LOCUS       XM_075562877            6438 bp    mRNA    linear   MAM 22-JUL-2025
DEFINITION  PREDICTED: Tenrec ecaudatus ATPase copper transporting beta
            (ATP7B), mRNA.
ACCESSION   XM_075562877
VERSION     XM_075562877.1
DBLINK      BioProject: PRJNA1291776
KEYWORDS    RefSeq.
SOURCE      Tenrec ecaudatus (tailess tenrec)
  ORGANISM  Tenrec ecaudatus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Afrotheria; Afrosoricida; Tenrecidae;
            Tenrecinae; Tenrec.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_134540) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_050624435.1-RS_2025_07
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 07/16/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6438
                     /organism="Tenrec ecaudatus"
                     /mol_type="mRNA"
                     /isolate="mTenEca1"
                     /db_xref="taxon:94439"
                     /chromosome="11"
                     /sex="male"
                     /tissue_type="primary dermal fibroblasts"
                     /dev_stage="adult"
                     /geo_loc_name="USA: Las Vegas, Nevada"
                     /lat_lon="36.107 N 115.143 W"
                     /collection_date="2023-03-15"
                     /collected_by="Allyson Hindle"
     gene            1..6438
                     /gene="ATP7B"
                     /note="ATPase copper transporting beta; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 8 Proteins, and 97% coverage of the annotated genomic
                     feature by RNAseq alignments"
                     /db_xref="GeneID:142461195"
     CDS             46..4299
                     /gene="ATP7B"
                     /codon_start=1
                     /product="copper-transporting ATPase 2"
                     /protein_id="XP_075418992.1"
                     /db_xref="GeneID:142461195"
                     /translation="

MKQDFAYDNAGYESSENSVATSTVHIVGMTCQSCVKTIESMVSSIDGLVSVKVSLEQGSAAVRYMPSVVSLQQICYLIEDMGFEASVPEGKAASWPPRPSPVGEALVKLRVEGMTCQSCVNSIEGNLGKLQGVVRAKVSLGNQEAVIAYQPYLIQPEDLRDHVNDMGFEATIKHKAAPLSLGPIDIGRLQSTNPKRLSAPVPQSPRGPEPPGDQGSPSVTLQLRVEGMRCKSCVFNIENNIGRLPGVREIQVSLEHGTARVHLEPSLISPETLQEAIEALPPGNFQVSLPGGSEGSGTECLPGVGPAERQAPGCSQRSEEPGVHRRVTLAIAGMMDASCVQWIKGVLSQREGVRRVSVSLAEGTGSILFHPALLNPEELRAAVQDMGFEVTILSDNSSSNHTGSPGVGNSAVQTPGGTPMSTQAPPDRRSPRSPRPGHSSGSPPSPEVAPQKCFLQITGMTCASCVSNIERSLLKEAGILSVLVALMAGKAEVKYNPEVIQPLEIAQLVESMGFGATVMEDYTGPEGSFELVIRGMTCASCVHNIESKLTRTNGITYASVALATSKAHVKFDPEIIGPRDIVKIIEETGFHASLAPRDPNAHHLDHRLEIKQWKKSFLCSLVFGIPVMGLMIYMLIPSQEAHEAMVLDHNIIPGLSILNLIFFILCTFVQFLGGWYFYVQAYKSLKHGTANMDVLIVLATSIAYAYSLVILVVAIAEKAERSPVTFFDTPPMLFVFIALGRWLEHVAKSKTSEALAKLMSLQATEATVVTLGEDNVIIREEQVPMELVQRGDIIKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSLNAHGSVLVTATHVGRDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIISTVTLVVWIIIGFLDFGVVQKHFPGHSTHISQTEVILRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLELAHKIKTVMFDKTGTITHGVPKVTRFLLLVDVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTEALGYCTDFQTVPGCGIGCKVSSVDGTLAPKEHLNGVGNGLAEKDAAPETFSVLIGNREWMRRNGLTISSDVSDAMTDHEIKGQTAVLVAIDGVLCGMIAIADSVKQEAVLAVHTLKSMGVDVVLITGDNRKTARAIATQVGIHKVFAEVLPSHKVAKVQELQLQGKKVAMVGDGVNDSPALARADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVWRIRINLVLALIYNLIGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLELKCYRKPDLEWYEVQAHGRLKPLTPSQVSVHIGLDDRLRDAPRPSLWDQVSYVSQVSHTSDRLSRHSATADDSGDKWSLLLTDRDEEEYI"

     misc_feature    103..306
                     /gene="ATP7B"
                     /note="Copper chaperone CopZ [Inorganic ion transport and
                     metabolism]; Region: CopZ; COG2608"
                     /db_xref="CDD:442020"
     misc_feature    367..558
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(385..393,400..402)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    709..885
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(727..735,742..744)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1021..1218
                     /gene="ATP7B"
                     /note="Copper chaperone CopZ [Inorganic ion transport and
                     metabolism]; Region: CopZ; COG2608"
                     /db_xref="CDD:442020"
     misc_feature    1408..1596
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1423..1431,1438..1440)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1633..1824
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1651..1659,1666..1668)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1888..3972
                     /gene="ATP7B"
                     /note="P-type heavy metal-transporting ATPase, similar to
                     human copper-transporting ATPases, ATP7A and ATP7B;
                     Region: P-type_ATPase_Cu-like; cd02094"
                     /db_xref="CDD:319783"
     misc_feature    order(2881..2883,2887..2889,3901..3903)
                     /gene="ATP7B"
                     /note="putative Cu binding site [ion binding]; other site"
                     /db_xref="CDD:319783"
     misc_feature    order(3013..3021,3223..3225,3352..3360,3448..3450,
                     3568..3576,3634..3636,3643..3645,3652..3654,3709..3711,
                     3718..3720)
                     /gene="ATP7B"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319783"
ORIGIN      

gtctcgtctcaaccctctgtgcccacccgtgcctgggaagcggccatgaagcaggatttcgcctatgacaatgcgggctacgaaagcagtgagaacagcgtggccaccagcacggtccacattgtgggcatgacatgccagtcttgtgtcaagaccatcgagagcatggtgtccagcatagacggcctcgtgagcgttaaggtctccctggagcagggcagtgccgccgtgcggtacatgccatcggtcgtgagcctgcagcagatctgctacctcatcgaggacatgggcttcgaagccagtgtccccgaagggaaggctgcctcttggccccccaggccctcccccgtgggagaggccctggtcaagcttcgagtggaaggcatgacctgccagtcctgcgtcaactccatcgagggcaatctagggaagctgcaaggcgtggtgcgtgccaaagtctccctgggaaaccaggaggctgtcatcgcctatcagccttaccttattcagccagaggacctcagggaccatgtcaacgacatgggatttgaagccaccatcaagcacaaggcagcccccctgagcctggggccaatcgatattggacgcttgcaaagcacgaacccaaagaggctttcagctcctgttccccagagtccccgtggtcctgaacccccgggggaccaaggaagccccagtgtcaccctgcagctgagggtagaggggatgcggtgtaagtcttgtgtcttcaacattgaaaacaacattggccgacttcctggtgtccgcgagatccaagtgtccctagagcatggaacggcccgagttcaccttgagccttctctcatctctcccgagactctccaggaggccattgaagctcttcccccggggaacttccaagtttctcttcctgggggctcagaagggagtgggaccgagtgcctgccaggggtcgggcctgccgagcgccaggcccctggctgctcccagcggagcgaggagcctggagtgcacagaagggtgacgctcgccattgcaggcatgatggacgcgtcctgcgtccagtggatcaaaggtgtcctatcccagagggaaggcgtgcgtcgggtctctgtctccctggcagaagggactggcagtatcctctttcaccctgctctgctgaacccagaagagctcagagctgccgtccaagacatgggattcgaggtgaccatcctctctgacaactcttccagcaaccatactggaagcccgggtgttgggaattctgcggtacaaactccaggtggcacaccgatgtctacacaggcgccccctgacaggaggtcccctcggagcccccgccccggccactcgtccggctccccaccatctcccgaggtggctccacagaagtgctttttacagatcacaggcatgacttgtgcctcctgtgtgtccaacatagagcggagcctgctgaaagaagccggtatcctctccgtgctggtggccttgatggccggaaaggcagaggtcaagtataacccggaagtcatccagccactggagatcgcccagctggttgagagcatgggctttggggccacagtgatggaagactacacaggccccgagggcagcttcgagctggttatccgagggatgacctgcgcctcctgtgttcacaacatcgagtccaagctcacaaggacaaacggcatcacctacgcctccgtggccctcgccaccagcaaagcccacgtgaagtttgaccctgagatcatcggtccacgggatattgtgaaaatcatcgaggaaactggctttcatgcttccttggccccgagagaccccaacgctcatcacctggaccacagactggaaataaagcagtggaagaagtctttcctgtgtagcctggtgttcggcatccctgtgatgggtctgatgatctacatgctcatccccagccaagaggcccatgaggctatggtcctggaccacaacatcatccccggactgtccattctaaacctcatcttcttcatcttgtgtacctttgttcagttcctcggggggtggtatttctacgtccaggcctacaagtctctgaagcacgggacggccaacatggacgtgctcatcgtgctggccacaagcatcgcctacgcctactccctggtgatcctggtggtggccatcgcggagaaggccgagaggagcccggtgaccttcttcgacacgccgccgatgctctttgtgttcatcgccctgggacggtggctggagcacgtggccaagagcaaaacctcagaagccctagccaagctcatgtcactccaagccacagaggccaccgtcgtgaccctgggggaggacaacgtcattatcagagaggagcaggtgcccatggagctggtgcagcggggtgacatcatcaaggtggtccccgggggcaagttcccagtggacgggaaggtcctggaaggtaacaccatggccgacgagtccctcatcacaggagaagccatgccggtcaccaagaagccaggcagcacggtgatcgcgggctccctcaacgctcacggctctgtgctcgtgactgccacccacgtgggccgagacaccacgctggcccagattgtgaagctggtggaagaggcccagatgtcaaaggcacccattcagcagctggctgaccggttcagtgggtattttgtcccattcatcatcatcatttcgacggtgacgttggtggtatggattataatcggttttctcgattttggtgttgttcagaaacacttccctggccacagcacgcacatctcgcagacggaggtgatcctccggtttgccttccagacgtccatcaccgtgctgtgcatcgcctgcccctgctcgctgggcctggccacgcccacggccgtcatggtgggcaccggggtggccgcgcagaatggcatcctcatcaaggggggcaagcccctggagctggcgcacaagataaagaccgtgatgtttgacaagacaggcaccatcacccatggggtccccaaagtcacgcgcttcctcctgctggtggatgtggccacgctccctctcagaaaggtccttgctgtggtggggaccgccgaggccagcagcgagcaccccttgggcgtggcggtcaccaagtactgtaaagaggaacttggaacagaagccctgggctactgcacagacttccagacagtcccgggctgtggcatcggctgtaaggtcagcagcgtggatggcaccctggccccgaaggagcacctgaacggagtgggcaacgggcttgccgagaaagacgcggcccctgagaccttctccgtgctgattgggaaccgcgagtggatgaggcgcaatggcttaaccatctccagtgacgtcagtgacgcgatgacagaccacgaaataaaagggcagacagcggtcctggtggccatcgatggtgtcctctgcggaatgatcgccatcgcggactctgtcaagcaggaggcggtgctggctgtgcacacgctgaagagcatgggggtggacgtggttctgatcaccggggacaaccgcaagaccgcccgggccatcgccactcaggtcggcatccacaaggtctttgccgaggtgctgccctcccacaaggtggccaaggtccaggagctgcaactccaagggaagaaggtcgccatggtcggagacggggtcaacgactccccagccttggcccgggccgacgtgggcattgctattggaacgggcaccgacgtggccatcgaggcggccgatgtggtcctcatcaggaatgacctcctcgacgtggtggccagcatccacctttccaagaggaccgtgtggagaatacggatcaacctggtcctggcgttgatctacaacctgattgggatacccattgcggcaggtgtcttcatgcccatcggcatcgtgctgcagccctggatggggtcagcggccatggccgcctcctcggtctccgtggtgctgtcatccctggagctcaagtgctacaggaagccagacttggagtggtacgaggtgcaggcccatggccgcctgaagcccctgaccccatcccaggtcagcgtgcacatcggtttggacgaccgcctgcgggacgccccccggccctcgctgtgggaccaggtcagctacgtcagccaggtgtctcatacctcagacaggctgtcccgacacagtgccacagccgacgacagcggggacaagtggtccctgcttctaacggacagggacgaggaggagtacatctgaaggctccaggcaggtgccgatccagcaggcttgtctccagggagcagctgtgccccgaacacgctgttggcggcccgagggcaccgtgtggcacaacagccagggccagggtggtgtaggcatcaggccatcccggccatccctgtagccatagcccattggccctgcgagcagcatccgtctgaacaggactgacctccctgggccctgctggccccagggcataccgacctggtctcctcctccccttcctcctcctcctcctcagtaactttggcttggacaagaggagagcaaggtcggcctcctcctgggcctcatgtcttccactctggacaactacttgcaaaagacgggggaccctcatcagaaccaaaaactgatccaggcctttcctcaggactcaaaagcatcaggttgggctcttctggtgatgtccccacgcgtgtgagaccacagtttatacctcagctgcacctgttgttgtctgttagcgccacctcctcctcctcctccctctgtgctcggtatccagccgtcctggaggtccctgctgccgtcccccaaacacgctctgtctgtgcacttcctgcccaaggctgtcctctcccacacacgcctgcccggttcactgaggagaggccgcacttcctcaagttaagactcgtctcaaggagtctgggcttcccaacccgggctctggacagtccagacttcctgcgggtgggctgagtccctgtgggaggccttggtggtgctcgacgtgaatgccctttaggggtgcatgcggggtggctggccaggcccccagggagcagggcctaccttgtattctatgaagatgtcccttctcagaagctactagataatgcttgggaggggtgccctggagtcagcagggacatcccagtgagtgagtcatcctgctccactattagccttctccacgtgtgccttaggacagcggtgtccccaaaagagagcctctctttcttcccagggctccaaactggtcccaccatggccaaggcagcaaaatggaaactgacctgaatttgtaaaacgtgggtgtcccgagaggggaagatgatgagccctggaatgagaaactcagaagagccccagagagccctttccagagcctgaggctggagactggcttgtcgctaatgctgtaggccgccatctggaagctggccaccattggtttcacctctgtcagggctgcccttgttttctaagagggaggctaaggtcctaggagtatgccgcctgtaattttcccttttggggtatcattccagtacacccatattccaaaaatgtgagcttgtagggagctttgttgaccagcatggcgcccgagagaacctgttcagagcctcttcaggctttctcgctcttggcgacttcctggtggtggtgacccgccatccgagttgggagagtggaccatgcttcgaccctgaagtcggctggtgattggccagagccacacgggagtggacgggtggaatctgacattacatgcttcagaggcctgtggtcacccacaaaagataacgagactgtgaccgagtgtcagttatatcccaggtgaatgtcaccacttttgatatgttacctctgctcctcaaagcaaactagcaaggtagatctcagtggcccccctttcaggtgagggaacagattccctccgccagtatgtgttgccacgtctgttggctcggaagtcttcaactctgcagatcctcgaagctccgcatgctggataagaaggacgactcaagcaatcagttcttggcccgggaagaccgcagctgcggggctttgtctgtgttgcccgctagtgaggtctcgcgtacctggctgtgtggtttccttttgccatcagttgatgtctgctgagcttcgtcctctaaaagtcaagtgccagcgtggttcgattttgctttttgtcgttttcaagctttctctccctcccacctccttccccctgcactgggccaattatctcctccccattcttccacctgtccagggacacctcgtgtcattacattgtctctacaatgtagtgttttgtcttatgaaaaagcttttagtaccataaatgtatatatttatgggcatgggaat

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