LOCUS       XM_054463277            3634 bp    mRNA    linear   PRI 11-APR-2023
DEFINITION  PREDICTED: Pongo pygmaeus NLR family pyrin domain containing 12
            (NLRP12), transcript variant X2, mRNA.
ACCESSION   XM_054463277
VERSION     XM_054463277.1
DBLINK      BioProject: PRJNA945458
KEYWORDS    RefSeq.
SOURCE      Pongo pygmaeus (Bornean orangutan)
  ORGANISM  Pongo pygmaeus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Pongo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_072392) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_028885625.1-RS_2023_04
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 04/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3634
                     /organism="Pongo pygmaeus"
                     /mol_type="mRNA"
                     /isolate="AG05252"
                     /db_xref="taxon:9600"
                     /chromosome="19"
                     /sex="male"
                     /tissue_type="fibroblast"
     gene            1..3634
                     /gene="NLRP12"
                     /note="NLR family pyrin domain containing 12; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 3 Proteins"
                     /db_xref="GeneID:129019848"
     CDS             140..3325
                     /gene="NLRP12"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein 12
                     isoform X2"
                     /protein_id="XP_054319252.1"
                     /db_xref="GeneID:129019848"
                     /translation="

MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGRMEKAGPLEMAQLLITHFGPEEAWKLALSTFERMNRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQAQQQLLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPCTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLISSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKPPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQMSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGADVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDKGERGAGPDQDVTKLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWEVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFGCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKHCRSAQVLHLYGTTYSADGEDRARCSAGVHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKKCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMTLLCEGLRHPRCRLQMIQLRKCQLESGACQEMASVLSTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICHLTAAACEELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSAVLQANHNLRELDLSFNDLGDWGLWLLAKGLQHPACRLQKLWLDSCGLTAKACKNLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC"

     misc_feature    176..415
                     /gene="NLRP12"
                     /note="Pyrin death domain found in NALP proteins; Region:
                     Pyrin_NALPs; cd08320"
                     /db_xref="CDD:260032"
     misc_feature    524..739
                     /gene="NLRP12"
                     /note="Fish-specific NACHT associated domain; Region:
                     FISNA; pfam14484"
                     /db_xref="CDD:433982"
     misc_feature    773..1282
                     /gene="NLRP12"
                     /note="NACHT domain; Region: NACHT; pfam05729"
                     /db_xref="CDD:428606"
     misc_feature    1514..1675
                     /gene="NLRP12"
                     /note="NOD2 winged helix domain; Region: NOD2_WH;
                     pfam17779"
                     /db_xref="CDD:436037"
     misc_feature    1679..2023
                     /gene="NLRP12"
                     /note="NLRC4 helical domain HD2; Region: NLRC4_HD2;
                     pfam17776"
                     /db_xref="CDD:436035"
     misc_feature    2282..2368
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2288..3244
                     /gene="NLRP12"
                     /note="Leucine-rich repeats (LRRs), ribonuclease inhibitor
                     (RI)-like subfamily. LRRs are 20-29 residue sequence
                     motifs present in many proteins that participate in
                     protein-protein interactions and have different functions
                     and cellular locations. LRRs correspond...; Region:
                     LRR_RI; cd00116"
                     /db_xref="CDD:238064"
     misc_feature    order(2291..2293,2297..2299,2306..2308,2312..2314,
                     2369..2371,2378..2380,2384..2386,2393..2395,2399..2401,
                     2453..2455,2462..2464,2468..2470,2477..2479,2540..2542,
                     2549..2551,2555..2557,2564..2566,2570..2572,2624..2626,
                     2633..2635,2639..2641,2648..2650,2654..2656,2711..2713,
                     2720..2722,2726..2728,2735..2737,2741..2743,2795..2797,
                     2804..2806,2810..2812,2819..2821,2825..2827,2882..2884,
                     2891..2893,2897..2899,2906..2908,2912..2914,2966..2968,
                     2975..2977,2981..2983,2990..2992,2996..2998,3053..3055,
                     3062..3064,3068..3070,3077..3079,3083..3085,3137..3139,
                     3146..3148,3152..3154,3161..3163,3167..3169,3224..3226,
                     3233..3235,3239..3241)
                     /gene="NLRP12"
                     /note="Leucine-rich repeats [active]"
                     /db_xref="CDD:238064"
     misc_feature    2369..2452
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    order(2387..2392,2561..2563,2732..2734,2816..2818,
                     2987..2989,3065..3067,3071..3073,3149..3151,3236..3238)
                     /gene="NLRP12"
                     /note="Substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238064"
     misc_feature    2453..2539
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2540..2623
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2624..2710
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2711..2794
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2795..2881
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2882..2965
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    3053..3136
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
ORIGIN      

