LOCUS       XM_076053485           16347 bp    mRNA    linear   VRT 08-AUG-2025
DEFINITION  PREDICTED: Petromyzon marinus copper-transporting ATPase 2-like
            (LOC116955762), transcript variant X2, mRNA.
ACCESSION   XM_076053485
VERSION     XM_076053485.1
DBLINK      BioProject: PRJNA1269050
KEYWORDS    RefSeq.
SOURCE      Petromyzon marinus (sea lamprey)
  ORGANISM  Petromyzon marinus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
            Hyperoartia; Petromyzontiformes; Petromyzontidae; Petromyzon.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_133727) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_048934315.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/04/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16347
                     /organism="Petromyzon marinus"
                     /mol_type="mRNA"
                     /isolate="PM22_M1"
                     /db_xref="taxon:7757"
                     /chromosome="61"
                     /sex="male"
                     /tissue_type="testes"
                     /dev_stage="adult"
                     /ecotype="Great Lakes invasive population"
                     /geo_loc_name="USA: Great Lakes"
                     /collection_date="2022-08"
                     /collected_by="Jeramiah Smith"
     gene            1..16347
                     /gene="LOC116955762"
                     /note="copper-transporting ATPase 2-like; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 ESTs, 19 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     42 samples with support for all annotated introns"
                     /db_xref="GeneID:116955762"
     CDS             152..4747
                     /gene="LOC116955762"
                     /codon_start=1
                     /product="copper-transporting ATPase 2-like"
                     /protein_id="XP_075909600.1"
                     /db_xref="GeneID:116955762"
                     /translation="

MAEEEEVKAGVEVKADMEVWHATFTVEGMTCQSCVQSITQVLTDLPGIYSVQVSLENKSASVLYDPALHTPNSLKNSVEDIGFEAAHRGAVTVMMLEVADIDIVGMTCQSCVQSIEGKMSKLKGVLSFSVCLQKNNATVAFIPGVISMQKLCDEIDDMGFEARPVDRKPATDTAEEGRSTEDMVKMRLEGLIGQSAVNALEGKLSKLNGVLRVKVNLSSQEVVVWFQKLAISVDDIQNQIAECGLQTTVRSRPKQLRLSPQAVQKLQEMNGSVCHFKEAKPTSLGLGKCPNVVISVEGMHCKSCVFNIESNIGQLPGVHSIVVSLETKSAAVSYSPEDISPAALCQAIEALPPGIFQASVSPTSAKAVASTPPPPLSSVVVLRVERMESSAGVLAVERALLECPGVKTARASLVDGTATVHYDPRGASPAALCASITSKGFKASLLDGSDAKSRANHAQFLLEGSATPSLNGSRPGWHAPTTSGGKGSMQLVPTEEEAAVASAKEEEAKCFLMVTGMTCASCVANIERVLGRRRGVQSVLVSLMAGKAEVRYHPASVAPEEIAESVRDMGFGATLLDDQDIAPGCLELVVQGMRSASCAHAIESALMQCHGVTSASVALATNRAHVEFDPDQIGPRDIIKAVQNAGFLAVHLKRDRTGNHLDHSDKIHQWRRSFFFSLIIVVPTMGMMIYMMVTERHHEGHHTGILAKHIVPGLSLMNLAAFVLCTPVQFIGGWYFYKQAYGALRHGTANMDVLIVLATTVAYAYSCVVLFVAMGEQAMVSPITFFDTPPMLFVFVSLGRWLEHIAKSKTSEALVKLMSLQAAEATVVKYGLSNDIIGEEQVDVDLVHRGDVVRVLPGGKFPVDGKVIEGQSLADESLITGEAMPVMKKPGSLVIAGSINQNGGLLVKATHVGADTTLSQIVRLVEEAQTSKAPIQQFADKISGYFVPFIVGVSVVTLLSWVTIGYVDFSIAKKYFPEYDPRLSHGEVVWRLAFQAAITVLCIACPCSLGLATPTAVMVGTGVGAQLGILIKGGEPLEMAHKVRTVVFDKTGTITHGIPKVMRVSILEEHVKLPLRTFLAVVGTAEASSEHPLGSAVAKYCRQSLGTESLGSCADFQAIPGCGISCRVSDVEAVLASSKQGLAAGNSAAAAAAARTDGFPLLVDIADGGPAGSQAISSTDLGAGPAATSGQEYAVLIGNREWMNRNALLVAEPVDKAMAEHEEKGQTAVLVAINGKLCGMLAIADTVKPEAALAVRTLADMGLQVVLMTGDNRKTAQAIAAQVGIRRVFAEVLPSHKVAKVEQLQESGQTVAMVGDGVNDSPALARSDVGIALGTGTDVAIEAADIVLIRNDLLDVVASIHLSKKTVRRIHINFVFALIYNVVGIPIAAGVFMPAGLVLQPWMAAAAMAASSVSVVLSSLMLKRYKKPSRPRLEAQTRGRVRGCSLSEVSVAVGMGDRPAWVDGRTSPKLGVWDRVKFISQTSIASLTADKRMAGGGTAAGLSVQLLDRHSLLGDGGGGSGGSHHEFTTDV"

     misc_feature    215..409
                     /gene="LOC116955762"
                     /note="Copper chaperone CopZ [Inorganic ion transport and
                     metabolism]; Region: CopZ; COG2608"
                     /db_xref="CDD:442020"
     misc_feature    449..640
                     /gene="LOC116955762"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(467..475,482..484)
                     /gene="LOC116955762"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    698..883
                     /gene="LOC116955762"
                     /note="Copper chaperone CopZ [Inorganic ion transport and
                     metabolism]; Region: CopZ; COG2608"
                     /db_xref="CDD:442020"
     misc_feature    1028..1204
                     /gene="LOC116955762"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1046..1054,1061..1063)
                     /gene="LOC116955762"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1289..1480
                     /gene="LOC116955762"
                     /note="Copper chaperone CopZ [Inorganic ion transport and
                     metabolism]; Region: CopZ; COG2608"
                     /db_xref="CDD:442020"
     misc_feature    1685..1873
                     /gene="LOC116955762"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1700..1708,1715..1717)
                     /gene="LOC116955762"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1907..2092
                     /gene="LOC116955762"
                     /note="Copper chaperone CopZ [Inorganic ion transport and
                     metabolism]; Region: CopZ; COG2608"
                     /db_xref="CDD:442020"
     misc_feature    2165..4357
                     /gene="LOC116955762"
                     /note="P-type heavy metal-transporting ATPase, similar to
                     human copper-transporting ATPases, ATP7A and ATP7B;
                     Region: P-type_ATPase_Cu-like; cd02094"
                     /db_xref="CDD:319783"
     misc_feature    order(3164..3166,3170..3172,4289..4291)
                     /gene="LOC116955762"
