LOCUS       XM_022496242            2710 bp    mRNA    linear   MAM 20-SEP-2017
DEFINITION  PREDICTED: Enhydra lutris kenyoni protein argonaute-3
            (LOC111142870), transcript variant X3, mRNA.
ACCESSION   XM_022496242
VERSION     XM_022496242.1
DBLINK      BioProject: PRJNA407952
KEYWORDS    RefSeq.
SOURCE      Enhydra lutris kenyoni (northern sea otter)
  ORGANISM  Enhydra lutris kenyoni
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia;
            Musteloidea; Mustelidae; Lutrinae; Enhydra.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_019154093.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Version          :: Enhydra lutris kenyoni Annotation
                                           Release 100
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 7.4
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2710
                     /organism="Enhydra lutris kenyoni"
                     /mol_type="mRNA"
                     /isolate="GAN:26980312"
                     /sub_species="kenyoni"
                     /db_xref="taxon:391180"
                     /chromosome="Unknown"
                     /sex="male"
                     /tissue_type="blood"
                     /dev_stage="adult"
     gene            1..2710
                     /gene="LOC111142870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 6 mRNAs, 2 ESTs, 4 Proteins, and
                     99% coverage of the annotated genomic feature by RNAseq
                     alignments, including 1 sample with support for all
                     annotated introns"
                     /db_xref="GeneID:111142870"
     CDS             67..1947
                     /gene="LOC111142870"
                     /codon_start=1
                     /product="protein argonaute-3 isoform X3"
                     /protein_id="XP_022351950.1"
                     /db_xref="GeneID:111142870"
                     /translation="

MCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA"

     misc_feature    67..408
                     /gene="LOC111142870"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(202..204,247..249,289..291,301..303,355..357,
                     376..378,382..384)
                     /gene="LOC111142870"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    541..1818
                     /gene="LOC111142870"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(952..954,964..966,1000..1011,1018..1020,1042..1044,
                     1051..1053,1063..1065,1075..1077)
                     /gene="LOC111142870"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1156..1158,1162..1164,1372..1374,1786..1788)
                     /gene="LOC111142870"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

ccatcccccaagtctgaattagtttctgccactgccttctacaaagcacaacctgtaattcagttcatgtgtgaagttcttgacattcataatattgatgagcagccaagacctctgactgattctcatcgggtaaaattcaccaaagagataaaaggtctgaaggttgaagtgactcattgtggaacaatgagacggaaataccgtgtttgtaatgtaacaagaaggcctgccagtcatcaaacctttcctttacagttagaaaacggtcaaactgtggagagaacagtagcacagtatttcagagaaaagtacactcttcagctgaagtacccacaccttccttgtctgcaagtggggcaggaacagaaacatacctacctgccactagaagtctgtaatatcgtggcagggcaacgatgtatcaagaagttaacagacaatcagacttccacaatgatcaaggcaacagcaagatctgctccagatagacaagaggaaattagcagattggtaagaagtgcaaattatgaaacagatccatttgttcaggagtttcaatttaaagttcgggatgaaatggcccatgtaaccggacgtgtacttccagcacctatgctgcagtatggaggacggaatcggacagtagcaacaccaagccatggagtgtgggacatgcgggggaaacagtttcacacaggagttgagataaaaatgtgggctatagcttgttttgccacacagaggcagtgcagagaagaaatactgaagggtttcacggaccagctgcgtaagatttccaaggatgcagggatgcccatccagggccagccttgcttctgcaaatatgcgcagggggcagacagtgtggagcccatgtttcggcatctcaagaacacctactctgggctacagctcattatcgtcatcctgccagggaagacgcccgtatatgcggaagtgaaacgtgtaggagatacacttttgggtatggccacacagtgtgtccaagtcaagaatgtaataaaaacatcccctcaaactctctcaaacctgtgcctaaagataaatgttaaactcggagggatcaataatattcttgtacctcatcaaagaccttctgtgttccagcaaccagtgatctttttgggagcagatgtcactcatccaccagctggtgatgggaagaagccttcgattgctgctgttgtaggtagtatggatgcccacccaagcagatactgtgccacagtaagagttcagcgaccccgacaggagatcatccaagacttggcctccatggttcgagaacttctcattcagttttataagtcaactcggttcaaacctactcgtatcatcttttatcgggatggtgtttcagagggacagtttaggcaggtattatattatgaactactagcaattcgagaagcctgcatcagtctggagaaagactatcaacctggaataacctacattgtagttcagaagagacatcacactcgattattttgtgctgataggacagaaagggttggaagaagtggcaatatcccagctggaacaacagttgatacagatattacacacccatatgagtttgatttttacctctgtagccatgctggaatacagggtaccagccgtccttcacactatcatgttttatgggatgataactgctttactgcagatgaacttcagctcctaacttaccagctctgccacacttacgtgcgctgtacacgatctgtttctatacctgcaccagcgtattatgctcacctggtggcattcagagccagatatcatctcgtggacaaagagcatgacagtgctgaaggaagtcacgtttcaggacagagcaacgggcgagatccacaagctcttgccaaggctgtacagattcaccaagataccttacgcacaatgtactttgcttaaaaagtccaagaatattctctgagaggaagaactgaaagatgcatcgacatacagcatatgtttccagtggagtcagttgagtggggatgcctccagccatacagcaaccaacactgtgtggggaccagggtctgatttttatgttgatacaagaaagattgtttacttcatcaaggaacacagcaccattatgcaatatgaaaccagccaactgcttttttgtgcggtctccttaggaagtatcgccattgttttgttttcactttcttgtagtctaacccttttaatgcctttacctcaagttgcttggcagcacaactatctttgcaaaaaaaaaaagtaaagaaaaagtcaatgacagttaaaaaaaaacacacacctacgtgaataagcgattgttcacgattatgtgtgcaaaaaaattaatgtgcattcgagtattcttgtaaaaggtatctgtgtatattttaaatatatacatgtatacttcatgtgcatatatatctgatctacattgataatagatatatatgtgtctgtgcgtgtattttatagttcattccattggggaactttcttttccttttattatcttcccaccaccactttgatttttctctctacctcccttgccttcattacctacatttttttttcttaatgctaccagtgacattcagatgttcatgtatctggttcatttggatataaagcatggcaaactagatttttatttttattttgcacaccctattcctgtctc

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