LOCUS       XM_032314176            5621 bp    mRNA    linear   MAM 03-FEB-2020
DEFINITION  PREDICTED: Mustela erminea ATPase copper transporting beta (ATP7B),
            transcript variant X1, mRNA.
ACCESSION   XM_032314176
VERSION     XM_032314176.1
DBLINK      BioProject: PRJNA602914
KEYWORDS    RefSeq.
SOURCE      Mustela erminea (ermine)
  ORGANISM  Mustela erminea
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia;
            Musteloidea; Mustelidae; Mustelinae; Mustela.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_045628.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Mustela erminea Annotation Release
                                           100
            Annotation Version          :: 100
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.3
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5621
                     /organism="Mustela erminea"
                     /mol_type="mRNA"
                     /isolate="mMusErm1"
                     /db_xref="taxon:36723"
                     /chromosome="15"
                     /sex="male"
                     /tissue_type="spleen (genome), liver, muscle, kidney"
                     /dev_stage="adult"
                     /country="New Zealand: Coromandel"
                     /lat_lon="37.304717 S 175.755071 E"
                     /collected_by="Andrew Veale, Tim Cruickshank"
     gene            1..5621
                     /gene="ATP7B"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 18 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 48 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:116573862"
     CDS             500..5092
                     /gene="ATP7B"
                     /codon_start=1
                     /product="copper-transporting ATPase 2 isoform X1"
                     /protein_id="XP_032170067.1"
                     /db_xref="GeneID:116573862"
                     /translation="

MVGKGVTVDTAMEEAGGETPRSPEPSFLATLGDPQVTLVSVHKRWSFRRNPGARGSSRPVTSEEEGECSQKVLNGTRGIRSNQILSKLSLPARAREPAMKQSFAFDNVGYEGGLDTVDPPQTATGTISISGMTCQSCVKSIEGRISSLKGIVSIKVSLEQGSATVRYVPSILSLPQICRHIEDMGFEASVAEGKAASWPSRSSPGLEAVVKLRVEGMTCQSCVSSIEGKLGKLQGVVRVRVSLSTQEAVITYQPYLIQPQDLRDHVSDMGFEAVIKNKVAPVSLGPIDIGRLQSTNPKTPLASDNQSLNNSETSEHQGSHTVTLQLRVDGMHCTSCVMNIEENIGQLPGVQSVQVSLESRLAQVQYDPSRVTATALQRAIEALPPGNFKVSLPDGVTGNGTGRRSSNRVVPAPTLRPQVQGVCDTVVLAIAGMTCASCAQSIEGLISQREGVQRISVSVADGTGVVLYDPSVTNPEELRAAVEEMGFEASVISENYSTNHVGNHSAGTSPAPPEAGVPVFVQEVAPRAGEPPKNHNSGSSSEPPQASTTVAPQKCFLQIGGMTCASCVSHIEKSLQKEAGILSVLVALMAGKAEVKYNPEVIQPLEIAQLIQDMGFEATVMEDYTGSDGDLELIITGMTCASCVHNIESRLTRTNGITYASVALATSKAHVKFDPEIIGPRDIVRIIEEIGFHASPAQRNSGAHHLDHKVEIKQWRKSFLCSLVFGIPVMGLMIYMLVPSHEPHEAMVLDRNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYRSLKHGTANMDVLIVLATTIAYTYSFVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHVAKSKTSEALARLMSLQATEAIVVTLGEDNLIVREEQVPMELVQRGDVIKVVPGGKFPVDGKILEGNTMVDESLITGEAMPVTKKPGSIVIAGSINAHGSVLVNATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIISTLTLVVWIIIGFIDFGVVQKYFPTHSKHISQAEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPKVMRVLLLVDVAMMPLRKVLAVVGTAEASSEHPLGVAITKYCKEELGTDSLGYCTDFQAVPGCGIGCKVSSVEGLLAHSESQQSKQAAPPSRAGSAPEEIDVTPQTFSVLIGNREWMRRNGLTISSDVSDAMANHELKGQTAVLVAVDGVLCAMIAIADAVKQEAALAVHTLKSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNEGKKVAMVGDGINDSPALAQADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVWRIHLNLVLALIYNLIGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAQGRMKPLTASQVSVYIGMDDRRRDSPRATPWDQVSFISQVSLSSLKSDKLSRHSAAADDGGDKWSLLLNDRDEEQCI"

     misc_feature    875..1066
