LOCUS       XM_018879502            1257 bp    mRNA    linear   PLN 07-JAN-2024
DEFINITION  Sugiyamaella lignohabitans Ca(2+)-dependent cysteine protease MCA1
            (MCA1), partial mRNA.
ACCESSION   XM_018879502
VERSION     XM_018879502.1
DBLINK      BioProject: PRJNA342695
            BioSample: SAMN04417247
KEYWORDS    RefSeq.
SOURCE      Sugiyamaella lignohabitans
  ORGANISM  Sugiyamaella lignohabitans
            Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
            Saccharomycetes; Saccharomycetales; Trichomonascaceae;
            Sugiyamaella.
REFERENCE   1  (bases 1 to 1257)
  AUTHORS   Bellasio,M., Peymann,A., Valli,M., Sipitzky,M., Graf,A., Sauer,M.,
            Marx,H. and Mattanovich,D.
  TITLE     Complete genome sequence and transcriptome regulation of the
            pentose utilising yeast Sugiyamaella lignohabitans
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1257)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (04-JAN-2024) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (bases 1 to 1257)
  AUTHORS   Peymann,A. and Graf,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (18-FEB-2016) Department of Biotechnology, University of
            Natural Resources and Life Sciences, Muthgasse 18, Vienna, Vienna
            1190, Austria
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. This record is derived from an annotated genomic
            sequence (NC_031674).
            COMPLETENESS: incomplete on both ends.
FEATURES             Location/Qualifiers
     source          1..1257
                     /organism="Sugiyamaella lignohabitans"
                     /mol_type="mRNA"
                     /strain="CBS 10342"
                     /type_material="culture from holotype of Candida
                     lignohabitans"
                     /db_xref="taxon:796027"
                     /chromosome="B"
     gene            <1..>1257
                     /gene="MCA1"
                     /locus_tag="AWJ20_2553"
                     /db_xref="GeneID:30034477"
     CDS             1..1257
                     /gene="MCA1"
                     /locus_tag="AWJ20_2553"
                     /note="Ca2+-dependent cysteine protease; may cleave
                     specific substrates during the stress response; regulates
                     apoptosis upon H2O2 treatment; required for clearance of
                     insoluble protein aggregates during normal growth;
                     implicated in cell cycle dynamics and lifespan extension;
                     undergoes autocatalytic processing; similar to mammalian
                     metacaspases, but exists as a monomer due to an extra pair
                     of anti-parallel beta-strands that block potential
                     dimerization; GO_component: GO:0005737 - cytoplasm
                     [Evidence IEA,IEA]; GO_component: GO:0005829 - cytosol
                     [Evidence IDA] [PMID 24855027]; GO_component: GO:0005634 -
                     nucleus [Evidence IEA,IEA]; GO_component: GO:0005634 -
                     nucleus [Evidence IDA] [PMID 12062425]; GO_function:
                     GO:0004198 - calcium-dependent cysteine-type endopeptidase
                     activity [Evidence IDA,IMP] [PMID 22761449]; GO_function:
                     GO:0004197 - cysteine-type endopeptidase activity
                     [Evidence IEA]; GO_function: GO:0008234 - cysteine-type
                     peptidase activity [Evidence IEA]; GO_function: GO:0016787
                     - hydrolase activity [Evidence IEA]; GO_function:
                     GO:0008233 - peptidase activity [Evidence IEA];
                     GO_process: GO:0006915 - apoptotic process [Evidence IEA];
                     GO_process: GO:0006915 - apoptotic process [Evidence IDA]
                     [PMID 11983181]; GO_process: GO:0006915 - apoptotic
                     process [Evidence IMP] [PMID 16170310]; GO_process:
                     GO:0006915 - apoptotic process [Evidence IMP] [PMID
                     16301538]; GO_process: GO:0006515 - misfolded or
                     incompletely synthesized protein catabolic process
                     [Evidence IMP] [PMID 20624963]; GO_process: GO:0006508 -
                     proteolysis [Evidence IEA,IEA]"
                     /codon_start=1
                     /product="Ca(2+)-dependent cysteine protease MCA1"
                     /protein_id="XP_018737413.1"
                     /db_xref="GeneID:30034477"
                     /translation="

MSYPGQQHNSYGHHGSSGGGGGGYGPPSGPPPQQGGYGGGYDSSGYGSSGDYGPPSGPPPTGPRPDFGGSHSNGGSQYSSYGPPSGPPPGSHPGEYGHSVPTNQMHSYGPNDQLQYQLSDCSGKRKALCIGINYIGSKNALRGCINDAHAISAYLQDRHGYKKDDMVILTDDSRDPRSIPTKENILRAMQWLVSGAQTNDTLFLHYSGHGGQTRDLDGDEDDGFDETIYPVDFEQAGNIVDDQIHDIVVRPLMPGVRLTALFDSCHSGSILDLPYLYSTKGLLKEPNLAKDAGMGLMGAVTSYSRGDLMGVFNSLNSVYKKATTGGRANEITRRTKFSPADVIQLSGCKDDQTSADAVEGGTNTGAMSYSFIEVMSQNPNQSYISLLNNMRQVMARKYTQRPQLSCSHPLDMNLHFMI"

     misc_feature    370..1233
                     /gene="MCA1"
                     /locus_tag="AWJ20_2553"
                     /note="Caspase domain; Region: Peptidase_C14; pfam00656"
                     /db_xref="CDD:425803"
ORIGIN      

atgtcgtatcccggacagcagcataacagctacggtcaccatggatccagtggtggtggcggtggcggctacggaccaccttcgggccctcctcctcaacagggcggttatggaggtggttatgatagcagtggatatggtagcagcggcgattatggcccgccatcgggccctcctcctacaggaccgcgtcctgattttggtggaagtcatagcaatggtggtagccagtattcgagttatggacctccttcagggccacctccaggatcgcatcctggcgaatatggccacagtgttcctacgaaccagatgcacagctacggtccaaacgaccagctccagtaccaattgtccgactgttcaggcaagcgcaaggctttgtgtattggtatcaactatattggcagtaagaacgctttaagaggctgtatcaacgatgctcatgccatttctgcttatttacaagaccgtcatggatataagaaagacgatatggtcattttgaccgacgactcgcgtgacccacgatctattcctactaaagagaatatccttcgtgctatgcaatggctggtttctggagctcaaactaatgatactttgtttttacattattcaggccatggtggtcaaactcgtgatttggatggtgatgaagacgacggatttgatgagactatttatcctgtggactttgaacaggctggtaatattgtcgatgatcagatccacgatatagtggttcgtccattgatgccaggagtgagactgactgcccttttcgactcttgtcattcaggatctattctggatctgccctatttatactcgaccaagggactattgaaggagcccaatttggctaaagacgctggtatgggacttatgggcgctgtgacctcgtactcacgaggcgatctgatgggagtgttcaatagtttgaactccgtgtacaagaaagccaccacaggcgggcgagccaacgaaatcacccgtcgaaccaagttctcgccagcagacgtgatccaactatctggctgtaaggacgaccaaacgtctgccgacgccgttgaaggcggcactaacaccggagccatgtcgtactcgttcatcgaggtcatgagtcagaaccccaatcagtcctacatctcactactcaacaacatgcgccaggtcatggcccgcaagtacactcaacggccccagctcagttgcagccatcccctcgacatgaacctccacttcatgatctag

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