LOCUS       XM_074217194            7243 bp    mRNA    linear   MAM 03-JUN-2025
DEFINITION  PREDICTED: Macrotis lagotis ATPase copper transporting beta
            (ATP7B), transcript variant X2, mRNA.
ACCESSION   XM_074217194
VERSION     XM_074217194.1
DBLINK      BioProject: PRJNA1268559
KEYWORDS    RefSeq.
SOURCE      Macrotis lagotis (bilby)
  ORGANISM  Macrotis lagotis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Metatheria; Peramelemorphia; Peramelidae; Macrotis.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_133658) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_037893015.1-RS_2025_05
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 05/30/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7243
                     /organism="Macrotis lagotis"
                     /mol_type="mRNA"
                     /isolate="mMagLag1"
                     /db_xref="taxon:92651"
                     /chromosome="1"
                     /sex="female"
                     /tissue_type="kidney and spleen"
                     /dev_stage="adult"
                     /geo_loc_name="Australia: Perth Zoo"
                     /collection_date="2018-05-24"
     gene            1..7243
                     /gene="ATP7B"
                     /note="ATPase copper transporting beta; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 16 Proteins, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 9 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:141508513"
     CDS             373..4743
                     /gene="ATP7B"
                     /codon_start=1
                     /product="copper-transporting ATPase 2 isoform X2"
                     /protein_id="XP_074073295.1"
                     /db_xref="GeneID:141508513"
                     /translation="

MLSKVSSAPCVQELPINQEFAFNNLGFEGSSDSLPTSSSSTNTSVINILGMTCQSCVKSIEGKISNLKGIVNIKVSLEQSNATVKYIPLTINLQQICSEIGDMGFDANISEVKAASWPTKPSSADEAVTKLRVEGMTCQSCVSTIEGKVGKLQGVLKIKVSLSNQEAVITYQPYIIQPGDLRDHINDMGFEATIKNKMAPLSLGMIDLGLLQSNNLKKMSTQFSYSNTEAQGDQSSPAILQLGVEGMHCKSCVLNIEGNISELPGVQSIKVSLENKNAEVQFDPNYITPLFLKQTIETLPPGNFKVTLPNGIESSWLENSLDNLSSRLPLSRCSQENQAQGVWSTAVIGIVGMTCASCVQSIESLLSQREGVGKISVSLAQGIGTIHYNASVVSPEGLKAAIEDMGFEASIRTETSSRKHVGNSYAVDSNARTELKDSVSLQEEEVDTKGHQKTNILSHSPKSFPSGYPFHPKAVISEKCFLRITGMTCASCVSNIERNLLKEDGILSVLVALMAGKAEVKYNPQTIQPLEIAQLVQNLGFEATVMEDYTGSDGNIELIVTGMTCASCVHNIESRLTGTNGILYASVALATSKAHIKFDPEIVGPRDIIKIIEGIGFHASLAQRNPNAHHLDHKMEIKQWKKSFLCSLVFGIPVLCLMIYMLIPSSQPYESMVLEHNLIPGLSILNLIFFVLCTFVQFLGGWYFYVQAYKSLKHKTANMDVLIVLATSIAYVYSLVILVVAIAEKAEKSPVTFFDTPPMLFVFIALGRWLEHVAKSKTSEALAKLMSLQATEATVVTLGNDNLIIREEQVPMELVQRNDVIKVVPGGKFPVDGKVLQGSTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLITATHVGSDTTLAQIVKLVEEAQMSKAPIQQLADKFSGYFVPFIIVISTVTLVVWIVIGFIDFGVVQKYFPNANKHISQAEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHRIKTVMFDKTGTITYGVPRVMRVLLLVDMVSLPMRKVLAIVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNVEAILAQVEDSLKEQSNHLNGVGGSLPAERGAGMSQTYSVLIGNREWMRRNGLTISTDVSDAMTDHEMKGQTAILVAIDGVLCGMVAIADSVKQEAALAVHTLKSMGVDVVLITGDNRKTAKAIATQVGINKVFAEVLPSHKVAKVQELQNQGKKVAMVGDGVNDSPALAQADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLILALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKFYKKPDMEKYESQAHGRMKPLTPSQVSVHIGMDDRRRDNKATPWDQVSYISQVSLSSLTSDRLSRHSTLLEDGGDKWSLLLNDRDEEQSI"

