LOCUS       XM_018880669            1149 bp    mRNA    linear   PLN 07-JAN-2024
DEFINITION  Sugiyamaella lignohabitans sphinganine kinase LCB4 (LCB4), partial
            mRNA.
ACCESSION   XM_018880669
VERSION     XM_018880669.1
DBLINK      BioProject: PRJNA342695
            BioSample: SAMN04417247
KEYWORDS    RefSeq.
SOURCE      Sugiyamaella lignohabitans
  ORGANISM  Sugiyamaella lignohabitans
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Trichomonascaceae;
            Sugiyamaella.
REFERENCE   1  (bases 1 to 1149)
  AUTHORS   Bellasio,M., Peymann,A., Valli,M., Sipitzky,M., Graf,A., Sauer,M.,
            Marx,H. and Mattanovich,D.
  TITLE     Complete genome sequence and transcriptome regulation of the
            pentose utilising yeast Sugiyamaella lignohabitans
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1149)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (04-JAN-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 1149)
  AUTHORS   Peymann,A. and Graf,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-FEB-2016) Department of Biotechnology, University of
            Natural Resources and Life Sciences, Muthgasse 18, Vienna, Vienna
            1190, Austria
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. This record is derived from an annotated genomic
            sequence (NC_031674).
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..1149
                     /organism="Sugiyamaella lignohabitans"
                     /mol_type="mRNA"
                     /strain="CBS 10342"
                     /type_material="culture from holotype of Candida
                     lignohabitans"
                     /db_xref="taxon:796027"
                     /chromosome="B"
     gene            <1..>1149
                     /gene="LCB4"
                     /locus_tag="AWJ20_3638"
                     /db_xref="GeneID:30035682"
     CDS             1..1149
                     /gene="LCB4"
                     /locus_tag="AWJ20_3638"
                     /inference="similar to AA sequence:KEGG_Orthology:K04718"
                     /note="Sphingoid long-chain base kinase; responsible for
                     synthesis of long-chain base phosphates, which function as
                     signaling molecules, regulates synthesis of ceramide from
                     exogenous long-chain bases, localizes to the Golgi and
                     late endosomes; LCB4 has a paralog, LCB5, that arose from
                     the whole genome duplication; GO_component: GO:0005794 -
                     Golgi apparatus [Evidence IEA]; GO_component: GO:0005794 -
                     Golgi apparatus [Evidence IDA] [PMID 12459470];
                     GO_component: GO:0000139 - Golgi membrane [Evidence IEA];
                     GO_component: GO:0032541 - cortical endoplasmic reticulum
                     [Evidence IDA] [PMID 17686782]; GO_component: GO:0005783 -
                     endoplasmic reticulum [Evidence IEA]; GO_component:
                     GO:0005783 - endoplasmic reticulum [Evidence IDA] [PMID
                     12493772]; GO_component: GO:0005783 - endoplasmic
                     reticulum [Evidence IDA] [PMID 16141212]; GO_component:
                     GO:0005789 - endoplasmic reticulum membrane [Evidence
                     IEA]; GO_component: GO:0005768 - endosome [Evidence IEA];
                     GO_component: GO:0031902 - late endosome membrane
                     [Evidence IEA]; GO_component: GO:0016020 - membrane
                     [Evidence IEA]; GO_component: GO:0005886 - plasma membrane
                     [Evidence IEA,IEA]; GO_component: GO:0005886 - plasma
                     membrane [Evidence IDA] [PMID 16141212]; GO_function:
                     GO:0005524 - ATP binding [Evidence IEA]; GO_function:
                     GO:0017050 - D-erythro-sphingosine kinase activity
                     [Evidence IDA] [PMID 9677363]; GO_function: GO:0003951 -
                     NAD+ kinase activity [Evidence IEA]; GO_function:
                     GO:0004143 - diacylglycerol kinase activity [Evidence
                     IEA]; GO_function: GO:0016301 - kinase activity [Evidence
                     IEA]; GO_function: GO:0000166 - nucleotide binding
                     [Evidence IEA]; GO_function: GO:0008481 - sphinganine
                     kinase activity [Evidence IEA]; GO_function: GO:0016740 -
                     transferase activity [Evidence IEA]; GO_process:
                     GO:0019722 - calcium-mediated signaling [Evidence IMP]
                     [PMID 11278643]; GO_process: GO:0006629 - lipid metabolic
                     process [Evidence IEA]; GO_process: GO:0046834 - lipid
                     phosphorylation [Evidence IEA]; GO_process: GO:0008152 -
                     metabolic process [Evidence IEA]; GO_process: GO:0016310 -
                     phosphorylation [Evidence IEA]; GO_process: GO:0007205 -
                     protein kinase C-activating G-protein coupled receptor
                     signaling pathway [Evidence IEA]; GO_process: GO:0006665 -
                     sphingolipid metabolic process [Evidence IEA]; GO_process:
                     GO:0006665 - sphingolipid metabolic process [Evidence IDA]
                     [PMID 9677363]"
                     /codon_start=1
                     /product="sphinganine kinase LCB4"
                     /protein_id="XP_018738466.1"
                     /db_xref="GeneID:30035682"
                     /translation="

