LOCUS       XM_047341742            7776 bp    mRNA    linear   VRT 04-APR-2022
DEFINITION  PREDICTED: Hippoglossus stenolepis dicer 1, ribonuclease type III
            (dicer1), transcript variant X2, mRNA.
ACCESSION   XM_047341742
VERSION     XM_047341742.1
DBLINK      BioProject: PRJNA642014
KEYWORDS    RefSeq.
SOURCE      Hippoglossus stenolepis (Pacific halibut)
  ORGANISM  Hippoglossus stenolepis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Neoteleostei;
            Acanthomorphata; Carangaria; Pleuronectiformes; Pleuronectoidei;
            Pleuronectidae; Hippoglossus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_061492) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Hippoglossus stenolepis Annotation
                                           Release 101
            Annotation Version          :: 101
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 9.0
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7776
                     /organism="Hippoglossus stenolepis"
                     /mol_type="mRNA"
                     /isolate="QCI-W04-F060"
                     /db_xref="taxon:195615"
                     /chromosome="10"
                     /sex="female"
                     /tissue_type="fin"
                     /geo_loc_name="Canada: Haida Gwaii"
                     /lat_lon="51.671 N 130.70875 W"
                     /collection_date="2004-01-15"
                     /collected_by="IPHC"
     gene            1..7776
                     /gene="dicer1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 5 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 3 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:118116613"
     CDS             271..3612
                     /gene="dicer1"
                     /codon_start=1
                     /product="endoribonuclease Dicer isoform X2"
                     /protein_id="XP_047197698.1"
                     /db_xref="GeneID:118116613"
                     /translation="

MAGLQLVTPATSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALEHNTIVCLNTGSGKTFIAVLLTKELSHQIRGHYQRNAKRTVFLVNTALSVVQQAAAVRTHSDLQVGEYTDLEETSAWTDQRWSQEIIENQVLVMTCHIFLHVLRNKILLLSKLNLVVFDDCHLAITDHPYCEIMKLFEGCSCSPRILGLTASLLNGKCDPSELEQKIQNLETILKSNAETATDLVVLDRYSSQPREVVLDCGPYLDKSGLSSHLLMELDEALHFLNDCNISVDREDRNPTLISKQILSDCRAVLQVLGPWCADKAAGIMVRELQKYIKHEQEELNRKFLLFTDTILRKVHALCEEHFSPASLDLKYVTPKVFRLLEILHEYKPFERQQFESVEWYNNRNQDNYVSWSDSEDDDEDEEVESKERPESNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPDLAYISSNFITGQSIGKNQPRNKQMEVEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPVSNYIMLADSERTKAFEEDLATYKAIEKILRNKCSKSVEVSDFEVEQVLDDDNTLPPYVLRSEDGGPQVTINTAIGHINRYCARLPSDPFTHLAPKCKTLEMQDGCFQSTLYLPINSPLRVPVKGPTMTCARLAEKAVALVCCEKLHKTGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPVCLRDSYAVDIYYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPRIPYFPVYTRSGEVTISIELQKSGFMLTSNQLNLITRLHQYIFSHILRLEKPALEFKPTLADSAYCVLPLNVVGDSNTLDMDFKFMEDIEKSEARTGIPTTQYTKQNPFTFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLSNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASEAGVGAQTLPPDFRHRHVTSPYCYRCPGQTYRLEVASRNIQMKQHEFNR"

     misc_feature    364..957
                     /gene="dicer1"
                     /note="DEXH-box helicase domain of endoribonuclease Dicer;
                     Region: DEXHc_dicer; cd18034"
                     /db_xref="CDD:350792"
     misc_feature    order(364..375,382..384,433..456,577..579,766..768,
