LOCUS       XM_018056699            5184 bp    mRNA    linear   MAM 08-SEP-2016
DEFINITION  PREDICTED: Capra hircus ATPase copper transporting beta (ATP7B),
            transcript variant X2, mRNA.
ACCESSION   XM_018056699
VERSION     XM_018056699.1
DBLINK      BioProject: PRJNA340281
KEYWORDS    RefSeq.
SOURCE      Capra hircus (goat)
  ORGANISM  Capra hircus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia;
            Pecora; Bovidae; Caprinae; Capra.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_030819.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Version          :: Capra hircus Annotation Release 102
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 7.1
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5184
                     /organism="Capra hircus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9925"
                     /chromosome="12"
                     /sex="male"
                     /tissue_type="blood"
                     /dev_stage="adult"
                     /breed="San Clemente"
     gene            1..5184
                     /gene="ATP7B"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 4 ESTs, 2 Proteins, and 99%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 4 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:102183524"
     CDS             500..4963
                     /gene="ATP7B"
                     /codon_start=1
                     /product="copper-transporting ATPase 2 isoform X2"
                     /protein_id="XP_017912188.1"
                     /db_xref="GeneID:102183524"
                     /translation="

MERAGDQTPGNPEPSSLATLGDPQVTLLTVHKQWSFKRSPGTGGSSRPVISEEECPPPSEEGEFSQKVLNGSEEISSKQILSKLFQPAMKQSFAFDNNGYEDDLDGVCPSQTAAGTISIVGMTCQSCVKSIEGRVSSLKGIVSIKVSLEQGSAEVRYVPSVVSLMQICHQIEDMGFQASVAEGKATSWASRVSPTSEAVVKLRVEGMTCQSCVSSIEGKIGKLQGVVRVRVSLSNQEAVITYQPYLIQPQDLRDHITDMGFEAVIKNKVAPVSLGPIDVRRLQSTLSAAPPTPVNQNDNNSETPGGQGVPLHLRVDGMHCKSCVLNIEDNIGQLPGVQSIHVSLESRTAQVQYDPSLVSPGALQRAIEALPPGNFKVSFPNGAEGSGPDSRTPPAPSAPCTMMLAIAGMTCKSCVQSIEGLISQRAGVHQISVFLAEGTAVVLYDPSRTHPEELRAAVEDMGFEASILAENCSSNQVGNHSAGSAMGPAAAGTPVPMQEEAPQPGGLHTNHIPRQSPKSLPASTTVAPKKCFLQISGMTCASCVSNIERNLQKEPGILSVLVALMAGKAEVKYNPEAIQPLEIAKLVQDLGFEAAVMEDYTGSDGDLELMITGMTCASCVHNIESKLRRTEGITYASVALATSKAHVKFDPEIIGPRDIVKLIEEIGFRASLAQRIPNAHHLDHKVEIKQWKNSFLCSLVFGIPVMGLMIYMLIPSHEPQSSVLDHNVVPGLSILNLVFFILCTFVQFLGGWYFYVQAYKSLRHGMANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHVVKSKTSEALAKLMSLQATEATVVTLGEDNVIIREEQVLMELVQRGDIIKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSMVIAGSMNAHGSVLITATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIISTVTLVAPSKGISQAEVVLRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPKVSRVLLLVDVATLPLRKVLAVVGTAEASSEHPLGVAVTRHCKEELGTETLGCCMDFQAVPGCGISCKVSNVESILAQGERPQGPPTAHQNRVGSEPSETDAATQTFSVLIGNREWMRRNGLTVTSDVRDAMTDHETKGQTAILVAIDGVLCGMIAVADSVKQEAALAVHTLKSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNQGKRVAMVGDGVNDSPALAQADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSRRTVWRIRLNLVLALIYNLIGIPVAAGVFIPIGVVLQPWMGSAAMAASSVSVVLSSLQLKCYRKPDLAQYEAQAHGHMKPLSASQVSVRVGMDDRRRDSPRASAWDQVSYVSQVSLSPLKSDKLSRHSGAADDRGDKWSLLLNDRDEEQGI"

     misc_feature    845..1036
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(863..871,878..880)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1100..1288