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(893..901,908..910)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1130..1318
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1148..1156,1163..1165)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1472..1648
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1490..1498,1505..1507)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1778..1969
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1796..1804,1811..1813)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    2168..2356
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(2183..2191,2198..2200)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    2393..2584
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(2411..2419,2426..2428)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    2648..4756
                     /gene="ATP7B"
                     /note="P-type heavy metal-transporting ATPase, similar to
                     human copper-transporting ATPases, ATP7A and ATP7B;
                     Region: P-type_ATPase_Cu-like; cd02094"
                     /db_xref="CDD:319783"
     misc_feature    order(3641..3643,3647..3649,4685..4687)
                     /gene="ATP7B"
                     /note="putative Cu binding site [ion binding]; other site"
                     /db_xref="CDD:319783"
     misc_feature    order(3773..3781,3983..3985,4136..4144,4232..4234,
                     4352..4360,4418..4420,4427..4429,4436..4438,4493..4495,
                     4502..4504)
                     /gene="ATP7B"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319783"
ORIGIN      

gcagctgaagttattccaagaaagccctgtaagtttggtaataaaatgaagtgtcgtttctcccctgcctcaaggctggagttctggcagtgcacatggctgagaggaaactgtgctcagctttgggaggtgattacgtgctgggcgcccgcacatgctggcccggtgtcctggcagggctgggtgagggcacgcgcggggccgtgtgcaaagattcccagtgccgaatgcagtgtgatgagtgagagggtgccaattggttggaaggatgtaggtaaacaagagcaaatatatatccagcagcgtgcagcctgcccgagttctgaagccggctgctggacttggctggcagcctctcaccgaactggctccagagcagaggggactctgcaggactgagcacagcaggtggcctgcccctgctacttagggggacacttttaaagcatttgctcctcccatgaccaggtagtgtggtgagggtgaactgcttgctcgaatggtgggtaaaggtgtgactgtggacactgcgatggaggaagctgggggtgagacgcccaggagccctgagccatccttcctggcgaccctgggtgacccacaggtgaccctggtgtccgtccacaagcggtggtccttcaggaggaaccctggggccaggggctccagcaggccagtgacttcggaggaggaaggagagtgttcacagaaggttttgaatggaacacggggaatccgttccaatcagatcttgtctaaactttccttgcccgctcgtgcccgggagccagcgatgaagcagagttttgcctttgacaatgtcggctacgaaggcggcctggacactgtggacccccctcagacggccaccggcaccatcagcatttcgggcatgacttgccagtcatgtgtaaagtctatcgagggcaggatttccagcctgaaaggcatcgtgagcattaaggtttccctggaacagggcagtgcgacggtgaggtatgtgccgtccatcctgagcctgccgcagatttgccgtcacattgaggacatgggctttgaggccagcgttgcagagggaaaggctgcctcctggccttcgaggtcctcgcctggcctcgaggctgtggtcaagcttcgggtggaaggcatgacctgccagtcctgcgtcagctccatcgaaggcaagctcgggaaactgcagggagtagtgagagtccgagtgtccctcagcacccaggaggcagttattacataccagccttacctgattcagccccaggacctcagggaccacgtcagtgacatgggctttgaagctgtcatcaagaacaaagtggcgcccgtaagcctgggacccatcgatatcgggcgcttacagagcaccaatccaaagacccctttggcatctgataaccagtctctcaataactctgagacctcagagcaccaagggagccacacggtcaccctgcaactgagagtagatggaatgcactgtacgtcttgtgtcatgaatattgaagaaaacataggccagctgcccggggttcaaagtgttcaagtgtccttggagagcagactggcccaagtacagtatgacccttctcgcgtcaccgccaccgccctgcagagggccatcgaagcgcttccacctgggaacttcaaagtctctcttcctgatggtgtgacaggaaatgggacaggtcgcaggtcttccaaccgtgttgtccctgcccccacgctgagaccccaggtgcagggggtgtgcgatactgtggtgctcgccattgctggcatgacctgtgcgtcctgtgcccagtccatcgaaggcctcatctcccaaagggaaggggtacagcggatatcggtctctgtggctgacgggactggcgtggttctctatgatccgtctgttactaacccggaagaactccgagctgctgttgaagaaatgggatttgaggcttcagtcatttctgaaaactattccaccaaccatgttggaaaccacagtgcggggacttccccagcgccccccgaagctggcgttcctgtgtttgtacaggaagtggctccccgtgccggggagccccctaaaaaccacaactccggctcctcgtccgagcccccacaggcctctaccacggtggctccccagaagtgctttctacagattggaggcatgacctgtgcatcctgtgtgtcccacatagagaagagcctgcagaaggaagcaggtattctgtcagtgctggttgccctcatggctgggaaggcagaggtcaagtataacccagaagtcatccagcccctggagatagctcagctcatccaggacatgggctttgaggcgacagtaatggaagactacacaggctccgatggcgacctcgaactcatcatcacggggatgacctgtgcgtcctgtgttcacaacattgagtccagactcacaaggacaaacggcatcacttacgcctctgtggcccttgccaccagcaaagcccacgtgaaatttgatcctgaaattatcggtccacgggatattgtccgaattatcgaggaaatcggctttcatgcttccccggcccagagaaactccggcgcgcatcacttggaccacaaggtggaaataaagcagtggaggaagtctttcctgtgcagcctggtgttcggcatccccgtcatgggtctcatgatctacatgctggtgcccagccatgagccccacgaggccatggtcctggaccgcaacatcattccgggactgtccatcctcaatctcatcttctttatcttgtgtacctttgtccagctcctcggtgggtggtacttctacgtccaggcctacaggtctctgaagcatgggacagccaacatggacgtgctcatcgtgctggctaccaccatcgcctacacctactcatttgtcatcctagtggtggccgtagccgagaaggcggagaggagccccgtgaccttcttcgacaccccccccatgctctttgtgttcattgccctggggcggtggctggaacacgtggcaaagagcaaaacctcagaagcccttgccagactcatgtctctccaagccacagaagccatcgttgtcacccttggtgaggacaacttgattgtcagggaggagcaggtgcccatggagctggtgcagcggggcgacgtcatcaaggttgtccccggggggaagttcccagtggatgggaaaatcttggaaggcaacaccatggtggacgagtccctcatcacaggagaagccatgcctgtcacgaagaaacctggaagcatagtgattgctgggtctataaatgcacatggctctgtactcgttaatgccactcacgtgggcaatgacaccacattggctcagatcgtgaaattggtagaagaggctcagatgtcaaaggcacccattcagcaactggctgaccggtttagtgggtattttgtcccatttatcatcatcatttcaacgctgacgttggtggtatggattataatcggttttatcgattttggtgttgttcagaaatactttcctacccacagcaagcacatctcccaggcagaggtgatcatccggtttgcgttccagacgtccatcaccgtgctgtgcatcgcctgcccctgctccctgggcctggccacgcccacagcggtcatggtgggcaccggggtggccgcccagaatggcatcctcatcaaaggaggcaagcctctggagatggcccacaagataaagaccgtgatgtttgacaaaactggcaccatcacccatggggtccccaaagtcatgagggtcctcctgctcgtggatgtggccatgatgcccctcaggaaggttcttgctgtggtggggactgcagaggccagcagcgagcaccccttgggcgtggcaatcaccaagtactgtaaagaggaattgggaaccgactccttgggatactgcacggacttccaagcagtgcccggctgtggaatcggctgcaaagtcagtagtgtggagggcctcctggcccacagcgagagccagcagagcaaacaggcggctcccccgagcagggctggcagcgctcccgaggaaatagacgtgaccccccagaccttctctgtgctcatcgggaaccgcgaatggatgaggcgcaacggcctaaccatttccagcgacgtcagtgacgcgatggcgaatcatgagctgaaaggccagacggccgtgctggtggccgttgacggcgtgctctgtgccatgatcgccatcgccgacgcagtcaagcaggaggcagccctggccgtgcacacgctgaagagtatgggtgtggacgtggttctgatcacaggggacaaccggaagacggccagagccatcgccacccaggttggtatcaacaaagtctttgcagaggtgctaccttctcacaaggtggccaaggtccaggagctccagaatgaagggaagaaagttgccatggtaggagacgggattaatgactcgccggccttggcccaggctgatgtgggcattgccatcgggacaggcacggatgtcgccatcgaggctgctgacgttgtcctcattagaaacgatttgctcgatgtggtggctagcattcacctctccaagaggaccgtctggagaatacacctcaacctggtgctggcgttgatttataacctgatcggaatacccatcgcggcaggggtcttcatgcccatcggcatcgtgctgcagccgtggatgggctcggcggccatggcggcctcctctgtgtctgtggttctctcgtcgctgcagctcaagtgctataagaagcctgacctggagcggtatgaggcccaggcccagggccgcatgaagcccctgacagcgtcgcaggtgagcgtgtacatcggcatggatgaccggcggcgggactccccgagggccacaccctgggaccaggtcagcttcatcagccaggtgtctctgtcctccctgaagtccgacaagctgtctcgacacagtgctgcggctgatgatggtggggacaagtggtctctgctcctgaacgacagagatgaggagcagtgcatctgaaagctgcaggcgggtggagacccaggggtctgtctcctcactgagtagctggtccggcttccccggggaccgaggctcaggccgaacaggcacagctccagcggcaagatgggcgaagctcccctccagccctggggacttccactccctcctggagatggctggtcatccctcctagcatgggcggtgcccctatgtggctcctgggtcacccacctccccgtccccactgggatcccagcggcacaggggccaggcttcccggcctgaccatgctgtgggcctgggcttgtcgggaaccttgctggactctagcagagcagaggacggccagccttcctcacaggcctctgctttagtgtttggaacgactacttgtaaaaagaggaaaatctcatcgggaccaaaaacttagctgggcctttcctcacgagaagcctcgtgttgggttctttttgacaacacccacatgattgcgtatctgagaccacagtttacctcaaatacaccccactgatgtctgccggca

//