LOCUS       XM_024237520            3688 bp    mRNA    linear   PRI 11-APR-2023
DEFINITION  PREDICTED: Pongo abelii NLR family pyrin domain containing 12
            (NLRP12), transcript variant X1, mRNA.
ACCESSION   XM_024237520
VERSION     XM_024237520.2
DBLINK      BioProject: PRJNA944618
KEYWORDS    RefSeq.
SOURCE      Pongo abelii (Sumatran orangutan)
  ORGANISM  Pongo abelii
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Pongo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_072004) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Mar 23, 2023 this sequence version replaced XM_024237520.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_028885655.1-RS_2023_04
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.1
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 04/06/2023
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3688
                     /organism="Pongo abelii"
                     /mol_type="mRNA"
                     /isolate="AG06213"
                     /db_xref="taxon:9601"
                     /chromosome="19"
                     /sex="male"
                     /tissue_type="fibroblast"
     gene            1..3688
                     /gene="NLRP12"
                     /note="NLR family pyrin domain containing 12; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 1 long SRA read, 1 Protein"
                     /db_xref="GeneID:100449374"
     CDS             191..3379
                     /gene="NLRP12"
                     /codon_start=1
                     /product="NACHT, LRR and PYD domains-containing protein 12
                     isoform X1"
                     /protein_id="XP_024093288.2"
                     /db_xref="GeneID:100449374"
                     /translation="

MLRTAGRDGLCRLSTYLEELEAVELKKFKLYLGTATELGEGKIPWGRMEKAGPLEMAQLLITHFGPEEAWKLALSTFERMNRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRDYVRRKFRLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQAQQQLLDTGRGHARTVGHQASPIKIETLFEPDEERPEPPCTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYINCREMNQSATECSMQDLISSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKPPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAERKEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQMSRTTTAVYMLYLLSLMQPKPGAPRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGADVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGERGAGPDQDVTKLLTEYAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWEVSPHIKMDLLQWIQSKAQSDGSTLQQGSLEFFGCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKHCRSAQVLHLYGTTYSADGEDRARCSAGVHTLLVQLRPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKKCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMTLLCEGLRHPRCRLQMIQLRKCQLESGACQEMASVLSTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICHLTAAACEELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSAVLQANHNLRELDLSFNDLGDWGLWLLAKGLQHPACRLQKLWLDSCGLTAKACKTLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDIGC"

     misc_feature    227..466
                     /gene="NLRP12"
                     /note="Pyrin death domain found in NALP proteins; Region:
                     Pyrin_NALPs; cd08320"
                     /db_xref="CDD:260032"
     misc_feature    575..790
                     /gene="NLRP12"
                     /note="Fish-specific NACHT associated domain; Region:
                     FISNA; pfam14484"
                     /db_xref="CDD:433982"
     misc_feature    824..1333
                     /gene="NLRP12"
                     /note="NACHT domain; Region: NACHT; pfam05729"
                     /db_xref="CDD:428606"
     misc_feature    1565..1726
                     /gene="NLRP12"
                     /note="NOD2 winged helix domain; Region: NOD2_WH;
                     pfam17779"
                     /db_xref="CDD:436037"
     misc_feature    1730..2074
                     /gene="NLRP12"
                     /note="NLRC4 helical domain HD2; Region: NLRC4_HD2;
                     pfam17776"
                     /db_xref="CDD:436035"
     misc_feature    2336..2422
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2342..3298
                     /gene="NLRP12"
                     /note="Leucine-rich repeats (LRRs), ribonuclease inhibitor
                     (RI)-like subfamily. LRRs are 20-29 residue sequence
                     motifs present in many proteins that participate in
                     protein-protein interactions and have different functions
                     and cellular locations. LRRs correspond...; Region:
                     LRR_RI; cd00116"
                     /db_xref="CDD:238064"
     misc_feature    order(2345..2347,2351..2353,2360..2362,2366..2368,
                     2423..2425,2432..2434,2438..2440,2447..2449,2453..2455,
                     2507..2509,2516..2518,2522..2524,2531..2533,2594..2596,
                     2603..2605,2609..2611,2618..2620,2624..2626,2678..2680,
                     2687..2689,2693..2695,2702..2704,2708..2710,2765..2767,
                     2774..2776,2780..2782,2789..2791,2795..2797,2849..2851,
                     2858..2860,2864..2866,2873..2875,2879..2881,2936..2938,
                     2945..2947,2951..2953,2960..2962,2966..2968,3020..3022,
                     3029..3031,3035..3037,3044..3046,3050..3052,3107..3109,
                     3116..3118,3122..3124,3131..3133,3137..3139,3191..3193,
                     3200..3202,3206..3208,3215..3217,3221..3223,3278..3280,
                     3287..3289,3293..3295)
                     /gene="NLRP12"
                     /note="Leucine-rich repeats [active]"
                     /db_xref="CDD:238064"
     misc_feature    2423..2506
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    order(2441..2446,2615..2617,2786..2788,2870..2872,
                     3041..3043,3119..3121,3125..3127,3203..3205,3290..3292)
                     /gene="NLRP12"
                     /note="Substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:238064"
     misc_feature    2507..2593
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2594..2677
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2678..2764
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2765..2848
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2849..2935
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    2936..3019
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    3107..3163
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275380"
     misc_feature    3185..3277
                     /gene="NLRP12"
                     /note="leucine-rich repeat [structural motif]; Region:
                     leucine-rich repeat"
                     /db_xref="CDD:275381"
ORIGIN      

