LOCUS       XM_074043458           13714 bp    mRNA    linear   ROD 19-MAY-2025
DEFINITION  PREDICTED: Castor canadensis ATPase copper transporting beta
            (Atp7b), transcript variant X4, mRNA.
ACCESSION   XM_074043458
VERSION     XM_074043458.1
DBLINK      BioProject: PRJNA1254772
KEYWORDS    RefSeq.
SOURCE      Castor canadensis (American beaver)
  ORGANISM  Castor canadensis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
            Castorimorpha; Castoridae; Castor.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_133395) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_047511655.1-RS_2025_05
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 05/09/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13714
                     /organism="Castor canadensis"
                     /mol_type="mRNA"
                     /db_xref="taxon:51338"
                     /chromosome="10"
     gene            1..13714
                     /gene="Atp7b"
                     /note="ATPase copper transporting beta; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 20 Proteins, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 20 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:109676481"
     CDS             379..4782
                     /gene="Atp7b"
                     /codon_start=1
                     /product="copper-transporting ATPase 2 isoform X2"
                     /protein_id="XP_073899559.1"
                     /db_xref="GeneID:109676481"
                     /translation="

MWGMMPEQERLVTAREEARRKILSKLSLPARPWEKPMKQSFAFDNVGYEGSLDGICSSPTTSSTISILGMTCQSCVKSIEDRISSLKGVVSIKVSLEQGSAAVKYVPSIMSLQQICHQVGDMGFEASIAEGRAASWPSRSSSAQEAVVKLRVEGMTCQSCVSSIEGKVRKLQGVVRVKVSLSNQEAVITYQPYLIQPEDLRDHVTDMGFEAAIKNKMAPLSLGPIDVSRLESTNPKRLSAFANQNFNNSETSKYQGNHVATLQLGIEGMHCKSCVLNIEGNIGQLSGVQNIQVSLENKTAQVQYDPSLITPLSLKRAIEALPPGNFKVSLPDGAEESGPETGSSEIPSHGSPQRNQMQDACRTVVLSVTGMTCASCVQSIEGTVSQREGVRQISVSLAEGTGTILYDPSVITPEELRAAVEDMGFEASVIPENYSTSHVRNDSAGNSMLQTTGSTLGSVKEVAPCVRVLPENHGPGHSSNTPPPTSTVAPQKCFLQVKGMTCASCVSNIERNLQKEAGILSVLVALMSGKAEVKYNPEVIQPPTIAQLIQDLGFEATVMEDNAGSDGDIELIITGMTCASCVHNIESRLTRTNGITYASVALATSKAHVKFDPEIIGPRDIVKIIEEIGFHASLAQRRPSAHHLDHKMEIKQWKKSFLCSLVFGIPVMGLMIYMLIPSHEPHEAMVLDHNIIPGLSILNLVFFILCTFVQFLGGWYFYVQAYKSLKHKSANMDVLIVLATTIAYAYSLVILVVAIAEKAEKSPVTFFDTPPMLFVFIALGRWLEHVAKSKTSEALAKLMSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIIKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSMVIAGSINAHGSVLIKATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIISTLTLVVWIVIGFIDFGVVQKYFPNPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQHGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRVLLLSDVTALSLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTETLGYCTDFQAVPGCGIGCKVSNVEGIVAHSEHLLNEQASHLKGVGSLPTGKDAAPQTFSVLIGNREWMRRNGLTISSDISDAMTDHEMKGQTAILVAIDGVLCGMIAIADSVKPEAALAVHTLKSMGVDVVLITGDNRKTARAIATQVGIHKVFAEVLPSHKVAKVQELQNEGKKVAMVGDGVNDSPALAQADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRVNLVLALIYNMVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYRKPDLERYEAQAHGRMKPLSASQVSVHVGMDDRRRDSPRPTSWDQVSYISQVSLSSLTSDKLSRHGAADDSGDKWSLLLSDRDEEQCI"

     misc_feature    583..759
                     /gene="Atp7b"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(586..594,601..603)
                     /gene="Atp7b"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    823..1014
                     /gene="Atp7b"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(841..849,856..858)
