LOCUS       XM_054324552           11423 bp    mRNA    linear   PRI 05-AUG-2025
DEFINITION  PREDICTED: Homo sapiens PBX/knotted 1 homeobox 1 (PKNOX1),
            transcript variant X7, mRNA.
ACCESSION   XM_054324552
VERSION     XM_054324552.1
DBLINK      BioProject: PRJNA807723
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_060945) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_009914755.1-RS_2025_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.4
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/01/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..11423
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /isolate="CHM13"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /sex="female"
                     /cell_line="CHM13htert"
                     /tissue_type="hydatidiform mole"
                     /note="haploid cell line"
     gene            1..11423
                     /gene="PKNOX1"
                     /gene_synonym="pkonx1c; PREP1"
                     /note="PBX/knotted 1 homeobox 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 30 ESTs, 646 long SRA reads, 10 Proteins, and 84%
                     coverage of the annotated genomic feature by RNAseq
                     alignments"
                     /db_xref="GeneID:5316"
                     /db_xref="HGNC:HGNC:9022"
                     /db_xref="MIM:602100"
     CDS             6271..7581
                     /gene="PKNOX1"
                     /gene_synonym="pkonx1c; PREP1"
                     /codon_start=1
                     /product="homeobox protein PKNOX1 isoform X1"
                     /protein_id="XP_054180527.1"
                     /db_xref="GeneID:5316"
                     /db_xref="HGNC:HGNC:9022"
                     /db_xref="MIM:602100"
                     /translation="

MMATQTLSIDSYQDGQQMQVVTELKTEQDPNCSEPDAEGVSPPPVESQTPMDVDKQAIYRHPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEGKPFFCEDPETDNLMVKAIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEPGSPYSPVQSQQIQSAITGTISPQGIVVPASALQQGNVAMATVAGGTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQLQLQLNQDLSILHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTNLTLLQVNNWFINARRRILQPMLDSSCSETPKTKKKTAQNRPVQRFWPDSIASGVAQPPPSELTMSEGAVVTITTPVNMNVDSLQSLSSDGATLAVQQVMMAGQSEDESVDSTEEDAGALAPAHISGLVLENSDSLQ"

     misc_feature    6508..6765
                     /gene="PKNOX1"
                     /gene_synonym="pkonx1c; PREP1"
                     /note="N-terminal of Homeobox Meis and PKNOX1; Region:
                     Meis_PKNOX_N; pfam16493"
                     /db_xref="CDD:465140"
     misc_feature    order(7048..7062,7066..7068,7126..7128,7144..7146,
                     7183..7185,7189..7194,7201..7206,7210..7218)
                     /gene="PKNOX1"
                     /gene_synonym="pkonx1c; PREP1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(7054..7056,7063..7065,7192..7194,7201..7206,
                     7213..7215)
