LOCUS       XM_055391641           17034 bp    mRNA    linear   PRI 03-APR-2025
DEFINITION  PREDICTED: Gorilla gorilla gorilla argonaute RISC catalytic
            component 3 (AGO3), transcript variant X4, mRNA.
ACCESSION   XM_055391641
VERSION     XM_055391641.2
DBLINK      BioProject: PRJNA953048
KEYWORDS    RefSeq.
SOURCE      Gorilla gorilla gorilla (western lowland gorilla)
  ORGANISM  Gorilla gorilla gorilla
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Gorilla.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_073224) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Mar 7, 2024 this sequence version replaced XM_055391641.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_029281585.2-RS_2025_04
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 04/02/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..17034
                     /organism="Gorilla gorilla gorilla"
                     /mol_type="mRNA"
                     /isolate="KB3781"
                     /sub_species="gorilla"
                     /db_xref="taxon:9595"
                     /chromosome="1"
                     /sex="male"
                     /tissue_type="Fibroblast"
                     /dev_stage="Mature"
     gene            1..17034
                     /gene="AGO3"
                     /note="argonaute RISC catalytic component 3; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 65 long SRA reads, 9 Proteins"
                     /db_xref="GeneID:101130420"
     CDS             3333..5399
                     /gene="AGO3"
                     /codon_start=1
                     /product="protein argonaute-3 isoform X3"
                     /protein_id="XP_055247616.1"
                     /db_xref="GeneID:101130420"
                     /translation="

MKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA"

     misc_feature    3345..3497
                     /gene="AGO3"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:462567"
     misc_feature    3498..3860
                     /gene="AGO3"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(3654..3656,3699..3701,3741..3743,3753..3755,
                     3807..3809,3828..3830,3834..3836)
                     /gene="AGO3"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    3993..5270
                     /gene="AGO3"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(4404..4406,4416..4418,4452..4463,4470..4472,
                     4494..4496,4503..4505,4515..4517,4527..4529)
                     /gene="AGO3"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(4608..4610,4614..4616,4824..4826,5238..5240)
                     /gene="AGO3"
                     /note="active site"
                     /db_xref="CDD:240015"
     polyA_site      17034
                     /gene="AGO3"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

tatgcattcctgtattggaaaggtatatttttgaagtgtctccttttacacgcatttattaccatttttattacagtccatatatatgtgaatatttatcactgattgtttttaactttttgttttgaaataatttcaaacttaaagaaaagttgcaggaatcatgcagagaactctcatacaccctttacgtagattcactgaggttctgaacatttccacatttgttttattttttttctttctctcttgtacatacatacttattttttcctgaaccattcacaagtaggttgcacataccatgccccattaatatttattttattctattttattttgttttgagacagggtctcgctttgtcacctgggttggagtgcagtagtgtgatctcggctcactgcaacctctgcctcccagattcaagtgattcttgtacctcagcctgctgagtagctgggattacaggcacgtgctaccactcttggctaatttttttgtgtttgtagtagagacggggttttgccatgttggccagactggtctcaaacttctgacctcaagtaatccacccagctcaacctcccaaagttctgggattttaggagtaccactgcgctctgccagtatttaatactttaatgtatattcctaagaacaatgacaaaaacccttgtacagttatcaagttcgttaaatttaacattgatatgatacttttatttaatcaacaatacaaattccagttttaccagtttttccaatgatgccctttagtattatttttctcctctgttacagaatccagtccaggatcatgatagagataccatgtcgttctttccccagcctttttttatccttcatgacagtaacgtagttgaagattattggcaaattattttgtagaatgtccttcagtctgggtttgtctgatacttccccttgattacattctggttatgcattattggcaggaatattatataaccattctttccttatcagtgcatcatatcaggaagcacgcagtatgtatttgttccattattggtgattattggtgatgttaactttggtcagttgattaaattggtgtctgccagttttctcctattggggtattcttttcctccttgtagttaataagcatcttgtagggagattctttttgtaattgtgataaaacatatgtaacataaaatttaccatcaacgatttttaaggtatatttcagtggtattaagcacatttacattgttgtataattattaccaccttccatccccagaattgtctttatctttcaaaactgaaactccatatccattaaacagtatccattgctccctcccctcagccctggcaaccaccatagtactttctgtctctgaatttgactattctaggtacctcatgtaagtgaaatcatagattgattgtctttttatgactggcttatttcacaatttatccacattgtttcatgtgttagaatctccttttcaaggctgaataatattccattgtatgtatataacacattttgttaatctcttcatgcatcaatggacaccttttggctattgcaaataatcctgctatgaacatagatgtaaaagtattgaactctgctttcggttctttggatatatacccagaagtaaatttgccaggtcatgtgataattattaattttctgagaatctgctgtattgttttccagaatggctccatcattttacattcccaccaacagtgaacaagagttccaagctgtcacttccatgccaacacttgttttctgtttttttttttttgttcgttttctaatagtaaccatcctaatgggcgtgagatgatatctcattgtggttttgatttgcatgtcccccaacaattagtgatgttgagtataactttgtaggcttattggccatttgtatatcttctttggagaaatctgtagtcaagttgtttgtccattttttgaactgggttgtttgttttgtgttttggttagtgagttgtaggagttttttatttttagattttttattttttttagctaaactgatcaataccattgtaggagttctttatatatattctggatattaacttctgtattctggatattaactatatatatcctggacattaacttcttatcagatatataatttgcaaatattttcttatatttcacaggttgccttttcactatgttgtgtccgttgatacacagaagtttttaattttgaaatgggagatacttttaaggatcctgttgctcattagattttgattattcttgcttggcaattgattattcttgcttgaaaggattattactatgtagaagtggtgattttctaattctgccattccttctccatatgttcattaatctgctgtaagggagaatattttcttttactctatttattgatttcactgcccagattgtcccagatttggccagtgggaactcttttaagctgactcctgtgtccttttgaaatgacactttttggggaatacaatcctgcatcacctaaaacaatggggatatgctctgcgaaatgtgtccttgggcaattttgtcattgtgctgtcatcacagtgtatacttacgcaaacctgaatggtatagcttactacacacctacaccatataatatggtttattattgctataaacctatataggatgttactataccgaatactgtaggcacttgtaagacaatggtaaatatttgtgtatctaaacgtatctaactatagaaaaggtacagtaaaaatacattgtaaaagattgtttaaatggtacacctgtataaggcagcttcattataatctaatgggaccaccgtgtatatagggtccattgtggaccaaaaatcattacgtggtgcatgactctacttcattactttctggcacaggatgttcctggtttattttatgttttctctgctgcagtcctgcaactaaccatttctctgaggatctctggtttcttttagttggcaaatgcaattgtgaaatgaaaatctgggtactggtatgttcactgctgctggggtatatgtgcttctaagccctttcaatggatagaggtagatttagacgttactttacctggggaaggtggaaaagatcgacctttcaaggtgtcaatcaaatttgtctctcgggtgagttggcacctactgcatgaagtactgacaggacggaccttgcctgagccactggaattagacaagccaatcagcactaaccctgtccatgccgttgatgtggtgctacgacatctgccctccatgaaatacacgcctgtggggcgttcatttttctccgctccagaaggatatgaccaccctctgggagggggcagggaagtgtggtttggattccatcagtctgttcggcctgccatgtggaaaatgatgcttaatatcgatgtttctgccactgccttctacaaagcacaacctgtaattcagttcatgtgtgaagttcttgatattcataatattgatgagcaaccaagacctctgactgattctcatcgggtaaaattcaccaaagagataaaaggtttgaaggttgaagtgactcattgtggaacaatgagacggaaataccgtgtttgtaatgtaacaaggaggcctgccagtcatcaaacctttcctttacagttagaaaacggccaaactgtggagagaacagtagcgcagtatttcagagaaaagtatactcttcagctgaagtacccgcaccttccctgtctgcaagtcgggcaggagcagaaacacacctacctgccactagaagtctgtaatattgtggcagggcaacgatgtatcaagaagctaacagacaatcagacttccactatgatcaaggcaacagcaagatctgcaccagatagacaagaggaaattagcagattggtaagaagtgcaaattatgaaacagatccatttgttcaggagtttcaatttaaagttcgggatgaaatggctcatgtaactggacgcgtacttccagcacctatgctccagtatggaggacggaatcggacagtagcaacaccgagccacggagtatgggacatgcgagggaaacaattccacacaggagttgaaatcaaaatgtgggctattgcttgttttgccacacagaggcagtgcagagaagaaatactgaagggtttcacagaccagctgcgtaagatttctaaggatgcagggatgcccatccagggccagccatgcttctgcaaatatgcacagggggcagacagcgtagagcccatgttccggcatctcaagaacacatattctggcctacagcttattatcgtcatcctgccagggaagacaccagtgtatgcggaagtgaaacgtgtaggagacacacttttgggtatggctacacaatgtgttcaagtcaagaatgtaataaaaacatctcctcaaactctctcaaacttgtgcctaaagataaatgttaaactcggagggatcaataatattcttgtacctcatcaaagaccttctgtgttccagcaaccagtgatctttttgggagccgatgtcactcatccacctgctggtgatggaaagaagccttctattgctgctgttgtaggtagtatggatgcacacccaagcagatactgtgccacagtaagagttcagagaccccgacaggagatcatccaggacttggcctccatggtccgggaacttcttattcaattttataagtcaactcggttcaagcctactcgtatcatcttttatcgggatggtgtttcagaggggcagtttaggcaggtattatattatgaactactagcaattcgagaagcctgcatcagtttggagaaagactatcaacctggaataacctacattgtagttcagaagagacatcacactcgattattttgtgctgataggacagaaagggttggaagaagt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