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2020-03-31 05:18:01, GGRNA.v2 : RefSeq release 99 (Mar, 2020)

LOCUS       XM_023496518            3404 bp    mRNA    linear   MAM 31-DEC-2019
DEFINITION  PREDICTED: Sarcophilus harrisii argonaute RISC catalytic component
            2 (AGO2), transcript variant X1, mRNA.
ACCESSION   XM_023496518
VERSION     XM_023496518.2
DBLINK      BioProject: PRJNA596784
KEYWORDS    RefSeq.
SOURCE      Sarcophilus harrisii (Tasmanian devil)
  ORGANISM  Sarcophilus harrisii
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_045426.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Dec 31, 2019 this sequence version replaced XM_023496518.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Sarcophilus harrisii Annotation
                                           Release 103
            Annotation Version          :: 103
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.3
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3404
                     /organism="Sarcophilus harrisii"
                     /mol_type="mRNA"
                     /db_xref="taxon:9305"
                     /chromosome="1"
                     /cell_line="91H"
     gene            1..3404
                     /gene="AGO2"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 12 ESTs, 4 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 37 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:100935023"
     CDS             448..3036
                     /gene="AGO2"
                     /codon_start=1
                     /product="protein argonaute-2 isoform X1"
                     /protein_id="XP_023352286.1"
                     /db_xref="GeneID:100935023"
                     /translation="
MYSGAGPALTAPPTPPSPMQATYTFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKQVELEVTLPGEGKDRIFKVAIKWMSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPSEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA"
     misc_feature    727..954
                     /gene="AGO2"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:318646"
     misc_feature    982..1134
                     /gene="AGO2"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:312283"
     misc_feature    1135..1497
                     /gene="AGO2"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1291..1293,1336..1338,1378..1380,1390..1392,
                     1444..1446,1465..1467,1471..1473)
                     /gene="AGO2"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1630..2907
                     /gene="AGO2"
                     /note="Piwi_ago-like: PIWI domain, Argonaute-like
                     subfamily. Argonaute is the central component of the
                     RNA-induced silencing complex (RISC) and related
                     complexes. The PIWI domain is the C-terminal portion of
                     Argonaute and consists of two subdomains, one of...;
                     Region: Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(2041..2043,2053..2055,2089..2100,2107..2109,
                     2131..2133,2140..2142,2152..2154,2164..2166)
                     /gene="AGO2"
                     /note="5' RNA guide strand anchoring site; other site"
                     /db_xref="CDD:240015"
     misc_feature    order(2245..2247,2251..2253,2461..2463,2875..2877)
                     /gene="AGO2"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      