     misc_feature    505..693
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(523..531,538..540)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    760..951
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(778..786,793..795)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1093..1263
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1111..1119,1126..1128)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1420..1602
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1429..1437,1444..1446)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1816..2004
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1831..1839,1846..1848)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    2041..2232
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(2059..2067,2074..2076)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    2296..4410
                     /gene="ATP7B"
                     /note="P-type heavy metal-transporting ATPase, similar to
                     human copper-transporting ATPases, ATP7A and ATP7B;
                     Region: P-type_ATPase_Cu-like; cd02094"
                     /db_xref="CDD:319783"
     misc_feature    order(3289..3291,3295..3297,4339..4341)
                     /gene="ATP7B"
                     /note="putative Cu binding site [ion binding]; other site"
                     /db_xref="CDD:319783"
     misc_feature    order(3421..3429,3631..3633,3790..3798,3886..3888,
                     4006..4014,4072..4074,4081..4083,4090..4092,4147..4149,
                     4156..4158)
                     /gene="ATP7B"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319783"
ORIGIN      

ggacgaatgggaatctccgacgcttccctattgatctccctgggggcagagtccatcctttttatagctgtcgtggagatcccgcgagagaggcgggggccgcaggggccgctatctgcgtggggcagggagtctgtagggctgggaccccaggttccctccttttcctccccctccttgggaattgcaagcaccgcaggcagaggcggcccagtcccttttattccttagtagttcctactcttctgtggcaatcctagacttattagagaagaactctcatttctcagaagggaggatacctggaagagaaaatcagatcacagcaagaaggaacaccagccatcccagggctgcttccaacaagggaaaatgttatctaaagtctcctctgctccttgtgttcaagaattacctataaatcaggaatttgcttttaacaacttaggctttgaaggcagttcagacagtttacctacatcatcatcatccacaaataccagtgtaatcaacattttgggcatgacgtgccaatcatgtgtgaagtctatagaaggcaagatttctaacttgaaaggtattgtgaacataaaagtttcccttgagcagagcaatgctactgtcaaatatattccattgaccataaatctgcaacagatttgctctgaaattggggacatgggctttgatgctaacatatcagaagtaaaggctgcttcgtggcccacaaaaccctcatctgctgatgaagcagtgaccaaacttcgtgtagagggcatgacttgccagtcatgtgtcagtactatagaagggaaggttggaaaacttcaaggagttctgaaaatcaaagtctcccttagcaatcaagaggcagtcatcacttatcaaccttacatcattcaaccaggagacctcagggaccatatcaatgacatgggatttgaagccactatcaagaacaaaatggcaccattaagcctaggaatgattgaccttggactgttacaaagcaacaaccttaagaaaatgtcaactcagttctcttatagtaatacagaagcacaaggagaccagagcagcccagctattctacagctaggagtggaaggaatgcactgcaaatcctgtgtcttgaatattgaaggaaatatatctgaactaccaggtgtacaaagcattaaagtatctctggaaaacaaaaatgcagaagttcaatttgatccgaactacattaccccactatttttgaaacaaaccattgagactctcccacctgggaattttaaagtcactctccctaatggaatagaaagtagttggttggagaattcattagacaacttgtcttcaagacttcctctatctagatgttctcaggaaaaccaagcacaaggagtgtggagtactgctgtgattggcattgtgggaatgacctgtgcttcttgtgtgcagtccattgagagtttactatcccaaagggaaggggttggaaaaatttcagtctctttagctcaagggattggaaccatccactataatgcttcagtagtgagccctgaagggctcaaagctgctattgaagatatgggatttgaagcatccatcagaactgaaaccagttccagaaaacatgttggaaattcttatgctgtggattctaatgcccggacagagcttaaggattcagtttctcttcaggaggaagaagttgataccaagggacatcaaaaaacaaatatcttgagccactctccaaagtcttttccctcaggatacccatttcaccctaaggcagtgatttcggaaaaatgctttttgcgcataacaggcatgacctgtgcatcctgtgtctccaacatagaaagaaatctactgaaggaagatggtatactttccgttctggttgctctgatggctggaaaagctgaggtcaagtataatccacaaactatccaaccccttgaaatagctcagctcgtccagaacttgggctttgaagctacagtaatggaagattatactgggtcagatggcaatatcgagctgattgtcacagggatgacctgtgcttcatgtgttcacaacattgaatccagattgaccggaaccaatggcattctttatgcctccgtggcacttgctaccagcaaggctcacatcaagtttgatcctgaaattgtgggtcctagggatattataaaaattattgagggaattggctttcatgcttccttggcacagagaaatcccaatgctcatcatttggatcacaagatggaaatcaaacaatggaagaagtctttcctgtgcagtctggtgtttggtatccctgtcctgtgcttgatgatttacatgttaattcctagcagccagccttatgagtccatggtattggagcacaacctcatccctggattatccatcttaaatctcatcttctttgtcctgtgcacttttgtccagttcttaggtgggtggtatttctacgttcaagcctataaatcactgaaacacaagacggccaatatggatgtgctcattgtgctggccaccagcatcgcctacgtctactctcttgtgatcctggtggtagccattgctgagaaggcagagaagagccctgtcaccttctttgatacaccccccatgctttttgtgttcattgcactggggagatggttggaacatgtggcaaagagcaaaacatctgaagcccttgcaaagttaatgtctcttcaagccacagaagctactgtcgtgactttgggcaatgacaacctaatcatcagggaggaacaagtacctatggagctggttcagcggaatgatgtgatcaaggtagtacctggggggaagttcccagtagatggaaaagtcctacaaggcagcaccatggcagatgaatccctcatcacaggagaagctatgccagtcactaagaagccagggagcacggtgattgctggttcaatcaatgcccatggctcagtgctaattactgctactcatgttgggtctgataccacattggcacaaattgtgaaactggtggaggaggctcaaatgtcaaaggcacccattcagcaactggctgacaaatttagtggatattttgttccattcatcatcgtcatttcaactgtgacattggtggtatggattgtaatcggttttatcgattttggtgttgttcaaaaatattttcctaatgctaacaagcatatctcccaggcagaagtaattattcggtttgcgttccagacttccatcacggtgttgtgtattgcctgtccttgctctctgggcttggccacacccacagcagtgatggttggaacaggggtggctgcccaaaatggaattctcatcaaaggaggaaagccacttgaaatggcacaccggatcaagaccgtgatgtttgacaaaactggaaccatcacctatggcgtcccaagagtcatgagggttcttctgttggtcgacatggtttccctaccaatgaggaaagttctggctattgttggcactgctgaagccagtagtgagcatcctctaggtgtggctgtcactaaatactgtaaagaggaacttggaactgaaactctggggtattgcacggacttccaggctgtccctgggtgtggaattggctgtaaagtcagcaatgttgaagccatcctggcacaggttgaagactctttaaaggaacagagcaatcatctgaatggtgttggtggcagccttcctgctgaaagaggtgcaggtatgtcccagacctactccgtgctgattgggaaccgggaatggatgcgacgaaatggtttaactatatccactgatgtcagtgatgccatgacagaccatgaaatgaaggggcaaactgcgatattggtggctattgatggggtgctctgtgggatggtagccatagcagattctgtgaagcaggaggcagccctggctgtccataccctcaaaagcatgggcgtggatgtggtcctgatcactggggacaacaggaaaactgcgaaagcaatcgccacgcaggtgggcattaataaagtttttgcagaggttctcccctctcataaggtggccaaggtgcaagagcttcaaaaccaagggaagaaagtggccatggtaggagatggagtgaatgactctccagccttggcacaggccgatgttggcattgccattgggacagggacagatgtagctattgaagccgctgatgttgtcctcattaggaacgatttgcttgatgtggttgctagcatccatctttctaagaggactgtccggagaatacgaataaatctgatcttggccttaatttataacctagttgggatacccattgcagcaggtgtgttcatgcccattggcattgtgttacagccctggatgggatccgctgccatggctgcctcctccgtgtctgtggtactttcctcactacaactgaaattttataagaagccagatatggaaaagtatgaatcccaagcccatggccgcatgaaacctcttactccatcccaggtcagtgttcacattggaatggatgaccgacgaagggataacaaggccaccccatgggatcaggtcagctatatcagccaagtgtcgctgtcctccttaacctcagatagattgtcacgacacagcaccctgttagaggatggaggagacaaatggtcactgcttctgaatgatcgagatgaggagcagtccatctgaaaggcggcagctatcattagaacattcacagcaagatcatggtgccatgtttcctggaggatcaatgagttcccccatacacaaaaagaagtggggaggaagcttggccaaacaactgtagcatcacttttcctttgttgggatgaactgaaatcttctctggcattgggaacaatttattcttgaccaagacaacttatggcttttcccagatacaattttaggtcaaggaaaaagagttctagtttatggcaactgtcttcaacactggtttggaatatacaaggaaagtctccaccattttatcaattctttgattttggagaaggaaaaaaaatcccctacaaacaggaggaaagccaatgttcctcacgatttcccatttataccatttgggaggaattgtagtagtaaaatgtgagaaatcacactaggactaaaaagttggctaaacttttcagtagagtccgggtaaaaacttcacatagcttatttttcattaatgcaagtctttatgtttgtcatattgttgagaccatggtttacctcaaagtgccattttctaaaaggacatgacctctttttcaattctcagtctctctctctcccctcccatcaccctattccccttctccctgacccttcatgcttatattcccttaatttgtagtcatatcctttggtcctttgttctcctatctcagtaatccttgtatctactatgttctgttctgtctcctgtgcatttcctggataaatggtgcattcctatataagtgccagatggttcgccatctatctttgtgtgatgaggaatgcttttatcacctaaggcccttcaaccattgcttctcactgtggaggaatatggcacactctctggcggcagcagctgctgctaggagcaagagatttaagagcagattataaacctctcttcctagaagtcgtggggccctggcaaaaggagaccgtggtgccactctattaagtacagaacactattcaggtgcttgtgattagcaggcaggaagtggagagggaggaagtagtcactcaaacattgtttaggaaaccttagtaaagctttttcatgactttctgtagacctacgtgagccttgtaaaaaacagaggaagtatctttggggagtggaagggggacaacaggaccctttcaaatataaaatgcatatttttttatattcaacagctacttgcaaatgacatccacatcaagaaggcagatggatcttgttttattgtctaagttaattcactacagctgataattgaagggaccatatggaagtgggctggtggaagggccccactggttgaaatagttaccctttggagagtgggattagaggatttgtgaggacaaagggactataactgatacatatttgtgctttttcaagcaatgatcaatatttgccaccaaaaaaatatttttaaatgaaaaaaatgtacaccctagttttggggggtatgtgtgctatgtaaataaatattaattgcactgacattaagtggagtttaataacgaaacagtttcatctgttcataggaaggttagtttttttcccacattatggcctattttatttttcggaagttttttcctctgaaatccagagttctattttcttacctgtcccttttacccttttctttgtttttttcttttctatcgactctcagtaaaaatttccatttttttctaggttaataatgacatgaagaagataattttattgatttttaaaaagctttaaaaaccttaaatgccatgtttatatgcatatgaaaatatttatgtaattgtaaagaaaaaagacctcataaatgtgcaatagttgaaggatttattttggggctgatagaatgtttactatttttcaaatatttctcacgtgtccataaaataaagttgttgccttttatccatttccaaaactatttgttactctctcttttggaataggaggctgcacttttggtattaaatagtcagtctagggcaatgcttttccaaaacctgcccaatagtatacttaggtcactaaaataaataagagatataaagatagaatcaacaaggttcagcaatagattagacatggtggctgggtactttgcaagcctccttgactaggaggatttcttatatcttcagtgcctgactattcatacatagtagattgcataataaatatgggatgaccaactcaacagtaagaggaaagtttagaagagaggagggttttaggggaaagacaatgaatatagttttgaacacattgagtttcagttagagatgcaagtctggaggttcagaagagaagttagggcttgataaagatatgagaatcatgtacatagagatgataatcaaatccctgtgagttgaggagatcatcaagcaagagagtaacagcataatggtgttgcatctgcaaaaaggttaagagtcagaagatcagggtcctgatatc

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