LOCUS       XM_025450840           14585 bp    mRNA    linear   MAM 06-AUG-2020
DEFINITION  PREDICTED: Canis lupus dingo argonaute RISC catalytic component 2
            (AGO2), transcript variant X1, mRNA.
ACCESSION   XM_025450840
VERSION     XM_025450840.2
DBLINK      BioProject: PRJNA649359
KEYWORDS    RefSeq.
SOURCE      Canis lupus dingo (dingo)
  ORGANISM  Canis lupus dingo
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
            Canis.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_049956.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Aug 6, 2020 this sequence version replaced XM_025450840.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Canis lupus dingo Annotation Release
                                           101
            Annotation Version          :: 101
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.5
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14585
                     /organism="Canis lupus dingo"
                     /mol_type="mRNA"
                     /isolate="COOINDA"
                     /sub_species="dingo"
                     /db_xref="taxon:286419"
                     /chromosome="13"
                     /sex="female"
                     /tissue_type="whole blood"
                     /dev_stage="adult"
                     /ecotype="Alpine"
     gene            1..14585
                     /gene="AGO2"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 166 long SRA reads, 21 Proteins,
                     and 99% coverage of the annotated genomic feature by
                     RNAseq alignments, including 31 samples with support for
                     all annotated introns"
                     /db_xref="GeneID:112662254"
     CDS             45..2627
                     /gene="AGO2"
                     /codon_start=1
                     /product="protein argonaute-2 isoform X1"
                     /protein_id="XP_025306625.1"
                     /db_xref="GeneID:112662254"
                     /translation="

MYSGAGPVLAPPAPPPPPIQGYAFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLATMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA"

     misc_feature    321..545
                     /gene="AGO2"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:318646"
     misc_feature    573..725
                     /gene="AGO2"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:312283"
     misc_feature    726..1088
                     /gene="AGO2"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(882..884,927..929,969..971,981..983,1035..1037,
                     1056..1058,1062..1064)
                     /gene="AGO2"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1221..2498
                     /gene="AGO2"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1632..1634,1644..1646,1680..1691,1698..1700,
                     1722..1724,1731..1733,1743..1745,1755..1757)
                     /gene="AGO2"
                     /note="5' RNA guide strand anchoring site; other site"
                     /db_xref="CDD:240015"
     misc_feature    order(1836..1838,1842..1844,2052..2054,2466..2468)
                     /gene="AGO2"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

