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2021-10-17 15:37:55, GGRNA.v2 : RefSeq release 207 (Jul, 2021)

LOCUS       XM_039080221           13556 bp    mRNA    linear   ROD 21-JAN-2021
DEFINITION  PREDICTED: Rattus norvegicus argonaute RISC catalytic component 2
            (Ago2), transcript variant X1, mRNA.
ACCESSION   XM_039080221
VERSION     XM_039080221.1
DBLINK      BioProject: PRJNA677964
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_051342.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Rattus norvegicus Annotation Release
                                           108
            Annotation Version          :: 108
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.5
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..13556
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN/NHsdMcwi"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /sex="male"
                     /tissue_type="kidney"
                     /country="USA: Wisconsin, Milwaukee, Medical College of
                     Wisconsin"
                     /collection_date="2019-03-08"
                     /collected_by="Rebecca Schilling"
     gene            1..13556
                     /gene="Ago2"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 1 mRNA, 57 ESTs, 14 long SRA
                     reads, 25 Proteins, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 70 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:59117"
                     /db_xref="RGD:621255"
     CDS             171..2612
                     /gene="Ago2"
                     /codon_start=1
                     /product="protein argonaute-2 isoform X1"
                     /protein_id="XP_038936149.1"
                     /db_xref="GeneID:59117"
                     /db_xref="RGD:621255"
                     /translation="
MDIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA"
     misc_feature    306..530
                     /gene="Ago2"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:406799"
     misc_feature    558..710
                     /gene="Ago2"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:400854"
     misc_feature    711..1073
                     /gene="Ago2"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(867..869,954..956,966..968,1020..1022,1041..1043,
                     1047..1049)
                     /gene="Ago2"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1206..2483
                     /gene="Ago2"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1617..1619,1629..1631,1665..1676,1683..1685,
                     1707..1709,1716..1718,1728..1730,1740..1742)
                     /gene="Ago2"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1821..1823,1827..1829,2037..2039,2451..2453)
                     /gene="Ago2"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      
ggcttcccttgtaccctctcagaccttgggatggcaacacagtatcctgggttcttgcgtctcctgctccgacaacatcacccatcccaggatatgccttcaagcctccacctcggccggatttcggcaccaccgggagaacaatcaaactacaggccaatttctttgaaatggacatccccaaaattgacatctatcactatgaattggacatcaaacctgagaaatgccctcggagagtgaacagggaaatagtggagcacatggtccagcactttaaaacccagatcttcggggaccggaagccagtgtttgatggacggaagaatctgtacacagctatgccccttccaattggcagggacaaggtggaactggaggtcacgctgccaggagaaggcaaagatcgcatctttaaggtatccatcaagtgggtatcctgcgtgagcttgcaggcgttacacgatgcactttcggggcggctgcccagcgtccccttcgagacgatccaggccctggacgttgtcatgaggcacttgccatccatgaggtacacccctgttggccgttccttcttcactgcatcggaaggctgttccaaccctctgggagggggcagagaagtgtggtttggcttccatcagtccgtccgaccttctctttggaaaatgatgctgaacatcgatgtatcagcaacagcattttacaaggcacagccagtgatcgagtttgtttgtgaagtgttggattttaaaagtattgaagaacaacaaaaacctctgacagattcccaaagggtaaagtttaccaaagaaattaaaggtctaaaggtggagataacgcactgtggtcagatgaagaggaaataccgtgtctgcaatgtgacccggcggcctgccagtcaccaaacgttcccactgcagcaggagagtgggcagacagtggagtgtacagtggctcagtacttcaaggacaggcacaagctggttctgcgctacccccacctcccatgtttacaagttggacaagagcagaaacacacctaccttcctttggaggtctgtaacatagttgctggacagagatgtataaaaaaattaacagacaatcagacctcaaccatgatcagagcaactgccaggtcagcgcccgatcggcaagaggagatcagcaaattgatgcgaagtgcaagtttcaatacagacccgtatgttcgtgaatttgggatcatggtgaaagatgagatgacagatgtgacagggcgggttctgcagccgccctccatcctctacgggggcaggaacaaagcgattgccacccctgtccagggtgtgtgggacatgagaaacaagcagttccacacgggcatcgagatcaaggtgtgggccatcgcctgctttgcaccccagcgccagtgtacagaagtccatctcaagtccttcacagagcaactgaggaagatctcaagagatgctgggatgcctatccagggtcagccctgcttctgtaaatacgcacagggggcagacagtgtggaacccatgttccgacacctgaagaacacatacgctggtctccagctggtggtggttatcctgcctggcaagactcctgtgtacgcggaagtcaagcgtgtgggagacacggtgctgggcatggccacgcagtgtgtccagatgaagaacgtgcagaggaccacgccacagaccctatccaatctctgcttaaagatcaatgtcaaactgggaggagtcaacaacatcctgctgccacagggcaggcctccagtgttccagcagcctgtcatcttcctgggagccgatgtcacccacccaccagctggggatgggaagaaaccttcaattgctgccgtcgtgggcagcatggacgcacaccccaaccgctactgtgccaccgtgcgcgtacagcagcaccgacaggagatcatccaggacctggctgctatggtgcgagagctgctcattcagttctacaaatctacacgcttcaagcccacccgcatcatcttctaccgagacggcgtctctgagggccagttccagcaggttcttcaccatgagctcctggccatcagagaggcctgcataaagctggagaaggactatcagccagggatcacattcatcgtggtgcagaagcggcaccacacacgtctcttctgcacagacaagaatgagcgggttggaaagagtgggaacatcccagcaggcacaaccgtcgacacaaagatcacccacccaactgagtttgacttctacctgtgcagtcatgctggcatccaggggacaagccgtccttcccactaccacgtgctctgggatgacaatcgtttctcttctgatgagcttcagattctgacctaccagctgtgtcacacctacgtgcgctgcacacgctctgtgtcaattcctgcgccagcttactatgcccacctggtggccttccgagccaggtaccacctggtggataaagaacatgacagcgctgaaggaagccatacctctgggcagagcaacgggcgagatcaccaggcgctggccaaggcggtccaggtccaccaggacacactgcgcaccatgtactttgcttgacatgttgtattgtttagcgattgtgtaccaagttggattcacacgagaccagctacactcagaccaacagatgcccagcccttccgtgacagccagcatcgaacatgagacgtctttggttttattagatcctccattttccagaatgccttccgtcccagatttcagacttggattttgagctacaggcctgtatgagacccccattgtaggaaacgtggtttgccaaacctataagctgctcactgagagtctcgtttcctaaaagcaaaaaacaacaaaatgtcctaaaaccagtctatgaactctcagggctttaaaacattttaatttatttggtcattcgatttacttgtttttaacacctgattctcaatgaaatcgatgggctcaaactagctgtgaaggctctgagcgggaaagcagcaccattaccattggggttttaaagcctggccctagaagttgtcaccagtgttgagtgctaagggctgccatgtaccctgcagccccagggcactcggctgctaggtatccacagtgtccctcgctggccactgcctgccctcgaggcctgagtgaaggcatagtggccaaggggatggtcacgtgtgtttagggcagtgacaagtttgagagattggcagacaagtgccattttgataaaaatttatttaaaaagagaaaaaagacaatatactgacagtctaatcataagatttgtcctgtaggactgtgacatttattttccaaagtttctaaagaatacgggtctgtggtgatagatacagtacaatcctttttcactgttatgtctttaatgtaagagaagaatatatgtatctggtttgcagtattaatgtggtaggtagatgctgtttcccttttgttgacgaggggcgcttcttgtgacctgcttcacgtaccaggagctgtggagcctggagacagtccacctcttgtggcttttagtgcttaagtagaggaatatgcacctggcttcacgtaacagcgatgcctccttcttccctccccacccccagtgtggactgtgtagcctgtacctctgggaaggacagtgtgcttgccagtaatctgccgtcctccctgcctcgtccgtgtgtgtcgctcagctgatgaagcacaagtggaatttatttattctcccatggctgggaaacaagttcacgtaagcgtgcactgctctcagctatgtgcagttatggaaggtgggtttcataggatctatgcactgaagtggagagagagctgctcacagtggctctgccggcatgggattggcaggtaggactggaacatgccgaggagctgacggtgggcaaggccagcagggaaggcacggacttgctctgggtgtggcttgcttctgggccccaatgtgggtttgccagcctagagaccattgaactgaggggccactacgagtggctctgcaaatggcagcagccacctctgagtatgtgtcctgtggggctttttgtgcttgtaccgaagctgcgtgagcatccggtccgttccacagacaagttcccggaaggagacgagccttctcttctgtgctgctttgtgctctgtgggttttttctgcccctgctgacggccctcatcccccagctctgcgtcatttacctctgaccctgcggtggggggagggtgcccaccctctcccccagctgtggcacctcatgctagaggacacagtaccacctttaccccttcacccgtctgcactggggctggtgggaagggcgggcgcagtcacctgggaagtcacgccctcagcaggtgtgcgtctgtgtatgcatgtgggtgtcttactaatgacagtagtctcttcttgctgtgtctttagaaatcttttaaagtgacagacccctagtctaagaagcactgggactgcctgctatcccattggcaagtggcactttctcaaactgtttccgaaaggatataaaaacactcagctcacctaacatggtcaggctggagaactggttaaactagtgaacttttagaatctgagatggttttcagccattcttagaaccatgggttcctaaggtgtggcttcagccccttgccacgggatcttagtcatgcaagtgagtttttagagtgcagagtctcaggcctgctgccagcttcttggacctggcccttgcagccagctgggtatctgtgtttgaggccacccccacccacccaccaccatggctctgtgggctttcttaggccgtcccccatgatgccaggggaacaggaaggaagccctatgagagctctcacacggaggaacacttgtgggctggggggaaaatctgagctggaagttttgttttgatcatcttgaaggataagttttctttt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//

by @meso_cacase at DBCLS
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]