LOCUS       XM_070357903           10891 bp    mRNA    linear   MAM 12-DEC-2024
DEFINITION  PREDICTED: Bos mutus dicer 1, ribonuclease III (DICER1), transcript
            variant X7, mRNA.
ACCESSION   XM_070357903
VERSION     XM_070357903.1
DBLINK      BioProject: PRJNA1191006
KEYWORDS    RefSeq.
SOURCE      Bos mutus (wild yak)
  ORGANISM  Bos mutus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia;
            Pecora; Bovidae; Bovinae; Bos.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_091637) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_027580195.1-RS_2024_12
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/05/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10891
                     /organism="Bos mutus"
                     /mol_type="mRNA"
                     /isolate="GX-2022"
                     /db_xref="taxon:72004"
                     /chromosome="21"
                     /sex="male"
                     /tissue_type="blood"
     gene            1..10891
                     /gene="DICER1"
                     /note="dicer 1, ribonuclease III; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 3
                     Proteins"
                     /db_xref="GeneID:102270004"
     CDS             840..6500
                     /gene="DICER1"
                     /codon_start=1
                     /product="endoribonuclease Dicer isoform X3"
                     /protein_id="XP_070214004.1"
                     /db_xref="GeneID:102270004"
                     /translation="

MVLEGPRRPVLQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFNRNGKRTVFLVNSANQVAQQVSAVRTHSDLKVGEYSNLEVSASWTKEKWNQEFTKHQVLVMTCYVALNVLKNGYLSLSDINLLVFDECHLAILDHPYREIMKLCENCPSCPRILGLTASILNGKCDPEELEEKIQKLEKILKSNAETATDLVVLDRYTSQPCEIVVDCGPFTDRSGLYERLLMELEEALNFINDCNISVHSKERDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKHIKHEQEELHRKFLLFTDTFLRKIHALCEEHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDEEDEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEAEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYVMLADTDKIKSFEEDLKTYKAIEKILRNKCSKSVDTGEADTEPVVDDDDVFPPYVLRPEDGPRVTINTAIGHVNRYCARLPSDPFTHLAPKCRTRELPDGTFYSTLYLPINSPLRASIVGPPMSCIRLAERVVALICCEKLHKIGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRESYPRPGQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLSLQMLELITRLHQYIFSHILRLEKPALEFKPTDADSAYCVLPLNVVNDSSTLDIDFKFMEDIEKSEARIGIPSTKYSKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASDAGVGVRSLPVDFRYPNLDFGWKKSIDSKSFISIANSSSAENENYCKHSTIVVPENAAHQGANRTSPLENHDQMSVNCRTLFSESPGKLQIEVSTDLTAINGLSYNKSLANGSYDLANRDFCQGNHLNYYKQEIPVQPTTSYPIQNLYNYENQPKPSDECTLLSNKYLDGNANTSTSDGSPVTAAVPGTAETGEAPPDRTASEQSPSPGYSSRTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPGYVVNQDKSNTEKWEKDEMTKDCMLANGKLDDDFEEEEEEEEDLMWRAHKEDADDEDDFLEYDQEHIKFIDNMLMGSGAFVKKISLSPFSATDSAYEWKMPKKSSLGSLPFSSDFEDFDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGVDTGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIKRTDREKAMCPTRENFTSQQKNLSGSRAAASGAGYRASVLKDLEYGCLKIPPRCMFDHPDADRTLRHLISGFENFEKKINYRFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQLEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLETVWQVYYPMMRPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPQVPNS"

