LOCUS       XM_073349555            4655 bp    mRNA    linear   VRT 19-APR-2025
DEFINITION  PREDICTED: Lepidochelys kempii dicer 1, ribonuclease III (DICER1),
            transcript variant X18, mRNA.
ACCESSION   XM_073349555
VERSION     XM_073349555.1
DBLINK      BioProject: PRJNA1251686
KEYWORDS    RefSeq.
SOURCE      Lepidochelys kempii (Atlantic ridley)
  ORGANISM  Lepidochelys kempii
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
            Americhelydia; Chelonioidea; Cheloniidae; Lepidochelys.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_133261) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_965140265.1-RS_2025_04
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 04/18/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4655
                     /organism="Lepidochelys kempii"
                     /mol_type="mRNA"
                     /isolate="rLepKem1"
                     /db_xref="taxon:8472"
                     /chromosome="6"
                     /geo_loc_name="USA: Quincy, Massachusetts"
                     /collection_date="2018-12-12"
     gene            1..4655
                     /gene="DICER1"
                     /note="dicer 1, ribonuclease III; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     Protein"
                     /db_xref="GeneID:140913338"
     CDS             412..1833
                     /gene="DICER1"
                     /codon_start=1
                     /product="endoribonuclease Dicer isoform X5"
                     /protein_id="XP_073205656.1"
                     /db_xref="GeneID:140913338"
                     /translation="

MKSPALQSLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLAKELSYQIRGDFNKNGKRTVFLVNSANQVAQQVSAVRTHSDLKVGEYSVLEIIESWTKEKWNQEFAKHEVLVMTCHVILNVLKNEYLSLSNINLLVFDECHLAIQDHPYQEIMKICENCPSCPRILGLTASILNGKCDPAELEEKIQKLEKILKSNAETATDLVVLDRYTSQPCEIVVDCGPYTDKSGLYERLLKELDEALNFLNDCNISVHSKERDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTFLRKIHALCEEHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDEDEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRHTNENVCHGCTYEF"

     misc_feature    535..1128
                     /gene="DICER1"
                     /note="DEXH-box helicase domain of endoribonuclease Dicer;
                     Region: DEXHc_dicer; cd18034"
                     /db_xref="CDD:350792"
     misc_feature    order(535..546,553..555,604..627,748..750,937..939,
                     1030..1032)
                     /gene="DICER1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350792"
     misc_feature    order(712..717,784..789,862..864,868..873,880..882,
                     955..963)
                     /gene="DICER1"
                     /note="nucleic acid binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350792"
     misc_feature    1228..1506
                     /gene="DICER1"
                     /note="Partner-binding domain of the endoribonuclease
                     Dicer; Region: Dicer_PBD; cd15903"
                     /db_xref="CDD:277191"
     misc_feature    order(1237..1242,1249..1251,1255..1260,1435..1440,
                     1447..1452,1459..1461,1468..1473,1480..1482)
                     /gene="DICER1"
                     /note="Trbp binding interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:277191"
     misc_feature    1525..>1788
                     /gene="DICER1"
                     /note="Members of the P-loop NTPase domain superfamily are
                     characterized by a conserved nucleotide phosphate-binding
                     motif, also referred to as the Walker A motif
                     (GxxxxGK[S/T], where x is any residue), and the Walker B
                     motif (hhhh[D/E], where h is a...; Region: P-loop
                     containing Nucleoside Triphosphate Hydrolases; cl38936"
                     /db_xref="CDD:476819"
ORIGIN      

