LOCUS       XM_073894608            6883 bp    mRNA    linear   MAM 09-MAY-2025
DEFINITION  PREDICTED: Callorhinus ursinus ATPase copper transporting beta
            (ATP7B), transcript variant X2, mRNA.
ACCESSION   XM_073894608
VERSION     XM_073894608.1
DBLINK      BioProject: PRJNA481736
KEYWORDS    RefSeq.
SOURCE      Callorhinus ursinus (northern fur seal)
  ORGANISM  Callorhinus ursinus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia;
            Pinnipedia; Otariidae; Callorhinus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_027397069) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_003265705.2-RS_2025_05
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 05/07/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6883
                     /organism="Callorhinus ursinus"
                     /mol_type="mRNA"
                     /isolate="GAN/ISIS: 27379988/994484"
                     /db_xref="taxon:34884"
                     /chromosome="Unknown"
                     /sex="female"
                     /tissue_type="blood"
                     /dev_stage="adult"
     gene            1..6883
                     /gene="ATP7B"
                     /note="ATPase copper transporting beta; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 2 Proteins"
                     /db_xref="GeneID:112826796"
     CDS             298..4836
                     /gene="ATP7B"
                     /codon_start=1
                     /product="copper-transporting ATPase 2 isoform X2"
                     /protein_id="XP_073750709.1"
                     /db_xref="GeneID:112826796"
                     /translation="

MVVKGMTVDTAMEEAGGETSGSPEPSFLATLGDPQVTLVSVHKRRSFMRNAGARGSTRPVTSEEEGEFSQKVLNGTRGIRSNQILSKLSLPTRAGEPAMKQSFAFDNVGYEGGLDGVCPPQMTSSTISISGMTCQSCVKSIEGRISSLKGVVSIKVSLEQGSATVKYVPSILSLPQICRHIEDMGFEASIAEGKAASWPSRSSPGLEAVVKLQVEGMTCQSCVSSIEGRLGKLQGVVRVRVSLGTQEAVITYQPYLIQPQDLRDHVNDMGFEAVIKNRVAPVSLGPIDIGRLQRTDPKTPSASDNQNLNNSEPSGHHGSHVATLQLRVDGMHCKSCVLNIEENIGQLPGVQNIQVSLENRIAQVQYDPSRVTAGALQRAIEALPPGNFKVSPPDGAAGSGTGSRSSNCGAPGPASRTQAPGVCNTVVLVIAGMTCASCVQSIEGLISQREGVRQISVSLADGTGVVLYDPSVINPEELRAAVEDMGFETSVLFENCYSNHVGNHSAGNSSAHPTAGVPVSAQEGAPHAGGLPKSHNPSSSSQSLQASTTAAPQKCFLQIRGMTCASCVSNIERNLQKEAGILSVLVALMAGKAEVKYNPEVIQPLEIAQLIQDLGFEAAVMEDYTDSDGDLELIITGMTCASCVHNIESKLTRTNGITYASVALATSKAHVKFDPEVIGARDIVRIIEEIGFHASPAQRNPNAHHLDHKVEIKQWKKSFLCSLVFGIPVMGLMIYMLVPSNKPHESMVLDHNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYRSLRHRAANMDVLIVLATSIAYTYSLVILVVAMAEKAERSPVTFFDTPPMLFVFIALGRWLEHVAKSKTSEALAKLLSLQATEATVVTLGEDNLIIREEQVPMELVQRGDIIKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSTVIAGSINAHGSVLVNATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIISTLTLVTPNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPKVMRVLLLVDVATMPLRKVLAVVGTAEASSEHPLGMAVTKYCKEELGTKTLGYCTDFQAVPGCGIGCKVSSVEGILAHSEHQQSKQAAPLSRTGGVPEAIDATPQTFSVLIGNREWMRRNGLTISSDISDAMKDHEMKGQTAILVAIDGVLCAMIAIADAVKQEAALAVHTLKSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNEGKKVAMVGDGVNDSPALAQADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVWRIRLNLVLALIYNLIGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAQGRMKPLTASQVSVHIGMDDRRRDSPRTTPWDQVSFISQVSLSSLKSDKLSRHSAAADDGGDKWSLLLNDRDEEQCI"

