LOCUS       XM_072963658            3813 bp    mRNA    linear   MAM 07-APR-2025
DEFINITION  PREDICTED: Vicugna pacos dicer 1, ribonuclease III (DICER1),
            transcript variant X5, mRNA.
ACCESSION   XM_072963658
VERSION     XM_072963658.1
DBLINK      BioProject: PRJNA1244907
KEYWORDS    RefSeq.
SOURCE      Vicugna pacos (alpaca)
  ORGANISM  Vicugna pacos
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Tylopoda;
            Camelidae; Vicugna.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_132992) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_048564905.1-RS_2025_04
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 04/02/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3813
                     /organism="Vicugna pacos"
                     /mol_type="mRNA"
                     /db_xref="taxon:30538"
                     /chromosome="6"
     gene            1..3813
                     /gene="DICER1"
                     /note="dicer 1, ribonuclease III; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 3
                     mRNAs, 4 long SRA reads, 15 Proteins"
                     /db_xref="GeneID:102538448"
     CDS             823..3813
                     /gene="DICER1"
                     /codon_start=1
                     /product="endoribonuclease Dicer isoform X3"
                     /protein_id="XP_072819759.1"
                     /db_xref="GeneID:102538448"
                     /translation="

MKSPALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFNRNGKRTVFLVNSANQVAQQVSAVRTHSDLKVGEYSNLEVYASWTKEKWNQEFTKHQVLVMTCFVALNVLKNGYLSLSDINLLVFDECHLAILDHPYREIMKLCENCPSCPRILGLTASILNGKCDPEELEEKIQKLEKILKSNAETATDLVVLDRYTSQPCEIVVDCGPFTDRSGLYERLLMELEEALNFINDCNISVHSKERDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTFLRKIHALCEEHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDEEDEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEAEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYVMLADTDKIKSFEEDLKTYKAIEKILRNKCSKSVDTGETDIEPVVDDDDVFPPYVLRPDDGGPRVTINTAIGHINRYCARLPSDPFTHLAPKCRTRELPDGTFYSTLYLPINSPLRASIVGPPMSCIRLAERVVALICCEKLHKIGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRDSYPKPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLSLQMLELITRLHQYIFSHILRLEKPALEFKPTDADSAYCVLPLNVVNDSSTLDIDFKFMEDIEKSEARIGIPSTKYSKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSR"

     misc_feature    946..1539
                     /gene="DICER1"
                     /note="DEXH-box helicase domain of endoribonuclease Dicer;
                     Region: DEXHc_dicer; cd18034"
                     /db_xref="CDD:350792"
     misc_feature    order(946..957,964..966,1015..1038,1159..1161,1348..1350,
                     1441..1443)
                     /gene="DICER1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350792"
     misc_feature    order(1123..1128,1195..1200,1273..1275,1279..1284,
                     1291..1293,1366..1374)
                     /gene="DICER1"
                     /note="nucleic acid binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350792"
     misc_feature    1633..1917
                     /gene="DICER1"
                     /note="Partner-binding domain of the endoribonuclease
                     Dicer; Region: Dicer_PBD; cd15903"
                     /db_xref="CDD:277191"
     misc_feature    order(1648..1653,1660..1662,1666..1671,1846..1851,
                     1858..1863,1870..1872,1879..1884,1891..1893)
                     /gene="DICER1"
                     /note="Trbp binding interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:277191"
     misc_feature    1936..2514
                     /gene="DICER1"
                     /note="C-terminal helicase domain of the endoribonuclease
                     Dicer; Region: SF2_C_dicer; cd18802"
                     /db_xref="CDD:350189"
     misc_feature    order(2167..2175,2383..2385,2440..2442,2446..2448)
                     /gene="DICER1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350189"
     misc_feature    order(2395..2397,2401..2403,2476..2478,2482..2484)
                     /gene="DICER1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350189"
     misc_feature    2710..2976
                     /gene="DICER1"
                     /note="Dicer dimerization domain; Region: Dicer_dimer;
                     pfam03368"
                     /db_xref="CDD:460900"
     misc_feature    3478..3810
                     /gene="DICER1"
                     /note="PAZ domain, dicer_like subfamily. Dicer is an RNAse
                     involved in cleaving dsRNA in the RNA interference
                     pathway. It generates dsRNAs which are approximately 20 bp
                     long (siRNAs), which in turn target hydrolysis of
                     homologous RNAs. PAZ domains are named...; Region:
                     PAZ_dicer_like; cd02843"
                     /db_xref="CDD:239209"
ORIGIN      

