LOCUS       XM_025991756            2402 bp    mRNA    linear   MAM 01-APR-2025
DEFINITION  PREDICTED: Vulpes vulpes argonaute RISC catalytic component 3
            (LOC112914683), transcript variant X4, mRNA.
ACCESSION   XM_025991756
VERSION     XM_025991756.2
DBLINK      BioProject: PRJNA1241828
KEYWORDS    RefSeq.
SOURCE      Vulpes vulpes (red fox)
  ORGANISM  Vulpes vulpes
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
            Vulpes.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_132789) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 1, 2025 this sequence version replaced XM_025991756.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_048418805.1-RS_2025_03
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 03/26/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2402
                     /organism="Vulpes vulpes"
                     /mol_type="mRNA"
                     /isolate="BD-2025"
                     /db_xref="taxon:9627"
                     /chromosome="10"
                     /sex="female"
                     /cell_line="fibroblast"
                     /tissue_type="cell line"
                     /dev_stage="adult"
                     /geo_loc_name="Russia: Novosibirsk"
                     /collection_date="2008"
     gene            1..2402
                     /gene="LOC112914683"
                     /note="argonaute RISC catalytic component 3; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 37 long SRA reads, 1 Protein"
                     /db_xref="GeneID:112914683"
     CDS             145..2025
                     /gene="LOC112914683"
                     /codon_start=1
                     /product="protein argonaute-3 isoform X4"
                     /protein_id="XP_025847541.1"
                     /db_xref="GeneID:112914683"
                     /translation="

MCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA"

     misc_feature    145..486
                     /gene="LOC112914683"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(280..282,325..327,367..369,379..381,433..435,
                     454..456,460..462)
                     /gene="LOC112914683"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    619..1896
                     /gene="LOC112914683"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1030..1032,1042..1044,1078..1089,1096..1098,
                     1120..1122,1129..1131,1141..1143,1153..1155)
                     /gene="LOC112914683"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1234..1236,1240..1242,1450..1452,1864..1866)
                     /gene="LOC112914683"
                     /note="active site"
                     /db_xref="CDD:240015"
     polyA_site      2402
                     /gene="LOC112914683"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

tttcaatcactagttcaggtttcactctacacgttacttccttgagaagcagtatttgacacctttctcccccccacatccagccatcccccaagtctgatttctgccactgccttctataaagcacaacctgtaattcagttcatgtgtgaagttcttgacattcataatattgatgagcaaccaagacctctgactgattctcatcgggtaaaattcaccaaagagataaaaggtctgaaggttgaagtgactcattgtggaacaatgagacggaaataccgcgtttgtaatgtaacaagaaggcctgccagtcatcaaacctttcctttacagttggaaaacgggcaaactgtggagagaacagtagcacagtatttcagagaaaagtatactcttcagctcaagtacccacaccttccttgtctgcaagtggggcaggaacagaaacatacctacctgccgctagaagtctgtaatatcgtggcagggcaacgatgtatcaagaagctaacggacaatcagacttccactatgatcaaagcaacagcaagatctgcaccagatagacaagaggaaattagcagattggtaagaagtgcaaattatgaaacagatccatttgttcaagagtttcaatttaaagttcgggatgaaatggcccatgtaaccggacgtgtacttccagcacctatgctacagtatggaggacggaatcggacagtagcaacaccaagccatggagtatgggacatgcgggggaagcagtttcacacaggagttgagataaaaatgtgggctatagcttgctttgccacacagaggcagtgcagagaagaaatactgaagggtttcacagaccagctgcggaagatttccaaggatgcagggatgcccatccagggccagccttgcttctgcaaatatgcacagggggcagacagcgtggagcccatgttccggcatctcaaaaacacctactctgggctacagctcattattgtcatccttccaggaaagacgccagtgtatgcggaagtgaaacgtgtaggagatacacttctgggtatggccacacagtgtgtccaagtgaagaatgtaataaaaacatcccctcaaactctctcaaacctgtgcctaaagataaatgttaaactcggagggatcaataatattcttgtacctcatcaaagaccttctgtgttccagcaaccagtgatctttttgggagcagatgtcactcatccaccagctggtgatgggaagaagccttctattgctgctgttgtaggtagtatggatgcccacccaagcagatactgtgccacagtaagagttcagagaccccgacaggagatcatccaggacttggcctccatggttcgagaacttctcattcagttttataagtcaactcggttcaaacctactcgtatcatcttttatcgggatggtgtttcagagggacagtttaggcaggtattatattatgaactactagcaattcgagaagcctgcatcagtttggagaaagactatcaacctggaataacctacattgtagttcagaagagacatcacactcgattattttgtgctgataggacagaaagggttggaagaagtggcaatatcccagctggaacaacagtcgatacggatatcacacacccgtacgagtttgatttttacctctgtagccatgctggaatacagggtaccagccgtccttcacactatcatgttttatgggatgataactgctttactgcagatgaacttcagctgctaacttaccagctctgccacacttatgtgcgctgtacacgatctgtttctatccctgcaccagcgtattatgctcacctggtggcattcagagccagatatcatctcgtggacaaagaacatgacagtgctgaaggaagtcatgtttcaggacagagcaacgggcgagatccacaagctctcgccaaggctgtacagattcaccaagataccttacgcacaatgtactttgcttaaaaagtccaagaatattctgtgagaggaagaactgaaagatgcatcgacatacagcatatgtttccagtggagtcagttgagtggggatgcctccagccatacagcaaccaacactgtgtggggaccagggtctgatttttatgttgatacaaggaagattgtttacttcatcaaggaacacagcaccattatgcaatatgaaaccagccaactgcttttttgtgcggtctccttaggaagtatcgccattgttttgttttcactttcttgtagtctaacccttttaatgcctttacctcaagttgcttggcagcacaactatctttgcaaaaaaaagtaaagaaaaagtaaatgacagttttaaaaaaaaaaacaca

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