LOCUS       XM_018056698            6330 bp    mRNA    linear   MAM 08-SEP-2016
DEFINITION  PREDICTED: Capra hircus ATPase copper transporting beta (ATP7B),
            transcript variant X1, mRNA.
ACCESSION   XM_018056698
VERSION     XM_018056698.1
DBLINK      BioProject: PRJNA340281
KEYWORDS    RefSeq.
SOURCE      Capra hircus (goat)
  ORGANISM  Capra hircus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia;
            Pecora; Bovidae; Caprinae; Capra.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_030819.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Version          :: Capra hircus Annotation Release 102
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 7.1
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6330
                     /organism="Capra hircus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9925"
                     /chromosome="12"
                     /sex="male"
                     /tissue_type="blood"
                     /dev_stage="adult"
                     /breed="San Clemente"
     gene            1..6330
                     /gene="ATP7B"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 14 ESTs, 4 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 4 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:102183524"
     CDS             1..4518
                     /gene="ATP7B"
                     /codon_start=1
                     /product="copper-transporting ATPase 2 isoform X1"
                     /protein_id="XP_017912187.1"
                     /db_xref="GeneID:102183524"
                     /translation="

MERAGDQTPGNPEPSSLATLGDPQVTLLTVHKQWSFKRSPGTGGSSRPVISEEECPPPSEEGEFSQKVLNGSEEISSKQILSKLFQPAMKQSFAFDNNGYEDDLDGVCPSQTAAGTISIVGMTCQSCVKSIEGRVSSLKGIVSIKVSLEQGSAEVRYVPSVVSLMQICHQIEDMGFQASVAEGKATSWASRVSPTSEAVVKLRVEGMTCQSCVSSIEGKIGKLQGVVRVRVSLSNQEAVITYQPYLIQPQDLRDHITDMGFEAVIKNKVAPVSLGPIDVRRLQSTLSAAPPTPVNQNDNNSETPGGQGVPLHLRVDGMHCKSCVLNIEDNIGQLPGVQSIHVSLESRTAQVQYDPSLVSPGALQRAIEALPPGNFKVSFPNGAEGSGPDSRTPPAPSAPCTMMLAIAGMTCKSCVQSIEGLISQRAGVHQISVFLAEGTAVVLYDPSRTHPEELRAAVEDMGFEASILAENCSSNQVGNHSAGSAMGPAAAGTPVPMQEEAPQPGGLHTNHIPRQSPKSLPASTTVAPKKCFLQISGMTCASCVSNIERNLQKEPGILSVLVALMAGKAEVKYNPEAIQPLEIAKLVQDLGFEAAVMEDYTGSDGDLELMITGMTCASCVHNIESKLRRTEGITYASVALATSKAHVKFDPEIIGPRDIVKLIEEIGFRASLAQRIPNAHHLDHKVEIKQWKNSFLCSLVFGIPVMGLMIYMLIPSHEPQSSVLDHNVVPGLSILNLVFFILCTFVQFLGGWYFYVQAYKSLRHGMANMDVLIVLATSIAYVYSLVILVVAVAEKAERSPVTFFDTPPMLFVFIALGRWLEHVVKSKTSEALAKLMSLQATEATVVTLGEDNVIIREEQVLMELVQRGDIIKVVPGGKFPVDGKVLEGNTMADESLITGEAMPVTKKPGSMVIAGSMNAHGSVLITATHVGNDTTLAQIVKLVEEAQMSKAPIQQLADRFSGYFVPFIIIISTVTLVVWIVIGFIDFGVVQKYFPAPSKGISQAEVVLRFAFQTSITVLCIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHKIKTVMFDKTGTITHGVPKVSRVLLLVDVATLPLRKVLAVVGTAEASSEHPLGVAVTRHCKEELGTETLGCCMDFQAVPGCGISCKVSNVESILAQGERPQGPPTAHQNRVGSEPSETDAATQTFSVLIGNREWMRRNGLTVTSDVRDAMTDHETKGQTAILVAIDGVLCGMIAVADSVKQEAALAVHTLKSMGVDVVLITGDNRKTARAIATQVGINKVFAEVLPSHKVAKVQELQNQGKRVAMVGDGVNDSPALAQADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSRRTVWRIRLNLVLALIYNLIGIPVAAGVFIPIGVVLQPWMGSAAMAASSVSVVLSSLQLKCYRKPDLAQYEAQAHGHMKPLSASQVSVRVGMDDRRRDSPRASAWDQVSYVSQVSLSPLKSDKLSRHSGAADDRGDKWSLLLNDRDEEQGI"

