LOCUS       XM_073894611            6808 bp    mRNA    linear   MAM 09-MAY-2025
DEFINITION  PREDICTED: Callorhinus ursinus ATPase copper transporting beta
            (ATP7B), transcript variant X5, mRNA.
ACCESSION   XM_073894611
VERSION     XM_073894611.1
DBLINK      BioProject: PRJNA481736
KEYWORDS    RefSeq.
SOURCE      Callorhinus ursinus (northern fur seal)
  ORGANISM  Callorhinus ursinus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia;
            Pinnipedia; Otariidae; Callorhinus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_027397069) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_003265705.2-RS_2025_05
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 05/07/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6808
                     /organism="Callorhinus ursinus"
                     /mol_type="mRNA"
                     /isolate="GAN/ISIS: 27379988/994484"
                     /db_xref="taxon:34884"
                     /chromosome="Unknown"
                     /sex="female"
                     /tissue_type="blood"
                     /dev_stage="adult"
     gene            1..6808
                     /gene="ATP7B"
                     /note="ATPase copper transporting beta; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 5 Proteins"
                     /db_xref="GeneID:112826796"
     CDS             463..4761
                     /gene="ATP7B"
                     /codon_start=1
                     /product="copper-transporting ATPase 2 isoform X5"
                     /protein_id="XP_073750712.1"
                     /db_xref="GeneID:112826796"
                     /translation="

MKQSFAFDNVGYEGGLDGVCPPQMTSSTISISGMTCQSCVKSIEGRISSLKGVVSIKVSLEQGSATVKYVPSILSLPQICRHIEDMGFEASIAEGKAASWPSRSSPGLEAVVKLQVEGMTCQSCVSSIEGRLGKLQGVVRVRVSLGTQEAVITYQPYLIQPQDLRDHVNDMGFEAVIKNRVAPVSLGPIDIGRLQRTDPKTPSASDNQNLNNSEPSGHHGSHVATLQLRVDGMHCKSCVLNIEENIGQLPGVQNIQVSLENRIAQVQYDPSRVTAGALQRAIEALPPGNFKVSPPDGAAGSGTGSRSSNCGAPGPASRTQAPGVCNTVVLVIAGMTCASCVQSIEGLISQREGVRQISVSLADGTGVVLYDPSVINPEELRAAVEDMGFETSVLFENCYSNHVGNHSAGNSSAHPTAGVPVSAQEGAPHAGGLPKSHNPSSSSQSLQASTTAAPQKCFLQIRGMTCASCVSNIERNLQKEAGILSVLVALMAGKAEVKYNPEVIQPLEIAQLIQDLGFEAAVMEDYTDSDGDLELIITGMTCASCVHNIESKLTRTNGITYASVALATSKAHVKFDPEVIGARDIVRIIEEIGFHASPAQRNPNAHHLDHKVEIKQWKKSFLCSLVFGIPVMGLMIYMLVPSNKPHESMVLDHNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYRSLRHRAANMDVLIVLATSIAYTYSLVILVVAMAEKAERSPVTFFDTPPMLFVFIALGRWLEHVAKSKTSEALAKLLSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIIKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLVNATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIISTLTLVVWIIIGFIDFGVVQKYFPTPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPKVMRVLLLVDVATMPLRKVLAVVGTAEASSEHPLGMAVTKYCKEELGTKTLGYCTDFQAVPGCGIGCKVSSVEGILAHSEHQQSKQAAPLSRTGGVPEAIDATPQTFSVLIGNREWMRRNGLTISSDISDAMKDHEMKGQTAILVAIDGVLCAMIAIADAVKQEAALAVHTLKSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNEGKKVAMVGDGVNDSPALAQADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVWRIRLNLVLALIYNLIGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAQGRMKPLTASQVSVHIGMDDRRRDSPRTTPWDQVSFISQVSLSSLKSDKLSRHSAAADDGGDKWSLLLNDRDEEQCI"