aggaacctgacagctggggggagtgaggcggcggcggcggggaaatggcggcgggagcagcacaatgagacgcggcctgtagtctggaagctctgggctgggtccagtccggcaggttacctagggtgaaacaaaattacaggcttggaaactctggaaaagctctgtagcagcattagagagcagaagcttgcaaatgatgcaattaatgtacaaactgatatcatgatgtcaaaatgcagttcaaagaacacaaacacagatctcagaaattaaaacgcaggtcaggaagaatccgtcaggaactccagctgttgacaatactacatgggttatagaggaagctcttcagaggcagtaagctgtgctggaacaaaaatgcaatgaaagaaacactggatgaatgaatgaatgaaaagccctgctttgcaatccctcagcatggcaggactgcagcttatgacccctgcttcctcaccaatgggtcctttttttggactgccatggcaacaagaagcaattcatgataacatttacacgccaagaaaatatcaggttgaactgcttgaagcagctttggatcataatacgatagtctgtttaaacactggctcagggaagacttttattgcagtactacttgctaaagagctgtcctatcagatcaggggagacttcaacaaaaatggaaagagaacagttttcttggtcaactcagcaaatcaagttgctcagcaagtgtcagctgtcaggacccattcagatctgaaggtgggggagtattcagttttagaaataattgaatcatggacaaaggagaagtggaatcaagaatttgctaaacatgaggttctggttatgacatgtcatgtcattttgaatgttttaaaaaatgaatacttatccctgtcaaacattaatcttctggtgtttgatgagtgccatcttgcaatccaggaccatccgtatcaagaaattatgaagatctgtgagaactgtccatcctgtcctcgaatcctgggattaacagcttccattttaaatgggaaatgtgatcctgctgagttagaggagaagattcagaaactggagaaaatcctaaagagcaatgctgaaactgcaactgatttggtggtcttagatagatatacttctcagccatgtgagattgtggtagattgtggaccatataccgacaaaagcgggctgtatgaaagattgttaaaagaattggatgaagcacttaactttttaaatgactgcaacatatctgtacattcaaaagaaagagactctacgttaatttctaaacagatactgtcagactgtcgagctgtgttggttgttctgggaccctggtgtgcagataaggtagctggaatgatggtgagagagctacagaagtacatcaaacatgagcaagaggagctgcacaggaaatttttattgtttacagacactttcctaaggaaaatacatgcactgtgtgaagagcacttctcacctgcctcacttgatctgaaatttgtaaccccgaaagtaataaaactgcttgaaatcttgcgcaaatataaaccatatgagcggcagcagtttgaaagtgttgagtggtataataataggaatcaggataattatgtgtcttggagtgattctgaagatgatgatgaggatgaagaaattgaggagaaagaaaagccagagacaaatttcccttctccctttactaatattttatgtggaattatttttgtggaaaggagatacacagcagtcgtcctaaacagacacacaaatgaaaatgtctgccatggatgcacatatgaattctgaagaggcatgaattaagccatgtctgtttgaagatttggcccacattttattgaaaagcctgcagcagttacaagagcttattgatttttgttcagtggagttttcagtaaatgcttgctatactttttttaaaaaaactgcatagctaaataattttattttggaaagaaacgtaatgttctgcacctgccagtacttaatatttatttggaatttgggcctgatccaaaatccactaaagtcaatggaaagacttccattgatttccgagttttggatcagaacatttatgaagtgtgttttaattgaatgtacactttaattatttgatcacttgacctatcctttgaactgtgcatttccccacatgcacactttcagtgtattttatcctttttctttgcctttttgcacccataaatgttcatggaagtgtattatgtgatacaagtcaagtcttccagtgaaatgaatacatgtttttaataactttttaaaaggtctttacatttaatgaaatctgataaatatgcctggcaacctgaaataaatattacattatacttcagggagtaaaagattatgaagtcacagttcatatagactactaaatgataaatttgattcaaatgctattgtactttttccattgcactgtacatacctgcatactttacatgatatataaatcaaactacaccctggctgccacaacacttcaaacttacagtacattttatttatttaaatttataaagaattaacaaaaaggcacttaccttaagactccggacaaccttcacatgagttatggtgaccaaagtataaaatgagcattgagcatctaactcccactccaaaagtcaaccactgaacaaagattctcaaaaaaagtctccccacactcacgcgagttccaaacttaagctgcatcaaactcttccttctgcgtagaatcatatggttaaaaggtaccataagggttatggagtctaaccccctgccaaggtgcaggatttgttgtttctaaaccatccaagacagatggctatccagcctccttttgaaaacctccagtgaaagagcttccacaacctccctaggcagtctgttccattgtcctgctgttccaaaaacatttgtgaatagattgggtttacagattacttggaaggtcagcagatccaaggtgtttcagaccaaaggctgaagacccctcactactgccagttccttgccctttcagttgagagggattcagctcaaaggcatccgctgattgcagttgcagcaatagggcacacagagagaggcattcttcccaaatcagaagatcccaaaacatttagggttttatgtcataaccaacaccttaaatttcacctagaagccaataaccaagccctgcacatcatgaagtggggccagatcaatatacaggcactgttgacttgttttgctgctgttatagtaataattacacttggtctacagctcctggaattatgtaatggagtctgatactggtggtaaaaaggggtgcatggatatgtctacactgcaattgaaaatcctcggttgccttgtgccagctgacttggaccatgtttaattgtggtgtagacgctcgggctggtgggagagtcccagagctcaggctgcagcctgagcctgaatgtctatactgcagttaaacaacctgttagccccaggcctccgagcctgagtcagccagcacagagcagccttgggagtctaacgacagtgtacacataccctgtggcagaaacaggtaagaatttaatatgaaatgatacttaactactaatccctttcttcagaaacaggattattgcctaaattgtaaatattactggtcaaaccaaaaattggcctaatctgtgtatagttatgatcacgtatcattttcacccactagttacaaatgcacaacaaaatcagttgtcataaattattagatgtgtgttaaaagcatttgttcattcattgccataggtattttttaacttatatttcagttgtatacctcgggaaatgtggggggaaaattctatttaagaaggtttttgttatactttttactgttttttgtttgtccatattaaaaaaacacagtatatgtgtgacattcctgggaacaatccagactaatgaaaagttctgtcaccctgccttgcaccattgggtgccttacaatgccttgctgaaggggctcccacctctgccactcacaaacagccttccagcatgcaagccacaccctgtgtgtgtgtaactacagcctgccagccacacttgggttacactctggctctccccagcctggattatactgcagggtgcccccaacacaccctcagtcttagatttccccccagaaatctgcccagccctctcctgaataatacaagttttatataaagtccattattactttaataaaaataatatacatgcaacttgccatcccaactggatttttccagacacttcaatttaaacacacttgcttagctaaaacaataaaacaagtttgttaactaaaaagggagagattttaagtgagtacaagtaatggggcataaaagtctgaaatggttacaagaaaaacaaagataagttaagcactccagtagcattttaacttaacacggttacattcaaagcagagctttctctccacatccttcttaggatcaggtcaggaccccttctcccagaatccaatgaatgctttctttgttgcttcaggtttcagagtaacaggcgtgttagtctgtattcgcaaaaagaaaaggagt

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