LOCUS       XM_022464324            5219 bp    mRNA    linear   INV 06-JAN-2026
DEFINITION  PREDICTED: Crassostrea virginica copper-transporting ATPase 1-like
            (LOC111122539), transcript variant X1, mRNA.
ACCESSION   XM_022464324
VERSION     XM_022464324.2
DBLINK      BioProject: PRJNA1395139
KEYWORDS    RefSeq.
SOURCE      Crassostrea virginica (eastern oyster)
  ORGANISM  Crassostrea virginica
            Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
            Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae;
            Crassostrea.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_136048) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Jan 6, 2026 this sequence version replaced XM_022464324.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_053477285.1-RS_2025_12
            Annotation Pipeline         :: NCBI Eukaryotic Genome Annotation
                                           Pipeline (EGAP)
            Annotation Software Version :: 10.5
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 12/30/2025
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5219
                     /organism="Crassostrea virginica"
                     /mol_type="mRNA"
                     /isolate="SEPT_11B"
                     /isolation_source="whole tissue of the animal"
                     /db_xref="taxon:6565"
                     /chromosome="2"
                     /tissue_type="Pooled whole tissue"
                     /dev_stage="adult"
                     /geo_loc_name="USA: NY, long island sound"
                     /collection_date="2024-10"
                     /collected_by="Josephine Hoh"
     gene            1..5219
                     /gene="LOC111122539"
                     /note="copper-transporting ATPase 1-like; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 EST, 3 Proteins, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 44 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:111122539"
     CDS             16..4407
                     /gene="LOC111122539"
                     /codon_start=1
                     /product="copper-transporting ATPase 1-like isoform X1"
                     /protein_id="XP_022320032.2"
                     /db_xref="GeneID:111122539"
                     /translation="

MLGEETQEMEKVTDLHIEGMTCQSCIDKIQDHMAREPGVIHVQMFLEEKEAKITYSPTETSPPILAEQISDMGFPSKVKLVHPVRGDNCQDAIINVGGMTCQSCVKSIESKMLEVSGILGITVSLLKKQAYVQFNPGKISAESIASAIDDMGFEASVHSITRDKGLTTKIGVEGMTCQSCVNSIESAMRGKPGVREIKVSLSDKEAYIVYDPTLTSPGSLRDQIDDMGFEATLARESSIESEFDRLASRQSSTRSVQSELVCQIAVKGMTCQSCVKNIESNISPKPGVMSISVSLEKEMASVTYNPLVTNPTSIAGMIDDMGFEASVEGSDAEPSTDTVVVGVEGMTCHSCVKSIEEHISKNPAVKSIKVSLADQNANIEYYPNRATPSTLRDAIDDMGFTASLPTDDVAVKVVQPKKSSGIKPKSPSESLKIELDKGAVSFRKGGDIVDDDLEKCFLRVTGMTCASCVATIEKNLMKVEGIHSCLVALMAQKAEVKYDPAYLLPSQIAAKISSLGFEATVLESEGFGQGVVELLITGMTCSSCVHMIESSIMKKPGVIQASVALSTCKGKFTYNPEVTGPRAIIEAIKSLGYQAELYTDDDKDAARYDHRDEIKRWRTSFLWSLIFGVPSVVIMMYFMFTPPPEEHNSVTNTTAGNYTTTHKPQTSSEGHYQIMIVAGLSLDNLLMFILATPVQFIGGRYFYIQAFKALRHGAANMDVLVVLATTISYVYSCVVVIVAMIMKEKTSPVTFFETTPMLMVFISLGRWLEHVAKGKTSEALAKLMSLQASEAVLVEIDKEFNILNEQTINVDLVQRGDVLKVVPGEKIPVDAKIIEGTTTCDESLITGESMPVSKKPGSSVIGGSINQHGMILVQATHVGSDTTLSQIVKLVEEAQTSKAPIQQLADKIAGYFVPGVVILSTLTVIAWAIVGYVDVTKVMPDFVNDGTISRDEVIFQKAFQYAITVLSIACPCALGLATPTAVMVGTGVGATNGILIKGGEPLECSHKLKCIVFDKTGTVTHGVPRVARVAMFVENSICSFVKLIAIAGTAENSSEHPLASAIVKYAKQTLKTETLGKTQNYQAVPGCGLKCTVTQIDGILVDIDMEGVNNRKNLMGSTRVKTDNVLYDREEISATIEESSLVGAVASRPYDVLIGNREWMTRNGLIVTDKMDETMIEHEHQGQTAILCAIDGNIIAMLAVADTVKSEAHLAISVLKDMGLQVVLLTGDNQKTARAIARQIGIHKVFAEVLPSHKVKKIKQLQKQGMKVAMVGDGVNDSPALAQADVGIAIGTGTDVAVEAADVVLIKNDLLDVAAAIQLSKKTVQRIRINFFAASIYNLIGIPIAAGIFVPWGLSLKPWMASAAMAMSSVSVVFSSLLLKTFKKPNKEKMLTPKYYAKFAADQELDNISVHRGVESMPSSREGSKQGSIISRLSGRKKPTTPDHTSLLEMGENSDSDSSDQLG"

     misc_feature    40..252
                     /gene="LOC111122539"
