LOCUS       XM_060295248            3467 bp    mRNA    linear   MAM 26-NOV-2024
DEFINITION  PREDICTED: Globicephala melas dicer 1, ribonuclease III (DICER1),
            transcript variant X4, mRNA.
ACCESSION   XM_060295248
VERSION     XM_060295248.1
DBLINK      BioProject: PRJNA1026603
KEYWORDS    RefSeq.
SOURCE      Globicephala melas (long-finned pilot whale)
  ORGANISM  Globicephala melas
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha;
            Cetacea; Odontoceti; Delphinidae; Globicephala.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_083315) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_963455315.2-RS_2024_11
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 11/21/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3467
                     /organism="Globicephala melas"
                     /mol_type="mRNA"
                     /db_xref="taxon:9731"
                     /chromosome="2"
     gene            1..3467
                     /gene="DICER1"
                     /note="dicer 1, ribonuclease III; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 15
                     Proteins"
                     /db_xref="GeneID:115867276"
     CDS             477..3467
                     /gene="DICER1"
                     /codon_start=1
                     /product="endoribonuclease Dicer isoform X3"
                     /protein_id="XP_060151231.1"
                     /db_xref="GeneID:115867276"
                     /translation="

MKSPALQPLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFNRNGKRTVFLVNSANQVAQQVSAVRTHSDLKVGEYSNLEVSASWTKEKWNQEFTKHQVLVMTCYVALNVLKNGYLSLSDINLLVFDECHLAILDHPYREIMKLCENCPSCPRILGLTASILNGKCDPEELEEKIQKLEKILKSNAETATDLVVLDRYTSQPCEIVVDCGPFTDRSGLYERLLMELEEALNFINDCNISVHSKERDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTFLRKIHALCEEHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDEEDEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEAEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYVMLADTDKIKSFEEDLKTYKAIEKILRNKCSKSVDTGETDIEPVVDDDDVFPPYVLRPDDGGPRVTINTAIGHINRYCARLPSDPFTHLAPKCRTRELPDGTFYSTLYLPINSPLRASIVGPPMSCIRLAERVVALICCEKLHKIGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRDSYPKPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLSLQMLELITRLHQYIFSHILRLEKPALEFKPTDADSAYCVLPLNVVNDSSTLDIDFKFMEDIEKSEARIGIPSTKYSKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSR"

     misc_feature    600..1193
                     /gene="DICER1"
                     /note="DEXH-box helicase domain of endoribonuclease Dicer;
                     Region: DEXHc_dicer; cd18034"
                     /db_xref="CDD:350792"
     misc_feature    order(600..611,618..620,669..692,813..815,1002..1004,
                     1095..1097)
                     /gene="DICER1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350792"
     misc_feature    order(777..782,849..854,927..929,933..938,945..947,
                     1020..1028)
                     /gene="DICER1"
                     /note="nucleic acid binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350792"
     misc_feature    1287..1571
                     /gene="DICER1"
                     /note="Partner-binding domain of the endoribonuclease
                     Dicer; Region: Dicer_PBD; cd15903"
                     /db_xref="CDD:277191"
     misc_feature    order(1302..1307,1314..1316,1320..1325,1500..1505,
                     1512..1517,1524..1526,1533..1538,1545..1547)
                     /gene="DICER1"
                     /note="Trbp binding interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:277191"
     misc_feature    1590..2168
                     /gene="DICER1"
                     /note="C-terminal helicase domain of the endoribonuclease
                     Dicer; Region: SF2_C_dicer; cd18802"
                     /db_xref="CDD:350189"
     misc_feature    order(1821..1829,2037..2039,2094..2096,2100..2102)
                     /gene="DICER1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350189"
     misc_feature    order(2049..2051,2055..2057,2130..2132,2136..2138)
                     /gene="DICER1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350189"
     misc_feature    2364..2630
                     /gene="DICER1"
                     /note="Dicer dimerization domain; Region: Dicer_dimer;
                     pfam03368"
                     /db_xref="CDD:460900"
     misc_feature    3132..3464
                     /gene="DICER1"
                     /note="PAZ domain, dicer_like subfamily. Dicer is an RNAse
                     involved in cleaving dsRNA in the RNA interference
                     pathway. It generates dsRNAs which are approximately 20 bp
                     long (siRNAs), which in turn target hydrolysis of
                     homologous RNAs. PAZ domains are named...; Region:
                     PAZ_dicer_like; cd02843"
                     /db_xref="CDD:239209"
ORIGIN      

