LOCUS       XM_074158680            4449 bp    mRNA    linear   VRT 27-MAY-2025
DEFINITION  PREDICTED: Numenius arquata ATPase copper transporting beta
            (ATP7B), transcript variant X3, mRNA.
ACCESSION   XM_074158680
VERSION     XM_074158680.1
DBLINK      BioProject: PRJNA1265768
KEYWORDS    RefSeq.
SOURCE      Numenius arquata (Eurasian curlew)
  ORGANISM  Numenius arquata
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Neoaves; Charadriiformes;
            Scolopacidae; Numenius.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_133576) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_964106895.1-RS_2025_05
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 05/22/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4449
                     /organism="Numenius arquata"
                     /mol_type="mRNA"
                     /db_xref="taxon:31919"
                     /chromosome="1"
     gene            1..4449
                     /gene="ATP7B"
                     /note="ATPase copper transporting beta; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 13 Proteins"
                     /db_xref="GeneID:141471923"
     CDS             49..4449
                     /gene="ATP7B"
                     /codon_start=1
                     /product="copper-transporting ATPase 2 isoform X3"
                     /protein_id="XP_074014781.1"
                     /db_xref="GeneID:141471923"
                     /translation="

MPGTVFSRRNLRSFMYTALSDTDSLPDCKLDPTMKHNFAFDNMGYEESFETVPSPSSQEHTVTVSIVGMTCQSCVQSIEGRISKVKGIVNIKVSLEQDNAVIKYQQSEISPEQICQEIQDMGFDTNIAEERLTTATTNLSCLREAVVKLRVEGMTCQSCVTNIEGKVRKLHGVARIKVSLGNREAIIAYYPYIIQPDDLKNHISNLGYECTIKSKSAPLKLGVLDLERLQNANPKETPASLESDGVDSLVVEMSGTATVAVRIEGMHCKSCVRNIEGNISDLPGIQSIKVSLEHKRAVVQYSPNLITLSALQQAIESLPPGNFKVGLLNGSEANKGASPSPALRCDLSREPLQDTTCTAVIRIDGMTCNSCVQSIEGTISQRQGVQRIAVSLAGRTGTIHYDPAVTNGEELRAAIEDMGFDASVLTDTAAGGRRHQPDAINAVVQPRAPERPSQGCASDAFPDRPHLDGPNQPSGATAEKCFLQITGMTCASCVSTIERNLQKEHGIISVLVALMAGKAEIKYKPEFIQPLEIAQLIQNLGFEATVIEDHAGTEGNVELLITGMTCASCVHSIESKLMRTNGIFYASVALATCKAHIQFDPEITGPRDIIKIIEEIGFHASVARRVPNTHNLDHKKEIQQWRKSFLCSLLFGIPVLILMIYMLIPDGEHHGSMVLEQNLIPGLSILNLLFFILCTFVQFLGGWYFYVQAYKSLKHRTANMDVLIVLATTIAYVYSCVILMVAIIEKAEKSPVTFFDTPPMLFVFIALGRWLEHIAKSKTSEALAKLISLQATEATVVTLGPDHSIVREEQVAVELVQRGDIVKVVPGGKFPVDGKVIEGSSMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLVTATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADKFSGYFVPFIIIISTVTLIAWITIGFINFDIIQKYFPNQNKHVSKTELILRFAFQTSITVLSIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITCGVPKVMRVLLLGETAVLSLKKVLAVVGTAEASSEHPLGVAVTKYCREELSTQSLGFCTDFQAVPGCGISCKVGGVEAVLATAEKGLDKLDANRSTDSNASLGDNELIALPESQKGPSASHTYSVVIGNREWMRRNGLHIANDVNDAMTDHEMKGQTAILVAIDGVLCGMIAIADTVKQEAALAVHTLKNMGIDVVLITGDNRKTAKAIATQVGIKKVFAEVLPSHKVAKVQELQSGRRKVAMVGDGVNDSPALARADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLILALIYNLLGIPIAAGVFMPVGLVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDTESYEAQAQGRMKPLTPSQISVHIGMDDRRRDSSRPAPWDQISQVSLSSLTSDKLPRRNGFVEEEGDKWSLLMNGEDDEEQYI"

     misc_feature    235..420
