LOCUS       XM_019797391           16208 bp    mRNA    linear   MAM 26-MAY-2020
DEFINITION  PREDICTED: Ailuropoda melanoleuca argonaute RISC catalytic
            component 3 (AGO3), transcript variant X1, mRNA.
ACCESSION   XM_019797391
VERSION     XM_019797391.2
DBLINK      BioProject: PRJNA633539
KEYWORDS    RefSeq.
SOURCE      Ailuropoda melanoleuca (giant panda)
  ORGANISM  Ailuropoda melanoleuca
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
            Ailuropoda.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_048219.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On May 26, 2020 this sequence version replaced XM_019797391.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Ailuropoda melanoleuca Annotation
                                           Release 103
            Annotation Version          :: 103
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.4
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..16208
                     /organism="Ailuropoda melanoleuca"
                     /mol_type="mRNA"
                     /isolate="Jingjing"
                     /db_xref="taxon:9646"
                     /chromosome="2"
                     /sex="female"
                     /tissue_type="blood"
                     /dev_stage="adult"
     gene            1..16208
                     /gene="AGO3"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 29 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 27 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:100465651"
     CDS             332..2914
                     /gene="AGO3"
                     /codon_start=1
                     /product="protein argonaute-3 isoform X1"
                     /protein_id="XP_019652950.1"
                     /db_xref="GeneID:100465651"
                     /translation="

MEIGSAGPVGAQPLLMVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPDKCPRRVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRPFKVSIKFVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRTMYFA"

     misc_feature    548..832
                     /gene="AGO3"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:465134"
     misc_feature    860..1012
                     /gene="AGO3"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:462567"
     misc_feature    1013..1375
                     /gene="AGO3"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1169..1171,1214..1216,1256..1258,1268..1270,
                     1322..1324,1343..1345,1349..1351)
                     /gene="AGO3"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1508..2785
                     /gene="AGO3"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1919..1921,1931..1933,1967..1978,1985..1987,
                     2009..2011,2018..2020,2030..2032,2042..2044)
                     /gene="AGO3"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(2123..2125,2129..2131,2339..2341,2753..2755)
                     /gene="AGO3"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

