LOCUS       XM_020158576            3405 bp    mRNA    linear   ROD 15-FEB-2017
DEFINITION  PREDICTED: Castor canadensis nuclear factor kappa B subunit 1
            (Nfkb1), mRNA.
ACCESSION   XM_020158576
VERSION     XM_020158576.1
DBLINK      BioProject: PRJNA371604
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Castor canadensis (American beaver)
  ORGANISM  Castor canadensis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
            Castorimorpha; Castoridae; Castor.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_017870064.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Version          :: Castor canadensis Annotation Release
                                           100
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 7.3
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 5% of CDS bases
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3405
                     /organism="Castor canadensis"
                     /mol_type="mRNA"
                     /isolate="Ward"
                     /db_xref="taxon:51338"
                     /chromosome="Unknown"
                     /sex="male"
                     /tissue_type="Leukocyte"
                     /dev_stage="adult"
     gene            1..3405
                     /gene="Nfkb1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 19 Proteins, and 94% coverage of
                     the annotated genomic feature by RNAseq alignments"
                     /db_xref="GeneID:109682963"
     CDS             1..2832
                     /gene="Nfkb1"
                     /codon_start=1
                     /product="nuclear factor NF-kappa-B p105 subunit"
                     /protein_id="XP_020014165.1"
                     /db_xref="GeneID:109682963"
                     /translation="

MTVGQVHRLECLKPALQSHSGELGYAALSTFLVPLITHTAFAMKNCDESAEENILICNYVGPAKVIVQLVTNGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANLGILHVTKKKVFETLEARMTDACVRGYNPGLLVHPELGYLQAEGGGDRQLTDQEKELIRQAALQQTKEMDLSVVRLMFTAFLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTAGCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGDFSPTDVHRQFAIVFKTPKYKDVNITKPASVFVQLRRKSDLETSEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGSGAGAGGGGMFGSGGAGGSTGNPGPGYGFPHYGFPTYGGITFHPGTTKSNAGMKHGIINTECENDPEGYDNSDDRETVNLSGKESKPTEQDKESGKSSSRNEVTLTYRVGVKEENACRFQDNLFLEKAMQLAKRHANALFDYAVTGDVKVLLAVQRHLTAVQDENGDSVLHLAIIHLHAQLVRDLLEVTSGLVSDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRSGADLSLLDRLGNSVLHLAAKEGHDTILSIVLKHRKAALLIDHPNGEGLNAIHIAVMSNSLPCLLLLVASGADVNARERKSGRTALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTKLAALLKAAGADPLVENFEPLYDLDDPWENAGEDEGVVPGTTPLDMAANWQVFDILNGKPYEPEFTPDEQGDMKQLNEDAKLQLYKLLEIPDPDKNWATLAQKLGLGILNNAFRLSPAPSKTLMDNYEVSGGTIKELVEALRQMGYTEAIEVIQAAFCTSGTTVSSPKKNTSQAHLLPHSPSSTRQHIDELQDSDSICDSGVETSFRKLSFTESLTGSSSLITLNKMPHNYGQEGPIEGKI"

     misc_feature    145..639
                     /gene="Nfkb1"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD); Region: RHD-n; cl08275"
                     /db_xref="CDD:447596"
     misc_feature    658..963
                     /gene="Nfkb1"
                     /note="IPT domain of the transcription factor NFkappaB and
                     related transcription factors. NFkappaB is considered a
                     central regulator of stress responses, activated by
                     different stressful conditions, including physical stress,
                     oxidative stress, and exposure to...; Region:
                     IPT_NFkappaB; cd01177"
                     /db_xref="CDD:238582"
     misc_feature    order(661..663,667..675,679..687,805..813,850..852,
                     886..888,943..945,952..954,958..960)
                     /gene="Nfkb1"
                     /note="ankyrin protein binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:238582"
     misc_feature    order(667..672,676..678,715..717,721..723,727..729,
                     826..831,838..840,844..846)
                     /gene="Nfkb1"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238582"
     misc_feature    order(730..732,736..738,829..834)
                     /gene="Nfkb1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238582"
     misc_feature    1396..2217
                     /gene="Nfkb1"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     Region: ANKYR; COG0666"
                     /db_xref="CDD:440430"
     misc_feature    order(1534..1536,1540..1542,1552..1557,1564..1572,
                     1576..1581,1591..1593,1600..1602,1645..1647,1651..1653,
                     1657..1659,1669..1674,1681..1689,1693..1698,1708..1710,
                     1717..1719,1744..1746,1750..1752,1756..1758,1768..1773,
                     1780..1788,1792..1797,1807..1809,1816..1818)
                     /gene="Nfkb1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    1534..1647
                     /gene="Nfkb1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1651..1746
                     /gene="Nfkb1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    order(1858..1860,1864..1866,1876..1881,1888..1896,
                     1900..1905,1915..1917,1924..1926,1951..1953,1960..1962,
                     1966..1968,1978..1983,1990..1998,2002..2007,2020..2022,
                     2029..2031,2056..2058,2062..2064,2068..2070,2080..2085,
                     2092..2100,2104..2106)
                     /gene="Nfkb1"
                     /note="oligomer interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:293786"
     misc_feature    1858..1953
                     /gene="Nfkb1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    1960..2058
                     /gene="Nfkb1"
                     /note="ANK repeat [structural motif]; Region: ANK repeat"
                     /db_xref="CDD:293786"
     misc_feature    2347..2571
                     /gene="Nfkb1"
                     /note="Death domain of the Nuclear Factor-KappaB1
                     precursor protein p105; Region: Death_NFkB1_p105; cd08797"
                     /db_xref="CDD:260063"
ORIGIN      