                     /note="Copper chaperone CopZ [Inorganic ion transport and
                     metabolism]; Region: CopZ; COG2608"
                     /db_xref="CDD:442020"
     misc_feature    289..486
                     /gene="LOC111122539"
                     /note="Copper chaperone CopZ [Inorganic ion transport and
                     metabolism]; Region: CopZ; COG2608"
                     /db_xref="CDD:442020"
     misc_feature    514..717
                     /gene="LOC111122539"
                     /note="Copper chaperone CopZ [Inorganic ion transport and
                     metabolism]; Region: CopZ; COG2608"
                     /db_xref="CDD:442020"
     misc_feature    802..993
                     /gene="LOC111122539"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(820..828,835..837)
                     /gene="LOC111122539"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1042..1224
                     /gene="LOC111122539"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1051..1059,1066..1068)
                     /gene="LOC111122539"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1387..1575
                     /gene="LOC111122539"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1402..1410,1417..1419)
                     /gene="LOC111122539"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1612..1803
                     /gene="LOC111122539"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1630..1638,1645..1647)
                     /gene="LOC111122539"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1876..4092
                     /gene="LOC111122539"
                     /note="P-type heavy metal-transporting ATPase, similar to
                     human copper-transporting ATPases, ATP7A and ATP7B;
                     Region: P-type_ATPase_Cu-like; cd02094"
                     /db_xref="CDD:319783"
     misc_feature    order(2923..2925,2929..2931,4024..4026)
                     /gene="LOC111122539"
                     /note="putative Cu binding site [ion binding]; other site"
                     /db_xref="CDD:319783"
     misc_feature    order(3055..3063,3265..3267,3475..3483,3571..3573,
                     3691..3699,3757..3759,3766..3768,3775..3777,3832..3834,
                     3841..3843)
                     /gene="LOC111122539"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319783"
     polyA_site      5219
                     /gene="LOC111122539"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

ttaaggaaggcaacaatgttgggagaagaaacacaggagatggaaaaggtaacagacctccatattgagggcatgacctgccagtcgtgtattgataaaatccaagaccacatggctcgggaaccaggggttattcatgtacagatgtttctggaggaaaaagaggcaaagattacttacagtcccactgagacatcccctcccatactggctgaacaaatctcagacatggggttcccttcaaaggtcaagctagtgcatccagtgaggggagacaactgtcaggatgccatcatcaatgtagggggcatgacatgtcagtcttgtgtcaagtccatagagtccaaaatgttggaggtcagtgggatactgggaataacagtgtccctgttgaagaaacaggcctatgtccagttcaacccgggcaaaatatctgctgagagtattgcttcagccatagatgacatgggttttgaggcctcggtacattccatcacacgtgataagggtctgaccaccaagataggggtggagggcatgacatgccagtcttgtgtcaactccattgaatctgccatgagaggcaagccaggagtaagagaaataaaggtgtctcttagtgataaagaggcctacatagtgtatgatcccaccctcaccagtccgggatcactccgggatcagattgatgatatgggatttgaagcaacactggcaagagagtcctctattgagagtgaatttgaccgcttggcgtcacgacagtcatccaccagatcagtgcaaagtgaattagtctgccaaatagctgtgaaagggatgacctgtcaatcttgtgtgaagaatattgaaagcaacatttcacccaaacccggagtaatgtctatatctgtgtcattggaaaaagaaatggccagtgtgacttacaaccccctggttaccaatcccacctccatagctgggatgatcgatgacatgggatttgaggcctcggtagagggttcggacgcagagccgtccactgatacggtggttgtgggagtagaaggcatgacctgccattcctgtgtaaaaagcatcgaggaacacatctccaagaacccggctgtcaagtccatcaaggtctctctggcagatcagaatgccaacattgagtattatcccaatagggccactccatccactttgagagatgccatagatgacatgggctttactgcatctctaccaacagatgatgtagcagtgaaggttgtacagcccaaaaagagcagtgggatcaaaccaaagtctccttcagagagtttgaagattgagctagataaaggagctgtgtctttcaggaagggaggggacattgttgatgatgacctagagaagtgctttctgagagtcacagggatgacctgtgcttcctgtgtggccaccatagagaaaaatctaatgaaagtagagggtatacacagttgtttggtagccctgatggcacagaaagcagaggtgaaatatgacccagcctatttattgccatcccagattgcggctaaaatttccagcttggggtttgaagccaccgttttggagagtgaaggatttggccagggagttgtggaacttttgataacagggatgacatgttcttcatgtgtgcacatgattgaatcctccatcatgaagaagccgggggtgatccaggcctcagtggccctatccacctgtaaaggcaagttcacctataacccggaagtcacaggtccaagggcaatcattgaggccatcaagtctttgggataccaagctgagttgtacactgatgatgataaagatgctgctcgttatgaccatagagacgaaatcaaaaggtggagaacctcctttctgtggtctctgatctttggagttccatctgtggtgatcatgatgtacttcatgtttactcctccccctgaggagcacaattctgtcactaatactaccgcagggaattacaccaccacccacaaaccccagacgtcatctgaaggtcactaccagatcatgatagtagccggtctctcactggacaaccttcttatgtttattttggccacaccggtacagtttattggtggacgatacttctacatacaagctttcaaggcgctccgacacggagcagcaaacatggacgtcctggttgttcttgccaccactatctcctacgtgtactcctgtgtggtggtcattgtggccatgatcatgaaggagaaaactagccccgtgactttctttgaaacaactcccatgttgatggtgtttatatcccttggtagatggctggaacatgtagcaaagggtaaaacatcagaagctcttgccaagctgatgtctctgcaggcttcagaggctgtgctggtggagattgataaagaattcaatattctgaatgaacaaacaattaatgtggatttagtgcagagaggggatgtacttaaggttgttcctggtgaaaagattcctgtggatgccaagatcattgagggaaccaccacttgtgatgagtcccttattacaggggagtctatgcctgtctctaagaagccaggttcctctgtgattggtggttccatcaatcagcatggcatgattctagtgcaggctacacatgtggggtctgacaccaccctgtcccagattgtcaagctcgtggaagaggctcagacctcaaaggcgcctatacagcagcttgctgacaagatagctgggtatttcgtacctggggtggtcattctgtccactcttactgtcattgcttgggccatagtgggctatgttgatgtcaccaaagtcatgccagacttcgtgaatgatgggaccatttccagagatgaggtcatcttccagaaggctttccagtatgccatcacagttctaagtattgcctgtccttgtgccctggggctggccacacccacagctgtcatggtgggaactggtgtaggggccacaaatgggatactgatcaaggggggtgaacccctggaatgttctcacaaattgaagtgtatagtgtttgataagactgggacggttacccatggggttcctcgtgtcgcccgtgtggccatgtttgtggagaactcaatctgctcatttgtcaaactgatcgccattgctggaactgctgaaaatagcagtgaacatcccctggcttcagccatcgtcaagtatgcaaaacagactctgaagacggagaccttgggtaagacccagaactaccaggcagtgccaggctgcggtctcaagtgtaccgtgacccagatcgacgggatactggtggacattgacatggagggtgtgaacaacaggaagaacctaatgggcagcaccagagtcaagaccgacaatgtcctgtatgacagggaggagatcagcgctactattgaagagagtagtttggttggtgcagtggcctccaggccctacgacgtactgattggaaaccgtgaatggatgacaaggaatggattgattgtgacagataaaatggacgaaacgatgattgagcacgaacatcagggacaaacagccattctgtgtgctattgatggtaatattatagcgatgttggctgtggccgacactgtgaagtcggaggctcacctggcaatcagtgtccttaaagacatggggctacaggtggttctactgactggagacaaccagaaaactgccagagccattgctagacagattggaatccacaaagtctttgctgaagtcctaccctctcacaaagtaaagaagataaaacagcttcagaagcagggtatgaaggtggcaatggtaggggatggggtgaatgactcgcctgccctggcccaggcagatgtgggcatcgccataggaaccgggaccgatgtagctgtggaggcggctgatgttgtcctcatcaagaatgatcttctagatgtggcagcagccattcagctctcaaagaaaactgtccagagaatacgcatcaactttttcgctgcttccatttacaacttgattggcatcccaattgcggctgggatctttgtgccgtggggtctgtccctcaagccctggatggcatcagcagctatggccatgtcctctgtatctgtagtcttttcctctttactcctcaaaacgtttaagaagcccaacaaggaaaagatgctgactcctaaatattatgcaaagtttgctgcggaccaggagctggacaatatttctgttcatcgaggcgtggagagtatgccatccagccgtgaaggaagtaagcaaggaagcatcatttcacgcttgagtggtcggaagaagccaaccacgccagatcacacaagtctgctggagatgggagagaactctgactccgactccagtgatcagctgggataagcatcaactggatgctttagtttgtgaatcatgaacttgtataaacttgtttcaggtggataccactgtcatcataatgttgtaatcagacactaagataaggaaaaagtcagccatatttatagctcagtggtccaatgcatttagtttcaaattaggcatttgagccccaagtttttaaaaatattatacaacacattatgctaaattatgttcagtaaattggtacaattgtattacacaaattcaagtcacagaactgtgatacattaacatttgattcagagcttatttctccttccccttttcaaaaatgtgtcacgcattagatatttggtttttatattaatttgaagctttcacaagaattagttttgcatcatggtagaatatttatctagtttccacaactgtagaatgtatatatcacttatgacaaacttaatacaatcatgtaatcattgtcatgttgttttcttttaaggattttgcttggtaacacttacaggagtatttttactactcaattgtgtacttaagagtcccaaccatttaccagtttttaaccgttgatgatgtgtcccctttgttgtccatcttttacatacacaccttctagtgtagtccctcaaatacatctgtaatacagtccagttcaaacaacacaagtgatttgttgttcagaatagaacaggccaataatctggataaagcagagctttgacagacagtttcatctgtctcctactgaatttgttatgacttgtaactgttgcttatacatgtgtgttatgaataaaaatcttatatta

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