                     859..861)
                     /gene="dicer1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350792"
     misc_feature    order(541..546,613..618,691..693,697..702,709..711,
                     784..792)
                     /gene="dicer1"
                     /note="nucleic acid binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350792"
     misc_feature    1051..1335
                     /gene="dicer1"
                     /note="Partner-binding domain of the endoribonuclease
                     Dicer; Region: Dicer_PBD; cd15903"
                     /db_xref="CDD:277191"
     misc_feature    order(1066..1071,1078..1080,1084..1089,1264..1269,
                     1276..1281,1288..1290,1297..1302,1309..1311)
                     /gene="dicer1"
                     /note="Trbp binding interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:277191"
     misc_feature    1354..1932
                     /gene="dicer1"
                     /note="C-terminal helicase domain of the endoribonuclease
                     Dicer; Region: SF2_C_dicer; cd18802"
                     /db_xref="CDD:350189"
     misc_feature    order(1585..1593,1801..1803,1858..1860,1864..1866)
                     /gene="dicer1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350189"
     misc_feature    order(1813..1815,1819..1821,1894..1896,1900..1902)
                     /gene="dicer1"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350189"
     misc_feature    2128..2394
                     /gene="dicer1"
                     /note="Dicer dimerization domain; Region: Dicer_dimer;
                     pfam03368"
                     /db_xref="CDD:460900"
     misc_feature    2890..3258
                     /gene="dicer1"
                     /note="PAZ domain, dicer_like subfamily. Dicer is an RNAse
                     involved in cleaving dsRNA in the RNA interference
                     pathway. It generates dsRNAs which are approximately 20 bp
                     long (siRNAs), which in turn target hydrolysis of
                     homologous RNAs. PAZ domains are named...; Region:
                     PAZ_dicer_like; cd02843"
                     /db_xref="CDD:239209"
     misc_feature    order(3079..3081,3118..3120,3136..3138,3148..3150,
                     3202..3204,3226..3228,3232..3234)
                     /gene="dicer1"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239209"
ORIGIN      

tagtaccgcggatagttacgtaatatacgttatatttctagcgtagcggggcccaagtgaaaggacgtggtcccaccgtgagaggaaacccatcaaatcggataagcaagggtggatgcagtgaggatatcaaacgaatgatttcaagctatttagtcaagacgatcaatctacaaacatacaccagtgaacttgccagtgacaattatgaaatgaaataaagtggacgactggaggagcccagccccctgacctccacctctttgaaacatggcaggcttacagcttgtcacccctgctacttcacccatggggcctttctttggtctgccatggcagcaggaggctatccatgacaacatctatacacctaggaaatatcaggtagaacttcttgaagcagctcttgaacataatactattgtctgcttgaatactggctcagggaagacctttattgcagtacttctaacaaaagagctctcccaccaaatccgtggacattatcaaagaaatgccaagaggactgtttttctggtgaacacagctttgtctgtagttcagcaagcagctgcagtcaggactcactctgaccttcaggtgggagagtacacagatttggaggaaacctcagcatggactgaccaacggtggagtcaagagataatcgagaatcaggtgctggtcatgacttgccacatattcctgcatgttttgaggaataaaatcttactgttgtctaaactcaacttggtggtttttgatgattgtcacctggccattacagaccacccctactgtgagataatgaagctgtttgaagggtgttcatgtagtcctcgtatcctgggtctcacagcttctcttctcaatggaaaatgtgacccttcagaactggagcagaagatccagaatttggaaacaatcttgaagagcaatgctgagactgccaccgaccttgttgtcctggacagatactcctctcagccaagagaagtggtgctggactgcggcccctatttggacaagagtggtctttcctcccatttgctgatggaactggacgaagctctccacttcctgaacgattgcaacatatctgttgacagggaggatcgcaatcctacattaatttccaaacagatcctgagtgactgccgggctgtgctgcaggtgctggggccctggtgtgcagataaggcggcaggcattatggtgcgggagctccaaaagtatatcaaacatgagcaggaagagctcaaccgtaagttcctgctcttcactgacaccatcctgcgcaaagtgcatgccctctgcgaagagcacttctcccccgcttcactggacctcaagtatgtcacccctaaggtcttccggctgcttgaaatcctgcacgaatacaagccctttgagaggcagcagtttgaaagcgtggagtggtacaacaatcggaaccaggacaactatgtgtcctggagtgactcagaggatgacgatgaggatgaggaggtggagtccaaagagaggcctgaatccaactttccctcacctttcaccaacattctgtgtgggatcatctttgtggagaggcgttacacagctgttgttctcaaccgtcttatcaaagaggcggggaagcaggacccagacctggcttatatcagcagcaacttcataactggccaaagcattggcaaaaaccagccacggaacaaacagatggaggtggagtttaggaaacaagaggaggttctccgcaaattccgggctcatgaaaccaacctccttattgccaccagcattgtggaggaaggtgtggatattccaaagtgtaacctggtagtgcgatttgacctgcccactgagtacaggtcctacgtccagtccaaaggcagagctcgggctcctgtctccaactatataatgctggctgacagtgagaggaccaaagctttcgaggaagatctcgctacatacaaggccatagagaagatcctgaggaacaagtgttctaagtcagtggaggtgagtgactttgaagtggagcaggttctggatgatgacaacacccttccaccttatgtgcttcgatctgaggatggaggtccccaggtcaccattaacacagccattgggcacattaacaggtattgtgctcggctacccagcgatccatttacccacttggcacccaaatgtaaaactttggagatgcaggacggatgcttccagtccacactctacttacccatcaattcccctctgcgagtccctgttaagggtcctacaatgacctgtgccagattagcagagaaagctgttgcactagtatgctgtgagaaactccacaaaacgggtgagttggatgatcacctgatgcccgtggggaaggagactgtcaagtatgaggaggagctggaccttcatgatgaggaggagaccagtgtcccaggccgacctggttctaccaaaaggaggcagtgctaccctaaagctataccagtgtgtctgagggacagttatgctgtagacatatactatctatatgtgattgggatggtccttaccacccctctcccagatgaactcaacttccgcagaaggaagctctacccaccagaggacaccaccaggtgctttggcatccttactgccaaacccatacctcgaatcccttatttcccagtgtacactcgctcgggtgaagtgaccatctccattgagctgcagaagtctggcttcatgctcacatccaaccagctcaacctcatcacccgcctgcaccagtacatcttttcccacatactccgcctggagaaacctgcactggagttcaagcccacgctagcagactctgcttactgcgttctacctctgaatgttgttggggactccaacacacttgatatggattttaagttcatggaggacattgagaagtctgaggcccgcactggcattcctaccactcagtacaccaaacagaaccccttcaccttcaagttggaggactaccaggatgctgtcatcattccaaggtatcgtaactttgaccagcctcatcgcttctatgtcgccgatgtgtacacagacctgacgccgcttagcaagtttccttcacccgaatacgagacgtttgctgagtactacaaaaccaagtacaacctggatctgtccaacctaaatcagcctctcctggatgttgatcatacctcctccagactaaacctgttgacccctcggcacctcaaccagaagggaaaagccctgccactcagcagtgcagagaagaggaaggccaagtgggagagcctgcagaacaaacagatcctggttccagagctgtgtgccatccaccctatccctgcctccctgtggaggaaagcagtgtgtctgccgagcattctctaccgcctccactgcctcctgactgctgaggagctcagagcccagacagccagtgaagctggagtgggagcccagaccctcccacctgacttcagacatcgccatgttacatcgccatattgctacagatgcccggggcagacataccgtttagaggttgcgtctcgcaatatacaaatgaagcagcacgaattcaatagatgaagaagaaccgtgcccgtaaataacatagaagaagtcgtcggaacaagtaggtagttattaaaagcttgtagaaagtgtgccaaaagaccttacgttaaatgacggataatacttgcatgtacagacgtcggcaaagaagcgaacacgcgacgaggtgaaatgaatcgcgtcatgatgacagaaattaggataaaccatacggttttctccaggattgaaatctctgctgagaggctttcagactgacactgaagtctgcagttttctgctgaacaggtaattaacccaatcaatgtaaattcaatttgttgtttgatagatcagttttattacttaccagaaatacaatgtttttattcagttcgttgctagtatagtaacatttacattgttccagatagatccatattgttatgcattcatgccaaagatcatagttgtgattgttgagacatcctagtttatttatttgtatttgttttgtttcgtgaacttcccaccacttcagtatgtaagagtacaccactgtgtcatgtagcacttattttcttactgttcttttacagctaccagacagaccctgatacatcaagtccaatgaaggcaaaacaacttgtctgtttgtttccattgaaacatccagcctggatacaaactttaattatatatgaataccatgccttttttcaacagtgaacgacaaacagtgtgagaacataagactcaacaactaagtgcattatttaaatgcacaatcactgttcaaagtagttaacatatatcacgtatatcagatattgaatggttcaaaattgtgatttcagcttcagaaggccaaaagatagtgtcagtgccccgaaataaaaaataatactatgcatacatctaagggctgcgagcaagagatctgaatctcagagtcacaagtggattcgggatgcctcaaagtaggagccttcatccagatgaccccagagaactagaattggtacccccccataattgcaccatccacaacacaattgctgcagacacaagtcaggagacgtctaggtaaataagtttatctttttttgtgtcatataaacccttttacaagtagtgccagtttcacatgaataaatatgtgaaattgctttattatattaatgagtaatgcaagtgttttcaacaggaatgtggaatgatccagatggaaggtcacgattcgttcttgaaaagcacagcagaatcatggtgcctctcggggacaccaacctgtgtaaacaaatcagtttatgtatataataaataaatacaacaaatctgttaaatagttttcttattgcacttttcattccagtgtaaactcatttgaacaaatataaataatgggcaatatgaatatattcataaaaaataacaaatagtaataaaaatacatttacaacagaaataataattgccccccattataatcacatgtttgatgcatatggaggtgtgtgaattgttactgtatgaaggagggcctggaaggaaactctgtactgtccttgtttataggatcagggacaagatccaaaacatagcagccggggatgacaagacggtttctctggtctagagtgccatgttgccaataaataatgtgctgatatgcttcataacagtactccctgttgtcatccccaggcgctctaatatggcctaatatcgcaatgatctcccagtagtctgtaaatatataccctgctcaacaaaattcagggaacacttaaatcacacatcagagtcactttgtataatttgttgagaacaatatgacgaaaaaatggtcaatggaaaccaaacattatcaaccaattgaggtctggattcaaaaccacactgaaaatctaagtaaaaaaatgtaaatcacatgctcatccaacttgcgtgaatttcatcccggcaattcataatgtgggcatcagtgagctcctggcagtacttggcgacttcggatacaccgataaataccagggcccactgcaccagcgtaaggtctgacaatcgctctcaggatttgatggcactaccaaacaacagtcagggtaccgttggctatgacatggaggtctgtgcgaccctccaaggatatgtcgggttgccagcaggtatctcctccatgctcgtgagattgtgctgggagacacagcaaacctacttgtgaccgtataacatatgtgagtagggcatgaaggatgaggactcaaaggactatttttcctgcttttttccctcctgcagaagacatttaaacacattaaccgtcttctgatctcctctctgcacttctgctccatcagcaatgcaagacggaactgtctgagctcaccctctttctaaaaacacaaacattatgatttatgacattttgtgtagcacaataagagctattgaagttagcaggaaaacattaacagtgcaaataattatagtgacacctagtgggcaaaatagaatggtgtgaggggagtgggtaactaaacagaaataactaattataaatttaacaaaagaaaatatacctgcagaagacattaaaacacattaaccggcttctgatctcctctatgcacttatgttcctaaacatgcaaaacaacagcattcactctgggaaatgctccagactgccggaagtaaaatagcaccaaaatgtgatcttttaaatgtctataaaacttatattagcagtgaaacaaagcataaaaacagcttggcaacacaacataaacagttatatgctataaatgttacaacataaacagatcaaactaaaaagaaattgatacaatagcgcagcagcattttgccacacaacttaccctcagcaatgcaagacgtgaaggacagagggaaggatctatggaagcccaagaagtgcagaagggacaaagtgcaaaaacataatttccaggggaaacattaattaatataaagataaataaaaataactcaggatgtactatcctggaggagcttgactacctgtccaacctgattgtgatgcaggtactgcctaatgctaccagtagtgacaaggacactagcagaacacaaaactagagaagactcagtcaggaaggataaagagagggcagttgttctgtggccaccacatgcaaagtcattccctttttgcgagttgtcttgcttttgcctcttcattgcacctgttgtagtggtagactcgcacagtttttaggatccgagccacagtctcctcctcctcacttctactcctgctccaggaactatccctcgtatctcccttacagataatttgcccctgcctgtctgttgtcttcctctcctcctctccctcttcattttcctctccctctttatcttactgtctttagtctttgctgctatcagacgagtctgtttgctaatgttagcttgcattagcattcagctaattcagttaactaacatcagtaataaagggctgccacacagggacgtgcacagacattttggggggcaggggctcaagtgagaaaaagggcacttctcatttatttataaaaaaaaaaacattttttaaacaaacaggtaaatatagtagacttactagtaacttacttatcaatttattttaataccttcacattcacacaattgttaaatactcaacagttcacacagagacaatggtcttctttagtatcactaggtttatcacaagagcaggcaacaacaaaggaaaccatgttttctatgctactgtagtttctagtttatatttatagtagcacacacacaactagtagaattaatagttattagatgaggaggctacaatcaaaatgatggttacttttaaaggcaggacacgacaagcaaaacattttttttcatgtactggaacctcatttataaaacagtgcgtaggattcatactaatactagtacgtgcgcacaaaaaacagttcagctcagtgatccaagatcacagatctatagaatatatcagctgatcagtcatcgtcatggtacaaaaaatgtgatcgctgaaaccctcatttcctcctcatccttccattcacgtgtatccatcacagagcattgcgcacgcgtgtcaccacagtatttatatatttagagcaatcggaccgattacttctcacatcag

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