LOCUS       XM_022502772            4870 bp    mRNA    linear   MAM 20-SEP-2017
DEFINITION  PREDICTED: Enhydra lutris kenyoni ATPase copper transporting beta
            (LOC111146971), transcript variant X6, mRNA.
ACCESSION   XM_022502772
VERSION     XM_022502772.1
DBLINK      BioProject: PRJNA407952
KEYWORDS    RefSeq.
SOURCE      Enhydra lutris kenyoni (northern sea otter)
  ORGANISM  Enhydra lutris kenyoni
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia;
            Musteloidea; Mustelidae; Lutrinae; Enhydra.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_019154099.1) annotated using gene prediction method: Gnomon,
            supported by mRNA evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Version          :: Enhydra lutris kenyoni Annotation
                                           Release 100
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 7.4
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4870
                     /organism="Enhydra lutris kenyoni"
                     /mol_type="mRNA"
                     /isolate="GAN:26980312"
                     /sub_species="kenyoni"
                     /db_xref="taxon:391180"
                     /chromosome="Unknown"
                     /sex="male"
                     /tissue_type="blood"
                     /dev_stage="adult"
     gene            1..4870
                     /gene="LOC111146971"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 7 mRNAs, 11 Proteins, and 99%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 1 sample with support for all
                     annotated introns"
                     /db_xref="GeneID:111146971"
     CDS             48..4346
                     /gene="LOC111146971"
                     /codon_start=1
                     /product="copper-transporting ATPase 2 isoform X2"
                     /protein_id="XP_022358480.1"
                     /db_xref="GeneID:111146971"
                     /translation="

MKQSFAFDNVGYEGGLDTVDPPQTATGTISISGMTCQSCVKSIEGRISSLKGIVSIKVSLEQGSATVRYVPSILSLLQICRHIEDMGFEASVSEGKAASWPSRSSPGLEAVVKLRVEGMTCQSCVSSIEGKLGKLQGVVRVRVSLSTQEAVITYQPYLIQPQDLRDHVSDMGFEAVIKNKVVPVSLGPIDIERLQSTNPKTPLASDNRSLNNSETLEHQGSHTVTLQLRVDGMHCTSCVLNIEENIGQLPGVQSVQVSLESRMAQVQYDPSHLTATALQRAIEALPPGNFKVSLPDGVAGNGTGRRSSNRVVPAPTQRPQVLGVCDTVVLAIAGMTCASCAQSIEGLISQREGVQRISVSVADGTGVVLYDPSVTNPEELRAAVEEMGFEASVISENYSTNHVGNHSAGNSTAPPTAGVPASVQEVAPRAGGLPKNHNSGSLSKPPQASTTVTPQKCFLQIAGMTCASCVSHIEKSLQKEAGILSVLVALMAGKAEVKYNPEVIQPLEIAQLIQDMGFEATVMEDYTGSDGDLELIITGMTCASCVHNIESRLTRTNGITYASVALATSKAHVKFDPEIIGARDIVRIIEEIGFHASPAQRNSSAHHLDHKVEIKQWRKSFLCSLVFGIPVMGLMIYMLVPSHEPHEAMVLDRNIIPGLSILNLIFFILCTFVQLLGGWYFYVQAYRSLKHGTANMDVLIVLATTIAYTYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHVAKSKTSEALAKLMSLQATEATVVTLGEDNLIVREEQVPMELVQRGDIIKVVPGGKFPVDGKILEGNTMVDESLITGEAMPVTKKPGSIVIAGSINAHGSVLVNATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIISTLTLVVWIIIGFIDFGVVQKYFPTHNKHISQTEVIIRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPKVMRVLLLVDVAMMPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELGTDSLGYCTDFQAVPGCGIGCKVSSVEGILAHGESQQSKQAAPPSRAGSAPEEIDVTPQTFSVLIGNREWMRRNGLTISSDVSDAMANHELKGQTAVLVAIDGVLCAMIAIADAVKQEAALAVHTLKSMGVDVVLITGDNRKTARAIATQVGIKKVFAEVLPSHKVAKVQELQNEGKKVAMVGDGVNDSPALAQADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVWRIHLNLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYKKPDLERYEAQAQGRMKPLTASQVSVYIGMDDRRRDSPRATPWDQVSFISQVSLSSLKSDKLSRHSAAAEDGGDKWSLLLNDRDEEQCI"

     misc_feature    129..320
                     /gene="LOC111146971"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(147..155,162..164)
                     /gene="LOC111146971"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    384..572
                     /gene="LOC111146971"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(402..410,417..419)
                     /gene="LOC111146971"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    726..902
                     /gene="LOC111146971"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(744..752,759..761)
                     /gene="LOC111146971"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1026..1232
                     /gene="LOC111146971"
                     /note="Copper chaperone CopZ [Inorganic ion transport and
                     metabolism]; Region: CopZ; COG2608"
                     /db_xref="CDD:442020"
     misc_feature    1422..1610
                     /gene="LOC111146971"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1437..1445,1452..1454)
                     /gene="LOC111146971"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1647..1838
                     /gene="LOC111146971"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1665..1673,1680..1682)
                     /gene="LOC111146971"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1902..4010
                     /gene="LOC111146971"
                     /note="P-type heavy metal-transporting ATPase, similar to
                     human copper-transporting ATPases, ATP7A and ATP7B;
                     Region: P-type_ATPase_Cu-like; cd02094"
                     /db_xref="CDD:319783"
     misc_feature    order(2895..2897,2901..2903,3939..3941)
                     /gene="LOC111146971"
                     /note="putative Cu binding site [ion binding]; other site"
                     /db_xref="CDD:319783"
     misc_feature    order(3027..3035,3237..3239,3390..3398,3486..3488,
                     3606..3614,3672..3674,3681..3683,3690..3692,3747..3749,
                     3756..3758)
                     /gene="LOC111146971"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319783"
ORIGIN      

agatcttgtctaaactttctttgcccgctcgtgcccgggagccagcgatgaagcagagttttgcctttgacaatgtcggctacgaaggcggcctggacactgtggacccccctcagacggccactggcaccatcagcatttcgggcatgacttgccagtcatgtgtaaagtctattgagggcaggatttccagcctgaaaggcatcgtgagcattaaggtttccctggaacagggcagtgcgacggtgaggtatgtgccgtcaatcctgagcctgctgcagatttgccgtcacattgaggacatgggcttcgaggccagcgtctcagagggaaaggctgcctcctggccctcgaggtcctcgcctggcctcgaggctgtggtcaagcttcgggtggaaggcatgacctgccagtcctgcgtcagctccattgaaggcaagctcgggaaactgcagggagtagtgagagtccgagtgtccctcagcacccaggaggcagtcattacttaccagccttacctgattcagccccaggacctcagggaccacgtcagcgacatgggctttgaagctgtcatcaagaacaaagtggtgcctgtaagcctgggacccattgatatcgagcgcttacagagcaccaacccaaagacccctttggcttctgataaccggtccctcaataactctgagaccttggagcaccaagggagccacacagtcaccctgcaactgagagtagatggaatgcactgtacgtcttgtgtcctgaatattgaagaaaacataggccagctccccggggttcaaagtgttcaagtgtccttggagagcagaatggcccaagtacagtatgacccttctcacctcaccgccactgccctgcagagggccatcgaagcgcttccacctgggaacttcaaagtctctcttcctgatggtgtggcaggaaatgggacaggtcgcaggtcttccaaccgtgtcgtccccgcccccacgcagagaccccaggtgttgggggtgtgcgatactgtggtgctcgccattgctggcatgacctgtgcgtcctgtgctcagtccatcgaaggcctcatctcccaaagggaaggggtacagcggatatcggtctctgtggctgatgggaccggcgtggtgctctatgatccgtctgttactaatccggaagaactccgagctgctgttgaagaaatgggatttgaggcttcagtcatttctgaaaactattccaccaaccatgttggaaaccacagtgcagggaattccacagcgccccccacagctggcgttcctgcgtctgtacaggaagtggctccccgtgccggggggctccctaaaaaccacaactctggctccttgtccaagcccccacaggcctctaccacagtgactccccagaagtgctttctacagatcgcaggcatgacctgtgcatcctgtgtgtcccacatagagaagagcctgcagaaggaagcaggtattctgtcggtgctggttgccctcatggctgggaaggcagaggtcaagtataacccagaagtcatccagcccctggagatagctcagctcatccaggacatgggctttgaggcgacagtaatggaagactacacaggctctgatggcgacctcgaactcatcatcacggggatgacctgcgcgtcctgtgttcacaacattgagtccagactcacaaggacaaacggcatcacctacgcctctgtggcccttgccaccagcaaagcccatgtgaaatttgatcctgaaattatcggtgcacgggatattgtccgaattatcgaggaaatcggctttcatgcttccccggcccagagaaactccagcgcgcatcacttggaccacaaggtggaaataaagcagtggaggaagtctttcctgtgcagcctagtgttcggcatccccgtcatgggcctcatgatctacatgctggtgcccagccatgagccccatgaggccatggtgctggaccgcaacatcattccgggactgtccatcctcaatctcatcttctttatcttgtgtacctttgtccagctcctcggcgggtggtacttctacgtccaggcctacaggtctctgaagcatgggacggccaacatggacgtgctcatcgtgctggccaccaccatcgcctacacctactcgctcgtcatcttagtggtggccgtagctgagaaggcggagaggagccccgtgaccttcttcgataccccccccatgctctttgtgttcattgccctggggcggtggctagaacacgtggcaaagagcaaaacctcagaagcccttgccaaactcatgtctctccaagccacagaagccaccgttgtgacccttggtgaggacaacttgattgtcagggaggagcaggtgcccatggagctggtgcagcggggcgacatcatcaaggttgtccccggggggaagttcccagtggatgggaaaatcctggaaggcaacaccatggtggacgagtccctcatcacaggagaagccatgcctgtcacgaagaaacccggaagcatagtgattgctgggtctataaatgcacatggctctgtactcgttaatgccactcacgtgggcaatgacaccacgttggctcagatcgtgaaattggtagaagaggctcagatgtcaaaggcacccattcagcaactggctgaccggtttagtgggtattttgtcccatttatcatcatcatttcaacgctgacgttggtggtatggattataatcggttttatcgattttggtgttgttcagaaatactttcccacccacaacaagcacatctcccagacagaggtgatcatccggtttgcgttccagacgtccatcacggtgctgtgtatcgcctgcccctgctccctgggcctggccacgcccacggcggtcatggtgggcaccggggtggccgcccagaatggcatcctcatcaaaggaggcaagcctctggaaatggcccacaagataaagaccgtgatgtttgacaaaactggcaccatcacccatggggtccccaaagtcatgagggtcctcctgctcgtggatgtggccatgatgcccctcaggaaggttcttgctgtggtggggactgcggaggccagcagcgagcaccccttgggtgtggcagtcaccaagtactgtaaagaggaattgggaactgactccctgggatactgcacggacttccaagcagtgcccggctgtggcatcggctgcaaagtcagtagtgtggagggcatcctggcccacggcgagagccagcagagcaaacaggcggctcccccgagcagggctggcagcgctcccgaggaaatagacgtgaccccccagaccttctctgtgctcatcgggaaccgcgaatggatgaggcgcaacggcctaaccatttccagcgacgtcagtgacgcgatggcgaatcatgagctgaaaggccagacggccgtcctggtggccattgacggcgtgctctgtgccatgatcgccatcgccgacgcggtcaagcaggaggcagccctggccgtgcacacgctgaagagcatgggtgtggacgtggttctgatcacaggggacaaccggaagacggccagagccatcgccacccaggttggtatcaagaaagtctttgcagaggtgctgccttctcacaaggtggccaaggtccaggagctccagaatgaagggaagaaagttgccatggtaggagacggggttaacgactcgccggccttggcccaggccgatgtgggcattgccatcgggacgggcacggatgtcgccatcgaggccgctgacgttgtcctcatcagaaacgatttgctcgatgtggtggctagcattcacctctccaagaggaccgtctggagaatacacctcaacctggtgctggcgttgatttataacctggtcggaatacccatcgcggcaggggtcttcatgcccatcggcatcgtgctgcagccgtggatgggctcagcggccatggcggcctcctctgtgtctgtggttctctcgtcgctgcagctcaagtgctataagaagcctgacctggagcggtatgaggcccaggcccagggccgcatgaagcccctgacggcgtcgcaggtgagcgtatacatcggcatggatgaccggcggcgggactccccgagggccacgccctgggaccaggtcagcttcatcagccaggtgtctctgtcctccctgaagtccgacaagctgtctcgacacagtgctgcggctgaggatggtggggacaagtggtctctgctcctgaacgacagagatgaggagcagtgcatctgaaagctgcgggcaggtggagacccaggggtctgtctcctcactgagtagctggcccggcttccccggggaccgaggctcgggcggaacaggcacagctccagcagcaagatgggcgaagctcccctccagccctggggacttccactccctggagatggctggtcatccctcctagcatgggcggtgccccaatgtgactcctgggccccccccttcccgcccccactgggatcccagcggcacaggggccaggcttcccggcctgaccatgctgtgggcctgggcttgtcgggaaccttgctggactctagcagagcaggggacagccagccttcctcgcaaacctttgctttagtgtttggaacgactgcttgtaaaacaaggaaaatctcatcgggaccaaaaacttagctgggcctttcctcacgagaagcctcgtgttgggttctttttgacaacacccacatgattgcgtatctgagaccacagtttacctcaaatacacccactgatgtctgctggca

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