LOCUS       XM_054721880            6402 bp    mRNA    linear   MAM 31-MAR-2023
DEFINITION  PREDICTED: Eptesicus fuscus mediator of DNA damage checkpoint 1
            (MDC1), mRNA.
ACCESSION   XM_054721880
VERSION     XM_054721880.1
DBLINK      BioProject: PRJNA948460
KEYWORDS    RefSeq; corrected model.
SOURCE      Eptesicus fuscus (big brown bat)
  ORGANISM  Eptesicus fuscus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Chiroptera; Microchiroptera;
            Vespertilionidae; Eptesicus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_072482) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_027574615.1-RS_2023_03
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 03/28/2023
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            frameshifts :: corrected 2 indels
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-378               JANZWY010000007.1  1096720-1097097     c
            379-517             JANZWY010000007.1  1094960-1095098     c
            518-898             JANZWY010000007.1  1093656-1094036     c
            899-974             JANZWY010000007.1  1093504-1093579     c
            975-2265            JANZWY010000007.1  1091927-1093217     c
            2266-2422           JANZWY010000007.1  1091768-1091924     c
            2423-2488           JANZWY010000007.1  1090322-1090387     c
            2489-2581           JANZWY010000007.1  1090069-1090161     c
            2582-2797           JANZWY010000007.1  1089487-1089702     c
            2798-2841           JANZWY010000007.1  1088785-1088828     c
            2842-4332           JANZWY010000007.1  1086866-1088356     c
            4333-5154           JANZWY010000007.1  1086043-1086864     c
            5155-5274           JANZWY010000007.1  1085843-1085962     c
            5275-5457           JANZWY010000007.1  1085537-1085719     c
            5458-5583           JANZWY010000007.1  1085224-1085349     c
            5584-5694           JANZWY010000007.1  1085004-1085114     c
            5695-6402           JANZWY010000007.1  1083119-1083826     c
FEATURES             Location/Qualifiers
     source          1..6402
                     /organism="Eptesicus fuscus"
                     /mol_type="mRNA"
                     /isolate="TK198812"
                     /db_xref="taxon:29078"
                     /chromosome="10"
                     /sex="male"
                     /tissue_type="liver"
                     /dev_stage="adult"
                     /country="USA: Silver Falls Park - Crosbyton, TX"
                     /collection_date="2020-07-16"
                     /collected_by="David Ray"
     gene            1..6402
                     /gene="MDC1"
                     /note="mediator of DNA damage checkpoint 1; The sequence
                     of the model RefSeq transcript was modified relative to