     misc_feature    346..537
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(364..372,379..381)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    601..789
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(619..627,634..636)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    937..1110
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(952..960,967..969)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1207..1398
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1225..1233,1240..1242)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1597..1785
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1612..1620,1627..1629)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1822..2013
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1840..1848,1855..1857)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    2077..4182
                     /gene="ATP7B"
                     /note="P-type heavy metal-transporting ATPase, similar to
                     human copper-transporting ATPases, ATP7A and ATP7B;
                     Region: P-type_ATPase_Cu-like; cd02094"
                     /db_xref="CDD:319783"
     misc_feature    order(3067..3069,3073..3075,4111..4113)
                     /gene="ATP7B"
                     /note="putative Cu binding site [ion binding]; other site"
                     /db_xref="CDD:319783"
     misc_feature    order(3199..3207,3409..3411,3562..3570,3658..3660,
                     3778..3786,3844..3846,3853..3855,3862..3864,3919..3921,
                     3928..3930)
                     /gene="ATP7B"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319783"
ORIGIN      

atggagagagctggggaccagacccccgggaaccccgagccatcctccctggcgactctgggtgacccacaggtgaccctgctgactgtccacaaacaatggtccttcaagaggagccctgggaccgggggctccagcaggccggtgatttcagaggaggaatgccctcccccatcagaggaaggagaattttcacagaaggttttgaatggatcggaagagatcagttccaagcagatcctgtctaagcttttccagccagcaatgaagcagagctttgcctttgacaacaatggctacgaggatgacctggatggcgtgtgcccctcccagacggccgctggcaccatcagcattgtgggcatgacctgccagtcgtgtgtcaagtccatcgagggcagggtctccagtttgaaaggcattgtgagcattaaggtttccctggagcagggcagtgctgaggtgagatacgtgccctcagtggtaagcctgatgcagatttgccatcagattgaagacatgggcttccaggccagtgtggccgagggaaaggccacctcctgggcctccagggtctcgcccacctcggaggccgtggtcaagcttcgggtggagggcatgacctgccagtcctgtgtcagctccatagaaggcaagatcgggaaactgcagggcgtcgtgagggtccgcgtctcgctcagcaaccaggaggcagtcatcacttaccagccttaccttatccaaccccaagacctcagggaccatataaccgatatggggtttgaagccgtcatcaagaacaaggtggccccagtaagcctgggacccatagacgtcaggcgactccagagcaccctctcagcggcccctccaactcccgttaatcagaatgacaataactctgagaccccagggggccagggggtccccctgcacctgagagtggatggaatgcactgtaagtcttgtgtcctgaacattgaagacaatatcggccagctccccggggttcagagtattcacgtgtccctggagagcaggaccgcccaagtccagtacgacccttctctcgtctccccaggggccctgcagagggccatcgaggccctgcctcctgggaactttaaagtctcttttcccaatggggcggaagggagtgggccagactccaggacccccccggcacccagtgcgccctgtaccatgatgctggccattgctggcatgacctgtaagtcctgcgtccagtccatcgaaggcctgatctcccagagggcgggcgtgcaccagatctcagtctttttggccgaaggaactgcagtggttctctatgatccatctcgaactcacccagaagaactgcgagccgcggtggaggacatgggattcgaggcctccatcctggctgaaaactgttccagcaaccaggttggcaaccacagtgctgggagtgccatggggcctgcggcagctggcacacctgtgcccatgcaggaagaggctccccagccaggggggctccacactaaccacatcccccgccagtcgcccaagtccctcccggcctccaccacggtggccccaaagaagtgcttcctacagatctcaggcatgacctgtgcgtcctgtgtgtccaacatagagaggaacctgcagaaagaacctgggatcctgtctgtgctggttgccctgatggcaggaaaggcagaggtgaagtacaacccggaagccatccagcccctggagatagcaaagctcgtccaggacctgggctttgaggcagcagtgatggaagactacacgggctcggatggcgacctcgagctgatgatcacggggatgacctgcgcctcctgtgttcacaacatagagtccaaactcaggaggacagaaggcatcacctacgcctctgtggctctcgccaccagcaaagcccacgtgaagtttgatcctgaaattattggtccgcgggatattgtcaaacttatcgaggaaattggctttcgtgcctccctggcccagaggatccccaacgctcatcacttggaccacaaggtggaaataaagcagtggaagaactctttcctgtgcagcctggtgtttggcatccccgtcatgggtttaatgatctatatgttgatacccagccatgagcctcagtcctcagtccttgaccacaacgtcgtcccaggactgtccatcctgaatctcgtcttctttatcttgtgcacctttgtgcagttccttggcggctggtacttctatgtccaggcctacaaatctctgagacacgggatggccaacatggacgtgctcatcgtgctggccacgagcatcgcctacgtctactccctcgtcatcctggtggtggccgtggccgagaaggccgagaggagccccgtgaccttctttgacacgccccccatgctcttcgtcttcatcgccctggggcggtggctggaacacgtggtgaagagcaaaacctcagaagcgcttgccaaactcatgtctctgcaagccacggaagccaccgtcgtgacccttggtgaagacaacgtgatcatcagggaggagcaggtgctcatggagctggtgcaacgaggtgacatcatcaaggtggtccccgggggcaagtttcccgtggacgggaaagtcctagaaggcaacaccatggccgacgagtccctcatcacaggagaggccatgcctgtcaccaagaagcccggaagcatggtaatcgccgggtccatgaacgcccatggctctgtgctcatcactgccacccacgtgggcaatgataccaccttggcccagattgtgaagctagtggaagaggcccagatgtccaaggcacccattcagcaactggctgaccggtttagtggatattttgtcccatttatcatcatcatttcaactgtgacgttggtggtatggattgtaatcggttttatcgattttggtgttgttcagaaatactttcctgcccccagcaagggcatctcccaggccgaggtggtcctgcggttcgcgttccagacgtccatcacggtgctctgcatcgcctgcccctgctcgctgggcctggccacgcccacggccgtcatggtgggcaccggggtggccgcccagaacggcatcctcatcaagggcggcaagcccctggagatggcccacaagataaagaccgtgatgttcgacaaaaccggcaccattacccacggggtccccaaagtctcgagggtcctcctgctcgtggacgtggccacgctgcccctgcggaaggtgcttgctgtggtggggaccgcggaggccagcagtgagcaccccctgggcgtggcagtgaccagacactgtaaagaggaacttggcacggagaccctggggtgctgcatggacttccaggcggtgcccggctgtggaatcagctgcaaagtcagcaacgtggagagcatccttgcccagggcgagcgcccgcagggcccaccaactgctcaccagaacagagtcggcagcgagccctcagaaacagacgcagccactcagaccttctctgtgctgatcggaaaccgggaatggatgaggcgcaacggcctgaccgtcaccagcgacgtccgcgacgccatgaccgaccacgagacaaagggccagacggccatcctggtcgccatcgatggtgtactgtgcggcatgatcgccgtcgcggactcggtcaagcaggaggccgccctggccgtgcacacgctgaagagcatgggcgtggacgtggtgctcatcaccggggacaaccgcaagacagccagggccattgccacccaggttggcatcaacaaagtctttgcagaggtgctgccttctcacaaggtggccaaagtccaggagctgcagaaccaggggaagagagtggccatggtgggcgacggcgtgaacgactccccagccctggcgcaggctgacgtgggcattgccatcggcacgggcactgacgtggccatcgaggcggccgacgtcgtcctcatcaggaatgacctgctcgatgtggtggccagcatccacctctccaggaggaccgtctggagaatacggctcaacctggtgctggcgctgatctacaacctgatcgggatccccgtcgcggcaggtgtcttcatacccattggcgtcgtgctgcagccgtggatgggctcagcggccatggcggcctcctccgtgtctgtggtcctctcgtcactgcagctcaagtgctacaggaagccggacctggcgcagtacgaggcgcaggcgcacggccacatgaagcccctgagcgcgtcgcaggtcagcgtgcgcgttggcatggacgaccgccggcgcgactccccgcgggcctcggcctgggaccaggtcagctacgtcagccaggtgtccctgtcccccctcaagtccgacaagctgtcccggcacagtggcgcggccgacgacaggggcgacaagtggtctctgcttctgaatgaccgggacgaggagcagggcatctgaaagccgcccccgcggctgaggctcccagcccgcagcggcagcagcaggcggccgagcccctccaggcctaggcgaacattctggatcaccccttccctgcgcccgggggcgcgattccccgggttccatgggctcaggggaaggcgtgcttgcctacgcgctcgtgggctcatcggacaccttgctgcggcctcaagaagaggaaggacaagccctcctcgcatcccctgccttagcatttgtgacacgaccagtctcattgggtccagcatcttcgctgcgcccctccacagagctcatagaaacttcggggtctggctctttctgacagcacccgtgcgcatcgcgtgcctgagaccacctgtacctcaggcgcccccttgttttctgctggggccttctcttcctcctctgcccttgacagtgggggtgtgacaccccgtcatctgagggcagggctgacatcctcacatcctctctgctgctctccaaggggctcctgtgctcctgcctgaaccccttgcccacgcaaccaccagaaagcctgccacacttctccttggtgaccagaggtcttggttgcccgcgaaccgcttcttcctagagtcccggcttctcatgcttaatccagtgtggttgctgactgtcgctgcctagctgggctgagggtctgagagcctgaggcttgagaaattcggcttcctgtggggtcctgggggaggcatgtggctcaagatactgcttgcctggtttcaggggcttcagttgcatggcctgtggtgtgacagtcacctcacagggtctggtatggggttcaggtctgtgctccccagagctgcgcagccctggggcagtgagacccaagtaagaggacaccccagccctccacacgcttcgactcctgcacatggagctggtgccttaggaagggggggggggtgcccaccactcccaagggaactgtttctaacttccagtggcctttatggttgcatgataatcagcgcaacagcagtgggcccacggcagactccgagcttggtggtgattggcagagcctgtggaggtctggtaatgctagccaaatctgactaagtgagtagagcctgttctcagtttcaagggagaagcccttatcacacacttcacgcacactttagttatttattgtcagttatttttcagggggatataagcactttttattgcttacctctaatcgtcacaatgaactagcaaagtagatacaacattgtccacatttcacacaggcgggaaacaggctcagagaggctaggaatcccgccaaggatcacacagcaagtgtgcgtgccggagcagggatctgaattcatgtccgcgggccctgaagtcttttcgctaatttggccctaccgtcaactgtttgtttgataagaagcaacaaggaaaaagcccttgttcctggaagaacaaagctgccaggtgacgtattccctgaactggcttgaaatgtgacctcgaggtcatgtcacattgcctttggatagctccttcccatttgcatgtcattgagtctatgctgcatcttaccctctaaaatccgtgtgcagggtggaggtgtggttttgtttccagtcttccttccccagccccgtcctgctgtgttctcagttgtgtccttctccgttcccagctgctgctctgggaatgtttcctgtttccttggagaaggctaatcatatctaaagaatacaattgtatcaacttttcaaaaagcttttaggaccataaatgttatgtgtatagggacatggagatatttatgtaatt

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