                     /gene="Atp7b"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1165..1341
                     /gene="Atp7b"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1183..1191,1198..1200)
                     /gene="Atp7b"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1465..1668
                     /gene="Atp7b"
                     /note="Copper chaperone CopZ [Inorganic ion transport and
                     metabolism]; Region: CopZ; COG2608"
                     /db_xref="CDD:442020"
     misc_feature    1861..2049
                     /gene="Atp7b"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1876..1884,1891..1893)
                     /gene="Atp7b"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    2086..2277
                     /gene="Atp7b"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(2104..2112,2119..2121)
                     /gene="Atp7b"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    2341..4449
                     /gene="Atp7b"
                     /note="P-type heavy metal-transporting ATPase, similar to
                     human copper-transporting ATPases, ATP7A and ATP7B;
                     Region: P-type_ATPase_Cu-like; cd02094"
                     /db_xref="CDD:319783"
     misc_feature    order(3334..3336,3340..3342,4378..4380)
                     /gene="Atp7b"
                     /note="putative Cu binding site [ion binding]; other site"
                     /db_xref="CDD:319783"
     misc_feature    order(3466..3474,3676..3678,3829..3837,3925..3927,
                     4045..4053,4111..4113,4120..4122,4129..4131,4186..4188,
                     4195..4197)
                     /gene="Atp7b"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319783"
     polyA_site      13714
                     /gene="Atp7b"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

accccccaccccctggcccagagcccgcggccggttggagagcaaatgggagttcctgtcgggtgccggatcgatcttccaggtgcagagttcgttcacccagcggttgcgcgtttgccacccacgacgtctaggagctgggcgccaagtctgagaggggggctgcgcggaacccacccgccaccgcgccgccgctccacgccgaatcgtttccccagaaggtgggcgagccctgcgacccgagtctccggtccccggctgcgctgctggccagtcctccctccgcggcactcggcggagatacgaggaccgagtcccgagcgcatcagctccaggtgacctgtgggctctgggtcggatcagagaaggagctggcgtatgtggggaatgatgcctgagcaggagaggctggtgacagccagagaagaggccaggcggaaaatcttgtctaaactttccttgcctgctcgtccctgggaaaaaccaatgaagcagagttttgcctttgacaatgttggctacgaagggagtctggatggcatatgctcctcaccaacgaccagcagcacaatcagcattctgggcatgacttgccagtcatgtgtcaagtccattgaggacaggatttctagtttgaaaggtgttgtgagcattaaggtttcactggaacaaggcagcgcagcagtgaaatatgtgccatccatcatgagcctgcaacagatttgccatcaagtcggggacatgggttttgaggccagcattgcagaaggaagggctgcctcctggccctcaaggtcctcatcagcccaggaggcagtggtcaagctccgggtagagggcatgacctgtcagtcctgtgtcagctccattgaaggcaaggtccggaaactgcaaggagtagtgagagtcaaagtctcccttagcaaccaagaggccgtcatcacttaccagccttatctcattcaacccgaagacctcagggaccatgtaactgacatgggatttgaagctgccatcaagaacaaaatggctcccttaagcctgggaccaattgacgtcagtcggttagaaagcactaacccaaagagattgtcagcttttgctaaccagaatttcaataactctgagacctcgaagtaccaaggaaaccatgtggccaccctccaactgggaatagagggaatgcattgtaaatcttgtgttttgaatattgaaggaaatataggccaactctcaggggttcaaaatattcaagtgtccttggagaacaaaactgcccaagtccagtatgacccttctcttatcacccctttgtccctaaagagggccattgaggcacttccacctgggaattttaaagtttctcttcctgatggagcagaagagagtgggccagagactggatcttctgagattccatcccatggctccccccagagaaaccagatgcaggatgcgtgcagaactgtggtgctgtccgtcactggcatgacctgtgcgtcctgtgtccagtccattgaaggcacagtctcccagcgggaaggggtgcggcaaatatcggtctctttggctgaagggactggaacgattctttatgatccctctgtaattacaccagaggaactccgagctgctgtagaagacatgggatttgaggcttcagtgattcctgaaaactattctaccagccatgttagaaatgacagtgctgggaattctatgctacaaactacaggcagcacacttgggtctgtgaaggaagtggctccctgtgtcagggtgctccctgagaaccacggtcctggccactcatcaaataccccaccacccaccagtacagtagccccacagaagtgctttttacaagtcaaaggcatgacctgtgcatcctgtgtgtctaacatagaaaggaatcttcagaaagaagctggtattctctctgtattggttgccttgatgtcgggaaaggcagaggtcaagtataatccagaggtcatccagccacccacaattgctcagctcatccaggacctgggctttgaggcaacagtcatggaagacaacgcaggctctgacggtgatatcgagctgattatcacggggatgacctgtgcttcctgtgttcacaacatagagtccagactcaccaggacaaatggcatcacctatgcctctgtagccctcgccaccagcaaagcccatgtgaagtttgatccagaaatcattggtccacgggatattgtgaaaattattgaggaaattggctttcatgcttccctggcccagagaaggcccagcgctcaccacttggaccacaagatggaaataaagcagtggaagaaatctttcctgtgcagcctggtgtttggcattcctgttatgggcttaatgatctacatgctaatccccagccacgagccccacgaggccatggtcctggaccacaatatcatcccaggactatccattctcaatcttgtcttctttatcttgtgtacctttgtccagttccttggtggatggtacttctatgttcaggcctacaagtctctgaaacacaagtcagccaacatggatgtgctcatcgtgttggccacaaccattgcctatgcctactccctcgtcatcctggtggtcgctattgcagagaaggctgagaagagcccagtgaccttctttgacacaccccccatgctcttcgtctttattgccctggggcggtggctggaacacgtggccaagagcaaaacctcagaggcccttgccaaactcatgtctctccaagccacagaagctacagttgtgaccctcggtgaggacaacttaatcatcagagaggagcaggtgcccatggagctggtacagcggggcgatatcattaaggtcgtgcctgggggcaagttcccagtggatgggaaagtcctggaaggcaataccatggctgacgagtccctcatcacaggagaggccatgcctgtcaccaagaaacctgggagcatggtgattgctgggtcaataaatgcacatggctctgtgctcattaaagccacccatgtgggcaatgacaccactttggctcagattgtgaagttggtggaagaggcacagatgtcaaaggcacccattcagcagctggctgaccggtttagtggatattttgtcccatttatcatcatcatttcaactttgacgttggtggtatggattgtaatcggttttatcgattttggtgttgttcagaaatactttcctaaccccaataagcacatctcacagaccgaggtcatcatccggttcgccttccagacatccatcactgtgctgtgcatcgcctgcccctgctccctggggttggccacacccacagcggtcatggtgggcaccggggtggctgcccagcatggcatcctcatcaagggaggcaaacctctggagatggcacacaagataaagacggtgatgtttgacaaaaccggcaccattacccacggggttcccagagtcatgcgggtcctgctgctctcggatgtgactgcgttgtccctcaggaaggttctggctgtagtgggcactgcggaggccagcagtgagcatcccctgggcgtggcagtcaccaaatactgcaaagaggaacttggaacagagaccctgggatattgcacggacttccaggcagtgccaggctgtggaatcggctgcaaagtcagcaacgtggaaggcatcgtggcccacagcgagcacctgctgaatgagcaggccagtcacctgaagggggttggcagccttcccacaggaaaagatgcagccccccagaccttctctgtgctgattggaaaccgcgaatggatgaggcgcaatggcttaaccatctcaagtgacatcagtgacgccatgacagatcatgagatgaaaggacagacggccatcctggtggctattgatggtgtgctctgcgggatgattgccatcgcagactctgtcaagccagaggctgccctggctgtgcacactctgaaaagcatgggtgtggacgtggttctgatcacgggggacaaccgaaagacagccagagccattgccactcaggtgggcatccacaaagtctttgctgaggtgctaccctctcacaaggtagccaaggtccaggagctccagaacgaaggaaagaaagttgccatggtgggagacggggtgaatgactctccagccttggctcaggctgacgtgggcattgccattgggaccggcacggatgttgccattgaggcagctgatgtggtcctcatcagaaatgacttgctggatgtggtggccagcattcacctctccaagaggactgtccggaggatccgagtcaatctggtgctggcgttgatttacaacatggttgggatacccattgcggcaggtgttttcatgcccatcggcattgttctgcagccgtggatgggttcggcggccatggcggcctcttccgtgtctgtggtgctctcttctctgcagctcaagtgctataggaagcctgacctggagcggtacgaggcacaggcccatggccgcatgaagcccctgagcgcatcccaggtcagcgtgcacgttggcatggatgatcggcggcgggactcccccaggcccacatcttgggaccaggtcagctacatcagccaagtgtctctatcttccctgacatcggacaagctgtctcggcatggcgctgcagatgacagtggggacaagtggtctctgctcctgagtgacagggatgaagagcagtgcatctgaaagttccaggtgatacacagggcaactgaaggtctgactcacctccccttgctgtgcaggtgcacccccagcagcaggaggcagcaggatgggtgaagctcgccataatgctgggctcccactccctggtcatcctatcagccctccctgcagcccgtggcattgcctggagcctcctccccttaccatgttggtggcacaggcaatgttggaacctt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