aaaaacccggcagtctgtacagtacagcccgcaccgcacgttgcaagctcccctttctcgtcagccgtcacaactgggcatgctcatttagtcagggctgggttttcccccctcccttcttggtcgcaagtagctttccttcccccccccccctcttttttcccctcttctgcactacaacggctccccggctcccggcggctggccggccctccctccctccttccttccctcttcccttccctccctctctctccccccttccttccctccctccttccttccttcccttcccctccactcctctgccggcacagtgtcgcgtaaacctgtttggtgaggcgcccgcctgaaggcgcagggtcggaccgcactcgcggctgctgcgttgggggggcccgattctcactccttggctcccgggagcccccctgcccagggacagacatgtattcgggagcaggacccgcacttacggctcctccaacaccaccctcaccaatgcaggcaacatatacctttaagcctccacctagaccagactttgggacttctgggagaacaatcaagctgcaggctaatttctttgaaatggacattccaaaaattgacatctatcattatgaattagatatcaagccagagaaatgccctagaagagttaacagagaaatagtggagcatatggtccagcactttaaaacacagatctttggggatcgtaaaccagtatttgatggaagaaaaaacctctatacagcaatgcctcttcccattgggagagataaacaggtggagttggaggtcacattgcctggagaaggaaaagaccggatatttaaggtggccataaaatggatgtcatgtgtgagtctacaagctttgcatgatgcgctctccggtcgcctgcctagtgtcccttttgaaaccattcaggcattggatgtagtgatgagacatttaccatccatgaggtatacacccgtggggcgatcattttttactgcatcagagggatgctcaaaccctcttggtggaggaagggaagtttggtttggattccatcaatcagttcgaccctcactttggaaaatgatgttgaacattgatgtttcagcaacagccttttacaaggcacagccagtaattgagtttgtttgtgaagttttggatttcaaaagtattgaagagcaacagaaacctctgacagattcccaaagggtaaagtttaccaaagaaatcaaaggtctaaaggttgagataacacactgtgggcaaatgaagagaaagtaccgtgtgtgtaatgtcaccagacgaccagcaagtcaccaaacattcccacttcagcaagagagtggccagactgttgaatgtacggtggcacagtattttaaagacagacacaaattggttctacgttatcctcaccttccatgtttacaagttggacaggagcaaaagcatacataccttcctcttgaggtatgcaacatagtggcaggacagagatgtataaagaaactgactgacaatcaaacctctactatgatacgggcaactgcaagatcagcacctgatcggcaagaagagatcagcaaattgatgcgaagtgcaagtttcaatacagacccttatgttcgtgagtttggcataatggttaaagatgaaatgacagatgtcactggccgggtcttgcagccaccatcaatcctctatggaggcaggaataaagcaattgctacacctgtccagggggtttgggatatgaggaataaacagttccacactggaattgaaatcaaggtctgggcgattgcttgctttgcacctcaacggcagtgtactgaagtccatcttaaatccttcacagaacaactcagaaagatttcaagagatgcaggaatgccaatccagggtcagccatgtttctgcaaatatgcccaaggagcagatagtgttgagcctatgtttaggcacttaaagaacacatatgctggactgcaattagtagtggtcattctgcctggaaaaactcctgtctatgcggaagtgaaacgtgttggggacaccgtgctgggcatggccacacagtgtgttcagatgaaaaatgtgcagagaaccacgccacagactctgtcaaatctttgcttaaagatcaatgtcaagctaggaggagtaaacaatatcttacttccccaaggaaggcctccagtatttcagcagcctgtcatctttttgggtgcagatgtcactcaccccccagcaggagatggaaaaaagccttctattgccgcagttgtagggagcatggatgcccaccccaatcgttattgtgcaacagtgcgtgttcagcagcatcggcaagaaatcatccaagatttggctgcaatggtccgagaacttcttattcaattctataaatcaacacgcttcaaaccaactcgcatcatcttctatagggatggtgtttctgagggtcaatttcagcaggttcttcatcatgagctgttggccatccgagaggcatgtattaaactagaaaaagattaccagcctggaattacatttattgttgttcagaaaaggcaccacaccaggcttttctgtaccgacaaaaatgaacgggttggaaagagtggaaatattccagcagggacaacagtagacaccaaaattacccacccatctgaatttgatttttacctgtgcagccatgctggtattcagggaacaagcaggccttcacattatcatgtcctttgggatgacaatcgtttttcttcagatgaactacaaattttgacttatcaactgtgtcatacctatgtgcgctgtacacgctctgtgtccatccctgcaccagcctactatgcgcacctggtggccttcagggccagatatcatttggtggataaagaacatgacagtgctgaaggaagccacacgtctggtcagagtaatggcagagatcaccaagcacttgcgaaagcagtacaggttcatcaggacacgctgcgtaccatgtactttgcttaacatgttttagtgtttagcgatttagtacagagttggattcacatgagaccagctacactcagaccaactgttgcccagcccttccatgacagccagcaaggagcaggatgcatctaggttcttttccatgtgcaagaaagaaagccgtccctgcattaagacttggattttgagctgcagacctgtaaaactcccctccccctgccctcatctttcactcccatccctgacactgttgggaatgtggtttgccaaaatctataggctgctttttcagaaaacagacccaagtttcctaaaattaattcaagagctattatctcagggctttaaaaacaaacaaacaaaaaaaaaaaaccacacacaaa
//

by @meso_cacase at DBCLS
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]