LOCUS       XM_054463276            3637 bp    mRNA    linear   PRI 11-APR-2023
DEFINITION  PREDICTED: Pongo pygmaeus NLR family pyrin domain containing 12
            (NLRP12), transcript variant X1, mRNA.
ACCESSION   XM_054463276
VERSION     XM_054463276.1
DBLINK      BioProject: PRJNA945458
KEYWORDS    RefSeq.
SOURCE      Pongo pygmaeus (Bornean orangutan)
  ORGANISM  Pongo pygmaeus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Pongo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_072392) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_028885625.1-RS_2023_04
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Gnomon; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 04/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3637
                     /organism="Pongo pygmaeus"
                     /mol_type="mRNA"
                     /isolate="AG05252"
                     /db_xref="taxon:9600"
                     /chromosome="19"
                     /sex="male"
                     /tissue_type="fibroblast"
     gene            1..3637
                     /gene="NLRP12"
                     /note="NLR family pyrin domain containing 12; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 1 Protein"
                     /db_xref="GeneID:129019848"
     CDS             140..3328
                     /gene="NLRP12"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein 12
                     isoform X1"
                     /protein_id="XP_054319251.1"
                     /db_xref="GeneID:129019848"
                     /translation="

MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGRMEKAGPLEMAQLLITHFGPEEAWKLALSTFERMNRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQAQQQLLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPCTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLISSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKPPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQMSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGADVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDKGERGAGPDQDVTKLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWEVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFGCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKHCRSAQVLHLYGTTYSADGEDRARCSAGVHTLLVQLRPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKKCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMTLLCEGLRHPRCRLQMIQLRKCQLESGACQEMASVLSTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICHLTAAACEELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSAVLQANHNLRELDLSFNDLGDWGLWLLAKGLQHPACRLQKLWLDSCGLTAKACKNLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC"

     misc_feature    176..415
                     /gene="NLRP12"
                     /note="Pyrin death domain found in NALP proteins; Region:
                     Pyrin_NALPs; cd08320"
                     /db_xref="CDD:260032"
     misc_feature    524..739
                     /gene="NLRP12"
                     /note="Fish-specific NACHT associated domain; Region:
                     FISNA; pfam14484"
                     /db_xref="CDD:433982"
     misc_feature    773..1282
                     /gene="NLRP12"
                     /note="NACHT domain; Region: NACHT; pfam05729"
                     /db_xref="CDD:428606"
     misc_feature    1514..1675
                     /gene="NLRP12"
                     /note="NOD2 winged helix domain; Region: NOD2_WH;
                     pfam17779"
                     /db_xref="CDD:436037"
     misc_feature    1679..2023
                     /gene="NLRP12"
                     /note="NLRC4 helical domain HD2; Region: NLRC4_HD2;
                     pfam17776"
                     /db_xref="CDD:436035"
     misc_feature    2285..2371
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2291..3247
                     /gene="NLRP12"
                     /note="Leucine-rich repeats (LRRs), ribonuclease inhibitor
                     (RI)-like subfamily. LRRs are 20-29 residue sequence
                     motifs present in many proteins that participate in
                     protein-protein interactions and have different functions
                     and cellular locations. LRRs correspond...; Region:
                     LRR_RI; cd00116"
                     /db_xref="CDD:238064"
     misc_feature    order(2294..2296,2300..2302,2309..2311,2315..2317,
                     2372..2374,2381..2383,2387..2389,2396..2398,2402..2404,
                     2456..2458,2465..2467,2471..2473,2480..2482,2543..2545,
                     2552..2554,2558..2560,2567..2569,2573..2575,2627..2629,
                     2636..2638,2642..2644,2651..2653,2657..2659,2714..2716,
                     2723..2725,2729..2731,2738..2740,2744..2746,2798..2800,
                     2807..2809,2813..2815,2822..2824,2828..2830,2885..2887,
                     2894..2896,2900..2902,2909..2911,2915..2917,2969..2971,
                     2978..2980,2984..2986,2993..2995,2999..3001,3056..3058,
                     3065..3067,3071..3073,3080..3082,3086..3088,3140..3142,
                     3149..3151,3155..3157,3164..3166,3170..3172,3227..3229,
                     3236..3238,3242..3244)
                     /gene="NLRP12"
                     /note="Leucine-rich repeats [active]"
                     /db_xref="CDD:238064"
     misc_feature    2372..2455
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    order(2390..2395,2564..2566,2735..2737,2819..2821,
                     2990..2992,3068..3070,3074..3076,3152..3154,3239..3241)
                     /gene="NLRP12"
                     /note="Substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238064"
     misc_feature    2456..2542
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2543..2626
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2627..2713
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2714..2797
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2798..2884
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2885..2968
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    3056..3139
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
ORIGIN      