tgaagagtgagaaagcattatttcagcaaaaggtctttcctccctcgctcactcctcaaaccactggctcagcctctccgcccgctgcctgtgaatgatgcaatggaaggtgtgctggggtcgccccgtgtcccgtgcataggaacatctcagcctccaggtcctctcctttggggctcacggcacccccatgctacgaaccgcaggcagggacggcctctgtcgcctgtccacctacttggaagaactcgaggctgtggaactgaagaagttcaagttatacctggggaccgcgacagagctgggagaaggcaagatcccctggggacgcatggagaaggccggtcccttggaaatggcccagctgctcatcacccactttgggccagaggaggcctggaagttggctctcagcacctttgagcggatgaacaggaaggacctgtgggagagaggacagagagaggacctggtgagggacaccccacctggtggcccgtcctcacttgggaaccagtcaacatgccttctggaagtctctcttgtcactccaagaaaagatccccaggaaacctacagggactacgtccgcaggaaattccggctcatggaagaccgcaatgcgcgcctaggggaatgtgtcaacctcagccaccggtacacccggctcctgctggtgaaggagcactcaaaccccatgcaggctcagcagcagcttctggacacaggccgtggacacgcgaggaccgtgggacaccaggctagccccatcaagatagagaccctctttgagccagatgaggagcgccccgagccaccgtgcaccgtggtcatgcaaggcgcggcagggataggcaagtccatgctggcacacaaggtgatgctggactgggcggacgggaagctcttccaaggcagatttgattatctcttctacatcaactgcagggagatgaaccagagtgccacggaatgcagcatgcaagacctcatctccagctgctggcccgagcccagtgcgcctctccaggagctcatccgagttcccgagcgcctccttttcatcatcgacggcttcgatgagctcaagccttctttccacgatcctcagggaccctggtgcctctgctgggaggagaaaccgcccacggagctgcttcttaacagcttaattcggaagaagctgctccctgagctatctttgctcatcaccacacggcccacggctttggagaagctccaccgtctgctggagcaccccaggcatgtggagatcctgggcttctctgaggcagaaaggaaggaatacttctacaagtatttccacaatgcagagcaggcgggccaagtcttcaattacgtgagggacaacgagcctctcttcactatgtgcttcgtccccctggtgtgctgggtggtgtgtacctgcctccagcagcagctggagggtggggggctgttgagacagatgtccaggaccaccactgcggtgtacatgctctacctgctgagtctgatgcaacccaagcccggggccccgcgcctccagcccccacccaaccagagaggactgtgctccttggccgcagatgggctctggaatcagaaaatcctatttgaggagcaggacctccggaagcacggcctagatggggcagacgtctctgctttcctcaacatgaacatcttccagaaggacatcaactgtgagaggtactacagcttcatccatttgagtttccaggaattctttgcagctatgtactatatcctggacgagggggaacgcggggcaggcccagaccaggacgtgaccaagctgttgaccgagtacgcgttttctgaaaggagcttcctggcactcaccagccgcttcctgtttggactcctgaacgaggagaccaggagccacctggagaagagtctctgctgggaggtctcgccacacatcaagatggacctgttgcagtggatccaaagcaaagctcagagcgacggctccaccctccagcagggctccttggagttcttcggctgcttgtacgagatccaggaggaggagtttatccagcaggccctgagccacttccaggtgatcgtggtcagcaacattgcctctaagatggagcacatggtctcctcgttctgtttgaagcactgcaggagcgcccaggtgctgcacttgtatggcaccacttacagcgcggacggggaagaccgggcgaggtgctctgcaggagtgcacacgctgttggtgcagctcagaccagagaggaccgttctgctggacgcctacagtgaacatctggcagcggccctgtgcaccaatccaaacctgatagagctgtctctgtaccgaaatgccctgggcagccggggggtgaagctgctctgtcaaggactcagacaccccaactgcaaacttcagaacctgaggctgaagaagtgccgcatctccagctcagcctgcgaggacctctctgcagctctcatagccaataagaatttaacaaggatggatctcagtggcaacggtgttggattcccaggcatgacgctgctgtgcgagggcctgcggcatccccgatgcaggctgcagatgattcagttgaggaagtgtcagctggagtccggggcttgtcaggaaatggcttctgtgctcagcaccaacccacatctggttgagttggacctgacaggaaatgcactggaggatttgggcctgaggttactgtgccagggactgaggcacccagtctgcagactacggactttgtggctgaagatctgccacctcactgctgctgcctgtgaagagctggcctcaactctcagtgtgaaccagagcctgagagagctggacctgagcctaaatgagctgggggacctcggggtgctgctgctgtgtgagggcctcaggcatcccacgtgcaagctccagaccctccggttgggcatatgccgattgggctctgccgcctgtgagggtctttctgcggtgctccaggccaatcacaacctccgggagctggacttgagtttcaacgacctgggagactggggcctgtggttgctggctaaggggctgcaacatcccgcctgtagactccagaaactgtggctggatagctgtggactcacagccaaggcttgtaagactctttacttcaccctggggatcaaccagaccttgaccgacctttatctgaccaacaacgccctaggggacacaggtgtccgactgctttgcaagcggctgagccatcctggctgcaaactccgagtcctctggttatttgggatggacctgaataaaatgacccacagtaggttggcagcgcttcgagtaacaaaaccttatttggacattggctgctgaatagtcctatctgctggctctcccctgagatctggacagaggaagatgggagggtgctcatcacccctacagcataatgatcatgctccttcctagagacaaactcatgcagattgagatcagaagtccctctgcttgggatcaaattaatgtttgacagagctggccaggcatggtggctcatgtctgtaatcccagcacttcgagaggccgaggcaggtggatcacgaggtcaggagtttgagatcagcctggccaagatggtgaaaccctgtctctactaaaaataaaaaaaaaaattagccgggc

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