LOCUS       XM_019204284            6284 bp    mRNA    linear   ROD 23-APR-2020
DEFINITION  PREDICTED: Fukomys damarensis argonaute RISC component 4 (Ago4),
            mRNA.
ACCESSION   XM_019204284
VERSION     XM_019204284.2
DBLINK      BioProject: PRJNA625221
KEYWORDS    RefSeq.
SOURCE      Fukomys damarensis (Damara mole-rat)
  ORGANISM  Fukomys damarensis
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia;
            Hystricomorpha; Bathyergidae; Fukomys.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_022900935.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 23, 2020 this sequence version replaced XM_019204284.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Fukomys damarensis Annotation
                                           Release 102
            Annotation Version          :: 102
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.4
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6284
                     /organism="Fukomys damarensis"
                     /mol_type="mRNA"
                     /isolate="Sample0158"
                     /db_xref="taxon:885580"
                     /chromosome="Unknown"
                     /sex="female"
                     /tissue_type="blood from cranial vena cava"
                     /country="USA: Houston Zoo, Houston, TX"
                     /collection_date="05-Sep-2016"
                     /collected_by="Joseph P. Flanagan, Kelcie Pletch,
                     Christine Molter, Maryanne Tocidlowski, Lauren Howard,
                     Judilee Marrow, Andrea Lee, Jess Jimerson, Katie Plaeger,
                     Erin Neer"
     gene            1..6284
                     /gene="Ago4"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 42 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 22 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:104877011"
     CDS             195..2579
                     /gene="Ago4"
                     /codon_start=1
                     /product="protein argonaute-4"
                     /protein_id="XP_019059829.1"
                     /db_xref="GeneID:104877011"
                     /translation="

MVRHFKMQIFGDRQPGYDGKRNMYTAHPLPIGRDRVDMEVTLPGEGKDQTFKVSVQWVSVVSLQLLLEALAGHLNEVPDDSVQALDVITRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAFYRAQPIIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVLPAPMLQYGGRNKTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGLQLIVVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINAKLGGINNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTSRQEISQELLYSQEVIQDLTNMVRELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIAIRKACISLEEDYRPGITYIVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKDHDSAEGSHVSGQSNGRDPQALAKAVQIHHDTQHTMYFA"

     misc_feature    204..458
                     /gene="Ago4"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:435368"
     misc_feature    489..641
                     /gene="Ago4"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    642..1004
                     /gene="Ago4"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(798..800,843..845,885..887,897..899,951..953,
                     972..974,978..980)
                     /gene="Ago4"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1143..2450