                     /note="putative Cu binding site [ion binding]; other site"
                     /db_xref="CDD:319783"
     misc_feature    order(3296..3304,3506..3508,3740..3748,3836..3838,
                     3956..3964,4022..4024,4031..4033,4040..4042,4097..4099,
                     4106..4108)
                     /gene="LOC116955762"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319783"
     polyA_site      16347
                     /gene="LOC116955762"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

gagtcgccgtgacgtcacatcctcattatccttcttccgcctcctcgtgacgtaatcagcaagcgactccagcgcgcgccatcacgttgcgggcttcggcgcgagacggcaacgtgcggcttgaaaaccggagcaccgtgagccgctgggcatggcggaggaggaggaggtgaaggccggcgtggaagtaaaggccgacatggaggtgtggcacgccacattcaccgtggaaggcatgacgtgccagtcgtgcgtgcagagcatcacccaggtgctcacggatctgcccgggatctacagcgtacaggtgtctttggagaataagagcgcttcagttctgtacgacccggcacttcacaccccgaactctctgaaaaacagcgttgaggacattggcttcgaggcagctcacaggggagcagtcaccgtcatgatgctggaagtcgccgacattgacattgtgggcatgacctgtcagtcgtgtgtgcagagcatagaggggaaaatgtcaaagctcaagggagtgctgagcttcagcgtgtgcttgcagaaaaacaatgccacggtcgcattcattccgggggtgataagcatgcagaagctgtgcgacgaaatcgacgacatgggattcgaggcgcgccccgtcgatcggaagcctgccacggacaccgcggaagagggcagatcaaccgaggatatggtgaaaatgaggctcgaaggattgattgggcaatccgcggtgaatgcactggaggggaagttgagcaagttgaatggtgtcctgcgcgtgaaggttaacctgtccagccaggaggtggtcgtgtggttccagaagctcgccatcagcgtcgacgacatccaaaaccagatcgccgaatgtggtttgcaaaccaccgtgaggtcgcgtccgaagcagctgaggttgtcgccgcaggccgtgcagaaactgcaggagatgaacggctctgtgtgccattttaaagaagccaagccaacgtcgctaggcctagggaagtgtccgaacgtcgtcataagcgtcgaggggatgcactgcaagtcgtgcgtctttaacatcgaaagcaacatcggccagttgcccggagtgcacagcatcgtggtttctctcgagacaaagtcggctgcggtgagctacagcccggaggacatctcccccgcggctctgtgccaggccatcgaggcacttccacccggcatctttcaagcgagcgtttcgccaacgtcggcgaaggcggtggcttccacccctcctcccccgctgagcagcgtcgtggtgctgcgcgtggagcgcatggagagctccgctggcgtcctcgccgtggagcgcgccctgctggagtgccccggcgtgaaaacggcgcgcgcctcgctcgtcgacggcaccgccaccgtgcactatgacccccgcggcgccagccccgccgcgctctgcgccagcatcaccagcaagggcttcaaggcttccctgctcgatggcagcgatgccaagtcacgggcaaaccacgcgcagtttctactggagggctcggctactccctcgctcaacggcagcaggccgggctggcacgcgcccaccaccagcggcggcaaggggtccatgcagctcgtgcccaccgaggaagaggcagcggtggcatcggcgaaggaagaggaggccaagtgcttcctgatggtcacgggcatgacttgcgcctcgtgcgtggcaaacatcgagcgcgtgctcggcagaaggcgcggtgttcagtcggtgctggtgtcgctcatggccggcaaggcggaggtgcgctaccacccggcctccgtggcgccggaggagatcgcggagagcgtgcgagacatgggctttggggcgacgctcctcgatgaccaggacatcgcgccgggctgcctggagctcgtggtccagggcatgcggtcggcgtcgtgcgctcacgccatcgagtcggcgctcatgcagtgccacggcgtcacgagcgcctccgtggcgctcgccacaaaccgggcgcacgtggagttcgaccccgaccagatcggcccgcgggacatcatcaaggccgtccagaatgccgggttcctcgccgtccacctgaagagagaccgcactgggaaccacctcgaccactcggacaagattcaccagtggcgaaggtcattcttcttcagcctgataattgtggtgcctaccatggggatgatgatttacatgatggtgacagaacgtcaccacgagggccaccacaccggcatattggccaagcacatcgtgccggggctctctctgatgaacctggctgccttcgtgttgtgcaccccagtgcagttcatcggcggctggtacttctacaagcaggcctacggggccctgcgtcacggcacggccaacatggacgtgctgatcgtgctggcgaccaccgtggcgtacgcctactcctgcgtggttctcttcgtggcaatgggggagcaggcgatggtcagccccatcacgttcttcgatacgccgcccatgctcttcgtgttcgtgtcgctcggccgctggctcgagcacatcgccaagagcaaaacctcggaggcgctcgtcaagctgatgtcccttcaggctgcagaggccacggtggtgaagtacggactcagcaacgacatcatcggagaggagcaggtggacgtggacctggtgcaccggggggacgtggtgcgagtgctgcccggagggaagttcccagtcgacgggaaggtcatcgaggggcagtccctcgccgacgagtctctcatcaccggtgaggcgatgccagtgatgaaaaagccggggagcctggtgatcgctggctccatcaaccagaacggcggcctgctggtgaaggccactcacgtgggagcggacacaacgctgtcccaaattgtgcggctggtggaggaggcgcagacttccaaggcacctattcagcagttcgccgacaagatcagcggctactttgtgccgttcatcgtgggcgtttccgtggtgaccctgctctcctgggtcaccatcggctacgtggatttcagcatcgctaagaaatactttccggagtacgatccgaggctgtcgcacggcgaggtggtctggcgcctcgccttccaggcggccatcacggtcctgtgcatcgcgtgcccctgctcgctgggcctggccacccccacggccgtcatggtcggcacgggggtcggagcgcagctgggcatcctcatcaaaggcggcgagcccctggagatggctcacaaggtgcgcacggtagtgtttgacaagacgggcacaatcacgcatggcatcccgaaggtgatgcgcgtgtccatcctggaggagcacgtgaagctgcccctccgcacgttcctcgcggtggtgggcacagcggaggcaagcagcgagcacccgctgggctcggccgtcgccaagtactgtcggcagagcctcggcaccgaaagcctgggatcgtgcgccgacttccaggccatccctgggtgcgggatcagctgccgcgtgtccgacgtggaggccgtgctggcctcgtctaagcagggcctggccgccggcaactcggcggcggcggcggcggcggcgaggaccgacggctttccgctgctggtggacatcgccgacggcggacccgcgggctcccaggccatctccagcaccgatttgggggctggaccagcagcaacctcggggcaagaatacgccgttctgattggaaaccgcgagtggatgaaccggaatgcgctgctggtcgcggagcccgtcgacaaggccatggctgagcacgaggagaagggccagaccgccgtcttggtcgccatcaacggcaagctgtgcggcatgctggccatcgcggacacggtgaagcccgaggccgcgcttgccgtccgcacgctcgccgacatgggcctccaggtggtgctcatgacgggcgacaacaggaagacggcacaagcgatcgccgcccaggtgggcatcaggcgcgtgtttgcggaggtgctgccctcgcacaaggtggccaaggtggagcagctgcaagagagcggacagacggtggcgatggtgggcgacggcgtcaacgactcgccggcactcgcccgctccgacgtgggcatcgcgctcggcaccggcaccgacgttgccatcgaggcggcggacattgtcctcatccgcaacgacctgctggacgtcgttgccagcattcacctctccaagaagacggtgcgacgcatccacatcaacttcgtgttcgccctcatctacaacgtcgtcgggatccccattgctgcaggggtgttcatgccggcggggctggtgctgcaaccgtggatggcggccgcagcgatggctgcctcgtccgtgtctgttgtgctctcgtcgctgatgctcaagaggtacaagaagccgagccgcccgcgcctggaggcgcagacccggggccgcgtgcgcgggtgcagcctctcggaggtgagcgtcgccgtgggcatgggagaccgtcccgcctgggtggacgggcgcacgtccccgaagctgggcgtctgggaccgcgtcaagttcatcagccagacgtccatcgcgtcgctcaccgcggacaagcgcatggccggcggcggcaccgccgccggcctctcggtgcagctgctcgaccggcactcgctgctcggcgacggcggcggcggcagcggcggctcgcaccacgaattcacgaccgacgtgtgaacggcggcgagactggtgggacttgaccgtcgtcggccgccgcggccgatcgccgcgctctcgcctgtgccggggagagagcccgtcgtcgcgtgaagcctccacccgccgcgcctccctccctccctccctcccgcgcctccctccctccttcccgcgcctccccgggacctttccccagcagtgcatcttgtgcaataacgtgatggcaaccttggagtctatcgcacgcttgcgaggcaaggttttttag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