cgcgcggccgcccctcggccccggagcccctcggcggcgccaccatgtactcgggagccggccccgtgctcgcgcctcctgcgccgccgccgccgcccatccaaggatatgccttcaagcctccgcccagacccgacttcgggacctccgggagaacaatcaagttacaggccaacttctttgaaatggacattccaaaaattgacatctatcattatgaattggatatcaagccagagaaatgcccaaggagagttaacagggaaatagtggaacatatggtccagcactttaaaacacagatcttcggggatcggaaaccagtgtttgatggaagaaagaatctctacacagcgatgccgcttccaattgggagggataaggtggagctggaggtcacgttgcctggagaaggaaaggaccgcatcttcaaggtgtccatcaagtgggtgtcctgtgtgagcttacaggcgttacacgatgcactttcggggcggctgcccagcgtcccctttgagacgatccaggccctggatgtggtcatgaggcatttgccatccatgaggtacacccctgtgggccgctccttctttaccgcgtccgagggctgctccaacccccttggcgggggccgggaagtgtggtttggcttccatcagtccgtccgaccttctctttggaagatgatgttgaatattgatgtctcagcaactgcattttataaggcacagccagtaatcgagtttgtttgtgaagttttggattttaaaagtattgaagaacaacagaaacctctgacagattcccaaagggtaaagtttaccaaagaaatcaaaggtctaaaggtggagataacgcactgcgggcagatgaagaggaagtaccgcgtctgcaacgtgacccggcggcccgccagtcaccaaacgttcccgctccagcaggagagcgggcagacggtggagtgcacagtggcccagtacttcaaggacaggcacaagctggttctgcgctacccccacctcccatgtttacaagtcggacaggagcagaaacacacctaccttcccctcgaggtctgtaacatagtagcaggacagagatgtatcaaaaagctgaccgacaatcagacctcaaccatgatcagagcgactgccaggtcagcgccggatcggcaagaagagattagcaagctgatgcgaagtgcaagttttaacacagatccgtatgttcgtgaatttggaattatggtcaaggacgagatgacagacgtgaccgggcgggtcctccagccaccctccatcctctatgggggcaggaataaagcgattgccacccctgtccagggcgtgtgggacatgaggaacaagcagtttcacacaggcattgagatcaaggtgtgggccattgcgtgcttcgccccccagcgtcagtgtacagaagtccacctgaaatccttcacggagcagctcagaaagatctcgagggacgctgggatgcccatccagggccagccgtgcttctgtaaatatgcccagggggcggatagcgtggagcccatgttcaggcacctgaagaatacgtatgctggccttcagctggtggtggtcatcctgcctggcaaaacccccgtttacgccgaggtgaagcgcgtgggagacacggtgctggggatggccacgcagtgtgtgcagatgaagaacgtgcagaggaccaccccgcagaccctgtccaacctctgcttgaagatcaatgtcaaactgggaggcgtgaacaacatcctgctgccccaggggaggccgcccgtgttccagcaacccgtcatcttcctgggggccgacgtcactcacccacctgccggggatgggaagaagccttccattgccgccgtcgtgggcagcatggacgcgcaccccaaccgctactgcgccaccgtgcgggttcagcagcaccggcaggagatcatccaggacctggccaccatggtccgtgagctcctcatccagttctacaagtccacgcgcttcaagcccacgcgcatcatcttctaccgcgatggcgtctccgagggccagtttcagcaggttctccaccatgagttactggccattcgcgaggcatgtattaagctagaaaaagactaccagccagggatcactttcatagtggtacagaaaaggcaccacacgcggctcttctgcaccgacaagaacgagagggtcgggaaaagtggaaacattccagcaggcacaactgtggacacgaaaatcacccacccgaccgagtttgacttctacctgtgtagtcacgctggcatccagggaacaagcaggccttcccactatcacgtgctttgggatgacaatcgtttctcttccgatgagctgcagattctcacctaccagctgtgtcacacctatgtgcgctgcacacgctccgtgtccatcccggcgccagcatactatgcccacctggtggccttccgggccaggtaccacctggtggacaaagaacatgacagtgccgaaggaagccatacctccgggcagagtaatggacgagaccatcaagcgttggcaaaggcagtccaggttcatcaggacacgctgcgcaccatgtactttgcttgacgtgttttagtgtttacgattgtgtaccgagttggattcacatgagaccagctacactcagaccaacagatgcccagcccttccgtgacagccagcatcgaacatgagacgtcattgattttagtagattctccattttccagaatgccttccgtcccagatttcaaacttggattttgaactgcagacctgtatgagaccccattgtcgtaggaaatatggtttgccaaaatctataagctgcttattaaaaatagagtcccgtgtttcctaaaaatctcctaaaaccagtctatgaactcagggctttaaaacatttttaatttatttggtcattcaatttacttgtttttaacacatgattctctatgaaattggtgggctcaaactagctgtgaacgttctcagagagtgaaagcaacgcagatcgtggctgtggttttaaagccttgagcattctgaggtggtcactaaagttttatgtcagagtgatactagtgtgctcctgacagggctgacgcaagctcttcaggacctcgggcaggtggcccgccgaggcgcccatgggtgtcttgtcctgccattgcctgcctttcactcagcttgaaataaggagcgggggcagaggatgggccatgtgtgtttacaacatttataggtccagagagattggcagacaagtgccattttaataaaaatttatttaaaaaaaaaaaaagaaaaaagacaatatgccgacagtctaatcataagatttgtcctataggactgtgacatttattttccaaagtttctaaagaatacgggtctgtggtgataaatacagtacaatcctttttcactgttatgtctttaatgtaagagaaaaaatatatatatctggtttgcagtattaatgtgatagatagatgctgttttttcattttattgacttcggggtgcttattgtgatctgtttcgcatatcaagagtgttctggagactggaccacctcctgtggttctcagtgcttacatacaggagtatgcaattgagtcaatgtgaccgccacccgcctcccccccgcgtagattgcgtagcctgtaccttcggggggaccgagcgcaggcccggcggccgctcgccaccaccccacgtcctgccccctgtgcattgctcggccgattaagcacaaatggaatgtatttattcttccattcccgggaaacaagtccgtgtgtccgagtgtccctctctctgtccggttctgttagacgagttccgtaggacctatgcactgaagcgcgcagagagccgtgggcggaggcgccccgtgggcacgggcccggcgagccctgccctcggtggacgccgcgccagcagaagagccttgcatcctgggccctgcgtgtgggtttgcccagctagaaaccattgcactaagcatgataaccatggacaacttgaaaagggtaacagcggacaactctgtttgtgctaagtgggctgtttgtccttttggacaatttaaaaaggaaaaaaaaaatcaaatccactttcagtgtagagattcaggggaggagacgggccttcccctagtgctgctttgtgctctgtcggcctccctctccctgctgccggccccccgagcccagcctgacacttacctctggcactgcggcggaaaaggcacccccctgtgtgtcgcccgcggccctggggtgctgggggagtgcgggggggggggggcaggggagccgcgggcggagctgtaatggacactcggcctagatttcggcggcgatgacaaaggggagactattatttgtgaagatatatactcagagtggtgtgtgcgtgtgtgtgtccgtgtgtgcatgtgggtgtcttattaatggcattagcctcttcttgctgtatcttttttgtttgggggtttgtttgttgggtggttttttttttttttttttttttttttttttggtctttttaaacgaacagaagcctctgctctaagaaatgttgcaattccctgtcgttttattggcaagtggcactttctcctattttcagaaggatacctatacactcttggctgaaattaccaggagcattcaagcttaaggagggaatcttttcacttacacacttttgaaatctgaaattaggttagttttcagccattctgaggatcatctagaaccatgtgtctcaaaggtgtgtttctgctacctgcagcagggtcctggtggtcgaggcagtggtggtacttggtaaaaatgcagactcctgaatccgattctccagagccggggctgggcatctgtattttataccatcgactgaggttccagggctgcctaaagtcaggacctctgatctagagctttctga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