                     /gene="Ago4"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1554..1556,1566..1568,1602..1613,1620..1622,
                     1644..1646,1653..1655,1665..1667,1677..1679)
                     /gene="Ago4"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1758..1760,1764..1766,2004..2006,2418..2420)
                     /gene="Ago4"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

caatctctctaggtcctccgaccagcctctttcagccaccccgtcgccctggccttggaactgttggaaaaccgattcgactgttagccaatcattttcaggttcagattcctaaaatagatgtgtatcactatgatgtggacattaaaccagaaaaacggcctcggagagtcaacagggaggtagtagatacaatggtgcggcacttcaagatgcaaatatttggtgatcgacagcctggctacgatggcaaaagaaacatgtatacagcacacccactgccaatcggacgtgatagggttgacatggaggtgaccctcccaggcgagggtaaagaccaaaccttcaaagtatctgttcaatgggtgtcagttgtgagccttcagttgcttttagaagctttagctggacacttgaatgaagtcccggatgactccgtgcaagcactcgatgttatcacaagacaccttccctctatgaggtacactccggtgggccgttcttttttctcacctcccgaaggttactaccaccctctgggagggggcagagaagtttggtttggttttcaccagtctgtgagacctgctatgtggaatatgatgcttaatattgatgtatctgcaactgctttctaccgggctcagcccatcattgagttcatgtgtgaagttttagacattcagaacatcaatgaacagaccaaacctctaacggattctcagcgtgtcaagtttaccaaagaaatcagaggtctcaaagttgaggtgacccactgtggacaaatgaaacgaaaataccgagtttgtaatgtgactagacggccagccagtcatcaaacttttcccttgcagctagaaaatggtcaagctatggaatgtacagtagctcaatattttaagcaaaagtatagtctgcagctgaaatacccccatcttccctgtctccaagtgggacaagagcaaaagcatacgtacttaccacttgaggtgtgtaacatagtggcagggcagcgatgtataaagaagctcacagacaatcagacgtccacgatgatcaaagccacagcaagatctgctcccgacaggcaggaagaaatcagtagactggtgaagagtaacagcatggtgggtggacctgatccataccttaaagaatttgggattgttgtccacaatgaaatgacagagcttacaggcagggtactaccagcaccaatgctacaatatggaggccggaataaaacagtagccacacccaaccagggtgtctgggacatgcgaggaaagcagttttatgctggcattgaaattaaagtttgggcagttgcttgttttgcgcctcagaaacaatgtagggaagatttactaaagagtttcactgaccaactgcgtaaaatctccaaggatgcagggatgcctatccagggtcagccgtgcttctgcaagtatgcacaaggcgcagacagcgtggagcccatgtttaaacatctgaagatgacgtatgtgggcctgcagctaatagtggttatcttgcctggaaagacaccagtgtacgcggaggtgaaacgtgttggagatactcttttaggtatggccacccagtgtgtccaggtaaaaaatgtagtgaaaacttcaccccaaaccctttccaacctttgcctgaagataaatgcaaagcttggaggaatcaacaatgtgcttgttcctcatcaaaggccctcggtgttccagcagccggtcatcttcctgggggcagacgtcactcacccaccagcgggggacgggaagaaaccctccattgctgcggtggtgggcagtatggatggccaccccagccggtactgcgccacagtccgggtgcagacttcccggcaggagatctcacaggagctcctctacagccaggaggtcatccaggacctgactaatatggttagagagctgctgatccagttctacaaatccacgcgcttcaaacccactcgcatcatctactaccgtggaggggtctccgagggacagatgaagcaggtggcttggccagaactaatagcaattcgaaaggcatgtattagcttggaagaagattatcggccaggaataacatacattgtggtgcaaaagagacatcatacccgactcttctgtgcagataaaacagaaagggtggggaaaagtggtaatgtaccagcaggaactacagtggatagcaccatcacacatccatcggaatttgacttttacctctgtagtcatgcaggaattcagggaaccagccgtccttcacattaccaggtcttatgggatgacaactgcttcactgcagatgagctccagctactgacttaccagctgtgtcacacctatgtgaggtgcacacgctcagtctctattccagcccctgcatattatgcccggcttgtggcattcagggcgaggtatcatctggtggataaagatcatgacagtgcggaaggcagtcatgtgtcaggacagagcaacggccgagatcctcaggccttggctaaggctgtgcaaatccaccatgatacccaacacacgatgtattttgcctgagaatctcagaaaaggaactcaaccagtttggcaccccacacagcctcaaaatgtttcaaatgcctaccacctctagttagagccaagttgacttcaggtggtcttctaccagcagctcagaatagttgcactgaatctatactttgcagcactgtctgatgcatcaacaaaattgagccattttttaaaagtagtagatactcatagattatcttttctgatgcactggacagaatttttacctcatcgtgcaaaggctgatcagcctgaactttctaaaggactttacaagaaaggtttctacggattattttgctagctgtggtgttcaccgcatccctctagtcttataagaaagagtattccttctttctgtgttccttgagtggggtgtatgcgtaagtgagaaagaaaaaccaaacgatctacttcagttcagtgtaactatttagctgggtgggcccataagctttttaatggagattgctgactttgccactgtaaatgcctttaatgagcattaagttttgaaagttttacagagttttattagttttactactttatcttactgatctctgcagacttgtgctggtgcaagtacaggctgccaggcaattgcactatatttggctgcagattcaaacaagcaattctcttacttggttgacgtttgtgaatgtgtgacataaacataagtaatgcatgtcacagtgacagataacactgccatggtcaaagtactcatgtttctccctctttggaaaaaaaattagcttttagtatttttccagcttttcaaaagtgcccattttatgctgctgtgtggtttgttagatctaaatcattttaaaacttttctcatagaaagttaactttggcaataagcattttttaaggtccctccttttcctccccttgatgatgtagttttgtagatgaaattttggtatgattttatcagctatttcttatatatcataatctggcaatttctgagaccaatcagaaaagacatatatttccatgcctttttaaataattgtttttactaattttatagtcacagtcggtgtcctgtcactttgttttagaataagctagaaccaggatgctttttattggacaagtattaccagtccttagaggcacattgagtgatgctgcacttgcaaaaatgtaccagcatttaaatttttttttcctgggaatcaaaattacacaattatttgcagtgcaatgttttttcttgtctttcaaactgaaagagatgatgggttttccttccttttattcacctaagactgtagaaatggttgatttttcttaatagattctgggttccactcatagggagacaggattcctttcttgtccaaacaaaaggagttatctgaagcaagcatcagttaaaatgtagggggaaatgtattctgtatttagtgtagataacactttgtaatggacaataattacatagagtcttggtaggtccagccagcctttcccactccacatttgactgattgtactgttattctctatcctggaatggcaggaatgagagataaaggacccagaaccacacttcatatggctgacaatgaaggtgctgggggaaggaagagacagacacaatgtggtaaaaataattttgccacctctgtcttgaaactgctgctgggaaacactggatcagatgatgaagggcatttgcttgaactcattagttggtccaaatctcttaaggtagccttctcaaaatcccagcaatataaagcactgtttctcttcagtcttttaagcgatcttgtaaatacattgaagtttacattttcatgtgctgttactcagcgatgccaccagtgtttgctgagactggtctctgagaattttatagtgtctgtcaagtcctatagctcattgtgatgagttcagacatccttaatctctgcagatagtgggaagaaagtgagttctgtgactgaagcacaacataggcaggagtgaagtgatggaagacgttaatatcttaagattttcccttttcgcaaatacctcacttggataatacaaatcaggacatgttggtgaggggctggctgctgcttttattcacacttgttcagggagagcacagaaaatacccttcagcatggccactctggacccaaaaggagaaagaacaagccttgtaggaggaggaggactctctggagtccaagaagtaaagaactctggtggctggctggctggccagcaggcaccacacctgcacttgagtgcctcgggctcgtttgttgagaacgcacagaagaagctctcactgtatcctggcgtccacggaacagaggcaaagccaagtgcccagaaaccctaatctgcctgtctgcagttgggctctatgctcgaccttaaactatactgtttgtaagacctcagtcagtcttagtacactggggccaatcagcatggtggtggaggaaaagccgggaggcctatttttataggaaaacagtcccattaagggtgcaatgctgtcattttggacaaaaggaaagaaatatagaagtaggattactgggaaaaaaaaaaacttgtggaggggtgaatctttaaggggtactcactgcacagagttgcagcaatactgttgcaagcaagtctgacagcataattttagtttaatttggcttggcaagtctaatagttaaccccttcgagactaaatcgttatgcatgtgtcaatcaatgggaggtgtgcattctctagaagtagtgttaagatgtttgtttgttttttgtttttaatgcagcctgtttaggcactgtcatgtggtgtgaaagatttaaatgtggcgatgctaacgagtaacaatttggggataaggagtgggacgttaagagagtggtgaagacacaaatgttgaaccaattatgttttgtcgttgttagctgttgaatcctgagaggtttataaaatgaaccaactggcttactgcagccagagttctgggcagacagaacactctcatttttactgtaaattctatttgctgcttccaaaggtgatgatttataagcagacatgttctatatggtctgtactttaggatctggtgcccagcctatttcagagcttacctacctggctcaactaggtaccccatccccatgggaaatggtaatccactgtttaacaaggctcaccctctccaccctgccccatcaaccccttgtggatgtgctgtaagattttcctgctcaatagttaagtggtagctctgctttcattttaagaaagtggaggctaagggcattgtatcaatactgcttcaactccaagaatttttccttgtaaagttaaaggaaagatcttattgattaaccattttcttatcccttgctattgacatattaatgctctttctatgtctagtggctgaaaatgtttgcatttgttcatttgactaatggtgtgatttttgtttctatacctttagacttgtaatgttttaaaatgtattttattaactttggactggatgtatgtctctagcaatacgaggtactttctaagctatgaagggagggaatgtatccccatgataagataatggttgtttaaattttgcaatttttctctttttggcctgcagggatattttgtgttcatgtgtccccaaaaaagaataaattggcatt

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