2024-05-02 13:34:14, GGRNA.v2 : RefSeq release 222 (Jan, 2024)
LOCUS XM_054322605 3453 bp mRNA linear PRI 05-OCT-2023 DEFINITION PREDICTED: Homo sapiens NLR family pyrin domain containing 12 (NLRP12), transcript variant X10, mRNA. ACCESSION XM_054322605 VERSION XM_054322605.1 DBLINK BioProject: PRJNA807723 KEYWORDS RefSeq. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. COMMENT MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_060943) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Status :: Updated annotation Annotation Name :: GCF_009914755.1-RS_2023_10 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 10.2 Annotation Method :: Best-placed RefSeq; Gnomon; RefSeqFE; cmsearch; tRNAscan-SE Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Date :: 10/02/2023 ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..3453 /organism="Homo sapiens" /mol_type="mRNA" /isolate="CHM13" /db_xref="taxon:9606" /chromosome="19" /sex="female" /cell_line="CHM13htert" /tissue_type="hydatidiform mole" /note="haploid cell line" gene 1..3453 /gene="NLRP12" /gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2" /note="NLR family pyrin domain containing 12; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 3 ESTs, 8 long SRA reads, and 95% coverage of the annotated genomic feature by RNAseq alignments, including 5 samples with support for all annotated introns" /db_xref="GeneID:91662" /db_xref="HGNC:HGNC:22938" /db_xref="MIM:609648" CDS 218..2989 /gene="NLRP12" /gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2" /codon_start=1 /product="NACHT, LRR and PYD domains-containing protein 12 isoform X9" /protein_id="XP_054178580.1" /db_xref="GeneID:91662" /db_xref="HGNC:HGNC:22938" /db_xref="MIM:609648" /translation="
MEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQDVTRLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLYGATYSADGEDRARCSAGAHTLLVQLRPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC"
misc_feature 218..400 /gene="NLRP12" /gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2" /note="Fish-specific NACHT associated domain; Region: FISNA; pfam14484" /db_xref="CDD:433982" misc_feature 434..943 /gene="NLRP12" /gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2" /note="NACHT domain; Region: NACHT; pfam05729" /db_xref="CDD:428606" misc_feature 1175..1336 /gene="NLRP12" /gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2" /note="NOD2 winged helix domain; Region: NOD2_WH; pfam17779" /db_xref="CDD:436037" misc_feature 1340..1684 /gene="NLRP12" /gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2" /note="NLRC4 helical domain HD2; Region: NLRC4_HD2; pfam17776" /db_xref="CDD:436035" misc_feature 1946..2032 /gene="NLRP12" /gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2" /note="leucine-rich repeat [structural motif]; Region: leucine-rich repeat" /db_xref="CDD:275380" misc_feature 1952..2908 /gene="NLRP12" /gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2" /note="Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116" /db_xref="CDD:238064" misc_feature order(1955..1957,1961..1963,1970..1972,1976..1978, 2033..2035,2042..2044,2048..2050,2057..2059,2063..2065, 2117..2119,2126..2128,2132..2134,2141..2143,2204..2206, 2213..2215,2219..2221,2228..2230,2234..2236,2288..2290, 2297..2299,2303..2305,2312..2314,2318..2320,2375..2377, 2384..2386,2390..2392,2399..2401,2405..2407,2459..2461, 2468..2470,2474..2476,2483..2485,2489..2491,2546..2548, 2555..2557,2561..2563,2570..2572,2576..2578,2630..2632, 2639..2641,2645..2647,2654..2656,2660..2662,2717..2719, 2726..2728,2732..2734,2741..2743,2747..2749,2801..2803, 2810..2812,2816..2818,2825..2827,2831..2833,2888..2890, 2897..2899,2903..2905) /gene="NLRP12" /gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2" /note="Leucine-rich repeats [active]" /db_xref="CDD:238064" misc_feature 2033..2116 /gene="NLRP12" /gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2" /note="leucine-rich repeat [structural motif]; Region: leucine-rich repeat" /db_xref="CDD:275380" misc_feature order(2051..2056,2225..2227,2396..2398,2480..2482, 2651..2653,2729..2731,2735..2737,2813..2815,2900..2902) /gene="NLRP12" /gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2" /note="Substrate binding site [chemical binding]; other site" /db_xref="CDD:238064" misc_feature 2117..2203 /gene="NLRP12" /gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2" /note="leucine-rich repeat [structural motif]; Region: leucine-rich repeat" /db_xref="CDD:275380" misc_feature 2204..2287 /gene="NLRP12" /gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2" /note="leucine-rich repeat [structural motif]; Region: leucine-rich repeat" /db_xref="CDD:275380" misc_feature 2288..2374 /gene="NLRP12" /gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2" /note="leucine-rich repeat [structural motif]; Region: leucine-rich repeat" /db_xref="CDD:275380" misc_feature 2375..2458 /gene="NLRP12" /gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2" /note="leucine-rich repeat [structural motif]; Region: leucine-rich repeat" /db_xref="CDD:275380" misc_feature 2459..2545 /gene="NLRP12" /gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2" /note="leucine-rich repeat [structural motif]; Region: leucine-rich repeat" /db_xref="CDD:275380" misc_feature 2546..2629 /gene="NLRP12" /gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2" /note="leucine-rich repeat [structural motif]; Region: leucine-rich repeat" /db_xref="CDD:275380" misc_feature 2717..2773 /gene="NLRP12" /gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2" /note="leucine-rich repeat [structural motif]; Region: leucine-rich repeat" /db_xref="CDD:275380" misc_feature 2801..2887 /gene="NLRP12" /gene_synonym="CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2" /note="leucine-rich repeat [structural motif]; Region: leucine-rich repeat" /db_xref="CDD:275380" ORIGIN
ggccagaggaggcctggaggttggctctcagcacctttgagcggataaacaggaaggacctgtgggagagaggacagagagaggacctgataccccacctggtggcccgtcctcacttgggaaccagtcaacatgccttctggaagtctctcttgtcactccaagaaaagatccccaggaaacctacagggactatgtccgcaggaaattccggctcatggaagaccgcaatgcgcgcctaggggaatgtgtcaacctcagccaccggtacacccggctcctgctggtgaaggagcactcaaaccccatgcaggtccagcagcagcttctggacacaggccggggacacgcgaggaccgtgggacaccaggctagccccatcaagatagagaccctctttgagccagacgaggagcgccccgagccaccgcgcaccgtggtcatgcaaggcgcggcagggataggcaagtccatgctggcacacaaggtgatgctggactgggcggacgggaagctcttccaaggcagatttgattatctcttctacatcaactgcagggagatgaaccagagtgccacggaatgcagcatgcaagacctcatcttcagctgctggcctgagcccagcgcgcctctccaggagctcatccgagttcccgagcgcctccttttcatcatcgacggcttcgatgagctcaagccttctttccacgatcctcagggaccctggtgcctctgctgggaggagaaacggcccacggagctgcttcttaacagcttaattcggaagaagctgctccctgagctatctttgctcatcaccacacggcccacggctttggagaagctccaccgtctgctggagcaccccaggcatgtggagatcctgggcttctctgaggcagaaaggaaggaatacttctacaagtatttccacaatgcagagcaggcgggccaagtcttcaattacgtgagggacaacgagcctctcttcaccatgtgcttcgtccccctggtgtgctgggtggtgtgtacctgcctccagcagcagctggagggtggggggctgttgagacagacgtccaggaccaccactgcagtgtacatgctctacctgctgagtctgatgcaacccaagccgggggccccgcgcctccagcccccacccaaccagagagggttgtgctccttggcggcagatgggctctggaatcagaaaatcctatttgaggagcaggacctccggaagcacggcctagacggggaagacgtctctgccttcctcaacatgaacatcttccagaaggacatcaactgtgagaggtactacagcttcatccacttgagtttccaggaattctttgcagctatgtactatatcctggacgagggggagggcggggcaggcccagaccaggacgtgaccaggctgttgaccgagtacgcgttttctgaaaggagcttcctggcactcaccagccgcttcctgtttggactcctgaacgaggagaccaggagccacctggagaagagtctctgctggaaggtctcgccgcacatcaagatggacctgttgcagtggatccaaagcaaagctcagagcgacggctccaccctgcagcagggctccttggagttcttcagctgcttgtacgagatccaggaggaggagtttatccagcaggccctgagccacttccaggtgatcgtggtcagcaacattgcctccaagatggagcacatggtctcctcgttctgtctgaagcgctgcaggagcgcccaggtgctgcacttgtatggcgccacctacagcgcggacggggaagaccgcgcgaggtgctccgcaggagcgcacacgctgttggtgcagctcagaccagagaggaccgttctgctggacgcctacagtgaacatctggcagcggccctgtgcaccaatccaaacctgatagagctgtctctgtaccgaaatgccctgggcagccggggggtgaagctgctctgtcaaggactcagacaccccaactgcaaacttcagaacctgaggctgaagaggtgccgcatctccagctcagcctgcgaggacctctctgcagctctcatagccaataagaatttgacaaggatggatctcagtggcaacggcgttggattcccaggcatgatgctgctttgcgagggcctgcggcatccccaatgcaggctgcagatgattcagttgaggaagtgtcagctggagtccggggcttgtcaggagatggcttctgtgcttggcaccaacccacatctggttgagttggacctgacaggaaatgcactggaggatttgggcctgaggttactatgccagggactgaggcacccagtctgcagactacggactttgtggctgaagatctgccgcctcactgctgctgcctgtgacgagctggcctcaactctcagtgtgaaccagagcctgagagagctggacctgagcctgaatgagctgggggacctcggggtgctgctgctgtgtgagggcctcaggcatcccacgtgcaagctccagaccctgcggttgggcatctgccggctgggctctgccgcctgtgagggtctttctgtggtgctccaggccaaccacaacctccgggagctggacttgagtttcaacgacctgggagactggggcctgtggttgctggctgaggggctgcaacatcccgcctgcagactccagaaactgtggctggatagctgtggcctcacagccaaggcttgtgagaatctttacttcaccctggggatcaaccagaccttgaccgacctttacctgaccaacaacgccctaggggacacaggtgtccgactgctttgcaagcggctgagccatcctggctgcaaactccgagtcctctggttatttgggatggacctgaataaaatgacccacagtaggttggcagcgcttcgagtaacaaaaccttatttggacattggctgctgaatggtcctatctgctggctctcccctgagatctggacagaggaagatgggagggtgctcatcacccccccagcataatgatcagcctccttcctagagacagactcatgcagattgagatcaaaagtccctctgcttgggatcaaattaatgtttgacagagctggccaggcgtggtggctcatgtatgtaatcctagcacttcgagaggccgaggcaggtggatcacgaggtcaggagtttgagattagcctggccaagatggtgaaaccctgtctctactaaaaataaaaaaaaattagccaggcatggtggcgggcaccttagtcccagctactcaggaggctgaggcaggagaatcgcttgaacccgggaggtggaggttgcagtgagccgagatcgcgccactgcactccagcctgggcgacagagtgggactccatctcaaaaaaaaaaaaaaaaaaa
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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