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1118..1126,1133..1135)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1436..1609
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1451..1459,1466..1468)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1706..1897
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1724..1732,1739..1741)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    2096..2284
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(2111..2119,2126..2128)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    2321..2512
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(2339..2347,2354..2356)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    2576..4627
                     /gene="ATP7B"
                     /note="P-type heavy metal-transporting ATPase, similar to
                     human copper-transporting ATPases, ATP7A and ATP7B;
                     Region: P-type_ATPase_Cu-like; cd02094"
                     /db_xref="CDD:319783"
     misc_feature    order(3512..3514,3518..3520,4556..4558)
                     /gene="ATP7B"
                     /note="putative Cu binding site [ion binding]; other site"
                     /db_xref="CDD:319783"
     misc_feature    order(3644..3652,3854..3856,4007..4015,4103..4105,
                     4223..4231,4289..4291,4298..4300,4307..4309,4364..4366,
                     4373..4375)
                     /gene="ATP7B"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319783"
ORIGIN      

cccaggagctgtggaagaggcagctgaagttgttccaagaaagcgctctgagcttggtaataaaaggaagtgatatttcgcccctgcctccaggctggactcctgggagcgcacggggccaagaggaaacggctgggtgtagggagatcactcccggccctgggcccccgtacacgcagccctgggcgcgtgtggggctgtgtgcaaagatccccagtgccgaatgcaatgtgatgagtaagaggatgccagttggtttgagtgcggtagatcaacaagagcaaatatacatacagcggtgtgcagcctgcccgagttcgcggaggcttggctggcagccactcctgggctggcccaggggcagagggaaacctgcccgacttgacacagcaggtacctcccctctgctggttaggaggacgcttttggagcattttcttgtgacacgatcaaatagcccagagaaggtgaactgcgaggtaaaggcgtgaacgcggcaatggagagagctggggaccagacccccgggaaccccgagccatcctccctggcgactctgggtgacccacaggtgaccctgctgactgtccacaaacaatggtccttcaagaggagccctgggaccgggggctccagcaggccggtgatttcagaggaggaatgccctcccccatcagaggaaggagaattttcacagaaggttttgaatggatcggaagagatcagttccaagcagatcctgtctaagcttttccagccagcaatgaagcagagctttgcctttgacaacaatggctacgaggatgacctggatggcgtgtgcccctcccagacggccgctggcaccatcagcattgtgggcatgacctgccagtcgtgtgtcaagtccatcgagggcagggtctccagtttgaaaggcattgtgagcattaaggtttccctggagcagggcagtgctgaggtgagatacgtgccctcagtggtaagcctgatgcagatttgccatcagattgaagacatgggcttccaggccagtgtggccgagggaaaggccacctcctgggcctccagggtctcgcccacctcggaggccgtggtcaagcttcgggtggagggcatgacctgccagtcctgtgtcagctccatagaaggcaagatcgggaaactgcagggcgtcgtgagggtccgcgtctcgctcagcaaccaggaggcagtcatcacttaccagccttaccttatccaaccccaagacctcagggaccatataaccgatatggggtttgaagccgtcatcaagaacaaggtggccccagtaagcctgggacccatagacgtcaggcgactccagagcaccctctcagcggcccctccaactcccgttaatcagaatgacaataactctgagaccccagggggccagggggtccccctgcacctgagagtggatggaatgcactgtaagtcttgtgtcctgaacattgaagacaatatcggccagctccccggggttcagagtattcacgtgtccctggagagcaggaccgcccaagtccagtacgacccttctctcgtctccccaggggccctgcagagggccatcgaggccctgcctcctgggaactttaaagtctcttttcccaatggggcggaagggagtgggccagactccaggacccccccggcacccagtgcgccctgtaccatgatgctggccattgctggcatgacctgtaagtcctgcgtccagtccatcgaaggcctgatctcccagagggcgggcgtgcaccagatctcagtctttttggccgaaggaactgcagtggttctctatgatccatctcgaactcacccagaagaactgcgagccgcggtggaggacatgggattcgaggcctccatcctggctgaaaactgttccagcaaccaggttggcaaccacagtgctgggagtgccatggggcctgcggcagctggcacacctgtgcccatgcaggaagaggctccccagccaggggggctccacactaaccacatcccccgccagtcgcccaagtccctcccggcctccaccacggtggccccaaagaagtgcttcctacagatctcaggcatgacctgtgcgtcctgtgtgtccaacatagagaggaacctgcagaaagaacctgggatcctgtctgtgctggttgccctgatggcaggaaaggcagaggtgaagtacaacccggaagccatccagcccctggagatagcaaagctcgtccaggacctgggctttgaggcagcagtgatggaagactacacgggctcggatggcgacctcgagctgatgatcacggggatgacctgcgcctcctgtgttcacaacatagagtccaaactcaggaggacagaaggcatcacctacgcctctgtggctctcgccaccagcaaagcccacgtgaagtttgatcctgaaattattggtccgcgggatattgtcaaacttatcgaggaaattggctttcgtgcctccctggcccagaggatccccaacgctcatcacttggaccacaaggtggaaataaagcagtggaagaactctttcctgtgcagcctggtgtttggcatccccgtcatgggtttaatgatctatatgttgatacccagccatgagcctcagtcctcagtccttgaccacaacgtcgtcccaggactgtccatcctgaatctcgtcttctttatcttgtgcacctttgtgcagttccttggcggctggtacttctatgtccaggcctacaaatctctgagacacgggatggccaacatggacgtgctcatcgtgctggccacgagcatcgcctacgtctactccctcgtcatcctggtggtggccgtggccgagaaggccgagaggagccccgtgaccttctttgacacgccccccatgctcttcgtcttcatcgccctggggcggtggctggaacacgtggtgaagagcaaaacctcagaagcgcttgccaaactcatgtctctgcaagccacggaagccaccgtcgtgacccttggtgaagacaacgtgatcatcagggaggagcaggtgctcatggagctggtgcaacgaggtgacatcatcaaggtggtccccgggggcaagtttcccgtggacgggaaagtcctagaaggcaacaccatggccgacgagtccctcatcacaggagaggccatgcctgtcaccaagaagcccggaagcatggtaatcgccgggtccatgaacgcccatggctctgtgctcatcactgccacccacgtgggcaatgataccaccttggcccagattgtgaagctagtggaagaggcccagatgtccaaggcacccattcagcaactggctgaccggtttagtggatattttgtcccatttatcatcatcatttcaactgtgacgttggtggcccccagcaagggcatctcccaggccgaggtggtcctgcggttcgcgttccagacgtccatcacggtgctctgcatcgcctgcccctgctcgctgggcctggccacgcccacggccgtcatggtgggcaccggggtggccgcccagaacggcatcctcatcaagggcggcaagcccctggagatggcccacaagataaagaccgtgatgttcgacaaaaccggcaccattacccacggggtccccaaagtctcgagggtcctcctgctcgtggacgtggccacgctgcccctgcggaaggtgcttgctgtggtggggaccgcggaggccagcagtgagcaccccctgggcgtggcagtgaccagacactgtaaagaggaacttggcacggagaccctggggtgctgcatggacttccaggcggtgcccggctgtggaatcagctgcaaagtcagcaacgtggagagcatccttgcccagggcgagcgcccgcagggcccaccaactgctcaccagaacagagtcggcagcgagccctcagaaacagacgcagccactcagaccttctctgtgctgatcggaaaccgggaatggatgaggcgcaacggcctgaccgtcaccagcgacgtccgcgacgccatgaccgaccacgagacaaagggccagacggccatcctggtcgccatcgatggtgtactgtgcggcatgatcgccgtcgcggactcggtcaagcaggaggccgccctggccgtgcacacgctgaagagcatgggcgtggacgtggtgctcatcaccggggacaaccgcaagacagccagggccattgccacccaggttggcatcaacaaagtctttgcagaggtgctgccttctcacaaggtggccaaagtccaggagctgcagaaccaggggaagagagtggccatggtgggcgacggcgtgaacgactccccagccctggcgcaggctgacgtgggcattgccatcggcacgggcactgacgtggccatcgaggcggccgacgtcgtcctcatcaggaatgacctgctcgatgtggtggccagcatccacctctccaggaggaccgtctggagaatacggctcaacctggtgctggcgctgatctacaacctgatcgggatccccgtcgcggcaggtgtcttcatacccattggcgtcgtgctgcagccgtggatgggctcagcggccatggcggcctcctccgtgtctgtggtcctctcgtcactgcagctcaagtgctacaggaagccggacctggcgcagtacgaggcgcaggcgcacggccacatgaagcccctgagcgcgtcgcaggtcagcgtgcgcgttggcatggacgaccgccggcgcgactccccgcgggcctcggcctgggaccaggtcagctacgtcagccaggtgtccctgtcccccctcaagtccgacaagctgtcccggcacagtggcgcggccgacgacaggggcgacaagtggtctctgcttctgaatgaccgggacgaggagcagggcatctgaaagccgcccccgcggctgaggctcccagcccgcagcggcagcagcaggcggccgagcccctccaggcctaggcgaacattctggatcaccccttccctgcgcccgggggcgcgattccccgggttccatgggctcaggggaaggcgtgcttgcctacgcgctcgtgggctcatcggacaccttgctgcggcctcaagaagaggaaggacaagccctcctcg

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