     misc_feature    873..1448
                     /gene="DICER1"
                     /note="DEXH-box helicase domain of endoribonuclease Dicer;
                     Region: DEXHc_dicer; cd18034"
                     /db_xref="CDD:350792"
     misc_feature    order(1032..1037,1104..1109,1182..1184,1188..1193,
                     1200..1202,1275..1283)
                     /gene="DICER1"
                     /note="nucleic acid binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350792"
     misc_feature    1542..1826
                     /gene="DICER1"
                     /note="Partner-binding domain of the endoribonuclease
                     Dicer; Region: Dicer_PBD; cd15903"
                     /db_xref="CDD:277191"
     misc_feature    order(1557..1562,1569..1571,1575..1580,1755..1760,
                     1767..1772,1779..1781,1788..1793,1800..1802)
                     /gene="DICER1"
                     /note="Trbp binding interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:277191"
     misc_feature    1845..2423
                     /gene="DICER1"
                     /note="C-terminal helicase domain of the endoribonuclease
                     Dicer; Region: SF2_C_dicer; cd18802"
                     /db_xref="CDD:350189"
     misc_feature    order(2076..2084,2292..2294,2349..2351,2355..2357)
                     /gene="DICER1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350189"
     misc_feature    order(2304..2306,2310..2312,2385..2387,2391..2393)
                     /gene="DICER1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350189"
     misc_feature    2616..2882
                     /gene="DICER1"
                     /note="Dicer dimerization domain; Region: Dicer_dimer;
                     pfam03368"
                     /db_xref="CDD:460900"
     misc_feature    3384..3752
                     /gene="DICER1"
                     /note="PAZ domain, dicer_like subfamily. Dicer is an RNAse
                     involved in cleaving dsRNA in the RNA interference
                     pathway. It generates dsRNAs which are approximately 20 bp
                     long (siRNAs), which in turn target hydrolysis of
                     homologous RNAs. PAZ domains are named...; Region:
                     PAZ_dicer_like; cd02843"
                     /db_xref="CDD:239209"
     misc_feature    order(3573..3575,3612..3614,3630..3632,3642..3644,
                     3696..3698,3720..3722,3726..3728)
                     /gene="DICER1"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239209"
     misc_feature    4617..>4892
                     /gene="DICER1"
                     /note="Ribonuclease III family; Region: RIBOc; smart00535"
                     /db_xref="CDD:197778"
     misc_feature    order(4668..4673,4680..4685,4692..4694,4701..4706,
                     4713..4718,4722..4730,4758..4760)
                     /gene="DICER1"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238333"
     misc_feature    5775..6269
                     /gene="DICER1"
                     /note="Ribonuclease III C terminal domain. This group