     misc_feature    544..735
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(562..570,577..579)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    799..987
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(817..825,832..834)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1141..1317
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1159..1167,1174..1176)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1447..1638
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1465..1473,1480..1482)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1837..2025
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1852..1860,1867..1869)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    2062..2253
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(2080..2088,2095..2097)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    2317..4425
                     /gene="ATP7B"
                     /note="P-type heavy metal-transporting ATPase, similar to
                     human copper-transporting ATPases, ATP7A and ATP7B;
                     Region: P-type_ATPase_Cu-like; cd02094"
                     /db_xref="CDD:319783"
     misc_feature    order(3310..3312,3316..3318,4354..4356)
                     /gene="ATP7B"
                     /note="putative Cu binding site [ion binding]; other site"
                     /db_xref="CDD:319783"
     misc_feature    order(3442..3450,3652..3654,3805..3813,3901..3903,
                     4021..4029,4087..4089,4096..4098,4105..4107,4162..4164,
                     4171..4173)
                     /gene="ATP7B"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319783"
     polyA_site      6808
                     /gene="ATP7B"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

gaggcccttgcgcgtctcagatcgattttccaagtgcggagttcagccctgcggctgctgcagcgtctgggatccgctgtgctctggagccaggcgcggagcggagagggagctgtgccgagccgacccgaagccggcgcccgccacgccgcaccttccccggttggcgagccctggcatctgcatctccggtccggctctgcgccgctcgcccgctctcctgtccttttcagcacacgccggaggccgaagaccgagtccgcagcgcaccggcccgaggttttaacgccccgcttctcgtccactaaccaggtgacctgggggctctgggccgatcacagaagaaattggcccctccggaggaggttgcttgaacaggaaagacagattacagccagagaagaggccagtcggaaaatcctgtctaaactttctctgcccactcgtgccggggagccagcaatgaagcagagtttcgcctttgacaatgttggctatgaaggcggcctggatggcgtgtgcccccctcagatgaccagcagcaccatcagcatttcgggcatgacttgccagtcgtgtgtgaagtctatcgagggcaggatttccagcttgaaaggcgtcgtgagcattaaggtttccctggaacaaggcagcgcgaccgtcaagtacgtgccgtccatcctgagcctgccacagatttgccggcacattgaggacatgggctttgaggccagcatcgcagaaggaaaggccgcctcctggccttcaaggtcctcgcctggcctggaggccgtggtcaagctccaggtggagggcatgacctgccagtcctgcgtcagctccatcgaaggcaggcttgggaaactgcaaggggtagtgagggtccgagtgtccctcggcacccaggaagcagtcattacctaccagccttatcttatccagccccaggacctcagggaccatgtcaatgacatgggctttgaagctgtcatcaagaacagagtggcgcccgtaagcctgggaccaattgatattgggcggttacagaggacggacccaaagacaccttcggcttctgataaccagaatctcaataactctgagccctcggggcaccatgggagccatgtggccaccctgcaactgagagtggatggaatgcactgtaagtcttgtgtcctgaatattgaagaaaacataggccaactccccggggttcaaaatattcaagtgtccttggagaacagaatcgcccaagtacagtacgacccttctcgtgtcactgcaggcgccctgcagagggccattgaagctcttccacctgggaacttcaaggtctctcctcctgatggagcagcagggagtgggacaggtagcaggtcttccaactgtggggcccccggccccgcctcgagaacccaggcgccgggcgtgtgcaatactgtggtgctcgtcattgctggcatgacctgcgcatcctgtgtccagtccatcgaaggcctgatctcccaaagggaaggggtgcggcaaatatcagtctctctggctgacgggaccggagtggtgctctatgatccctctgtaattaacccagaagaactccgagctgctgttgaagacatgggatttgagacttcagttctttttgaaaactgttatagcaaccatgttggaaatcatagcgcggggaattcctcagcgcaccccacagctggcgtacctgtgtctgcgcaggaaggggctccccatgctggggggctccctaaaagccacaaccccagctcctcgtcacagtccctgcaagcctctaccacagcggcaccccagaagtgctttttacagatcaggggcatgacctgtgcatcctgtgtgtccaatatagagagaaacctgcagaaagaagcaggtattctctcggtgctggttgccctgatggccggaaaggcagaggttaagtataacccagaagtcatccagccactggagatagctcagctcatccaggacttgggctttgaggcagcagtaatggaagactacacagactcagatggcgacctcgagctgatcatcacggggatgacctgcgcgtcctgtgttcacaacatagagtccaaactcacaaggacaaacggcatcacctatgcctctgtggcccttgccaccagcaaagcccacgtgaagttcgatcctgaagttatcggtgcacgggatattgtccgaattattgaggaaatcggctttcatgcttccccggcccagagaaaccccaacgcgcatcacttggaccacaaggtggaaataaagcagtggaagaagtctttcctgtgcagcctggtgttcggcatccctgtcatgggtctgatgatctatatgttggtgcccagcaacaagccccacgagtctatggtcctggaccacaacatcattccaggactgtccattctaaatctcatcttctttatcttgtgtacctttgtccagctccttggcgggtggtacttctacgtccaggcctacagatctctgaggcacagggcagccaacatggacgtgctcatcgtgctggccaccagcatcgcctacacctactcgctcgtcatcctggtggtggccatggctgagaaggcggagaggagccctgtgaccttcttcgacaccccccccatgctctttgtgttcattgccctgggtcggtggctggaacacgtggcaaagagcaaaacctcagaagcccttgccaaactcttgtctctccaagccacagaagccactgttgtgacccttggcgaggacaacttgatcatcagagaggagcaagtacccatggagctggtgcagcggggtgatatcatcaaagttgtccccgggggaaagttcccagtggatgggaaagtcctggaaggcaacaccatggccgacgagtccctcatcacaggagaagccatgccggtcacaaagaaacctggaagcacagtgattgctgggtctatcaatgcacacggctctgtgctcgttaatgccacccatgtgggcaatgacaccacgttggctcagattgtgaaattggtggaagaggctcagatgtcaaaggcacccattcagcaactggctgaccggtttagtggatattttgtcccatttatcatcatcatttcaacattgacgttggtggtatggattataatcggttttatcgattttggtgttgttcagaaatactttcctacccccaacaagcatatctcccagacagaggtgatcatccggtttgcattccagacatccatcacggtgctgtgcatcgcctgcccctgctccctgggcttggccacgcccacggcggtcatggtgggcaccggggtggccgcccagaatggcatcctcatcaaaggaggcaagcctctggagatggcccacaagataaagaccgtgatgtttgacaaaactggcaccattacccacggggtccccaaagtcatgagggtcctcctgcttgtggatgtggccacgatgcccctcaggaaggttcttgctgtggtggggactgcggaggccagcagcgagcaccctttgggcatggcagtcaccaagtactgtaaagaggaattgggaaccaagaccttgggatactgcacggacttccaggcagtgccgggctgtggcatcggctgcaaagtcagtagcgtggagggcatcctggcccacagcgagcaccagcagagcaaacaggctgctcccctgagcaggactggcggcgttcccgaggcaatagatgcgaccccccagaccttctctgtgctgattgggaaccgcgaatggatgaggcgcaacggcctaaccatttccagcgacatcagtgacgcgatgaaagatcatgagatgaaaggccagacggccatcctggtggccattgacggtgtgctctgcgccatgattgccatcgcggacgcagtcaagcaggaggcagccctggctgtgcacacgctgaagagcatgggtgtggacgtggttctgatcacaggggacaaccggaagacagccagagccatcgccacccaggttggcatcaacaaagtctttgcagaggtgctaccttctcacaaggtggccaaggtccaggagctccagaatgaagggaagaaagtcgccatggtgggagacggggtcaatgactcaccggccttggcccaggccgatgtgggcatcgccatcgggacaggcacggacgtcgccattgaggccgctgacgttgtcctcatcagaaacgatctgctcgatgtggtggctagcattcacctctccaagaggaccgtctggagaatacgcctcaatctggtgctggcgttgatttacaacctgatcggaatacccattgctgcaggggtcttcatgcccattggcatcgtgctccagccgtggatgggctcggcggccatggcggcctcctccgtgtctgtggttctctcatcgctgcagctcaagtgctataagaagcccgacctggagaggtatgaggcgcaggcccagggccgcatgaagcccctgacagcatcacaggtgagcgtgcacatcggcatggatgaccggcgacgggactccccaaggaccacgccctgggaccaggtcagcttcatcagtcaggtgtctctgtcctccttgaagtctgacaagctgtctcgacacagtgctgcagctgatgacggtggggacaagtggtctctgctcctgaatgacagagatgaggagcagtgcatctgaaagctccaggcgggtgcagagccaggggtccatctcctcagtgagtagccggcccagctttccccatggccgaggctgagaccaaacaagtgcagcaccagcagcaagatgggcgaagctcccctccagccgtggggacttccactccctggacattcctggtcatccctcctagcatgtgccacatccagatgtgactcctgggtaggccctgccccccaccccccgtgcctggatcccgccagcacaggggccaggcttcccggcctgaccatgctgttggcctgggcttgttgggaaccttgctggactctaagagcagaggagaggacagccagccctcctcgcagacctctgctttggtgtttggaatgactacctgtaaaatgaggaaaatctcatcaggaccaaaatcttagctgggcctttccttagaactcaggagaagccttgtattgggttctttttgacaatacccacatgcattgcgtatctgagaccacagtttacctcaaatacaccccattgatgtctgccggcactgtctcttccttttctgtttttaacattggcgccagcccaccccagcccacccctgcctgatctctgacagcaggaccctagtgatccctgctgttgccctcaggcctgcatctgctccctcacacaccggccagagagccggccttgcttctcttcaggccgagagttctctgctgcctgtgtgccccctggccatggagtcctggcttctcgctcctcggaatggcatgctcttgtggactgtttctgccccgctggagtgagggtctcaaagcctgagacctaggaaatcctgcctcctctggggtccaggtccttgggatgcgtggaggcctgtggtgcttgaaaccacatcccgtggggaggtgtgtgcacttgccagaaccgccttgcacacccccgggagcttcaatgacatggtctgctatgggactgtcagctcatggatggtgcccctggtggtgtgcaactgcaaggaaacccatacccgaagaagaggaaatcacacttactctccaggagcttctacttctgcacacgggactggcgccttaggaaaggagtcaccactgcttccccaagggagagcctgtttcacactttcagtggctctttgtgattgtaggacgtcagactggcaggaatggagccagttttagacactcaagccggcggtgattgacagaaccacatggtagtacacgagtagaaagaaaataaattttaaggtagagagagcccttatcacacacaaaatagttttatttattgagtaccagttacgtttcagggagagtgtaagcactttttctaggctacttgtaatcttctcagcaaactagccagtgggtactgctgtccatgttggacgcgcagggcggtaggctcagagaggctgggtatcccgcccaggatcgcacagcccgcgcacatgccagaacagggaaatcttttctccgtggtggctgtcaccagaatatcagttggcaggaataaacaggaaaaagccactgctcctagaagaacaaatctgctgggtggccgattcattgttagcgacttagaatgaaacttgatctcaggatcagctcccggttccctcggatggtttgtttccatttttgcctctaatctcgtgttgctgggtcttacccactacaatcctgcgctggttccactgtgttcctgtcgttttcagtcttcctttcccccgggcctctccctgctctgtccttcctttactcctggctgtgctcaggagggtttcttgttttctaactaggttaatcattgtctaaaggatctaattgtattgatttcacaaaggcttttaggaccataaacctcatgcgtatatggccatgaaaatatttatataattgtacaggatataacctttagatgttcagggggtaagagttttttgtgtgtcagataagaagagttcctgtttcaaaaactttccatgccgtattagaataaagtttatttttattcatctaaa

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