ctcctcaaaccactggctcagcctctccgcccgctgcctgtgaatgatgcaatggaaggtgtgctggggtcgccccgtgtcccgtgcataggaacatctcagcctccaggtcctctcctttggggctcacggcacccccatgctacgaaccgcaggcagggacggcctctgtcgcctgtccacctacttggaagaactcgaggctgtggaactgaagaagttcaagttatacctggggaccgcgacagagctgggagaaggcaagatcccctggggacgcatggagaaggccggtcccttggaaatggcccagctgctcatcacccactttgggccagaggaggcctggaagttggctctcagcacctttgagcggatgaacaggaaggacctgtgggagagaggacagagagaggacctggtgagggacaccccacctggtggcccgtcctcacttgggaaccagtcaacatgccttctggaagtctctcttgtcactccaagaaaagatccccaggaaacctacagggactacgtccgcaggaaattccggctcatggaagaccgcaatgcgcgcctaggggaatgtgtcaacctcagccaccggtacacccggctcctgctggtgaaggagcactcaaaccccatgcaggctcagcagcagcttctggacacaggccgtggacacgcgaggaccgtgggacaccaggctagccccatcaagatagagaccctctttgagccagatgaggagcgccccgagccaccgtgcaccgtggtcatgcaaggcgcggcagggataggcaagtccatgctggcacacaaggtgatgctggactgggcggacgggaagctcttccaaggcagatttgattatctcttctacatcaactgcagggagatgaaccagagtgccacggaatgcagcatgcaagacctcatctccagctgctggcccgagcccagcgcgcctctccaggagctcatccgagttcccgagcgcctccttttcatcatcgacggcttcgatgagctcaagccttctttccacgatcctcagggaccctggtgcctctgctgggaggagaaaccgcccacggagctgcttcttaacagcttaattcggaagaagctgctccctgagctatctttgctcatcaccacacggcccacggctttggagaagctccaccgtctgctggagcaccccaggcatgtggagatcctgggcttctctgaggcagaaaggaaggaatacttctacaagtatttccacaatgcagagcaggcgggccaagtcttcaattacgtgagggacaacgagcctctcttcactatgtgcttcgtccccctggtgtgctgggtggtgtgtacctgcctccagcagcagctggagggtggggggctgttgagacagatgtccaggaccaccactgcggtgtacatgctctacctgctgagtctgatgcaacccaagcccggggccccgcgcctccagcccccacccaaccagagaggactgtgctccttggccgcagatgggctctggaatcagaaaatcctatttgaggagcaggacctccggaagcacggcctagatggggcagacgtctctgctttcctcaacatgaacatcttccagaaggacatcaactgtgagaggtactacagcttcatccatttgagtttccaggaattctttgcagctatgtactatatcctggacaagggggaacgcggggcaggcccagaccaggacgtgaccaagctgttgaccgagtacgcgttttctgaaaggagcttcctggcactcaccagccgcttcctgtttggactcctgaacgaggagaccaggagccacctggagaagagtctctgctgggaggtctcgccacacatcaagatggacctgttgcagtggatccaaagcaaagctcagagcgacggctccaccctccagcagggctccttggagttcttcggctgcttgtacgagatccaggaggaggagtttatccagcaggccctgagccacttccaggtgatcgtggtcagcaacattgcctctaagatggagcacatggtctcctcgttctgtctgaagcactgcaggagcgcccaggtgctgcacttgtatggcaccacttacagcgcggacggggaagaccgggcgaggtgctctgcaggagtgcacacgctgttggtgcagctcagaccagagaggaccgttctgctggacgcctacagtgaacatctggcagcggccctgtgcaccaatccaaacctgatagagctgtctctgtaccgaaatgccctgggcagccggggggtgaagctgctctgtcaaggactcagacaccccaactgcaaacttcagaacctgaggctgaagaagtgccgcatctccagctcagcctgcgaggacctctctgcagctctcatagccaataagaatttaacaaggatggatctcagtggcaacggtgttggattcccaggcatgacgctgctgtgcgagggcctgcggcatccccgatgcaggctgcagatgattcagttgaggaagtgtcagctggagtccggggcttgtcaggaaatggcttctgtgctcagcaccaacccacatctggttgagttggacctgacaggaaatgcactggaggatttgggcctgaggttactgtgccagggactgaggcacccagtctgcagactacggactttgtggctgaagatctgccacctcactgctgctgcctgtgaagagctggcctcaactctcagtgtgaaccagagcctgagagagctggacctgagcctaaatgagctgggggacctcggggtgctgctgctgtgtgagggcctcaggcatcccacgtgcaagctccagaccctccggttgggcatatgccgattgggctctgccgcctgtgagggtctttctgcggtgctccaggccaatcacaacctccgggagctggacttgagtttcaacgacctgggagactggggcctgtggttgctggctaaggggctgcaacatcccgcctgtagactccagaaactgtggctggatagctgtggcctcacagccaaggcttgtaagaatctttacttcaccctggggatcaaccagaccttgaccgacctttatctgaccaacaacgccctaggggacacaggtgtccgactgctttgcaagcggctgagccatcctggctgcaaactccgagtcctctggttatttgggatggacctgaataaaatgacccacagtaggttggcagcgcttcgagtaacaaaaccttatttggacattggctgctgaatagtcctatctgctggctctcccctgagatctggacagaggaagatgggagggtgctcatcacccctacagcataatgatcatgctccttcctagagacaaactcatgcagattgagatcagaagtccctctgcttgggatcaaattaatgtttgacagagctggccaggcatggtggctcatgtctgtaatcccagcacttcgagaggccgaggcaggtggatcacgaggtcaggagtttgagatcagcctggccaagatggtgaaaccctgtctctactaaaaataaaaaaaaaaattagccgggc

//