cgcgggctgcgggcgagcagggcgctgcgcagtctccgcaagcgccggcgggaggggtcgcggcggaggcgcggcgcagcgcggcgcaggctgcttcaggcccaggtgaatggagtaacctgacagcggggacgaggcgacggcgagcgggaggaaatggcggcggcggtggcggcgccgggcggcagcgggaggcctgggctgtgacgcgcgcgccggagcggggtccgatggttctcgaaggcccgcggcgccccgtgctgcaggttacctagggtatgaattaatacagacttggaaactgaaagaacttagaatcagcatttggagagcagaagcttgggtatgctgtgattttccaataaactgctatcacaatgtcaaaatgcagttcagacaacagcaacacagagatctcaaacattaagacgtaagctgtgctagaacaaaaatgcaatgaaagaaacactggatgaatgaaaagccctgctttgcaacccctcagcatggcaggcctgcagctcatgacccctgcttcctcaccaatgggtcctttctttggactgccatggcaacaagaagcaattcatgataacatttatacgccaagaaaatatcaggttgaactgcttgaagcagctctggatcataataccatagtctgtttaaacactggctcagggaagacgtttattgcagtactactcactaaagagctgtcctatcagatcaggggagacttcaacagaaatggcaaaaggacggtgttcttggtcaactctgcaaaccaggttgctcaacaagtgtcagctgtcagaactcactcagatctcaaggttggggaatactcaaacctggaagtaagtgcatcttggacaaaagagaaatggaaccaagagtttactaagcaccaggttctcgttatgacttgctatgtcgccttgaatgttttgaaaaatggttacttatcactatcagacattaaccttttggtgttcgatgagtgtcatcttgcaatcctagaccacccctaccgagaaattatgaagctctgtgaaaattgtccatcatgtcctcgtattttgggactaactgcttccattttaaatgggaaatgtgatccagaggaattggaagaaaagattcagaaactggagaaaattcttaagagtaatgctgaaactgcaactgacttggtggtcttagacagatatacttctcagccatgtgagattgtggtagactgtggaccatttactgacagaagtgggctttatgaaagactgctgatggaattagaagaagcacttaattttatcaatgactgtaacatatctgtacattcaaaagaaagagattctactttaatttctaaacagatactctcagactgtcgtgcggtattggtagttctgggaccctggtgtgcagataaagtagctggaatgatggtaagagaactacagaaatatatcaaacacgaacaagaggagctgcacaggaaatttctattgtttacagacactttcctaaggaaaatccatgcactatgtgaagagcacttctcacctgcctcacttgacctgaaatttgtaactccgaaagtaataaaactgcttgaaatcttacgcaaatataaaccgtatgagcgacagcagtttgaaagcgttgagtggtataataataggaatcaggataattacgtgtcttggagtgattctgaggatgatgaggaggatgaagaaattgaagaaaaagaaaagccagagacaaattttccttctccatttaccaatattttgtgtggaattatttttgtggaaagaagatatacagcagttgtcttaaacagattgataaaggaagctggcaaacaagatccagagctggcttacatcagcagcaattttataactggacatggcattggaaagaatcagcctcgcaacaaacagatggaagcggaattcagaaagcaggaagaggtacttaggaaatttcgagcacatgaaaccaacctgcttattgcaacaagtattgtggaggagggtgttgacataccgaaatgcaacttggtggttcgttttgatctgcccacagagtatcgatcctatgttcaatctaagggaagagcgagggcaccgatctctaattatgtaatgttagcagatacagacaaaataaaaagttttgaagaggaccttaaaacatacaaagctattgaaaagatcttgagaaacaaatgttccaagtcagttgataccggggagactgacattgagcctgttgtggatgatgatgatgttttcccaccatatgtgttgagacccgatgatggtggtccacgagtcacaatcaacacggccattggacacatcaatagatactgtgctagattaccaagtgatccgtttactcacctggctcctaaatgtagaacccgagagttgcctgatggtacattttattcaactctttatctgccaattaactcacctcttcgagcctccattgttggtcccccaatgagctgtatacgattggctgaaagagtcgtagctctcatttgctgtgaaaaactgcacaaaattggcgaactggatgaccatttgatgccagttgggaaagagacggttaaatacgaagaagagcttgatttacatgacgaagaagagaccagtgttccaggaagaccaggctccacaaaacgaagacagtgctacccaaaagcgattccagaatgtttgagggatagctaccccaagcccgatcagccttgttacctgtatgtgataggaatggttctaacgacacctttacctgatgaactcaactttagaaggcggaagctttatccccctgaggataccacaagatgctttggaatactgacagccaaacccatacctcagattccgcactttcctgtgtacacacgctctggagaggttaccatatctattgagttgaagaagtctggtttcacgttatctctacaaatgcttgagttgattacaagacttcaccagtatatattctcacatattcttcggcttgaaaaacctgcactagaatttaaacccacagacgctgactcagcatactgtgttctacctcttaatgttgttaatgactccagcactttggacattgactttaaattcatggaagatatcgagaagtctgaagctcgcataggcattcccagtacaaagtattcaaaagaaactccctttgtttttaaattagaagattaccaagatgcagttatcattccaagataccgcaattttgatcagcctcatcgattttatgtagctgatgtgtacactgatcttacccccctgagtaaatttccttcccctgaatatgaaacttttgcagaatattataaaacaaagtataaccttgacctgaccaatctcaaccagccgctgctggatgtggaccacacatcttcaaggtaa

//