LOCUS       XM_075086160            6270 bp    mRNA    linear   VRT 11-JUL-2025
DEFINITION  PREDICTED: Phalacrocorax aristotelis ATPase copper transporting
            beta (ATP7B), transcript variant X3, mRNA.
ACCESSION   XM_075086160
VERSION     XM_075086160.1
DBLINK      BioProject: PRJNA1289118
KEYWORDS    RefSeq.
SOURCE      Phalacrocorax aristotelis
  ORGANISM  Phalacrocorax aristotelis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Neoaves; Aequornithes; Suliformes;
            Phalacrocoracidae; Phalacrocorax.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_134276) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_949628215.1-RS_2025_07
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 07/10/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6270
                     /organism="Phalacrocorax aristotelis"
                     /mol_type="mRNA"
                     /db_xref="taxon:126867"
                     /chromosome="1"
     gene            1..6270
                     /gene="ATP7B"
                     /note="ATPase copper transporting beta; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 80 long SRA reads, 8 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 14 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:142053917"
     CDS             86..4381
                     /gene="ATP7B"
                     /codon_start=1
                     /product="copper-transporting ATPase 2 isoform X3"
                     /protein_id="XP_074942261.1"
                     /db_xref="GeneID:142053917"
                     /translation="

MKHSFGFDNMGYEGSFETVHSSSSQEHTVEVNVVGMTCQSCVQSIEGRISKVKGIVSIKVSLEQGNAIIKYLQSEISPEQICQEIQDMGFDASIAEKRLKTATVNLSCLREAVVKLRVEGMTCQSCVTNIEGKIRKLQGVAKIKVSLGNQEAIIAYYPYIIQPDDLKSHISNLGYECTIKSKSAPLKLGVLDLGCLQNANPKGTPASLKSDGVDPPDAKMSGIATVAVRIEGMHCKSCVRNIEGNISDVPGIQCIKVSLEHKRAVVQYSPNLITLSALQQAIESLPPGNFKVCLLNGSEVNKAASPSPALLCNLFGEPLQDTTCTAVIRIDGMTCNSCVQSIEGTISQRQGVQCIAVSLADGTGTVHYDPAVTNGEELRAAIEDMGFDASVLTDTAAGERRHRPDASNAAMEPRAPEPPRQGCPSDALPDSPHLDGPNQPSGATTEKCFLQITGMTCASCVSAIERNLQKEDGIVSVLVALMAGKAEIKYKPEFIQPLEIAQLIQNLGFEATIIEDHAETEGNVELLITGMTCASCVHNIESKLMRTNGISYASVALATCKAHIQFDPEITGPRDIIKIIEEIGFHASVARRVPNAHNLDHKKEIQQWRKSFLCSLLFGIPVLIIMIYMLISDGEHHESMVLEQNLIPGLSILNLLFFVLCTFVQFLGGWYFYVQAYKSLKHKTANMDVLIVLATTIAYVYSCVILIVAIIEKAEKSPVTFFDTPPMLFVFIALGRWLEHIAKSKTSEALAKLISLQATEATVVTLGPDHSIIREEQVAVELVQRGDIVKVVPGGKFPVDGKVIEGSSMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLVNATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADKFSGYFVPFIIIISTVTLIVWITIGFINFDVIQKYFPNQNKRVSKAELILRFAFQTSITVLSIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITCGVPKVMRVLLLGDMAVLSLKKVLAVVGTAEASSEHPLGVAVTKYCKEELGTQSLGYCTDFQAVPGCGISCKVRGVEAVLGMAVEGLDKPDTNRSRDSSAPLGDNALITLSESHGPSASQTYSVLIGNREWMRRNGLHIANDVNDAMTDHETKGQTAILVAIDGVLCGMIAIADTVKQEAALAVHTLKNMGIDVVLITGDNRKTAKAIATQVGIKKVFAEVLPSHKVAKVQELQNGRRKVAMVGDGVNDSPALARADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLILALIYNLLGIPIAAGVFMPVGLVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDTESYEAQAQGRMKPLTPSQISVHIGMDDRRRDSSRPAPWDQISQVSLSSLTSDKLPRRNGFVEEEGDKWSLLTNGADEEQYI"