                     its source genomic sequence to represent the inferred CDS:
                     deleted 3 bases in 2 codons; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 2
                     Proteins"
                     /db_xref="GeneID:103300547"
     CDS             307..5856
                     /gene="MDC1"
                     /note="The sequence of the model RefSeq protein was
                     modified relative to its source genomic sequence to
                     represent the inferred CDS: deleted 3 bases in 2 codons"
                     /codon_start=1
                     /product="LOW QUALITY PROTEIN: mediator of DNA damage
                     checkpoint protein 1"
                     /protein_id="XP_054577855.1"
                     /db_xref="GeneID:103300547"
                     /translation="

MTDPRGKDGAGAGRGGAGGSGHDTVMEDTQAVNWEVEEEEETERPSDSLGCSLEPLGRLHIFSSAHGPEKDFPLYLGKNVVGRMPDCSVALPFPSISKQHAVIEILAWDQAPVLWDCGSLNGTQVLRPPKFLSPGVRHRLRDQEVVVFADLPCQYHRLDVSLPFFSRGPLTVEETPRVQRETQPWGILLAEDSEEEVDPLSERYVVNEPRTMSSLLATVVPESDDEGPSAPDGPGPPYAFNFDSDTDEEERQQPATGWASSAATRDATAETDQPKAVRTEIQVEKDRSLGQESNSDIRVKRVASNGVILERSQPAGEDSETDVDDESRPPGKPAEDHLGRAQPSGFIDSDTDVEEEGIPTTPAMGPMKRRQIFHGVNAESPGGPDLAHLHESPAGSETDVEEAEAPLTVPLERSRASMVSDSNVGDKEGVSAALTLSHLMESRATGWNRDTDVEEDRAQPPAFLEQSQASAGRDRDTDTEVEGFPVEKREYVPKSHTDKAQTEKSQSLGDSDREVEEDGSSPGVLARSQASATEGINTPEEEGAPQGPAVTLPAKHGVPLARTHPTDGEAEGGPAKLPAVRPEEARPPPGGYCGTSAEEGASLAVSGVAGVRKSQLPAEEDAGTEWAVPVLQQERALEAAAQGGSRLAQVGQDSPCLKENLTDLLVDTGTAGEPTQAQRKGALTCRESGEEPHVDMTKNSEHSHDDSEDLDQQATQCFVERENQSLEAVLSMEDEPTQAFLCTLPREPGPSHGSFQASGALDEPWEVLATQPFCLREPEASETQPIAAHLEAHGSCPFSPRPTPLDQRLESPVRAEPSGMRGGGMQTAEKGHLNCKMSPAEKASRGDPGSLDVCLPPAVPEASAPVRNPLIPQNQKHLASQPLLAPSPPSLESPIPSSRQNRSQEAPENPLSSELDPLHAKPKCRPQGCSRMTPSPAPSIAPEVHPVTSREQPVPPVPTSRATRGRTHRASVKTPEPTVPTAPDLEPPAPADQPVTPAPTAPDLEPPAPADQPVTPAPTAPDLEPPAPADQPVTPAPTAPDLEPPAPADQPVTPAPTAPDLEPPAPADQPVTPAPTSRATRGRTHRASVKTPELTVPTAPDLEPPAPADQPVTPAPTSRATRGRTHRASVKTPELTVPTAPDLEPPAPADQPVTPAPTSRATRGRTHRASVKTPEPTVPTAPDLEPPAPADQPVTPAPTSRATRGRTHRASVKTPEPTVPTAPDLEPPAPADQPVTPAPTSRATRGRTHRASVKTPEPTVPTAPDLEPPAPADQPVTPAPTSRATRGRTHRASVKTPEPTVPTAPDLEPPAPADQPVTPAPTSRATRGRTHRASVKTPEPTVPTAPDLEPPAPADQPVTPAPTSRATRGRTHRASVKTPEPTVPTAPDLEPPAPADQPVTPAPTSRATRGRTHRASVKTPEPTAPTAPHLEPPAPTDQPVTPKAIAQGGQSRTLRSTRSTVPVPTTPEFQSPFPTDQPIPPEAIPQANCSRRPRVARQPLAAPIVCEPCSAPLEPNAWSSWSQRRGAMRATKSLKTIPEPAFAQLPGAPTRALQVKVEATGGYEFSPESQPKAFQNHTRPSDTVDSLPLPKRLRREVPQKTVFLEEEEEEKPGKEEDVVMPGPGKRKKDQAEDEAKGMPVRSLRRTKPNHESTAPKVLFTGVVDARGEQAVLALGGSLASSVAEASHLVTDRICRTVKFLCALGRGIPILSLDWLYQSRKAGCFLPPDEYVVTDPEQERNFGFSLRDSLSRARARRLLEGYEIHVTPGVQPPPPQMGEIISCCGGTVLPSMPRSYKPRRVVITCSQDAPRCTTPFRVGLPVVSAEFLLTGVLKQEANLEAFVLSTLEMS"

     misc_feature    475..774
                     /gene="MDC1"
