LOCUS       XM_072116266            2681 bp    mRNA    linear   VRT 14-MAR-2025
DEFINITION  PREDICTED: Engystomops pustulosus dicer 1, ribonuclease III
            (DICER1), transcript variant X3, mRNA.
ACCESSION   XM_072116266
VERSION     XM_072116266.1
DBLINK      BioProject: PRJNA1226277
KEYWORDS    RefSeq.
SOURCE      Engystomops pustulosus (Tungara frog)
  ORGANISM  Engystomops pustulosus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Amphibia; Batrachia; Anura; Neobatrachia; Hyloidea;
            Leptodactylidae; Leiuperinae; Engystomops.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_092417) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_040894005.1-RS_2025_03
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 03/12/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2681
                     /organism="Engystomops pustulosus"
                     /mol_type="mRNA"
                     /db_xref="taxon:76066"
                     /chromosome="7"
     gene            1..2681
                     /gene="DICER1"
                     /note="dicer 1, ribonuclease III; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     Protein"
                     /db_xref="GeneID:140069953"
     CDS             337..2577
                     /gene="DICER1"
                     /codon_start=1
                     /product="endoribonuclease Dicer isoform X3"
                     /protein_id="XP_071972367.1"
                     /db_xref="GeneID:140069953"
                     /translation="

MASLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNSGSGKTFIAVLLTKELSYQIRGDFNKAAKRTVFLVNSAKQVAQQVSAVRTHSDLTVGEYSSPEVVESWSKEKWQEEFVTHQILVMTCHIFLHVLKRENLSLSNINLLVFDECHLAIQDHPYREIMKICESCQTCPRILGLTASILNGKCDPRDLKEKIQKLEEILKSNAETATDLVVLDRYASQPCEIVLDCGPYHDRSGLYQRLLSELDDALHFLDDCNIPILSKERDSTSISKQILSDCQAVLLVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTTLRKIHALCEEHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDDEDEEIEEKEKPETSFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKSQLRNKQMEVEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYIMLADTERIKGFEEDLKTYKAIEKILRNKCSKSMDCGDTEPDSTVDDDGIFPPYVLRQDDGSPRVTLNNAIGHINRYCARLPSDPFTHLAPKCKTREVSCGVCQSTLYLPINSPLRAPIVGPSMNCARLAERAVALICCKMLHQIGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAEWC"

     misc_feature    430..1023
                     /gene="DICER1"
                     /note="DEXH-box helicase domain of endoribonuclease Dicer;
                     Region: DEXHc_dicer; cd18034"
                     /db_xref="CDD:350792"
     misc_feature    order(430..441,448..450,499..522,643..645,832..834,
                     925..927)
                     /gene="DICER1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350792"
     misc_feature    order(607..612,679..684,757..759,763..768,775..777,
                     850..858)
                     /gene="DICER1"
                     /note="nucleic acid binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350792"
     misc_feature    1117..1401
                     /gene="DICER1"
                     /note="Partner-binding domain of the endoribonuclease
                     Dicer; Region: Dicer_PBD; cd15903"
                     /db_xref="CDD:277191"
     misc_feature    order(1132..1137,1144..1146,1150..1155,1330..1335,
                     1342..1347,1354..1356,1363..1368,1375..1377)
                     /gene="DICER1"
                     /note="Trbp binding interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:277191"
     misc_feature    1420..2001
                     /gene="DICER1"
                     /note="C-terminal helicase domain of the endoribonuclease
                     Dicer; Region: SF2_C_dicer; cd18802"
                     /db_xref="CDD:350189"
     misc_feature    order(1654..1662,1870..1872,1927..1929,1933..1935)
                     /gene="DICER1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350189"
     misc_feature    order(1882..1884,1888..1890,1963..1965,1969..1971)
                     /gene="DICER1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350189"
     misc_feature    2197..2463
                     /gene="DICER1"
                     /note="Dicer dimerization domain; Region: Dicer_dimer;
                     pfam03368"
                     /db_xref="CDD:460900"
ORIGIN      