     misc_feature    173..364
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(191..199,206..208)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    428..619
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(446..454,461..463)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    767..940
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(782..790,797..799)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1058..1264
                     /gene="ATP7B"
                     /note="Copper chaperone CopZ [Inorganic ion transport and
                     metabolism]; Region: CopZ; COG2608"
                     /db_xref="CDD:442020"
     misc_feature    1433..1621
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1448..1456,1463..1465)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1658..1849
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1676..1684,1691..1693)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1913..4054
                     /gene="ATP7B"
                     /note="P-type heavy metal-transporting ATPase, similar to
                     human copper-transporting ATPases, ATP7A and ATP7B;
                     Region: P-type_ATPase_Cu-like; cd02094"
                     /db_xref="CDD:319783"
     misc_feature    order(2906..2908,2912..2914,3983..3985)
                     /gene="ATP7B"
                     /note="putative Cu binding site [ion binding]; other site"
                     /db_xref="CDD:319783"
     misc_feature    order(3038..3046,3248..3250,3434..3442,3530..3532,
                     3650..3658,3716..3718,3725..3727,3734..3736,3791..3793,
                     3800..3802)
                     /gene="ATP7B"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319783"
     polyA_site      6270
                     /gene="ATP7B"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

gccgtgtgcaaagattagcagtgctgaacgcagttcgcctttgtccaccactgattctcctcgtggctgtgagctggagcctacaatgaaacacagttttggttttgacaacatgggctatgaggggagctttgaaactgtgcactcctcatcttcccaagagcacactgtggaagtcaatgttgtgggaatgacttgccaatcttgtgtgcagtcgatagaaggacgaatttccaaggtgaagggtattgtgagtataaaagtatcccttgaacaaggcaatgctataataaagtatctgcagtcagaaataagccctgaacagatttgccaggaaattcaggatatgggcttcgacgccagcatagcagaaaagaggttgaaaacagcgacagtaaatttgtcgtgcttgagagaagcagtcgttaagcttcgggtagaaggcatgacgtgccagtcctgtgtcactaacattgaaggaaagattaggaaactgcaaggtgtggcgaaaatcaaggtctcacttggtaaccaggaagcaattattgcttactatccttacatcattcagcctgacgacctcaagagccatatcagtaacctggggtatgaatgcaccattaaaagtaaatcagcccctttgaagcttggtgtcctcgatcttgggtgcttgcagaatgcaaaccccaaggggacaccagcaagtctcaagagcgatggggtggatccaccagacgccaagatgagtggcatagctacagtggctgtacggatagaaggcatgcactgcaaatcctgtgtcagaaacattgaaggaaatatatcagatgttcccggcatacaatgtattaaagtgtctttggagcataaacgtgctgtggtacagtatagtccaaatttaattacactgtcagctctgcagcaagctattgaatcccttccacctggaaactttaaagtatgtctccttaatggttcggaagttaataaggcagcatctccatcacctgctttgctatgcaatctcttcggagagccactgcaagacacgacatgcacagctgttattaggattgatggcatgacttgcaattcctgtgtacagtccatagaagggaccatatcacagagacaaggagtgcaatgtatagcagtttctctggctgatgggactgggaccgtacattatgatccagctgtcactaatggagaagagttaagagctgccatagaagacatggggtttgatgcttctgtgctgacagataccgccgctggagaacgtaggcaccgacctgatgccagcaatgctgccatggagcctcgagctccagagcctcctcgccaaggctgtccctcagatgctcttccagacagtcctcaccttgatgggccaaaccagcctagcggagcgacaactgaaaagtgttttttacaaatcacagggatgacctgtgcgtcgtgtgtgtctgccattgaaagaaatctgcagaaagaagatggaattgtttcagtgttggtagcgctgatggcaggtaaagcagagataaaatacaagccagaattcatacagcctcttgaaatagcacagctgatccagaatttgggttttgaagctaccatcatagaagatcatgcagaaacagaaggaaatgtggagcttcttattacagggatgacttgtgcttcttgtgttcacaatatcgaatccaaactcatgagaacaaatggcatatcctacgcctcggtagcacttgctacttgcaaagctcacatccagtttgatcctgaaattactggacctcgagatattataaaaataatcgaggaaattggctttcacgcttccgtggctagaagagttccaaatgcacataacctggatcataaaaaggaaatacagcagtggaggaagtctttcttgtgcagcctactgtttggtatccctgtcttaatcataatgatttatatgctaatatccgacggtgagcaccatgagtctatggtgctggaacagaatctcattcctggattatctattttaaaccttctcttctttgtcctgtgcacttttgttcagtttcttggtggatggtatttttatgtacaagcttacaaatcgctgaagcacaagacggccaatatggatgtgctcatcgtactggccacgacgattgcttatgtgtattcttgtgtgatcctgatcgtagcgataattgaaaaggcagagaaaagccctgtcactttctttgacactcctccaatgctgtttgtattcattgcccttgggagatggctggaacacatagcaaagagtaagacctcagaagctcttgctaaacttatctcccttcaagccacagaagccactgtggtgactcttggacctgaccactctatcatcagggaggaacaggtagctgttgaactggttcaaaggggtgatattgtaaaggttgttcccggtggaaagttcccggtggatggaaaggtcattgaaggcagttctatggcagatgagtctctcattactggggaagctatgccagttactaaaaagcctgggagcacagtgattgctggttctataaatgcgcatggatcagttcttgttaatgcaactcatgttggtaatgataccactctggcacaaatcgtgaagttggtggaagaagctcaaatgtcaaaggcacccatccagcagctggcagataagttcagtggatattttgttccatttatcatcatcatttcaacagtgacattgatagtatggatcacaattggttttataaattttgatgttattcaaaaatattttcctaaccagaacaaacgtgtttcaaaagctgaactaatactgaggtttgcgtttcaaacctcaatcactgtgctgagcattgcatgcccctgttctttaggcttggctacccccacagctgtgatggtgggcacgggagttgctgcgcagaatggtattctcatcaaaggtggaaaacccctggaaatggcacacaagatcaagactgtgatgtttgataaaacggggaccatcacctgtggagttcctaaagtcatgagggtgcttttgctgggagacatggctgtgctctctctgaagaaggtactggcagtggttggcactgcagaagccagcagcgagcatcctttaggagtggcagtcactaaatattgcaaagaggagcttggcactcagagcctgggatattgcactgacttccaggcagtccccggctgtggcatcagctgcaaagtcagaggtgttgaggccgtcctgggcatggctgtggagggtctcgacaagccggacaccaacaggagcagggacagcagtgctcctctgggagataacgcactgatcacactctcagaatcacatggtccatcagcttctcaaacatactcggtgttgattggaaatcgtgagtggatgagacgcaatggcttacatattgcaaatgacgtaaatgatgcaatgacagaccatgaaacgaaaggacagactgccatactagtggctatagatggtgtgttatgtggaatgatcgcaatagcagacactgtcaagcaggaggcagcccttgctgtgcacacactgaaaaacatgggaatagatgtggtgttgataacgggggacaacagaaaaactgcaaaagccattgctactcaggttgggatcaaaaaagtctttgctgaggttcttccttctcacaaggttgcaaaggtccaggagctccaaaatgggaggaggaaggttgcgatggttggtgatggagtcaatgattcccctgcactagccagggccgatgttggaattgcaattggaacgggcaccgatgttgccattgaagcagcagatgttgttcttatccgaaacgacttgctggatgtagttgctagtattcatttatcaaagagaacagtccgaagaatacgaataaatctgattcttgccttaatttataatctgcttggaatacccatagcagcaggtgtgttcatgcctgttggccttgtgcttcagccttggatgggatcagctgcaatggcagcttcttctgtgtctgtcgtgctgtcttccctgcagctgaaatgttataagaagccagacacagaaagttatgaagcacaagctcaaggccgcatgaagccacttactccttcccaaatcagtgttcatattggaatggatgataggaggagggattcatccagaccggctccttgggatcagattagccaagtgtctctctcttccttgacttcagacaagctgccgagacgtaacggttttgttgaggaggaaggggacaagtggtcactgctcacgaatggagcagatgaagaacagtacatctgaagtactgtattcttagtacaggaggaaacattcctcctcaccagtgatgggagggactgatttatgtcatcaagagcttcaaggttgtaggtgaaatcattctttcagctcaaaaaacaattgcaactcagctcgatattggtttttatggattgtggattttttttcaggtcaccaattatttctagacatggaaagaatctgtgactctataatgaactggctcctttgcacacaacaatcagtgaaataatgtaagatcgttattttcagagtctaaaagagtttcttctggaccatttgctgggcaccaaatttcatacttttcactctttctaacttcattctttcaaacacatgaagcaaaaatattttcagagctgccaaatattaattgctgtgtccaagagaaaatagctatggcataaggagctctgtggtttggaagttgtattgtttaccctgaatcctaattagtcacatcactgtgagagcactttgtatttaggattcatgtgcatctccttggaccaaaaacgcttcagtgtttcactgactgtaactctctgaaaggtctctttcaaagattttcaggcatcttgtccttttgatgtgcatttccattgctaaacttgttctgtgattcccactgctctcctagactttctcttttgctccgtatgagctgtttttcccccttcctttgcacgagagatcttctctgagttcttagtatgtttacagatattcctgtttgggtcaaactcctttaagtcaccaggaacttttttgttcctattgaagtccacaaaggcagggcaattcctggtccaagctatcatataattttcctgtggataccttgcaggaccccaagaagctcctgacaatggggcagttgtctgtctcttccctctgacagggagaagaatttacgccagtgtgagcaaaggtggtatttaccgtggtgaggctgagagcagaactagcactggtgtgattcccagcatggctgaatggagtgagcttattgcataagttaaccccagcttggtggttgcttaaaacggagccaaaatgtggggcttctatttgctgtcatataaataaccttttctgatgacacaaggacttgaactaagaagatttgtaatagactgaattttcatgtaaatttttattcatgttttgagttggttttaatttccctctttgctctagtttcatgagaaatcaaggtgctgaacaaccattgctttttttttcactttaacgtctttaccaaagcttgcagtaactttatcgctgtgaatgtcaaattcatcgcttaacgctttttagtcaggacagtaggaatcaacggctttggtgcactgaatccggtcctggggtgctgtgttgctcaactgtgggacattgaagcgagcagatgagagttttatagtctaaactaaaaagtgaaagaacaggaattactgtgctgagcaatgagaagtaactgcttaatttcagtgacctaaatacagaactgtttccaacacgggtccaaatcctgctcgtcctaatgtaaaaatgaaaaacaagtcagagatgaaaagaactgtgcttaaagcattgagcaggtcctcctattctttcttcctcttatagttgaactttctttataaacatcaacagcactgtcttaaagataattacaaatcagttttaaaactgtaaaatctctttacgggtgtagagattactttcacagcgcacacacttttcaaacatgccataggttcctatacatgtgcctgtggggaagatgttctactgtttcactgttttatattttcttaccagtgcttacagtaaatatattgtgtttttttaaaacaaacaaacaa

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