                     consists of eukaryotic, bacterial and archeal ribonuclease
                     III (RNAse III) proteins. RNAse III is a double stranded
                     RNA-specific endonuclease. Prokaryotic RNAse III is
                     important in post-transcriptional...; Region: RIBOc;
                     cd00593"
                     /db_xref="CDD:238333"
     misc_feature    order(5835..5840,5847..5852,5859..5861,5868..5873,
                     5880..5885,5889..5897,5925..5927,6189..6191,6222..6224)
                     /gene="DICER1"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238333"
     misc_feature    order(5835..5837,5844..5846,5856..5858,6159..6161,
                     6168..6170)
                     /gene="DICER1"
                     /note="active site"
                     /db_xref="CDD:238333"
     misc_feature    order(5844..5846,6159..6161,6168..6170)
                     /gene="DICER1"
                     /note="metal binding site [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:238333"
     misc_feature    6282..6470
                     /gene="DICER1"
                     /note="double-stranded RNA binding motif of
                     endoribonuclease Dicer and similar proteins; Region:
                     DSRM_DICER; cd10843"
                     /db_xref="CDD:380680"
     misc_feature    order(6282..6287,6291..6296,6303..6308,6315..6320,
                     6330..6332,6345..6353,6357..6359,6363..6365,6414..6425,
                     6432..6434)
                     /gene="DICER1"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:380680"
     polyA_site      10891
                     /gene="DICER1"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

atctcattttctggtcatcctagttccgggttggggatggggtgggttgggggaaggaggtggggttaattgtcttccctaatacggagggccctggaccacaaaccctggggaaatgcaggcgagtgggacggtcctttaaaaaggggatggggcggtgaaaaagagcgccgagctctcgggagaacaattaacggccaaggcgaagggccacgtttagggggcggtccgtgccagaaggggcaaccatgaaggcggacgaattccgagcgccagcagaattctcgccgagccaagcgagcgtccgcaggccgggcgtgcaggcaccgggcgggcggcgaaggtgcctggcctccgcgcgggcccgctgaacgtccacgtccagccccggctcctccgggccgcaaacaccgccaggggcctctgccgctcgcgtccactgtctcccggctcctgagtggctggggggccgggattaacctttcaccgccgcgcgctgtccaatcacaggctcgctctcatgccggcgcggggcgagcgggggagagcgggggcgcgggcgccggggagattctccaagccgccgtgcgccgttgccgcggggccgtgcgcgggccgcgagcgagccgggcgctgcgcagtctccgcaggcgccggcgggaggggtcgaggctcggaggcgcggcgcggcgcgggctgctccaggccccaggttggatggagtgacctgacagcggggacgaggcgacggcgagcgggaggacatggcggcggcggcggcggcgccgggcggcaccgggaggcctgggctgtgacgcgcgcgccggagcgggggtccgatggttctcgaaggcccgcggcgccccgtgctgcaggttgaactgcttgaagcagctctggatcataataccatagtctgtttaaacactggctcagggaagacgtttattgcagtactactcactaaagagctgtcttatcagatcaggggagacttcaacagaaatggcaaaaggacggtgttcttggtcaactctgcaaaccaggttgcccaacaagtgtcagctgtcagaactcactcagatctcaaggtcggggaatactcaaacctagaagtaagtgcatcttggacaaaagagaaatggaaccaagagtttactaaacatcaggttctcgttatgacttgctatgtcgccttgaatgttttgaaaaatggttacttatcactgtcagacattaaccttttggtgtttgatgagtgtcatcttgcaatcctagaccacccctaccgagaaattatgaagctttgtgaaaattgtccatcatgtcctcgtattttgggactaactgcttccattttaaatgggaaatgtgatccagaggaattggaagaaaagattcagaaactggagaaaattcttaagagtaatgctgaaactgcaactgacttggtggtcttagacagatatacttctcagccatgtgagattgtggtagactgtggaccatttactgacagaagtgggctttatgaaagactgctgatggagttagaagaagcacttaattttatcaatgactgtaacatatctgtacattcaaaagaaagagattctactttaatttctaaacagatactctcagactgccgtgcggtcctggttgtcctgggaccctggtgtgccgataaagtagctggaatgatggtcagagagctgcagaaacacatcaaacatgagcaagaggagctgcaccggaagtttctgttgttcacagacactttcctacggaaaatccacgccctgtgtgaagagcacttctcccctgcctcgcttgacctgaagtttgtcactcctaaagtaataaagctgctcgagatcttacgcaaatacaaaccgtatgagcggcagcagtttgaaagcgtggagtggtataataataggaaccaggataattacgtgtcctggagcgattctgaggatgacgaggaagatgaagagattgaagagaaagaaaagccagagacaaattttccttctccgtttaccaacattttgtgtggaattatttttgtggaaagaagatacacagccgtggtcttaaacagattgataaaggaagctggcaaacaagatccagagctggcttacatcagcagcaattttataactggacatggcatcggaaagaatcagcctcggaacaaacagatggaagcggaattcagaaaacaggaagaggtacttaggaaatttcgagcacatgaaaccaacctgcttattgcaacaagtattgtggaggagggtgttgacataccgaaatgcaacttggtggttcgtttcgatctgcccacagagtatcgatcctatgttcagtcgaagggaagagcgagggcacccatctctaattatgtaatgttagcagacacagataaaataaagagttttgaagaagaccttaaaacatacaaagctattgaaaagatcttgcgaaacaaatgttccaagtcggttgataccggggaggccgacacggagcctgtggtggatgacgacgatgttttcccaccgtatgtgctgaggcctgaggatggtccccgcgtcacgatcaacacagccattgggcacgtcaacagatactgtgctagattaccaagtgatccgtttactcatctggctcctaaatgtagaacccgagagttgcctgatggtacattttattcaactctttatctgccaattaactcacctcttcgagcctccattgttggtcccccaatgagctgcattcggttggctgaaagagtcgtggctctcatttgctgtgaaaaactgcacaaaattggcgaactggatgaccatttgatgccagttgggaaggagactgttaaatatgaggaagagctggatttacacgatgaagaagagaccagtgttccaggaagaccaggttccacaaaacgaagacagtgctacccaaaagcaattccagaatgtttgagggagagctaccccaggcccggtcagccctgttacctgtacgtgatcggaatggtcctgacgacacctttacctgatgagctcaacttcagaaggcggaagctctacccccctgaggacaccacaagatgctttggaatactgacagccaagcccatacctcagatcccacactttcctgtgtacacgcgctctggagaggtgaccatatctattgagttgaagaagtccggcttcacgttatctctgcaaatgcttgagttgatcacaaggcttcaccagtatatattctcacatattcttcggcttgaaaaacctgcactagaatttaaacccacagacgcggactcagcctactgcgttctacctcttaatgttgttaatgactccagcactttggacattgactttaaattcatggaagatatcgagaaatctgaagctcgcataggcattcccagcacaaagtattcaaaagaaactccctttgttttcaaattagaagattaccaagatgcagttatcattccaagataccgcaattttgatcagcctcatcgattttatgtcgctgacgtgtacactgatcttacccccctgagtaaatttccttcccctgagtatgaaacgtttgcggagtattataaaacaaagtataaccttgacctgaccaatctcaaccagccgctgctggacgtggaccacacgtcttcacgactcaatcttttgacacctcgtcatttgaatcagaaggggaaagctctccctctgagcagtgctgagaagaggaaagccaagtgggagagcctgcagaataagcagatactggttccagaactctgtgctatacatccaattccagcatcactgtggagaaaagccgtttgtctcccgagcatactttaccgccttcactgccttctgactgcagaggagctcagagcccagacggccagcgacgctggtgtgggagtcaggtcacttcctgtggattttagataccctaacttagacttcgggtggaaaaaatctatcgacagcaaatctttcatctcaattgctaactcctcttcagctgaaaatgagaattactgtaagcacagcacaattgtcgtccctgaaaatgctgcacatcaaggtgctaatagaacctcccctctagaaaatcatgaccaaatgtctgtgaactgcagaacgttgttcagcgagtcacctggtaagctccaaattgaagtttcaacagatctgacagcaattaatggtctttcttacaataaaagtcttgccaatggcagttacgatttagctaacagagacttttgccaaggaaaccatctgaattactacaagcaggaaatacctgtacaaccaactacctcatatcccattcagaatttatacaattacgagaaccagcccaagcccagcgatgaatgtactctactgagtaataaataccttgatggaaatgctaacacatctacctcagatggaagtcccgtgacggctgccgtgcccggtactgcagagactggggaggcgcccccggacaggacggcttctgagcagagcccttctcctgggtactcctcgaggacgcttggccccaaccctgggctcattcttcaggctttgaccctttcgaacgctagtgatggatttaacctggagcggctcgagatgcttggcgactccttcctcaagcatgcgatcaccacgtatctcttctgcacttaccctgatgcgcatgagggccgcctttcctacatgagaagcaaaaaggtcagcaactgtaatctgtatcggcttggaaaaaagaaggggctgcccagccgcatggtggtgtccatatttgacccccctgtgaattggcttcctcctggttacgtagtaaatcaagacaaaagtaacacagagaaatgggaaaaagatgaaatgacaaaagactgcatgttggctaatggcaaactggacgatgacttcgaggaggaggaagaggaggaggaggacctgatgtggagggctcacaaggaggatgcggacgacgaggacgacttcctggaatacgatcaggagcacatcaagttcatagataacatgctgatggggtcaggggctttcgtcaagaaaatctctctttctcctttttctgccaccgattctgcatacgagtggaaaatgcccaaaaagtcctcccttggtagtctgccattctcatccgattttgaggatttcgactacagctcctgggatgcgatgtgctatctggatccgagcaaagccgttgaagaggatgactttgtggtggggttctggaatccatcagaagaaaactgtggtgtggacacagggaagcagtccatctcttacgacctgcacaccgagcagtgcattgccgacaaaagcatagccgactgtgtggaagccctgctgggctgctatttaaccagctgtggcgagagggctgctcagcttttcctctgttcgctggggctgaaggtgctcccggtaattaaaaggactgatcgggaaaaggccatgtgcccgaccagggagaatttcaccagccaacaaaagaacctttcagggagccgtgcggccgcctctggagccggctaccgagcctctgtgttgaaagacttggagtatgggtgtttgaagatccccccgaggtgtatgtttgatcaccctgacgcagacaggacactgcgtcacctgatctcgggttttgaaaatttcgaaaagaaaatcaactacagattcaagaataaggcttaccttctacaggcttttacacacgcctcctaccactacaatacgatcacggattgttaccagcgcttagaattcctgggagatgcaattttggactacctcataactaagcacctttatgaagacccacggcagcactccccaggggtcctgactgacctgcgctctgctctggtcaacaataccatcttcgcgtcgttggctgtgaagtatgactaccacaagtactttaaggccgtttctcccgagctcttccacgtcatcgacgatttcgtgcagtttcagctcgagaagaacgaaatgcaaggaatggattctgagcttaggagatccgaggaggatgaagagaaggaagaggatattgaagttccaaaggccatgggggatattttcgagtcactcgcgggcgccatttacatggacagcgggatgtcgctggagacggtctggcaggtgtactatcccatgatgcggccgctgatcgaaaaattttctgcaaatgtgccccgttcccctgtgcgagaattgcttgaaatggaaccagaaactgccaaattcagcccagctgagagaacctacgatggcaaggtcagagtcaccgtggaagtggtcgggaaggggaagttcaaaggcgttggccgaagttacaggattgccaagtctgcagcagcaagaagagccctgcgaagcctcaaagctaatcaacctcaggttcccaatagctgaaaacccctttttaaatttaaaaaaaaaaaaaaaaaaaaaaagcagaattaaggtggaaaatatttaagttgaaaaggatgatttaaaactgatagtgagtggaatgagttgaaggcagaacgtaaagtttgtttgataacaagatagattacagaataaaacatttaacctatgtataaaaattttggaactaaccgtagttttagttttttgcgcaaacacaatctttcttgtcttctttcctcacttctgctttgtttaaatcacgagagtgctttactgatgacattttcgcaagtgttcaaagtgattcttgacagtttttgtcttgtttcattttagtttaatttcggtcggttttgcttagagttaggagtccaaggagcttaaacctgaaacagcaccccccccccacaacgggttctgttgagagctctgggcagccatcagcgtgcgtggcagagcccgccctgcggcgtcgataagccgagcagagggatgcggtttgagagaggagtgtgctggtgctgtctctcctttccacgttgtgtcgcataagatgatgcttcccggtcactgttgcacttactagtaagggacagactgttgatcagcatgggccggcgtgttggcagatcacattcaagttttctcatgccatgctatcttgcataaaagaggttcttgccttaaaagtaaaatccttgtggatattctttcacttctgatctttctggaacaaactgttcacattcccttcattctgtctattatgcattagacctcgagacagcgtgatacttaacgactcactagtatagctgtaacctaactaatgacaggattatatgagaatttctgtcaggtgtactgaagacattttcaaaaccagaatatgtaacctatggattttttaaaagatacatcataagaatcatctttggctaaataccccacttttactagaaacctccagctaggtagttccacagatggaaattgtctgtggcaaataaaccttgccctgtaggctgttgctctaacaaaataaactttatacatatcacacctaaaatatgctgcagatcttacaatggattgattacttacttaaagaagcagaacagagcaccttaccctgagtcttctcacatacatttcttactgtgcttttcacagtgttgcatgcagacttcacctaccaaagctgtgctgttaatgccatgaaagtttaacgtttgcgataaactgccgtaattttgatacgtctgtgatttaggccattaaaaatttaggtaaactagctcattgtttccatctttggaaaaggaagaaaaaagacacttttaggcgtttgcctaagtttctttaattagacttgtaggcactcttcacttaaatacctcagttcttttcttttgcatgcatgtttcccctccccatttggtgctacgtttatgtattatgcttgaaattttaattttttttttttgcactgtaactataatacctcttaatttacctttttaaaagctgtgggtcagtcttgcactcccaccaacgtaccagtagagttttgctgcaattgccccttaattatgcttgaaattcaagaaagctgagcagaggtgtctcgtaatttccagcacatcattctgaacgtgacgcctcatataatgctgcattgatattttgaattgcagtcgaatactgtacttctcgctttatctgcgccacccacccccagagaaacacctctgcacgcgtgtacccagaaacctgtccgctccgctttctaaggagacccgagtgaagggagcattcagcttctcccacatgatttgtcgtctccaaccttaaacttccactgagatctcagttactaaacgagctttagagcaaatttatttggatggacatgttttttaaaaatttaattctgatttggaacctttgatttctatttgatttttttttaaagacacctccatgtaagatctcctgacaatgtaaaaccaggcgcttcttgaattacataactgtaaatgtgtcaggctggatatgaattttccttgtgagggtgattcgtgataaagctgtatcacaaatctcttgataattataaactacctgctgccaggagcttagggcctttgcgttgtgtctaatgcactaatcccagtgtcgaggcgtcctctggcctcctggcaccaaaatcagattgtttcacagttacaatccccgttgggaaaaaaatgcctcaatatattttgtaaccttaagaagagtattttttgttaatactaaaaagttcagacttggataagattaggtcacacagtctcaggggttcaaatttcctgctatcattaaaaatgttttatcaacagcagactttagctattgcttttttttttttttttccttttggttggaggacagtagcagactttagtttgtgactcacactttgaagcaatctctgatcccctggttcccaagttgaaaagtcaaaactctgatgtagatatacgaaatggttatgaatgcttttgtgctgctgattttttaatgctgtaaacttccccccagtttagcttactgaaatgttttgcatccatttaattaagggacaaaaaaaaattgctctctgtcacccactcgaccaccttgtctgtcatccttttgttgctgtgattgccacgtgagacccggtgtgatctggaagcccccctggtgggcggtgtggttgtacggccagcacacgcgggaaggactgggcgggcacgttttgaaaagcaactgcagaaattccttacgatgattgtgtggaggttagttggcatgaaccttcattgtaaatgttttttgattttttttttttaaataatactttcagcagtcctgactatgctgcgttttgtaaaagctttttccccctctgttctgttcatgtagcacagataagcattgcacttggtaccatgctttacctcatttcaaggaaaatatgcttaaccgagaggaaaaaatgtggtttggcctcgctgctgttttgataaaccgaatttgaaaaaaagataattataatgcctgcaatgtgtcatatacttgcacaacttaaataggtcatttttgtctgtggcatttttactgtttgtgaaagtatgacaaagatttgttaactgaactcttaattatgttttaaagatgtttgttaactttttcttttctcttttacgttatgtgaaatgattaaatttagaacaacctctaacactcctgtaaattatcttttaaaatgctagtatttttcctctcttaataatagcttgccctcagaaagattcaaactaccctgcctaaatagcaagagactagaggctactctggttctgtcggttcagttcataagtacaattattcacacagcagtcggctcttggagtcatcacctgacattggccggtgactgcagagtgcagagactgatcgagatgcagacccacctcagttcagtcttcaggccccgttgatttaaaactttctatcttgctctgttagggtatctaatccttttacacaacatttaagccaccaaactgagaccttgatatcttcatttgaaacagcatctgaagttctgttagcgccctgaaccagtttgtgttcgctacggaactgaaactcatgtcttgtttattacctatatggttattttaattacatttaaataggtatattttttcaaccactgattgcttttcaggaacttaattatttccaaataaatttctttattttatattgtacatgagaagtttttaagatatgtttaagaccaagaatattgaaatgattttaaaagttgttggaatttgccagtagcaatacctagggaatttgcattgagactattgtattttccactagaggtgaaaatgatgttttgaaactaacttgtaaatatattttaatcattgtgtttttgttttttttccccctctagtccatttttatttggacatcacccaccatttaaattttctagatgcactcagaattcactgcagcagcaggttacgtagcaaaaatgcaaaggtgaacagaaagtgaaatttctggcttttctgctgtaaatagaacgaaagaaaaatgactaaaatcaagtaagactaacatgtataatttgacaataaaatacttagcatcacatgctgcagctgtttttaaggaacatgatgtgattcgttcatacaggaatcatgctgcagaagttcgcagtctgcaccttaagggtcacgattacctttagtcgttttttgtttttgtttctttcttttgtaataattgtagccaagtaaatctccaataaagttatggtctgttca

//