atgaccgtgggccaagtccacaggcttgagtgtctaaagccagccctccagtcacatagtggggagttaggatacgctgctctgtctaccttccttgttcccttgatcactcacacagcttttgctatgaaaaattgtgatgagagtgcagaggaaaacattttgatctgcaactatgtgggacctgcaaaagttattgttcagttggtcaccaatggaaaaaatatccacttgcatgcccacagcctggtgggaaaacactgtgaggacgggatctgcactgtgactgctggacccaaggacatggtggtcggctttgcaaatttgggaatacttcatgtgacgaagaaaaaagtctttgaaacactggaggcacgaatgacggatgcatgtgtaaggggctataatcctggactgttggtgcaccctgaacttggctatctgcaggcagaaggtggaggggaccgacaactcacagatcaagaaaaggagcttatccggcaagcagcgctgcagcagacaaaggagatggatctcagcgtggtgcgcctcatgttcacggcttttctccctgacagcactgggagcttcacaaggcgtctggaacccgtggtatcagacgccatctatgacagcaaagcccccaatgcatccaacttgaaaattgtaagaatggacaggacagcaggatgtgtaactggaggggaagaaatttatcttctctgtgacaaagttcagaaggatgacatccagattcgattttatgaagaggaggaaaacggtggagtttgggagggatttggagatttttctcccacagatgtccatagacaatttgccattgtcttcaaaactccaaagtataaggatgtcaacattacgaaaccagcttctgtgtttgtccaacttcggaggaaatctgatttggaaactagcgaaccaaaaccttttctctactacccggaaatcaaagataaagaggaagtgcagaggaagcggcagaagctcatgcccaacttttcggatagtttcggtggtggcagtggtgcgggagctggaggcggaggcatgtttggtagtggcggtgcaggagggagtactggaaatccaggtccagggtatggctttccacactatggatttcctacatatggtgggattaccttccatcctggaaccactaaatccaatgctgggatgaagcatggaatcataaacactgaatgtgaaaatgaccctgaaggttatgacaacagtgatgacagagagactgtaaatctctctgggaaagaaagcaaacccacagaacaagataaggagtcgggcaagtccagcagcaggaatgaggttactctgacgtacagggtgggagtaaaggaagagaatgcttgtaggtttcaggataacctcttcctagagaaggccatgcagctcgccaaacgtcacgccaatgccctttttgactatgcagtaacgggagatgtgaaggtgctgctggctgtccagcgccatctcactgcagtgcaggatgagaatggagacagtgtcttacacttagccatcatccaccttcatgctcagcttgtgagagatctgctagaagtcacatctggtttggtttctgatgacattatcaacatgagaaacgatctgtaccagacacccttacacttggcagtgatcactaagcaggaagatgtggtggaggacttgctgaggtctggggccgacctgagccttctggaccgtttgggtaactctgttttgcacctagctgccaaagaaggacatgatacaattctcagtatcgtactcaaacacagaaaggcagcactacttattgaccaccccaatggggaaggtctgaatgccatacacatagccgtgatgagcaatagtctgccatgtctgctgctgctggtggcctctggggcagatgtcaatgctcgggagcggaagtctgggcgcacggcactgcacctggctgtggaacatgacaacatttctttggcgggctgcctactcctggagggtgatgcccatgtggacagtaccacctatgatggaactacacccttacatattgcagctgggagagggtccaccaaactggcagcgcttctcaaagcagcaggagcagatcccttggtagagaactttgagcctctctatgacctagatgacccatgggagaatgctggagaggatgagggagtggtgcctggaaccacacctctggatatggctgccaactggcaggtgtttgacatattaaatgggaaaccatatgagccagagttcacacctgatgaacaaggagatatgaaacagcttaacgaagatgcaaagctacaactctacaagttgctagaaattcctgatccagacaaaaactgggctactctggcacagaaattaggtctggggatacttaataatgcctttcggctgagtcctgctccttctaaaactcttatggataactatgaggtctctgggggaactatcaaagagctggtggaggccttgcgacagatgggctacactgaggcaattgaagtgatccaggcagccttctgcacctcaggaaccacagtgtccagccccaagaagaacacctctcaggctcacttgctgccccactcaccttcttccacaaggcagcacatagatgagcttcaagacagtgacagcatctgtgacagtggtgtggagacatccttccgcaaactcagctttacagagtctctgactggcagcagctcattgataactctgaacaaaatgccccacaattacgggcaggaaggaccaatagaaggcaaaatttagcctacagacgatttccctcaccagtaaaccaaaaccctaaaattccagtgcatcgtcccaaagaaggaaggtaaagtgcatccagaggtgctcagaggagaaccagcctgccgggatcattctggatttccttccaggccttctaaacttggcttcctttcttggttcttacatgaattttagttggtccacgtacagatagtatatagcaatcacagcactcggggtgagctgacatgtcgctgggggtgacgggtttattgagctttaccggctgctgctggattacagctgcttcctgttgtccttgctgctgtccctctgctgccgtcccaatgtccccacctggtgatctttctagccgccatggcacaatgttcattcagattaaggattaagaaaagagatattttaaaatgagagtcacttgatatgcaataaaaaggcttattgctttttctaatgtgcttctctgtgatttgaaaaaaaaaaacccatgaacttattaatatttaaacatggctgcaatcagtgccgaaaatagtattttcccctttttctgcattttgctat

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