ccggggacggcccccggggaggtcggcggcggcgccgcagtcgtggaggggcagtaggagcgtaagcggccgcgggcgacgcaagttccgcactgggctctcctttcctcgtctcacgcttctccttcctctcgcatagtcgcgtgctgcctccccacggcggctcttcccgacgaaagctttcggagtgcggttgctgaggagaagccatcgccacctcgtcttggggccgagtgagggtgcctgtcgcgccgcgtcgccccctgcgctgcctccttgcccccagtggtgggcgcccttctcgttcgaagcactccccccagctccatgaatggaaatcggctccgcaggacccgttggggcccagcccctactcatggtgcccagaagacctggctatggcaccatgggcaaacccattaaattgctggctaactgttttcaagttgaaatcccaaagattgatgtctacctctatgaggtagatattaaaccagacaagtgtcctaggagagtgaacagggaggtggttgactcaatggttcagcattttaaggtgactatatttggggaccgtagaccagtttatgatggaaaaagaagcctttacacagccaatccactacctgtggcaactactggggtagatttagatgttactttacctggggaaggtggaaaagatcgacctttcaaggtgtcaattaaatttgtctctcgggtgagttggcacctgctccacgaagtactgacaggacggaccttgcctgagccactggaattagacaagccaatcagcactaatcctgtccatgccgttgatgtggtgctacgacatctgccctccatgaaatatacacctgtggggcgttcctttttctcagctccagaaggatatgaccaccccctgggagggggcagggaagtatggtttggattccatcaatctgttcgacctgccatgtggaaaatgatgcttaatattgatgtttctgccactgccttctacaaagcacaacctgtaattcagttcatgtgtgaagttcttgacattcataatattgatgagcaaccaagacctctgactgattctcatcgggtaaaattcaccaaagagataaaaggtctgaaggttgaagtgactcattgtggaacaatgagacggaaataccgtgtttgtaatgtaacaagaaggcctgccagtcatcaaacctttcctttacagttagaaaacggccaaactgtggagagaacagtagcacagtatttcagagaaaagtatactcttcagctgaagtacccacaccttccttgtctgcaagtggggcaggaacagaaacatacctacctgccactagaagtatgtaatatcgtggcagggcaacgatgtatcaagaagctaacagacaatcagacttccactatgatcaaagcaacagcaagatctgcaccagatagacaagaggaaattagcagattggtaagaagtgcaaattatgaaacagatccatttgttcaggagtttcaatttaaggttcgggatgaaatggctcatgtaaccggacgtgtactcccagcacccatgctacagtatggaggacggaatcggacagtagcaacaccaagccatggagtatgggacatgcgggggaagcaatttcacacaggagttgaaataaaaatgtgggctatagcttgttttgccacacagaggcagtgcagagaagaaatactgaagggtttcacggaccagctgcgtaagatttcaaaggatgcagggatgcccatccagggccagccttgcttctgcaaatacgcgcagggggcagacagcgtggagcccatgttccggcatctcaagaacacctactctgggctacagctcattatcgtcatcctgccagggaagacgccagtgtatgcggaagtgaaacgtgtaggagatacacttttgggtatggccacgcagtgtgtccaagtcaagaatgtaataaaaacatctcctcaaactctctcaaacctgtgcctaaagataaatgttaaactcggagggatcaataatattcttgtacctcatcaaagaccttctgtgttccagcaaccagtgatctttttgggagcagatgtcactcatccaccagctggtgatgggaagaagccttcgattgctgctgttgtaggtagtatggacgcccacccaagcagatactgtgccacagtaagagttcagagaccccgacaggagatcatccaggacttggcctccatggttcgagaacttctcattcagttttataagtcaactcggttcaaacctactcgtatcatcttttatcgggatggtgtttcagagggccagtttaggcaggtattatattatgaactactagcaattcgagaagcctgcatcagtttggagaaagactatcaacctggaataacctacattgtagttcagaagagacatcacactcgattattttgtgctgataggacagaaagggttggaagaagtggcaatatcccagctggaacaacagttgatacagatattacacacccatatgagtttgatttttacctctgtagccatgctggaatacagggtaccagccgtccttcacactatcatgttttatgggatgataactgctttactgcagatgaacttcagctgctaacttaccagctctgccacacttatgtgcgctgtacacgatctgtttctatacctgcaccagcgtattatgctcacctggtggcattcagagccagatatcatctcgtggacaaagaacatgacagtgctgaaggaagtcacgtttcaggacagagcaatgggcgagatccacaagctcttgccaaggctgtacagattcaccaagataccttacgcacaatgtactttgcttaaaaagtccaagaatattctctgagaggaagaactgaaagatgcatcgacatacagcatatgtttccagtggagtcagttaagtggggatgcctccagccatacagcaaccaacactgtgtggggaccagggtctgatttttatgttgatacaaggaagattgtttacttcatcaaggaacacagcaccattatgcaatatgaaaccagccaactgcttttttgtgcggtctccttaggaagtatcgccattgttttgttttcactttcttgtagtctaacccttttaatgcctttacctcaagttgcttggcagcacaactatctttgcaaaaaaaaaaaaaagtaaagaaaaagtaaatgacagtttaaaaaaaaaaacacacctacatgaataatcaaagtgattgttcacgattatgtgtgcaaaaaaattaatgtgcattcgtgtattcttgtaaaaggtatctgtgtatattttaaatatatacatgtatacttcacatgcatatatatctagatctacactgataatagatatatatgtgtctgtgcgtgtattttatagttcattccactggggaactttctttcccttttattattttcccaccaccactttgatttttctctctacctcccttgccttcatcacctacatttttttttcctaatgctaccagtgacattcagatgttcatgtatctggttcatttggatatgaagcatggcaaactagatttttatttttaattttgcacaccctactcctgtctcttgtctcatacacaattgcaagtcctcaactcttgatattgctttcttaagaaacaaaattttatatatatatacatatatatgtgtgtatatatataatgtttctgtgagagtgcgtgtctgccccctcctgctctgaaactacatttgccatttgtgcaatgtgtacataagcagtagcaaccgtaaactattctttttctttattttgttaaagctgctataaatataaaaccttgtcagaagttgtaactcagaaatttctctctgtaagtgatatgtattctaaagccttctgtttctatgggttatacatgaaaatcccttatagcttttataaagggcaaatattctaaatgattggaactctttagggttgaggcctctgaaattgggtggagagagagaaggtgttcttgaggggttttttaattttaattttttttttttgctagtttacttgctgcctctcataccttaatgtgattttcatatatatatatttttatatatatgtgcgtatatataaacatatatgtatgtgttttgaagtacagcttccttttctttcatatttattagaatagtgctttaataattagagaactgtattggcaacatcttttatagaaatgtaatcatgtttattttaagaactgacaacttgttctgctgtcttttagtgcaataagcagttttaaaggaaagctgtgtccgtttgatatctttaccacggatagtgggagaaacagcacctccataattttaaaagggcaaagtaatacagccttaatttcagaaggaaagttttgtaatttttcaagtttaaagcctgtcttctaaaaattgtaatgaaaatgaaggaagttaaatttcctaagtgaatttgaccttgaatattagagataagagttgagctttgatttaagaaatgacagtgagtaggggcacctggctggctccgtcactagagcatgtgactcttgatctcggggttgtgagttcaagccccacattggtcacggagcctacttaaaaaaaaaaaaaaaagtgaatagcttaatatttagaagacatttaattctttgaaaataaatcacgtttattgaacaatcatactgattaggtgcccattttcatttactcaaatgaatcaggaaaatataaaatgatattttaaaaacattttttgccaatttatcagcagtgtaactttccttttaaaattagggttacggtggcaaaggaagttaggagtttgatcattttaaataagttaaatcactgaaatgtggaagaagatttacattga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