                     /note="forkhead associated (FHA) domain found in mediator
                     of DNA damage checkpoint protein 1 (MDC1) and similar
                     proteins; Region: FHA_MDC1; cd22665"
                     /db_xref="CDD:438717"
     misc_feature    order(553..555,586..600,664..669,751..756)
                     /gene="MDC1"
                     /note="phosphopeptide binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:438717"
     misc_feature    2545..>3660
                     /gene="MDC1"
                     /note="transcriptional regulator ICP4; Provisional;
                     Region: PHA03307"
                     /db_xref="CDD:223039"
     misc_feature    <3106..4728
                     /gene="MDC1"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     misc_feature    5269..5481
                     /gene="MDC1"
                     /note="first BRCT domain of mediator of DNA damage
                     checkpoint protein 1 (MDC1) and similar proteins; Region:
                     BRCT_MDC1_rpt1; cd17744"
                     /db_xref="CDD:349375"
     misc_feature    order(5284..5289,5386..5394,5398..5400)
                     /gene="MDC1"
                     /note="histone H2AX interaction site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:349375"
     misc_feature    5575..5817
                     /gene="MDC1"
                     /note="second BRCT domain of mediator of DNA damage
                     checkpoint protein 1 (MDC1) and similar proteins; Region:
                     BRCT_MDC1_rpt2; cd18441"
                     /db_xref="CDD:349394"
     misc_feature    order(5614..5619,5719..5724,5788..5790)
                     /gene="MDC1"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:349394"
     misc_feature    5614..5619
                     /gene="MDC1"
                     /note="gamma-H2AX interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:349394"
     polyA_site      6402
                     /gene="MDC1"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

cgccccgagctggggtgcgggcgctggagacgggcccggagggcggcctgtgggtgggagccggggtcccgctgagtcccggtccgggcgcgcggggactgccctccctgtcagcggcttctccccagggtggcctttctcagtgaattccactcgtgctattttgagttttcatccccctcattggtcctttggtcggtagagcgggatgtgcctccaggcgggcagggttgcctcttcgttcggttcatgagtgggtctgacacttgggtcggcaccagggcgtgctaagtaccgtgggcgaagatgacggaccctcgagggaaagacggtgccggtgccggccgcgggggtgccggcggcagtggccacgacacggtcatggaggacactcaggctgttaactgggaggttgaagaagaggaggagacagagagacccagtgactccttggggtgtagcttggagcccctagggcgactgcatatcttcagtagtgcccacggaccagaaaaagatttcccactctacctcgggaaaaatgtggtaggccgaatgcctgattgctctgtggccctgccctttccatccatctccaagcaacatgcagtgattgaaatcttggcgtgggaccaggcacctgtcctctgggattgtgggagtctcaatggtacgcaagtcctgaggcctcctaagttcctgagccctggggtgaggcatcgtctgagggaccaggaggtggtggtctttgctgacttgccctgccagtaccatcgcctggatgtctctctgccctttttctcccggggccccctaactgtagaggagacacccagggtacagagagaaactcaaccctgggggatcctattggctgaggactcagaagaggaagtagatcctctttctgaaaggtacgtggtgaatgaaccaaggaccatgtcctcccttttggcaacagtcgttccagagagtgatgacgaggggccttctgccccagatggccctgggcccccctatgccttcaactttgacagcgacacagatgaggaagaaaggcagcaaccggcaacagggtgggcctcctcagctgccacgagagatgctactgcagagacagatcagcctaaggccgtcagaactgaaatccaggttgaaaaggatcggtctttgggacaggagagcaacagtgacatcagagtcaagagagttgcaagcaatggggtgattctggagaggagccagcctgctggggaggacagtgagacagatgtggatgatgagagcaggcctccaggaaagcctgctgaggatcatctgggaagggcccagccttctggcttcatagacagtgatactgacgtggaagaagaggggattcccacgaccccagctatgggtcccatgaaaagaaggcagatcttccacggagttaatgcagagagtcctggggggcctgacctggcacatcttcacgagagtccggctggcagtgagacagatgtggaagaggctgaggcccccctcacggtccctctggagcgaagccgagcctccatggtgagcgacagcaatgtaggtgacaaggaaggagtgtcagccgcgctcactttgtcacatctgatggagagccgagccactggctggaacagagatacagatgtggaggaggacagagcccagcctccggcttttcttgagcaaagccaagcctctgctgggagagaccgtgacacagacacagaggtggaggggttcccagtggaaaagagagaatatgtccccaagagtcacacagacaaagctcagacagaaaagagccagtctcttggggacagtgaccgagaagtggaagaagatgggagctcacccggagtcctggcgagaagccaggcctctgccacagaaggcatcaacacaccagaggaagagggagccccccaggggccagctgttacactaccagcgaagcatggggtgcctctggcacgcacacacccgacagatggggaagcagaagggggcccagcaaagctgcctgccgtgcgcccagaggaagcccggcctcctccaggtgggtactgtggaacaagtgctgaggagggtgcatccttagcagtctccggagtggcaggtgtaagaaagagccagcttccagcagaagaggatgctgggacagagtgggctgttcctgtccttcagcaggagagagctcttgaggcagcagcccagggtgggtcacgtttagcacaagtgggacaggactctccttgtctcaaggagaacctaacagatctcttggtagacacaggtactgcaggggaacctacccaggcacagagaaagggagccctgacctgcagagaaagtggggaagaaccccatgtggacatgaccaagaactctgaacacagccatgatgattctgaagatctagaccaacaagcgacccagtgctttgtggagagggagaatcagagcctggaagcagtcctgagcatggaggatgagcccacccaggccttcctgtgtactctgccccgagagcctggcccttcccatggcagcttccaggcctcaggtgccctggatgagccttgggaagtcttggctacacagccattctgtctaagagaacctgaggcctctgagacccagcccattgctgcccaccttgaggcccatggatcttgccccttttcacccaggccaacacctctagaccaacgtctggaaagcccagttcgcgcagagccatcggggatgcgaggcggagggatgcagactgcggagaaaggccacctgaactgcaagatgtcacctgctgagaaggcttctaggggtgatccaggatccctagatgtttgtctgcctccagcagtccctgaagcctcagccccagtccgaaaccccctcatccctcagaaccaaaaacatcttgcttcacagcccctccttgctccatctccaccttctttagagtcccccattcccagctccaggcaaaacaggagtcaggaagctccggagaatcccttgtcctcagagctggaccctcttcatgcaaaacccaaatgcaggccccaggggtgttccaggatgacaccctctccagctccttctatagcccctgaggtccaccctgtcacctcccgagagcagcctgtcccccctgtgcccacatctcgggccactcggggtaggacacacagggcctctgtgaagacccctgaaccgactgtccccacagcccctgaccttgaacctccggcccctgcagaccagcctgtcacccctgcgcccacagcccctgatcttgaacctccggcccctgcagaccagcctgtcacccctgcccccacagcccctgaccttgaacctccggcccctgcagaccagcctgtcacccctgcgcccacagcccctgatcttgaacctccggcccctgcagaccagcctgtcacccctgcgcccacagcccctgatcttgaacctccggcccctgcagaccagcctgtcacccctgcacccacatctcgggccactcggggcaggacacacagggcctctgtcaagacccctgaactgactgtccccacagcccctgatcttgaacctccggcccctgcagaccagcctgtcacccctgcacccacatctcgggccactcggggcagaacacacagggcctctgtcaagacccctgaactgactgtccccacagcccctgaccttgaacctccggcccctgcagaccagcctgtcacccctgcgcccacatctcgggccactcggggcaggacacacagggcctctgtcaagacccctgaaccgactgtccccacagcccctgaccttgaacctccggcccctgcagaccagcctgtcacccctgcgcccacatctcgggccactcggggcaggacacacagggcctctgtcaagacccctgaaccgactgtccccacagcccctgaccttgaacctccggcccctgcagaccagcctgtcacccctgcgcccacatctcgggccactcggggcaggacacacagggcctctgtcaagacccctgaaccgactgtccccacagcccctgatcttgaacctccagcccctgcagaccagcctgtcacccctgcgcccacatctcgggccactcggggcaggacacacagggcctctgtgaagacccctgaaccgactgtccccacagcccctgaccttgaacctccggcccctgcagaccagcctgtcacccctgcacccacatctcgggccactcggggcaggacacacagggcctctgtcaagacccctgaaccgactgtccccacagcccctgaccttgaacctccggcccctgcagaccagcctgtcacccctgcgcccacatctcgggccactcgaggcaggacacacagggcctctgtcaagacccctgaaccgactgtccccacagcccctgaccttgaacctccggcccctgcagaccagcctgtcacccctgcacccacatctcgggccactcgaggcaggacacacagggcctctgtcaagacccctgaaccgactgcccccacagcccctcaccttgaacctcccgcccctacagaccagcctgtcacccccaaggccatagctcagggtggtcagagcaggacactgaggtctacaagaagtactgtgccagttcctaccacccctgaattccagtctcctttccccacagaccagcctattccccctgaggccatccctcaagccaattgtagcaggaggccaagggtcgctaggcagcccctcgcagctcccattgtctgtgagccctgctctgcaccccttgaacctaacgcctggtcctcatggagccaaaggcgaggagcaatgagagcaacgaagtcccttaagaccattcctgagcctgcctttgcccagcttcctggtgcacccactcgtgctctccaggtaaaggtagaggcaacaggtggatatgagttcagcccagagtcccagcctaaggcctttcaaaaccacacgaggccttcagatactgtggattcgctcccacttccaaaacggctgcgaagagaagtccctcagaagacagtgttcctcgaggaagaagaggaagagaagccagggaaggaagaggatgtggtgatgccaggaccaggcaagagaaagaaagaccaggctgaggacgaggccaaaggaatgccagtccgcagcctccgacggaccaaacctaaccacgagtccacagcccccaaagtgctcttcacaggagtggtggatgcccgtggagagcaggccgtgctggccctgggcgggagtctggccagctcagtggcagaggcgtcccacctggtgactgatcgaatctgccggacagtcaagttcctgtgtgccctagggcgggggatccctatcctctccctggactggctgtaccagtcccgcaaggccggctgcttcttgcccccggatgaatatgtggtgactgaccctgagcaggaaaggaactttggcttcagcctccgtgactccctgagccgggctcgtgcgcgaaggctgctagagggctatgagattcacgtgacccctggagtccagccgccaccacctcagatgggagagatcatcagctgctgtggaggcactgtcctacccagcatgccccggtcctataagcctcgcagagtcgtgatcacatgctcccaggacgccccgcgatgcaccacgccatttcgggttgggctgcccgtcgtctcagctgagttcctgctgacaggagtgctgaagcaggaagccaacctggaggcctttgttctctccactttggaaatgtcgtgaccctttttcttcccagaccagtaaacaggaaatagtggggagaaagaacttagggcttaggaaggattggggtgtgctgatctgatttgtctggaaacgggtggggctgaaaaggcttatgggaaaacaaagacagggagagtgggagccacagactttcttaaacggccatttacagtagcttagtctcgtgctcacatgtcgtcagtgtcgctcatctttagtgtctgaggccctgactgctcagtgccctgcctcccatttggacgccatctcactttttctttgttattggaattcttacttatcctccaaaacatagtggaaataattcaatgccagaaattgaagggatgcttggagtgagtaagtttgagggtggagttatggaatgctacgaaaatatttacctctctcctggccccatcttgttagaagaccctttagcttggactttgagcaagtctctgcctgcttttccggtatttatcaaattagagcttaggcttaaacttcatgataaataaatattcactctgtgcctta

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