ctcctcaaaccactggctcagcctctccgcccgctgcctgtgaatgatgcaatggaaggtgtgctggggtcgccccgtgtcccgtgcataggaacatctcagcctccaggtcctctcctttggggctcacggcacccccatgctacgaaccgcaggcagggacggcctctgtcgcctgtccacctacttggaagaactcgaggctgtggaactgaagaagttcaagttatacctggggaccgcgacagagctgggagaaggcaagatcccctggggacgcatggagaaggccggtcccttggaaatggcccagctgctcatcacccactttgggccagaggaggcctggaagttggctctcagcacctttgagcggatgaacaggaaggacctgtgggagagaggacagagagaggacctggtgagggacaccccacctggtggcccgtcctcacttgggaaccagtcaacatgccttctggaagtctctcttgtcactccaagaaaagatccccaggaaacctacagggactacgtccgcaggaaattccggctcatggaagaccgcaatgcgcgcctaggggaatgtgtcaacctcagccaccggtacacccggctcctgctggtgaaggagcactcaaaccccatgcaggctcagcagcagcttctggacacaggccgtggacacgcgaggaccgtgggacaccaggctagccccatcaagatagagaccctctttgagccagatgaggagcgccccgagccaccgtgcaccgtggtcatgcaaggcgcggcagggataggcaagtccatgctggcacacaaggtgatgctggactgggcggacgggaagctcttccaaggcagatttgattatctcttctacatcaactgcagggagatgaaccagagtgccacggaatgcagcatgcaagacctcatctccagctgctggcccgagcccagcgcgcctctccaggagctcatccgagttcccgagcgcctccttttcatcatcgacggcttcgatgagctcaagccttctttccacgatcctcagggaccctggtgcctctgctgggaggagaaaccgcccacggagctgcttcttaacagcttaattcggaagaagctgctccctgagctatctttgctcatcaccacacggcccacggctttggagaagctccaccgtctgctggagcaccccaggcatgtggagatcctgggcttctctgaggcagaaaggaaggaatacttctacaagtatttccacaatgcagagcaggcgggccaagtcttcaattacgtgagggacaacgagcctctcttcactatgtgcttcgtccccctggtgtgctgggtggtgtgtacctgcctccagcagcagctggagggtggggggctgttgagacagatgtccaggaccaccactgcggtgtacatgctctacctgctgagtctgatgcaacccaagcccggggccccgcgcctccagcccccacccaaccagagaggactgtgctccttggccgcagatgggctctggaatcagaaaatcctatttgaggagcaggacctccggaagcacggcctagatggggcagacgtctctgctttcctcaacatgaacatcttccagaaggacatcaactgtgagaggtactacagcttcatccatttgagtttccaggaattctttgcagctatgtactatatcctggacaagggggaacgcggggcaggcccagaccaggacgtgaccaagctgttgaccgagtacgcgttttctgaaaggagcttcctggcactcaccagccgcttcctgtttggactcctgaacgaggagaccaggagccacctggagaagagtctctgctgggaggtctcgccacacatcaagatggacctgttgcagtggatccaaagcaaagctcagagcgacggctccaccctccagcagggctccttggagttcttcggctgcttgtacgagatccaggaggaggagtttatccagcaggccctgagccacttccaggtgatcgtggtcagcaacattgcctctaagatggagcacatggtctcctcgttctgtctgaagcactgcaggagcgcccaggtgctgcacttgtatggcaccacttacagcgcggacggggaagaccgggcgaggtgctctgcaggagtgcacacgctgttggtgcagctaccagagaggaccgttctgctggacgcctacagtgaacatctggcagcggccctgtgcaccaatccaaacctgatagagctgtctctgtaccgaaatgccctgggcagccggggggtgaagctgctctgtcaaggactcagacaccccaactgcaaacttcagaacctgaggctgaagaagtgccgcatctccagctcagcctgcgaggacctctctgcagctctcatagccaataagaatttaacaaggatggatctcagtggcaacggtgttggattcccaggcatgacgctgctgtgcgagggcctgcggcatccccgatgcaggctgcagatgattcagttgaggaagtgtcagctggagtccggggcttgtcaggaaatggcttctgtgctcagcaccaacccacatctggttgagttggacctgacaggaaatgcactggaggatttgggcctgaggttactgtgccagggactgaggcacccagtctgcagactacggactttgtggctgaagatctgccacctcactgctgctgcctgtgaagagctggcctcaactctcagtgtgaaccagagcctgagagagctggacctgagcctaaatgagctgggggacctcggggtgctgctgctgtgtgagggcctcaggcatcccacgtgcaagctccagaccctccggttgggcatatgccgattgggctctgccgcctgtgagggtctttctgcggtgctccaggccaatcacaacctccgggagctggacttgagtttcaacgacctgggagactggggcctgtggttgctggctaaggggctgcaacatcccgcctgtagactccagaaactgtggctggatagctgtggcctcacagccaaggcttgtaagaatctttacttcaccctggggatcaaccagaccttgaccgacctttatctgaccaacaacgccctaggggacacaggtgtccgactgctttgcaagcggctgagccatcctggctgcaaactccgagtcctctggttatttgggatggacctgaataaaatgacccacagtaggttggcagcgcttcgagtaacaaaaccttatttggacattggctgctgaatagtcctatctgctggctctcccctgagatctggacagaggaagatgggagggtgctcatcacccctacagcataatgatcatgctccttcctagagacaaactcatgcagattgagatcagaagtccctctgcttgggatcaaattaatgtttgacagagctggccaggcatggtggctcatgtctgtaatcccagcacttcgagaggccgaggcaggtggatcacgaggtcaggagtttgagatcagcctggccaagatggtgaaaccctgtctctactaaaaataaaaaaaaaaattagccgggc

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