcaagtggagagtcccttggggcgggaacatgcgccacaggcggccttctccctgcagaatggcctgctgctgtgggtcgttgctgccctgccggagtgagggtctcagggcctgagacctgagaaattctgctcactgtggggtccaggtactggggaccccgagaggcctgtggtgcctgaaacgggtgccccatggtgggggtgcatgtgctcatgggaacctccttgcaggcttccaggagcttcgtggtacatggtctgctgtgtgactgttgcttcatggaattcaattcagaattcctgggggggggggtgcccccgtggtgcgcaagtctaaggaaacagtggtacccaaaccagaggaaatcacacttgttctccatgagctcctacttctgcacagtcagtgccttaggaaaggggtcaccacaacttccccaagggaaagcctgtcacactttcagcagctctttgtgctggtaagacctcagaggggcaggaatgggtccggttttaggctctaacgtcggtggtagttgacagagttacatgggggtagacaagtaggatgaaaataaattctaaggtagagcccttatcacacaataattttatttattgagcatcagctatttttcagggacaacgcaagcactttctataggttacctctaatcctcccaacataccagcaaagtagatactattggccccattttataggcggggcagcaggctcagagagaagtatcctgcccaggaccacacagccagcacacttgccaaaacggggatccagatccatgtctcgtggctctgaagtcttttcttctttgctgctgccacctgagtgtcagtttggtaagagacaagaggaaaaggcccctgctcttcgaacaaaggtgccaggcgatacactcgttatcgacttgggatgaaatttgacctcggggtcaacttactcaccgcccccttggatggtttgtttccatttttgcatataattccattgtgtcgcgtcttgccctctaaaatccaggtcccgggatctgttgtgtctgtactgttttccgtcctcgcctccttgcaggcccttcccgttctctcctttctttattcctggctgtgctcgggagcgtctcctgttttctaaactaggttaatcattgtctaaagaatctaactattgattttttcaaaggcttttaggaccataaacatcatgtgtgtatatatatatatggccatgaaaatatttatataattgcacaaaatgtaacctttagacattcaaggggtaagaattttttttgcgtgtcagagaagagcagttcctatttcaaaaa

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