LOCUS       XM_075490056            6347 bp    mRNA    linear   VRT 21-JUL-2025
DEFINITION  PREDICTED: Mycteria americana ATPase copper transporting beta
            (ATP7B), transcript variant X4, mRNA.
ACCESSION   XM_075490056
VERSION     XM_075490056.1
DBLINK      BioProject: PRJNA1289900
KEYWORDS    RefSeq.
SOURCE      Mycteria americana (wood stork)
  ORGANISM  Mycteria americana
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Neoaves; Aequornithes;
            Ciconiiformes; Ciconiidae; Mycteria.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_134365) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_035582795.1-RS_2025_07
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 07/11/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6347
                     /organism="Mycteria americana"
                     /mol_type="mRNA"
                     /isolate="JAX WOST 10"
                     /db_xref="taxon:33587"
                     /chromosome="1"
                     /sex="female"
                     /tissue_type="blood"
                     /dev_stage="chick"
                     /ecotype="Jacksonville Zoo and Gardens"
                     /geo_loc_name="USA: Jacksonville Zoo and Gardens,
                     Jacksonville, FL"
                     /collection_date="2021-05"
     gene            1..6347
                     /gene="ATP7B"
                     /note="ATPase copper transporting beta; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 7 Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 2 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:142403770"
     CDS             160..4458
                     /gene="ATP7B"
                     /codon_start=1
                     /product="copper-transporting ATPase 2 isoform X3"
                     /protein_id="XP_075346171.1"
                     /db_xref="GeneID:142403770"
                     /translation="

MKHNFAFDNMGYEESFETAPSPSSQEHTVAVNVVGMTCQSCVQSIEGRISKVKGIVSIKVSLEQNNAVIKYLQSDISPEQICQEIQDMGFDANIAEERLTTATVNLSCLREAVVKLRVEGMTCQSCVTNIEGKIRKLHGVAKIKVSLGNQEAIIAYYPYIIQPDDLKSHISNLGYECTIKSKSAPLKLGVLDLGHLQNANPKETPASLESGGVDPPVAKMSGTATVAVRIEGMHCKSCVRNIEGNISDLPGIQSIKVSLEHKRAVVQYSPNLITLSALQQAIESLPPGNFKVCLPNGSEVNKGASPSPALLCDLFREPLQDTTRTAVIRIDGMTCNSCVQSIEGTISQRQGVQCIAVSLADRTGTIHYDPAVTNGEELRAAIEDMGFDASVLTDTTAGERGHWPDTSNAAVQPQVPEPPHQGCASDAFPDSPHLDGPNQPSGVTAEKCFLQITGMTCASCVSTIERNLQKEDGIVSVLVALMAGKAEIKYKPEFIQPLEIAQLIQNLGFEATVIEDHAEIEGNVELLITGMTCASCVHNIESKLMRTNGISYASVALATCKAHIQFDPEITGPRDIIKIIEEIGFHASVARRVPNAHNLDHKKEIQQWRKSFLCSLLFGIPVLILMIYMLIPDGEHHGSMVLEQNLIPGLSILNLLFFVLCTFVQFLGGWYFYVQAYKSLKHKTANMDVLIVLATTIAYVYSCVILMVAIIEKAEKSPVTFFDTPPMLFVFIALGRWLEHIAKSKTSEALAKLISLQATEATVVTLGPDHSIVREEQVAVELVQRGDIVKVVPGGKFPVDGKVIEGSSMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLVNATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADKFSGYFVPFIIIISTVTLIVWITIGFINFDVIQKYFPNQNKHVSKAELILRFAFQTSITVLSIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITCGVPKVMRVLLLGDTAVLSLKKVLAVVGTAEASSEHPLGVAVTKYCKEELGTQSLGYCTDFQAVPGCGISCKVRGIEAVLGMAEEGLDNLDTNRNRDSSAPLGDDNMLITLSESHGPSASHTYSVLIGNREWMRRNGLHIANDINDAMTDHETKGQTAILVAIDGMLCGMIAIADTVKQEAALAVHTLKNMGIDVVLITGDNRKTAKAIATQVGIKKVFAEVLPSHKVAKVQELQNGRRKVAMVGDGVNDSPALARADIGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLILALIYNLLGIPIAAGVFMPVGLVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDTESYEAQAQGRMKPLTPSQISVHIGMDDRRRDSSRPAPWDQISQVSLSSLTSDKLPRRNAFVEEEGDKWSLLMNGGDEEQYI"

     misc_feature    250..435
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(265..273,280..282)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    502..693
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(520..528,535..537)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    841..1014
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(856..864,871..873)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1126..1338
                     /gene="ATP7B"
                     /note="Copper chaperone CopZ [Inorganic ion transport and
                     metabolism]; Region: CopZ; COG2608"
                     /db_xref="CDD:442020"
     misc_feature    1507..1695
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1522..1530,1537..1539)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1732..1923
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1750..1758,1765..1767)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1987..4131
                     /gene="ATP7B"
                     /note="P-type heavy metal-transporting ATPase, similar to
                     human copper-transporting ATPases, ATP7A and ATP7B;
                     Region: P-type_ATPase_Cu-like; cd02094"
                     /db_xref="CDD:319783"
     misc_feature    order(2980..2982,2986..2988,4060..4062)
                     /gene="ATP7B"
                     /note="putative Cu binding site [ion binding]; other site"
                     /db_xref="CDD:319783"
     misc_feature    order(3112..3120,3322..3324,3511..3519,3607..3609,
                     3727..3735,3793..3795,3802..3804,3811..3813,3868..3870,
                     3877..3879)
                     /gene="ATP7B"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319783"
ORIGIN      

aaaggcaagagggtgacagctaatttcagcctgtggaggtacagggagaagagcagcccaaaacctctgaagatactgggcgagaggttcagtgagatccggcattcgtgggctttgtccaacactgattctcctcctgactgtgagctggagcctacaatgaaacacaattttgcttttgacaacatgggttacgaggagagctttgaaactgcaccctctccatcttcccaagaacacactgtggcagtcaatgttgtgggaatgacttgccaatcttgtgtgcagtcgatagaaggccgaatttccaaggtgaagggcattgtgagtattaaagtctcccttgagcagaacaacgctgtaataaagtatctgcagtcagatataagtcctgaacagatttgccaggaaattcaggatatgggctttgacgccaacatagcagaagagaggttgactacagcgaccgtaaatttgtcatgcttgagagaagcagtagttaagcttcgggtagaaggcatgacatgccagtcctgtgtcaccaacattgaaggaaagatcaggaaactgcatggtgtggcgaaaatcaaggtgtcacttggtaaccaggaagcaattattgcttactatccctacatcattcagcctgacgacctcaagagccatatcagtaacctgggatatgaatgcaccattaaaagtaaatcagcccctttgaagcttggtgtcctcgatctcgggcacctgcagaatgcaaaccccaaggagacaccagcaagtctcgagagtggtggggtggatccaccggtcgccaagatgagtggcacagctacagtggctgtacggatagaaggcatgcactgcaaatcctgtgtcagaaacattgaaggaaatatatcagatcttcctggcatacaaagtattaaagtgtctttggagcataaacgtgctgtggtacagtatagcccaaatttaattaccctgtcagctttgcagcaagctattgaatcccttccacctggaaactttaaagtatgtctccctaatggttcagaagttaataagggagcatctccatcacctgctttgctatgtgatctcttcagagagccactgcaagacacgacacgcacagctgttattaggattgatggcatgacctgcaattcctgtgtacagtccatagaagggaccatatcacagaggcaaggagtgcaatgcatagcagtttctctagctgacagaactgggaccatacattatgatccagctgtcactaatggagaagagttaagagctgccatagaagacatggggtttgatgcttctgtgctgacagataccactgctggagaacgtgggcactggcctgacaccagcaatgctgccgtgcagcctcaagttccagagcctcctcaccaaggctgtgcctcggatgcttttccagacagtcctcaccttgatggaccaaaccagcccagcggagtgacagctgaaaagtgttttttacaaatcacaggcatgacctgtgcgtcgtgtgtgtctaccattgaaagaaatttgcagaaagaagacggaattgtttcagtgttggtagcactgatggcaggtaaagcagagataaaatacaagccagaattcatacagcctcttgaaatagcacagctgatccagaatttgggttttgaagctaccgtcatagaagatcatgcagaaatagaaggaaatgtggagcttcttattacagggatgacttgtgcttcttgtgttcacaatattgaatccaaactcatgagaacaaatggcatatcctatgcctcagttgcacttgctacttgcaaagctcacatccagtttgatcctgaaattactggacctcgagatattataaaaataattgaggaaattggctttcatgcttctgtggctagaagagttccaaatgcacataacctggatcataaaaaggaaatacagcagtggaggaaatctttcttgtgcagcctactgtttggtatccctgtcttaatcctaatgatttatatgctaatacccgacggcgagcaccatgggtctatggtgctggaacagaatctcattcctggattatctattttaaatcttctcttctttgtcctgtgcacttttgttcagtttctaggtggatggtatttttacgtacaagcttacaaatcactgaagcacaagacagccaatatggatgtgctcattgtattggccacgacgattgcttatgtgtattcgtgtgtgatcctgatggtagcgataattgaaaaagcagagaaaagccctgtcactttctttgacactcctccgatgctgttcgtgttcattgcccttgggagatggctggaacacatagcaaagagtaagacctcagaagctcttgctaaacttatatctcttcaagccacagaagccactgtggtgactcttggacctgaccactctatcgtcagggaggagcaggtagctgttgaactggttcaaaggggtgatattgtaaaggttgttcctggtggaaagttcccagtggatggaaaggtcattgaaggcagttctatggcagatgagtctctcattactggggaagctatgccagtcactaaaaagcctgggagcacagtgattgctggttctataaatgcacatggctcagttcttgttaatgcaactcatgttggtaatgataccactctggcacaaatcgtgaaattggtggaagaagctcaaatgtcaaaggcacccatccagcaactggcagataagtttagtggatattttgttccatttatcatcatcatttcaacagtgacattgatagtatggatcacaattggttttataaattttgatgttattcaaaaatattttcctaatcagaacaaacacgtttcaaaagctgaactaatactgaggtttgcatttcaaacctcaatcactgtgctgagcattgcatgcccctgttctttaggcttggctacccccacagctgtgatggtgggcacaggagttgctgcgcagaatggtattctcatcaaaggtggaaaacctctggaaatggcacacaagatcaagactgtgatgtttgataaaactgggaccatcacctgtggagttcctaaagtcatgagggtgcttttgctgggagacacggctgtgctctctctgaagaaggtactggcggtggttggcactgcagaagccagcagcgaacatcctttaggagtggcagtcactaaatattgcaaagaggagcttggcactcagagcctaggatactgcaccgacttccaggcagtcccgggctgtggcatcagctgcaaagtcagaggtattgaggccgtcctgggcatggccgaggagggtcttgataatctggacactaacaggaacagggacagcagtgctcctctgggagatgataacatgctgatcaccctctccgaatcacatggtccatcagcttctcatacatactcggtgttgattggaaatcgtgagtggatgcgacgcaatggcttgcatattgcaaatgacataaatgatgcaatgacagaccatgaaacaaaaggacagactgccatactagtggctatagatggcatgttgtgtggaatgattgcaatagcagacactgtcaagcaggaggcagcccttgctgtgcacacgctgaaaaacatgggaatagatgtggtgctgataacaggggacaacagaaaaactgcaaaagccattgctactcaggttgggatcaaaaaagtctttgctgaggttcttccttctcacaaggttgcaaaggtccaggagctccaaaatgggaggaggaaggttgcgatggttggtgatggagtcaatgattcccctgcgctagccagggctgacatcggaattgcaattggaacgggcaccgatgttgccattgaagcagcagatgttgttctcatccgaaacgacttgctggatgtagttgccagtattcacttatcaaagagaacagttcgaagaatacgaataaatctgattcttgccttaatttataatctgcttggaatacccatagcagcaggtgtgttcatgcctgttggcctcgtgcttcagccttggatgggatcagctgcaatggcagcttcttctgtgtctgttgtgctgtcttccctgcagctgaaatgttataagaagccagacactgaaagttatgaagcacaagctcaaggccgcatgaagccacttactccttcccaaatcagtgttcatattggaatggatgataggaggagggattcatccaggccggctccttgggatcagattagccaagtttctctctcttccttgacttcagacaagctgccaagacgtaatgcttttgttgaggaggaaggggacaagtggtcattgcttatgaatggaggagatgaagaacagtacatctgaagcactgtattcttagtacaggaggaaacgttccccctcatcagtgacgggagcgaccaacttatgtcatcaagagcttcagggttgtagtgaagtcattgcttcagctcacaaaatgattgcaactcagctcaatgttgggctgtatggatggtggatttttttcaggtcaccagttacttctagtcatggaaagaatctgtggctctctaatgaactggctcctttgcacacagcaattagtgaaataatgtaaaattttaattttcagagtctaaaagagcttctctcttctagactgtttgctgggcaccaaatttcatacttttagctctttctaactttattctttcaagagcacatgaagcaaaaatattttcagagctgccaaatattaatttctgtgtccaagtgaaaatagccatggcataaggagctctgtggttggaagttgtagttttacacagaatcctaactagtcatgtcactgtgagagcactttgtatttaggattcatatgcgtctccttggaccaaaaatgctttggtgtttcactgactagaactctctgaaaggtctctttcaaagattttcacttgctttcaggtattgcatccttttgatgcacatttccattgctaaacttgttctgtcattcccactgctctcctagattttctcttttgctccgtatgagctcttttttcccttttctttgcacaagatatcttcgatgagttatggttatgtttacagatattcctgtttgggacaaactcctttaagtcaccaggaacttttccattcctattgaagacctcaaaggcagagcaattcctggtccaagttagcatatcattttcctgtagataccttgcaggaccccgtgaagctcctgacaactgggtagttgtctgtctcgtccctctgacagagtgaagaatttatgccagtgtgagtgaaggtggtatttacatggtgtgactgaaagcagaactagcactggtgtgactccagcatggctgaaagaagtgagtttattgcatgagttaaccccagcttgcttaaaatggagccaaaagtttaaatggtaaaggtggaaaaatggccttaaaatgtggggcttctatttgctatcatataaataaccttttctgatgacagaaggacttgaactaagatttgtaatggcttgaattttaatgtaaatttgtgttcatgttttgaataggttttaatttcctctatgctctagtttcatgagaaatcaaggtgctgaacaaccctttttttcactttaacgtctctaccaaagcttgcagtaactttatcactgtgaatgtcaaattcatcccttaacacttttcagtcaggacagtaggaatcaatggctttggtgcactgaatccggtcctggggtgctgtgttgctcaactgtgggactctgaagcaagcagaccagagttttaagtctaatctaaaaagtgaaagagcaggaattactgtgctaagcaatgtgaaataaccattggacttcactgacttaaatacagaattgtttccaatacgggttcaaaccctgctcctcctaatgtaaaaacgaaaaacaagtcagagaggaaaagaactgtgcttaaagcattgagcaggtcttcctattctctcttcctcttaatattatatttcagctttccttatcaaacatcgacagcactgtcttaaatattcagttttaaaactgtaaaaatctctttacatgtgtagagattactttcacagcacacacactttttaaacatgccgtaggttcctatacatgtccctgtggggaagatggtctactgttttatgttttcttaccagtgcttacagtaaaaatattgtggttt

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