MAEAYKGIKAEKKLLVLINPHGGQGKAKSIYKKYGAPIFAAAHCKTTVITTTHHYHAAQIAEELDIDMYDAIVCCSGDGIPHEVINGFAKRSDSHRALAEVSICQFPCGSGNSMAMSLNGTASPSIAALNIVKGMPMPIDLMCMTQGNQRAVSFLSQTYGLVADADLGTESLRWMGGTRFAIGALMRALSEATYPCELHVKYAHETKKAVSEHFNRSYQSSSQQNIQEGSQSEYRESGSLFKKSLQYGSINDPVPSDWQTLTRNKLGFFYVGKMPWMASDALVFPASLPNDGTLDLVTWDSTIGRLTAIDLLLKIEKGHHVHSNDVQYAKIEAYRLIPKIQDGYLSIDGESFPLQPFQVEVIRNAACLLSSTGSYANTNVNL"

     misc_feature    <34..1050
                     /gene="LCB4"
                     /locus_tag="AWJ20_3638"
                     /note="diacylglycerol kinase/D-erythro-sphingosine kinase;
                     Region: PLN02958"
                     /db_xref="CDD:215517"
ORIGIN      

atggctgaagcttacaagggtatcaaagcggagaaaaagctgctagtccttattaaccctcatggtggccaaggaaaagccaaatctatttataagaagtacggtgctccgatatttgctgccgcccattgtaaaaccacggtgataacaactacccatcattatcacgcagcacaaattgcggaagaactggatattgatatgtatgacgctatcgtatgctgttccggtgatggcattccacacgaggtcatcaatggatttgccaaaagatccgattctcacagggcattagccgaggtatctatttgccagtttccatgtggctcgggaaactcaatggccatgtcattgaatggaactgcatctccaagcatagctgctctgaacattgtcaaaggtatgccgatgcctatcgatttgatgtgcatgacccagggaaatcagagagcagtatcattcttgagtcaaacttatggattagttgctgatgctgatttgggaacagagtctttgagatggatgggtggtactagatttgccattggtgctctgatgagagcgttatctgaggccacttatccatgtgaactgcatgttaagtatgcccatgagacaaagaaggcagtctccgaacattttaaccggtcataccaatcgtcatcacaacagaacattcaagagggaagccaatcagaatatagagagtcaggatctctattcaaaaagtcccttcagtatggttctatcaatgatccagtaccatccgactggcagacattgacaagaaacaagcttggatttttctatgttggaaagatgccctggatggccagtgatgctttggtattcccagccagtttaccgaacgacggtactctggacttggtcacctgggactcaaccattggtagactaactgccattgacttgttattaaaaatagagaaaggtcatcatgttcatagcaatgacgtacaatatgccaagattgaagcataccgcctgattccaaaaatccaagatgggtacctaagcattgatggggagtcgtttcctctccaaccttttcaagtcgaggttattagaaacgcagcttgtttgttgtcttcaaccggtagctacgcaaacactaatgtgaacctgtag

//