cggtcacatgaccgtgacgtcaggcggcgagctgttggcggcggccggtggatgggcccgtcatcctcccgtagctaggatcgcacgctctgggagaggagcccggtggccggcctcgtacctggcagtgcggggtcacatgagcgcggcccgggggtaactaggtctggcaaactctgtggcggctcctaatctgctctaaggtgaattactcagttatgacgatgttacaggatggttcaagcctttttgcatttgtgagctatcagacagaaagagagagctgtgctgaaccggaactgcaatgatctgaccactggatgaaagaccgtcagcatggcaagcctgcagctcatgaccccggcctcctcacccatgggtcctttctttggactgccttggcagcaggaggcaattcatgacaatatatataccccaaggaaatatcaggtggagctgctggaagccgctttggaccacaatacaatagtgtgtctgaactctggctcagggaagacgttcattgccgtactacttactaaagagttatcctatcagatccggggagactttaataaagctgccaagagaacagtgttccttgtcaattctgctaagcaagttgcccagcaagtgtctgccgtacgcactcattcagatctgacagtcggtgaatattccagcccagaagttgtggaaagttggtcaaaggaaaaatggcaggaggagtttgtgactcatcagattctggttatgacttgtcacatattcctccatgtcctaaagagagagaacctgtctttatcgaacatcaacctcctggtgttcgacgaatgccaccttgccatccaggatcacccatatcgtgagatcatgaagatctgtgaaagttgccagacatgtccacgaatcttgggactgaccgcctccatactgaacgggaaatgtgacccccgcgaccttaaagagaagatccagaaactagaggaaattttgaagagtaatgctgagacggcaactgatctggtggttttagacaggtatgcctcgcagccttgtgagattgtgttggactgtggcccctatcatgacagaagcggactctatcagaggctcctatctgaactggacgatgcacttcacttcctggatgactgcaacattcctattctttctaaagagagagattcaacatcaatctccaaacagatcctgtcagactgccaggcagttttgctcgttctgggtccgtggtgtgctgataaagttgctggaatgatggtgagagaactgcagaaatatataaaacatgagcaagaagagctgcatcggaagttcctgctgtttacagacaccaccctgaggaagatccatgctctctgtgaggagcatttctccccagcatcccttgacttgaaatttgtcacccccaaagtcatcaagcttttggagatcctacggaagtataaaccctatgaacggcagcagtttgagagtgtggaatggtacaacaaccgcaatcaggataactatgtgtcatggagtgactctgaggacgacgacgatgaagatgaggagatagaggagaaagagaagccagagactagctttccctctccatttaccaacatcttgtgtggaatcatctttgtagagcgaagatacaccgcagttgtcttgaataggttgatcaaggaggccgggaagcaggaccctgagctggcatacattagcagcaacttcataactggacacggcattgggaagagccagctccgaaacaagcagatggaagtagagttcagaaaacaggaggaggttctccgtaagttcagagctcatgaaaccaacctgctcattgccaccagcattgtggaggagggggtggacatccctaaatgcaacttggttgtccgatttgacctgccaacagagtacaggtcgtatgttcaatccaaaggacgagcgcgggcccccatctcaaactacatcatgttggcagacacagagcggataaaggggtttgaagaggatctgaaaacctataaagccattgagaagatcctgcgcaataagtgctccaagtccatggattgtggtgacacagagccggactccactgtggatgatgacgggatctttcctccatacgtgttgcggcaagatgacggcagccccagagttaccctaaacaatgctattggtcacatcaaccgttattgtgcccggctgcccagtgacccattcactcacctcgctccaaaatgtaaaactcgggaggtgtcctgtggtgtctgccagtcaaccctttacctgccaatcaactccccgctcagagcccccattgttggcccatccatgaactgtgccaggcttgccgaacgagcagtagccctcatatgctgcaagatgctgcatcagataggtgaactggatgaccatttgatgccagttggcaaggaaactgttaagtatgaggaggagcttgaccttcacgatgaggaggaaaccagtgtcccaggccgaccaggctcaaccaagaggaggcaatgctatccaaaagctgaatggtgttgacaacccctctacccgatgaactgaacttcaggagacggaagctctacccacctgaggacacaactagatgcttcggcatcctgactgccaaacccatacctcag

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