ccgccgcgctctgtccaatcacaggctcgctctcatgccggcgcggggcgagccgagcgtgggggcgcggaggggcggcgcgggcaccggtgggattctccaagcggctgtgcgctgttgccgcgggccgtgcgcgggctgcgggcgagccgggcgctgcgcagtctccgcaggcgccggcgggaggggtcgaggcggaggcgcggcgcggcgcggcgcaggctgctccaggcccaggtgaatggagtaacctgacagcggggacgaggcgacggcaggcgggaggaaatggcggcggcggcgccgggcggcaccgagaggcctgggctgtgacgcgcgcgccggagcggggtccgatggttctcgaaggcccgcggcgccccgtgctgcaggcaaagaaacaaccttagagagaggtagtggagtctgataaaccttggtcttcctgacactggactctgctggcattcagatgattttaaatgaaagataaaagaaagaaagaaagaaaagactgctttctgcatccccagtggccttacccagtgtccctcccacaccagagggcctccgtgaggagggagtgactgtgtatgccagagtgctcagaggttacctagggtatgaattaatacagacttggaaactgaaagaacttagaatcagcatttttgagagcagaagcttgagtatgctgtgattttccaataaactgctatcacaatgtcaaaatgcagttcagacaacagcaacacagagatctcaaacattaagacgtaagctgtgctaggacaaaaatgcaatgaaagaaacactggatgaatgaaaagccctgctttgcaacccctcagcatggcaggcctgcagctcatgacccctgcttcctcaccaatgggtcctttctttggactgccatggcaacaagaagcaattcatgataacatttatacgccaagaaaatatcaggttgaactgcttgaagcagctctggaccataataccatagtctgcttaaacactggctcagggaagacgttcatcgcagtgctgctcactaaagagctgtcctatcagatcaggggagacttcaacagaaatggcaaaaggacggtgttcttggtcaactctgcaaaccaggttgctcaacaagtgtcagctgtcagaactcactcagatctcaaggttggggaatactcaaacctagaagtatatgcatcttggacaaaagagaaatggaaccaagagtttactaagcaccaggttcttgttatgacttgctttgtcgccttgaatgttttgaaaaatggttacttatcactgtcagacattaaccttttggtatttgatgagtgtcatcttgcaatcctcgaccacccctaccgagaaattatgaagctctgtgaaaattgtccatcatgtccacgtattttgggactaactgcttccattttaaatgggaaatgtgatccagaggaattggaagaaaagattcagaaactggagaaaattcttaagagtaatgctgaaactgcaactgacttggtggtcttagacagatatacttctcagccatgtgagattgtggtggactgtggaccatttactgacagaagtgggctttacgaaagactgctaatggaattagaagaagcacttaattttatcaatgattgtaacatatctgtacattcaaaagaaagagattctactttaatttctaagcagattctatcagactgtcgagcggtattggtagttctgggaccctggtgtgcagataaagtggctgggatgatggtgagagaactacagaagtatatcaaacacgagcaagaggagctgcacaggaaattcctattgtttacagacactttcctaaggaaaatacatgcactgtgtgaagagcacttctcacctgcctcacttgacctgaaatttgtaactcctaaagtcataaaactgcttgaaatcttacgcaaatataaaccatatgagcgacagcagtttgaaagcgttgagtggtacaataacaggaaccaggataattacgtgtcttggagtgattctgaggatgatgaggaggatgaagaaattgaagaaaaagagaaaccagagacaaattttccctctccatttaccaatattttatgtgggattatttttgtggaaagaagatacacggcagtcgtcttaaacagattgataaaggaagctggcaaacaagatccagagctggcttacatcagcagcaactttataactggacatggcattgggaagaatcagcctcgtaacaaacagatggaagcagaattcagaaaacaggaagaggtacttaggaaatttcgagcacatgaaaccaacctgcttattgcaacaagtattgtggaagagggtgtcgatataccaaaatgcaacttggtagttcgttttgatttgcccacagagtatcgatcctatgttcaatctaagggaagagcaagggcaccgatctctaattatgtcatgttagcagatacagacaaaataaaaagttttgaagaagaccttaaaacatacaaagctattgaaaagatcttgagaaacaaatgttccaagtcagttgacactggtgagactgacatcgagcctgtggtggacgacgacgacgttttcccgccgtacgtgctgaggcccgatgacgggggtccacgggtcacaatcaacacggccattggacacatcaatagatactgtgctagattaccaagtgatccatttactcatctggctcctaaatgtagaacccgagaattgcctgatggtacattttattcaactctttatctgccaattaactcacctcttcgagcctccattgttggtcccccaatgagctgtatacgattggctgaaagagttgtagctctcatttgctgtgaaaaactgcacaaaattggtgaactggatgaccatttgatgccagttgggaaagagactgttaaatacgaagaagagcttgatttacatgatgaagaagaaaccagtgttccaggaagaccaggttccacaaaacgaagacagtgctacccaaaagcaattccagaatgtttgagggatagctaccccaaacctgatcagccctgttacctgtatgtgataggaatggttctaacgacccctttacctgatgaactcaacttcagaaggcggaagctctatccccctgaggataccacaagatgctttggaatcctgacagccaaacccatacctcagattccacactttcctgtgtacacacgctctggagaggttaccatatctattgagctgaagaagtctggtttcacgttatccctgcaaatgctcgagttgattacaagacttcaccagtacatattctcacatattcttcggcttgaaaaacctgcactagaatttaaacccacagacgctgattcagcatactgtgttctacctcttaatgttgttaatgactccagcactttggacattgactttaaattcatggaagatattgagaaatctgaagctcgcataggcattcccagtacaaagtattcaaaagaaacaccctttgttttcaaattagaagattaccaagatgcagttatcattccaagataccgcaattttgatcagcctcatcgattttatgtagctgatgtgtacacagatcttactccactgagtaaatttccttcccctgagtatgaaacttttgcagaatattataaaacaaagtataaccttgacctgaccaatctcaaccagccgctgctggatgtggaccacacatcttcaaggtga

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