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(253..261,268..270)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    490..681
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(508..516,523..525)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    829..1002
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(844..852,859..861)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1120..1326
                     /gene="ATP7B"
                     /note="Copper chaperone CopZ [Inorganic ion transport and
                     metabolism]; Region: CopZ; COG2608"
                     /db_xref="CDD:442020"
     misc_feature    1495..1683
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1510..1518,1525..1527)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1720..1911
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1738..1746,1753..1755)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1975..4119
                     /gene="ATP7B"
                     /note="P-type heavy metal-transporting ATPase, similar to
                     human copper-transporting ATPases, ATP7A and ATP7B;
                     Region: P-type_ATPase_Cu-like; cd02094"
                     /db_xref="CDD:319783"
     misc_feature    order(2968..2970,2974..2976,4048..4050)
                     /gene="ATP7B"
                     /note="putative Cu binding site [ion binding]; other site"
                     /db_xref="CDD:319783"
     misc_feature    order(3100..3108,3310..3312,3499..3507,3595..3597,
                     3715..3723,3781..3783,3790..3792,3799..3801,3856..3858,
                     3865..3867)
                     /gene="ATP7B"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319783"
ORIGIN      

tgtgtagccctgagtcagtcatccagggctgctgtcttagctactgaaatgcctgggactgtttttagcagaaggaatcttagatcattcatgtacacagctttgtccgacactgattctcttcctgactgtaagctggatcctacaatgaaacataattttgcttttgacaacatgggctatgaggagagctttgaaaccgtgccctctccatcttcccaagagcacactgtgacagtcagcattgtgggaatgacttgccagtcgtgtgtgcagtcgatagaaggccgaatttccaaggtgaagggcattgtgaatattaaagtctcccttgaacaggacaacgctgtaataaagtatcagcagtcggaaataagtcctgaacagatttgccaggaaattcaggatatgggctttgacaccaacatagcagaagagaggttgacaacagcgaccacgaatttgtcatgcttgagagaagcagtagttaaacttcgggtagaaggcatgacatgccagtcctgtgtcaccaacattgaaggaaaggttaggaaactgcacggtgtggcgagaatcaaggtgtcacttggtaaccgggaagcaattattgcttattatccttacatcattcagcctgacgacctcaagaatcatatcagtaacctagggtatgaatgcaccattaaaagtaaatcagcccctttgaagctgggtgtcctcgatctcgagcggttgcagaatgcaaaccccaaggagacaccggcaagtcttgagagtgatggggtggattcgctggtcgttgagatgagtggcacagctacggtggctgtacggatagaaggcatgcactgcaagtcctgtgtcagaaacattgaaggaaatatatcagatcttcccggcatacaaagtattaaagtgtctttggagcataaacgtgctgtggtacagtatagtccaaatttaattaccctgtcagctttgcaacaagctatagaatcccttccacctggaaactttaaagtaggcctcctgaatggatcagaagcaaataaaggagcatctccatcacctgctttgcgctgtgatctctccagagagccgctgcaggacacgacatgcacagctgtcattaggattgatggcatgacctgcaattcttgcgtacagtccatagaagggaccatatcacagagacaaggagtgcaacgtatagcagtttctctagctggcagaactgggaccatacattatgatccagctgttactaatggagaagagctaagagctgccatagaagacatggggtttgatgcttctgtgctgacagatactgctgctggaggacgtaggcaccaacctgacgccatcaatgctgtcgtgcagcctcgagctccagaacgtccttcccaaggctgtgcctcggatgcttttccagacagacctcaccttgatggaccaaaccagcccagtggagcaacagctgaaaagtgttttttacaaatcacaggcatgacctgtgcgtcgtgcgtgtctaccattgaaagaaatttgcagaaagaacacggaattatttcagtgttggtagcactgatggcaggtaaagcggagataaaatacaaaccagaattcatacagccccttgaaatagcacagctgatccagaatttgggttttgaagctactgtcatagaagatcatgcaggaacagaaggaaacgtggagcttcttattacagggatgacttgtgcttcctgtgttcacagtattgaatccaagctcatgagaacaaatggcatattctacgcctcagttgcacttgctacttgcaaagctcacatccagtttgatcctgaaattactggacctcgagatattataaaaataattgaggaaattggctttcatgcttctgtggctagaagagttccaaatacacataacctggatcataaaaaggaaatacagcagtggaggaaatctttcttgtgcagcctgctgtttggtatccctgtcttaatcctaatgatttatatgctaatacctgacggtgagcaccacgggtctatggtgctggaacagaatctcatccctggattatctattttaaatctactcttctttatcctgtgcacttttgttcagtttcttggtggatggtatttttatgtacaagcttacaaatcactgaagcacaggacggccaatatggatgtgctcatcgtactggccacgacgattgcttacgtgtattcctgtgtgatcctgatggtagcgataattgaaaaggcagagaaaagccctgtcactttcttcgacactcctccgatgctgttcgtgttcattgccctggggagatggctggaacacatagcaaagagtaagacctcagaagctcttgctaaacttatatctcttcaagccactgaagccactgtggtgactcttggaccggaccactctatcgtcagggaggagcaggtagctgttgaactggttcaaaggggtgatattgtaaaggttgttcctggtggaaagttcccggtggatggaaaggtcattgaaggcagttctatggcggatgagtctctcattactggggaagctatgccagtcactaaaaagcctgggagcacagtgattgctggttctataaatgcacatggctcagttcttgttactgcaactcatgttggtaatgataccactctggcacaaatcgtgaagttggtggaagaagctcaaatgtcgaaggcacccatccagcaactggcagataagtttagcggatattttgttccatttatcatcatcatttcaacagtgacattgatagcatggatcacaattggttttataaattttgatattattcaaaaatattttcctaatcagaacaaacacgtttcaaaaactgaactaatactgaggtttgcgtttcaaacctcaatcaccgtgctgagcattgcatgcccctgttctttaggcttggccacccccacagctgtgatggtgggcacaggagttgctgcacagaatgggattctcatcaaaggcggaaaacccctggaaatggcacacaagatcaagactgtgatgtttgataaaactgggaccatcacctgtggcgttcctaaagtcatgagggtgcttttgctgggcgagacagctgtgctctctctgaagaaggttctggcggtggtcggcactgcagaagccagcagcgagcatcccttaggagtggcagtcactaaatattgcagagaggagctcagcactcagagcctgggtttctgcaccgatttccaggcagtcccaggctgtggcatcagctgcaaagtcggaggtgttgaggccgtcctggccacggccgagaagggtcttgataagctggacgccaacaggagcacggacagcaatgcttctctgggagataacgagctgatcgcactccccgaatcacagaaaggtccatcagcttctcatacctactcagtggtgattggaaatcgtgagtggatgcgacgcaacggcttgcatattgcaaatgacgtaaatgatgcaatgacagaccatgaaatgaaaggacagactgccatactagtggctatagatggtgtgctgtgtggaatgatcgcaatagcagacactgtcaagcaggaggcagcccttgctgtgcacacgctgaaaaacatgggaatagatgtggtgctgataacgggggacaacagaaaaactgcaaaagccattgctactcaggttgggatcaaaaaagtctttgctgaggttcttccttctcacaaggttgcaaaggtccaggagctccaaagtggaaggaggaaggttgcgatggttggtgatggagtcaatgattcccctgcgctagccagggccgacgttggaattgcaattggaacgggcaccgatgttgccattgaagcagcggatgttgttcttatccgaaatgacttgctggatgtagttgccagtattcacttatcaaagagaacagttcggagaatacgaataaatctgattcttgccttaatttataatctgctcggaatacccatagcagcaggtgtgttcatgcctgtcggcctcgtgcttcagccttggatgggatcggctgcaatggcagcttcttctgtgtctgtcgtgctgtcttccctgcagctgaaatgttataagaagccagacacagaaagttatgaagcacaagctcaaggccgcatgaagccacttactccttcccaaatcagtgttcatattggaatggatgataggaggagggattcatccagaccggctccttgggatcagattagccaagtgtctctctcttccttgacttcagacaagctgccgagacgtaatggttttgttgaggaggaaggggacaagtggtcattgctcatgaatggagaagatgatgaagaacagtacatctga

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