     misc_feature    673..864
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(691..699,706..708)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    928..1116
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(946..954,961..963)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1270..1446
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1288..1296,1303..1305)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1576..1767
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1594..1602,1609..1611)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1966..2154
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1981..1989,1996..1998)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    2191..2382
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(2209..2217,2224..2226)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    2446..4500
                     /gene="ATP7B"
                     /note="P-type heavy metal-transporting ATPase, similar to
                     human copper-transporting ATPases, ATP7A and ATP7B;
                     Region: P-type_ATPase_Cu-like; cd02094"
                     /db_xref="CDD:319783"
     misc_feature    order(3385..3387,3391..3393,4429..4431)
                     /gene="ATP7B"
                     /note="putative Cu binding site [ion binding]; other site"
                     /db_xref="CDD:319783"
     misc_feature    order(3517..3525,3727..3729,3880..3888,3976..3978,
                     4096..4104,4162..4164,4171..4173,4180..4182,4237..4239,
                     4246..4248)
                     /gene="ATP7B"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319783"
     polyA_site      6883
                     /gene="ATP7B"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

gggcacgtgtgagaccatgtgcaaagactcccagtgccagatgcggtgtgatgagtgagagtgtgccagttggctggaaggatgtaagtaaacaagaacaaatatctacccagcggtgtgcagcctccccgagttccgaagctgactgcagcctctcagcggactgtctccggagcagaggggagtccgcaggacagagcacagaaggtgcctccccctgctagttaggaggacacttttaaagcatttccttctcacatgaccacgtagtgtggtgcgggtgaactgcttgctcaaatggtggttaaaggtatgaccgtggacacagcgatggaggaagctgggggtgagacatccgggagccctgagccgtccttcctggcgaccctgggtgacccacaggtgacccttgtgtccgtccacaagcggaggtccttcatgaggaatgctggggccaggggctccaccaggccggtgacttcggaggaggaaggagagttttcccagaaggttttgaatggaacacggggaatccgttccaatcagatcctgtctaaactttctctgcccactcgtgccggggagccagcaatgaagcagagtttcgcctttgacaatgttggctatgaaggcggcctggatggcgtgtgcccccctcagatgaccagcagcaccatcagcatttcgggcatgacttgccagtcgtgtgtgaagtctatcgagggcaggatttccagcttgaaaggcgtcgtgagcattaaggtttccctggaacaaggcagcgcgaccgtcaagtacgtgccgtccatcctgagcctgccacagatttgccggcacattgaggacatgggctttgaggccagcatcgcagaaggaaaggccgcctcctggccttcaaggtcctcgcctggcctggaggccgtggtcaagctccaggtggagggcatgacctgccagtcctgcgtcagctccatcgaaggcaggcttgggaaactgcaaggggtagtgagggtccgagtgtccctcggcacccaggaagcagtcattacctaccagccttatcttatccagccccaggacctcagggaccatgtcaatgacatgggctttgaagctgtcatcaagaacagagtggcgcccgtaagcctgggaccaattgatattgggcggttacagaggacggacccaaagacaccttcggcttctgataaccagaatctcaataactctgagccctcggggcaccatgggagccatgtggccaccctgcaactgagagtggatggaatgcactgtaagtcttgtgtcctgaatattgaagaaaacataggccaactccccggggttcaaaatattcaagtgtccttggagaacagaatcgcccaagtacagtacgacccttctcgtgtcactgcaggcgccctgcagagggccattgaagctcttccacctgggaacttcaaggtctctcctcctgatggagcagcagggagtgggacaggtagcaggtcttccaactgtggggcccccggccccgcctcgagaacccaggcgccgggcgtgtgcaatactgtggtgctcgtcattgctggcatgacctgcgcatcctgtgtccagtccatcgaaggcctgatctcccaaagggaaggggtgcggcaaatatcagtctctctggctgacgggaccggagtggtgctctatgatccctctgtaattaacccagaagaactccgagctgctgttgaagacatgggatttgagacttcagttctttttgaaaactgttatagcaaccatgttggaaatcatagcgcggggaattcctcagcgcaccccacagctggcgtacctgtgtctgcgcaggaaggggctccccatgctggggggctccctaaaagccacaaccccagctcctcgtcacagtccctgcaagcctctaccacagcggcaccccagaagtgctttttacagatcaggggcatgacctgtgcatcctgtgtgtccaatatagagagaaacctgcagaaagaagcaggtattctctcggtgctggttgccctgatggccggaaaggcagaggttaagtataacccagaagtcatccagccactggagatagctcagctcatccaggacttgggctttgaggcagcagtaatggaagactacacagactcagatggcgacctcgagctgatcatcacggggatgacctgcgcgtcctgtgttcacaacatagagtccaaactcacaaggacaaacggcatcacctatgcctctgtggcccttgccaccagcaaagcccacgtgaagttcgatcctgaagttatcggtgcacgggatattgtccgaattattgaggaaatcggctttcatgcttccccggcccagagaaaccccaacgcgcatcacttggaccacaaggtggaaataaagcagtggaagaagtctttcctgtgcagcctggtgttcggcatccctgtcatgggtctgatgatctatatgttggtgcccagcaacaagccccacgagtctatggtcctggaccacaacatcattccaggactgtccattctaaatctcatcttctttatcttgtgtacctttgtccagctccttggcgggtggtacttctacgtccaggcctacagatctctgaggcacagggcagccaacatggacgtgctcatcgtgctggccaccagcatcgcctacacctactcgctcgtcatcctggtggtggccatggctgagaaggcggagaggagccctgtgaccttcttcgacaccccccccatgctctttgtgttcattgccctgggtcggtggctggaacacgtggcaaagagcaaaacctcagaagcccttgccaaactcttgtctctccaagccacagaagccactgttgtgacccttggcgaggacaacttgatcatcagagaggagcaagtacccatggagctggtgcagcggggtgatatcatcaaagttgtccccgggggaaagttcccagtggatgggaaagtcctggaaggcaacaccatggccgacgagtccctcatcacaggagaagccatgccggtcacaaagaaacctggaagcacagtgattgctgggtctatcaatgcacacggctctgtgctcgttaatgccacccatgtgggcaatgacaccacgttggctcagattgtgaaattggtggaagaggctcagatgtcaaaggcacccattcagcaactggctgaccggtttagtggatattttgtcccatttatcatcatcatttcaacattgacgttggtgacccccaacaagcatatctcccagacagaggtgatcatccggtttgcattccagacatccatcacggtgctgtgcatcgcctgcccctgctccctgggcttggccacgcccacggcggtcatggtgggcaccggggtggccgcccagaatggcatcctcatcaaaggaggcaagcctctggagatggcccacaagataaagaccgtgatgtttgacaaaactggcaccattacccacggggtccccaaagtcatgagggtcctcctgcttgtggatgtggccacgatgcccctcaggaaggttcttgctgtggtggggactgcggaggccagcagcgagcaccctttgggcatggcagtcaccaagtactgtaaagaggaattgggaaccaagaccttgggatactgcacggacttccaggcagtgccgggctgtggcatcggctgcaaagtcagtagcgtggagggcatcctggcccacagcgagcaccagcagagcaaacaggctgctcccctgagcaggactggcggcgttcccgaggcaatagatgcgaccccccagaccttctctgtgctgattgggaaccgcgaatggatgaggcgcaacggcctaaccatttccagcgacatcagtgacgcgatgaaagatcatgagatgaaaggccagacggccatcctggtggccattgacggtgtgctctgcgccatgattgccatcgcggacgcagtcaagcaggaggcagccctggctgtgcacacgctgaagagcatgggtgtggacgtggttctgatcacaggggacaaccggaagacagccagagccatcgccacccaggttggcatcaacaaagtctttgcagaggtgctaccttctcacaaggtggccaaggtccaggagctccagaatgaagggaagaaagtcgccatggtgggagacggggtcaatgactcaccggccttggcccaggccgatgtgggcatcgccatcgggacaggcacggacgtcgccattgaggccgctgacgttgtcctcatcagaaacgatctgctcgatgtggtggctagcattcacctctccaagaggaccgtctggagaatacgcctcaatctggtgctggcgttgatttacaacctgatcggaatacccattgctgcaggggtcttcatgcccattggcatcgtgctccagccgtggatgggctcggcggccatggcggcctcctccgtgtctgtggttctctcatcgctgcagctcaagtgctataagaagcccgacctggagaggtatgaggcgcaggcccagggccgcatgaagcccctgacagcatcacaggtgagcgtgcacatcggcatggatgaccggcgacgggactccccaaggaccacgccctgggaccaggtcagcttcatcagtcaggtgtctctgtcctccttgaagtctgacaagctgtctcgacacagtgctgcagctgatgacggtggggacaagtggtctctgctcctgaatgacagagatgaggagcagtgcatctgaaagctccaggcgggtgcagagccaggggtccatctcctcagtgagtagccggcccagctttccccatggccgaggctgagaccaaacaagtgcagcaccagcagcaagatgggcgaagctcccctccagccgtggggacttccactccctggacattcctggtcatccctcctagcatgtgccacatccagatgtgactcctgggtaggccctgccccccaccccccgtgcctggatcccgccagcacaggggccaggcttcccggcctgaccatgctgttggcctgggcttgttgggaaccttgctggactctaagagcagaggagaggacagccagccctcctcgcagacctctgctttggtgtttggaatgactacctgtaaaatgaggaaaatctcatcaggaccaaaatcttagctgggcctttccttagaactcaggagaagccttgtattgggttctttttgacaatacccacatgcattgcgtatctgagaccacagtttacctcaaatacaccccattgatgtctgccggcactgtctcttccttttctgtttttaacattggcgccagcccaccccagcccacccctgcctgatctctgacagcaggaccctagtgatccctgctgttgccctcaggcctgcatctgctccctcacacaccggccagagagccggccttgcttctcttcaggccgagagttctctgctgcctgtgtgccccctggccatggagtcctggcttctcgctcctcggaatggcatgctcttgtggactgtttctgccccgctggagtgagggtctcaaagcctgagacctaggaaatcctgcctcctctggggtccaggtccttgggatgcgtggaggcctgtggtgcttgaaaccacatcccgtggggaggtgtgtgcacttgccagaaccgccttgcacacccccgggagcttcaatgacatggtctgctatgggactgtcagctcatggatggtgcccctggtggtgtgcaactgcaaggaaacccatacccgaagaagaggaaatcacacttactctccaggagcttctacttctgcacacgggactggcgccttaggaaaggagtcaccactgcttccccaagggagagcctgtttcacactttcagtggctctttgtgattgtaggacgtcagactggcaggaatggagccagttttagacactcaagccggcggtgattgacagaaccacatggtagtacacgagtagaaagaaaataaattttaaggtagagagagcccttatcacacacaaaatagttttatttattgagtaccagttacgtttcagggagagtgtaagcactttttctaggctacttgtaatcttctcagcaaactagccagtgggtactgctgtccatgttggacgcgcagggcggtaggctcagagaggctgggtatcccgcccaggatcgcacagcccgcgcacatgccagaacagggaaatcttttctccgtggtggctgtcaccagaatatcagttggcaggaataaacaggaaaaagccactgctcctagaagaacaaatctgctgggtggccgattcattgttagcgacttagaatgaaacttgatctcaggatcagctcccggttccctcggatggtttgtttccatttttgcctctaatctcgtgttgctgggtcttacccactacaatcctgcgctggttccactgtgttcctgtcgttttcagtcttcctttcccccgggcctctccctgctctgtccttcctttactcctggctgtgctcaggagggtttcttgttttctaactaggttaatcattgtctaaaggatctaattgtattgatttcacaaaggcttttaggaccataaacctcatgcgtatatggccatgaaaatatttatataattgtacaggatataacctttagatgttcagggggtaagagttttttgtgtgtcagataagaagagttcctgtttcaaaaactttccatgccgtattagaataaagtttatttttattcatctaaa

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