                     /gene="PKNOX1"
                     /gene_synonym="pkonx1c; PREP1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    7102..7218
                     /gene="PKNOX1"
                     /gene_synonym="pkonx1c; PREP1"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
ORIGIN      

gtgtcgcgtggcccagcgtcggcgtgacggttggacgcgggcgcggcactgcgggtcccgattgctgcagccgcttgtcagtgtgatgaagattggcacccagctactttttgagatgggatcttgctctatcagccaagctggatcatgccactgcactcagcttccaaacctttgctcttgctggagatgcactactacaaataagccacaggacatcactttcttcagaccctgcagagcatgttacactcatgtggcttcggaagctgcattctggtcacagctgagcgtctttcgtggtgcttgcctcatgggccagctgcttcatcagctcaccctgtgtttcccattttgaataatgccgtaattcataggttgaattgatgtaattcactgttgcaggcaccagagttgtacagattgttgacaagtgtcctgtccttgtgagttcgaccttatcttagaagcacaattattttatcgtcagaggtcaggctgtgtagaagaaatagcagggctttggagctggacagattgaagtcacccaacctctggtacatctgtgtcctcaacagggaaacaaggacaactaacctatctgcgtcttctagagtagtctggtcacagctagtgtgaaccccccggtcacactgttagtggcaaaaaaccattttattatgtggacaaattctgtggaccaggaatatggagaggaagtggccgtctctcctccaggatgtctgagtcctcagctgggacgactcagcggctgggggtgacgtaatgactgaggaatggtatcttctggaggcgctttctgaaatctgtcagctggaacacgagctggggatactgaccagagcacacgtgcagactccacaggacctgggcttcttcacagattagaggagggcctacatcaacaggactcgcgggccgagcttccaggcgccttgagtggctgggccgggcctccacgttgccctgctgcagggttaggtgggagcgagactggccccactcctgttgactgttccaccagcaccttcagtttgtggaagtggttgtgtccaaagagattttcgtaaaaacatcacaattctaaaacttttttttttttttcacaattctaaaactttatgcatttttggcatttaaaaagccctggcaagtctactgccttatttctcctgctcccttggcctgtgggtctgttcctgtatggttacccactttgttttttttttttttttgctgttactgtggctttgtagtatattttaaaatttggtattcgttaactctttttttttttttttgaaacagagtctcgttctgttgcctggcctggagtgcagtggtgcagtctgggctcacagcagcctccgcttcccaggtgcaagtgattctcctggctcagcctccggagtagctgggattacaggcacacgccaccatgcccggctaatttttgtatttttagtagacacggggtttcaccatgttggccaggctggtctcagactcctgacctcaggtgatccaccggctcagcctctcaaagtgttgggattacaggtgtgagccgccgcgcccagcctttttttttttttttttttttaaggcaaggcggggtctccctttgtcgcccaggctggagtacagtggtatgatcacggctcactgcagcctcgacctcccggactcaagtgatccccctgcctcagcctctcaagcagctgggactacagacatgtgccaccatgcccagctaaatttttggatttttagtagagataaggtctcactttgttgcccaggctggtcttgaactcctgagctcaaacgatccttccacctcagcctcccaaagtgctgggattacaggcaggagccactgcacctggcctcttagctcttttaagggtaacctagctactcacagaccctttatttctccatttacatttgagagcagttttattttatgtattttattttatttactttggaggaagtttgattgagattatatctgcatgatttattatttatttatttatttatttatttatttatttatttatttgagacagagtcttgctctgtcgcccagactggagggcagtggcatgatcttggctcactgcaacctccacctcctggattcacgcaattctcctgcctcagcctcccgagtagctgggattacaggcatgcgcctccacgcccagctaattttttttgtatttttaagtggaaacgggatttcaccatgttggccagtctggtttcgaactccagaccacaagtgatccgcccgcctcagcctcccaaagtgttaggattacaggtgtgagccactgcgccggaccatatctgcatgatttatagataataacatttactgagaaaaccagtggaatctccgtaaactgttagaaccacaggaggatccagaacagttgccagatacaaggtcagtctacacaaaccagtgatacttctaccggcaacccaccagaaagtgtgactgctcttgagatggtaaccagaaaacccataaagtgtttaggaattaatctaagaagacctccagaaagaagaccatcagacttaatcctggatgaaggcgtgggtctgatgaatgaagaagatcccgtgctcatggaggggatgatctgttgttataatgatgtctcttttccccacatgagtccataaatacatttaaaaagtgttataaatttgatcaagcacggtggcttatgcctgtaatcccagcactttaggaagctgaggcaggaggagcgcttgagcccaggagtttgaggacagcctgggccgcatagtgagacaccgtctctgtaaaaaatacaaaaattagctgggcttggtgacacatgcccgtagtcctagctactaaggagactgaggtgggaggattgcttgagcctgggaagttgtggctacagtgagccatgaatgtgccactgcattccagcatgggtgacagagtgagaccctgtctcagaataaaataaattgtttcttgacagcagagacattgttttgtttgctgctctatcctcagcacttagaacagccaggcataaagaagacattcagtaagtatgtgtggaatgagtgaagggttcggtgaagtgtgtagagttgtatgccctaccttctcaccggacagtgacctcaaactctttcccactctgcctcgtgtgttgtgatcgcacaacggatgagtgcagttgacttccctgttccctgtcgatggatggataggtttgtttccaatttttgttattgtgaataaaaaaaacctttagcatctaggttttcttgctaaaagtttttaatgccctttaaaatgaggctttgacacagaaaagattatttaagtttatttttaaatgaacatttattaatgtagagagttacaggcttggttttcctctattttatatagaagttgctaattttattctctttataaagtttagaaaattttttttgaggcagagtcttgctctgtcacccacgctggcgtgcagtggcctgatctcagctcaccgcaacttccgcctctctggctcaagccttcctccctcctcagccccccaagtagctgggactataggcacaacaccacacccggctaatttttgtattttaatagcaatggggtcttaccatgttggcaaggctggtctcaaactcctggccccaagtgatctgcctgcctcagcctcccaaagtgctgggattacgtgtgtgagccaccatgcccagccaaatttagtaagttttaactttcacctttaagacagcctttgaacaacttaaattatcagaccatatatatatatatatatatatatattttttttttttttttttttttttgagacggagtcttgctctgtcacccaggctggagtgcagtgacacaatctcagctcactgcagcctctgcctcccgggttgaagcagttctcctgcctcggcctcccaaagtgctgggattacaggcgtgagccattgcacccagccaatttttgtatttttagtagaggcggggtttcaccatgttggccagactggtcttgaactcctggcctcaagtgatccacccacattggcttcccaaaatgctagtattacaggcacgtgccactgtacctgactgttttaaccagttttgttagagagaaggactaccaatctatacattttgaaattctgacttttccctcatattatgaacattttgaaagacaatctgagagtagaatcttgattatctgctacctagattcaacagttattgttatctggacccaatttatttatgtttatatttttattgatccatttgaaagtaagttttggatatcatggtcatacaactaaacattgagcacgtacttctcaaaatggtgatatttatgctgtgagcttatagctttatcacaccatcaaaataacactcaatctctaatagtatataatactatatattcacatctcctcaaatttccttaagttgtcttttacagtgtttgtttttgaaaccaagatcacataccacatttggttgttgtttcttttcttttctttttctttcttcttttttttttttttttttttttaagacggagtcttgctctgtcgcccaggctggagtgcagtggcacaatcttgacttactgcagcctccgcctcctgggttcaagcgatttttctgcttcagcctccccagtagctgggattacaggtgcctgccaccatatccagctgatttttgtatttttagtagagacggggttttaccatcttggccaggctggtctcgaactcctgacctcaggtaatccacctgcctaagcctcccaaagtgctgggattacaggtgtgaaccaccacacctggccgtttacttttatttttgccagtttctttatagagtgcctctcagtttgggttcctgggtgtgtcctgaggattggactcacagcttgcattttaggaaggactgcacagaagccagtagagtgtatccttttcattgcatcattgttttccctttgtaattaataagtgtcttgagcctggtgctgtggcacatgcctgtaatcccagcgctttgggaggcggaggtaggaggacggcttgagcccaagagttcaagaccagcctgggcaacagagtgagacccctgtctacaaaaaaatgcaaaaattagccaggtatggtggcatgtgcctatagttctagctactcaagagactgaagtgtgaggattgctttaacctgggaggttgaggctgcagtgagccagagtcttgccactgcattccagcctgggaatagagcaagaacccatctcaaaaaaataaaaaatgaaatgtatcttgtggcaggtactttgagattatgtacatttcctgtttctcatactttcacaaactagtgttagcatccatcaatgattcctgtctgaaacggcttactgtggtggttgccgaatggtgatgtttgaaagctgtcgtcatcctctacacgttagagaactcttgtattttagagctttttctgctccccatctattcatatatgtatttatatttttaaagaaaaacttattctgacccttattaaagatagcaaggcacttagtgctttgggaggcaaggcaggacgatagcttgaggccaggagcttgagaccagcctgggcaacaaagtgaaacctcatgtctacagaaatttttaaaaattagccaagtgtggtggtgtgagcctgtagtcctagctccgtgggaggctgaggcaggaggatcacttgagtccaggggttcgaggctgcatgattgcaccactgtactccagcctaggtgacagagcaagaccttgtctcagaaaagcaagacaaagggcaggctgttcaggatgatcatgataggtatagggactgctgcaatgggattgtgtagtgggggagacctaggagcaggagtgggggccatgcacggaaaatttaactaagaggaaacatcagggtgcagggggttctggctgaactgacctaacaggattcttgtggaaggccgctagcatcactcctctggaccataaacactcggggagtcccaatctctcctgagcagtgcattggcgccagctttccagatgtgtgtacaccattcgcttttcacccaagatgatttgatgtcttataaaactctgatgaaccatgatggctacacagacattaagtatagacagctatcaagatgggcaacagatgcaagtagtaacagagttaaagacagaacaagatccaaactgctctgaacccgatgcagaaggagtgagccctccccctgtggagtctcagaccccgatggatgtggacaagcaggccatttataggcatccactatttccattattagctttgttgtttgaaaaatgtgaacaatctacacagggctctgaaggcacaacttctgccagttttgatgtagacatcgaaaattttgtaagaaagcaagagaaggaagggaaacctttcttttgtgaagatccagaaaccgataatttaatggtaaaagcaatccaggttttgcgcattcatcttcttgagctggaaaaggttaacgaactctgcaaagatttctgcagtcgatacattgcttgtctgaaaacaaaaatgaacagtgaaactctgttgagtggagagcctggaagcccgtactcaccagtgcagtcccagcagattcaaagtgccatcacaggcaccatcagccctcagggaattgtggtgccggcgtccgcgctgcagcagggaaacgtagccatggcgacggtggcaggtggcacagtgtatcagcctgtcacggtcgtcactccccaaggccaagtggtcacacagacattgtcgcctgggacaattaggatccagaactcccagcttcagttacagttaaaccaagatctcagcatcttgcatcaagatgatggttcatctaagaacaagaggggcgtcctgccaaagcatgccacgaacgtgatgcggtcctggctcttccagcacatcgggcatccctacccaacagaggatgagaaaaaacagattgctgctcagacaaatttgacactactccaagtcaacaactggttcatcaatgccagaagacgaattcttcagccaatgttggattcaagttgttcagagacccccaaaacaaagaaaaaaactgctcagaaccggccagttcagaggttttggcctgattctattgcatcaggagtcgcacagccaccgccgagcgagctcaccatgtcggaaggagctgttgtcaccatcaccacgcccgtgaacatgaacgtggacagccttcagtctctgtcctcggacggggccaccctggcggtgcagcaggtcatgatggcagggcagagcgaggacgagtctgtggacagcacagaggaggatgcgggtgccctggcccctgcccacatcagcgggctggtcttggagaacagtgactccctgcagtaggggcaggagcagacgcacctgactttttggagtttgcacagcaaacattttacacagttttatttctaatatgttttatatgtagatatagaagagtgcacttttgtatttcatagtaagcttaaagcgcgtctttgccggtgcagcgacttctttcaagtgtgtgtgtgtgtgtgtgcgtgtgtgcgtgtgtgtggatttttaaagaaattctttaaaggtttaacgctagattgtgaggaatgacacaccactccctccccaccttgaatccctaattagattaaggaatagcgctgccattttctaaaccgtgatgcggttgtcacttagttctgtggttccagcagatctcagtgggctggttgatttgtgtggcccatggatttgaaagaagctgctgcacccgaaactgccagtgtgcggtgacaacggcacacgcctagactgagtgtggtttcgtcgtgagtggatggacggcaagcttagcaagcctaagtcccctcatgttcagtgagcctgtttcatttgctatatagaaaaagaaactcctatttttaccttgctggaattattggataaaaaagctatttttataaattcgttatgaattggatgatgactatattgaggataaaatttctagagaagaaacaatacatgcttgctattaatatttcaatttggaatgttctgaattgaccaaatttaacgaacctgcccaaagttagctaccgttccatggttctttgctctccccgggtagtgatgaacatttactactataaaagaaacagctatttaatgaaattttgatatctgcaaatttttgttgatatgtaatgctcagattgcattttacacttgatctaaacatatatcgaaagatatctgctaaacaggacttcaggtaagtgaggtgaaatggtagccagtgacccgttaggagctctcaccgtacatactccagtctaatttaaatctgaccacagttgcatggtcgctttaccatgttagctgtgtattgttttaaaagttttaacttcaaaatatgttatgcacagaatgtttattataaactaatataaaatgtgctctaccccattggctcagagctagggcaaacagcagatattcagactttattacttaactagcggacatccctggagtcccagcagcgagttggtctggcgagggcacctcggcagcccccacgggttggctcctacgtttgcgtttgtggctggtctcctggtgtcagtgttctcttgtacgttgttgctttcgacttttcagagccctcctgctcacttgaccacgtgagatttggaataactgtaggacttctgtttcctggtaacaagatgaaccgagagagtgggctgggttctgttttctttggttttgatttgttttcattgtttacttaggagtggtgctttttctcagaaaacaggccacggtgtttcatacagaatgtcttcatatcatctgaaatggtatggctgaagttcatttgtttacagggtcgggaatgtcttcagttcttgagagtcaacagtaatgattggttgtaagccaagggacattttaagctagtgaagagttttttctggaattgatttttcccaaaagaatatattaattaaggttaagaagtcagtgggaaacacacagaaatttattttaaaatctttcaggagctttaactgaaagacttggttatcaagtcttttggggagagaatgacattttttttttgagacagagttttgctcttgttgcccaggctggagggcaatggtgcaatctcagctcactgcaacctccacctcttatgttcaagcaattctccttccttagcctcctgagtagctgggattacaggcatgcgccaccacacccggctaattttgtatttttagtagagatgggtttctccatgttggtcgggctggtctcgaactcccgacctcaggtgatctgcctgcctcagcctcccaaagtgctgggattacaggtgtgagccaccgcgcccggccgagaatgacatcttaaagccaccattgcgttcctcatttgtgaactgtcttctcatattttaagtcaagtctataagatcatttttaacctaagttccaactttgttggactccttaaaataagcacccatgaaagccagccagcccttcctccttccctcaccaccctccgtctcttcgtccctcaccaccctccgtctcttcggctgcctgctctttagtgtagattagtggaagccattcacagaatgtagactcatgtataggtcaccgtttctttcccccactagaaatcacattcactaagcagtggattgaatttaagagtgctgcccctgcccggcgcagtagggcgtgcctctagttccagctactcgggagtctgaggcagaggatggcatgtgccaggagtttgaggctgcagtgcactatgcttgcacctgtgaatagccactgcactccatcttgggcaacacagtgagacccccatctataaaaagagagcactgcctgaaccttggtggcactgggaagctctggcctgagagttaaacacccatgctgaatggtacagtgtgcattctctccagctgaaaactttcttcaactttcctaaattcttactaaattcagaggaataggataaagatcacttagagaaagggtgcttatggacatagcctgagtttcctttaacctctctccaatgggtgcttttaactagcttctacatggcaagctgtttcagtttgcaaaatcactgcccagcatgtttgaggtcagttggcaccttaaaacacctgttctccagcccttggacagtggagagaatctgtaaaagtgtgaccccctctaagatttcgttttaaatgatcagattcggttccagttttattcttgttgagtttttccctatgaaggctccttttgaatgtgtcttgagacccaaattgagcatgttgctgttattcctgccctgcacctgtggagcaggagtggcagggctggctgtgctgggttccagctcgctcctgccgagggactagcttggcctttgcgctttgattccagatagtaagatgagtggaagtgtttatcgagcatgcaaaagaaaccctcacggctaacggctctgggagttgtgtctgtgtgacctgagagtgatccatctcctgcctgtgtgaggtagcagtgggcacttttcattgagacaaactccagggtgtccagagggggttctgccccttgtgaaggcccattcctggcacttagagacagaaagaactcagcaatctttcgttctagttatattcggtctttgaaactgacaatctttgaaatgtgaatactgtaacaatatgttttcttggattgttgtctttaaaaaggatttttgtgaagcaattgatttatcaaagcaaaaaaattaaaaatagaaacttgctttatggatgttttattttataaagctcatgtcaccaaaagctgcttctccattttatgtaaaacattgagaatgttttcatgttttctggtgacatgtagggtctgtagtcacccctgcatattgagaaactaggaccacactgcatcggactagtcaggtccatttacatgtccaagaatcttttcttaaattccttactttgttcattcattggctgttcaggcagaaaatggaaacaggtagcttttatgttttttattatagttttccacaaatctaattattttgatagttacaagaagataatgattcatcagtaagctaacataatccctttcatagttcatatt

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