LOCUS       XM_017895119           14476 bp    mRNA    linear   PRI 24-AUG-2016
DEFINITION  PREDICTED: Rhinopithecus bieti argonaute 2, RISC catalytic
            component (AGO2), mRNA.
ACCESSION   XM_017895119
VERSION     XM_017895119.1
DBLINK      BioProject: PRJNA339282
KEYWORDS    RefSeq.
SOURCE      Rhinopithecus bieti (black snub-nosed monkey)
  ORGANISM  Rhinopithecus bieti
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Cercopithecidae; Colobinae; Rhinopithecus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_016811810.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Version          :: Rhinopithecus bieti Annotation
                                           Release 100
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 7.1
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..14476
                     /organism="Rhinopithecus bieti"
                     /mol_type="mRNA"
                     /isolate="Rb0"
                     /db_xref="taxon:61621"
                     /chromosome="Unknown"
                     /sex="male"
                     /tissue_type="blood"
     gene            1..14476
                     /gene="AGO2"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 10 mRNAs, 364 ESTs, 38 Proteins,
                     and 100% coverage of the annotated genomic feature by
                     RNAseq alignments, including 1 sample with support for all
                     annotated introns"
                     /db_xref="GeneID:108544157"
     CDS             142..2583
                     /gene="AGO2"
                     /codon_start=1
                     /product="protein argonaute-2"
                     /protein_id="XP_017750608.1"
                     /db_xref="GeneID:108544157"
                     /translation="

MDIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPGEGKDRIFKVSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRVCNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSASFNTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHTSGQSNGRDHQALAKAVQVHQDTLRTMYFA"

     misc_feature    277..501
                     /gene="AGO2"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:435368"
     misc_feature    529..681
                     /gene="AGO2"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    682..1044
                     /gene="AGO2"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(838..840,883..885,925..927,937..939,991..993,
                     1012..1014,1018..1020)
                     /gene="AGO2"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1177..2454
                     /gene="AGO2"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1588..1590,1600..1602,1636..1647,1654..1656,
                     1678..1680,1687..1689,1699..1701,1711..1713)
                     /gene="AGO2"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(1792..1794,1798..1800,2008..2010,2422..2424)
                     /gene="AGO2"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

cagttcggaagcctttgagcagcacttgcgcctcctgcaccgccgccaccccccatccaaggatatgccttcaagcctccacctagacccgactttgggacctccggaagaacaatcaaattacaggccaatttcttcgaaatggacatccccaaaattgacatctatcactatgaattggatatcaagccagagaagtgcccaaggagagttaacagggaaatcgtggaacacatggtccagcactttaaaacacagatctttggggatcggaagcccgtgtttgacggcaggaagaatctgtacacggccatgccccttccgattgggagggacaaggtggagctggaggtcacgctgccgggagaaggcaaggatcgcattttcaaggtgtccatcaagtgggtgtcctgcgtgagcttgcaggcgttacacgatgcactttcagggcggctgcccagcgtcccttttgagacgatccaggccctggacgtggtcatgaggcacttgccatccatgaggtacacccccgtgggccgctccttcttcaccgcgtccgagggctgctccaaccctcttggcgggggccgggaagtgtggtttggcttccatcagtccgtccggccttctctctggaaaatgatgctgaatattgatgtgtcggcaacagcattttacaaggcacagccagtaatcgagtttgtttgtgaagttttggattttaaaagtattgaagaacaacaaaaacctctgacagattcccaaagggtaaagtttaccaaagaaattaaaggtctaaaggtggagataacgcactgtgggcagatgaagaggaaataccgcgtctgcaatgtgacccggcggcccgccagtcaccaaacattcccgctgcagcaggagagcgggcagacggtggagtgcacggtggcccagtacttcaaggacaggcacaagttggttctgcgctacccccacctcccatgtttacaagtcggacaggagcagaaacacacctaccttcccctggaggtctgtaacatagtggcaggacaaagatgtattaaaaaattaacggacaatcagacctcaaccatgatcagagcgactgctaggtcggcacccgatcggcaagaagagatcagcaaattgatgcgaagcgcaagtttcaacacagatccatacgtccgtgaatttggaatcatggtcaaagatgagatgacggacgtgactgggcgggtgctgcagccgccctccatcctctacgggggcaggaataaagcgattgcgacgcctgtccagggtgtctgggacatgcggaacaagcagttccacacgggcattgagatcaaggtgtgggccatcgcgtgctttgccccccagcgccagtgcacagaagtccatctgaagtccttcacagagcagctcagaaagatctccagagacgccggcatgcctatccagggccagccgtgcttctgcaaatacgcacagggtgcggacagtgtggagcccatgttccggcacctgaagaacacgtatgcaggcctgcagctggtggtggtcatcctgcctggcaagacgcccgtgtacgccgaggtcaagcgcgtgggagacacagtgctggggatggccacgcagtgcgtgcagatgaagaacgtgcagaggaccacaccgcagaccctgtccaacctctgcctgaagatcaacgtcaagctgggaggcgtgaacaacatcctgctgccccagggcaggccaccagtgttccagcagcccgtcatctttctgggagcggacgtcactcacccccccgccggggacgggaagaagccctccattgccgccgtggtgggcagcatggacgcccaccccaatcgctactgcgccactgtgcgcgtgcagcagcaccggcaggagatcatacaagacctggccgccatggtccgcgagctcctcatccagttctacaagtccacgcgcttcaagcccacccgcatcatcttctaccgtgacggcgtctccgaaggccagttccagcaggttctccaccacgagttgctggccatccgtgaggcctgtatcaagctggaaaaagactaccagcccgggatcaccttcatcgtggtgcagaagaggcaccacacacggctcttctgcacggacaagaatgagcgggtcgggaaaagtggaaacattccagcaggcacgactgtggacacgaaaatcacccaccccaccgagttcgacttctacctgtgtagtcacgctggcatccagggaacaagcaggccttcgcactatcacgtcctctgggacgacaatcgtttctcctctgacgagctgcagatcctcacctaccagctgtgtcacacctacgtgcgctgcacacgctccgtgtccatcccggcgccagcatactacgcccacctggtggccttccgggccaggtaccacctggtggataaggaacatgacagtgctgaagggagccatacctctgggcagagtaacgggcgagaccaccaagcactggccaaggcggtccaggttcaccaagacactctgcgcaccatgtactttgcttgacatgttttagtgtttagcgattgtgtaccgagtgggattcacgagaccagctacactcagaccaacagatggccagcccttccatgacagccagcattgaacatgagacgtcattgattttattagattctccgttttccagaatgccttccgtcccagatttcacacttggattttgaactgcagacctgtatgagaacccaatgtcataggaaatatggtttgctaaaatctataagctgcttattaaaatagagtcccgtgtttcctaaaaatctaaaaccagtctatgaactcagggctttaaaacatttttaatttatttggtcattcaatttacttgtttttaatacatgattctctatgaaattgatgggctcaaactagctgtgaatcttctgagagtgaaagcaacacaaaacacaattgtggttttaaagccttgaacattctgatgttgtcactaaagttgatttccaggcgatgctcgtgtgccgctggcgtggctcacccaaggtccttgaccgagggctggtggccatgcagaggcctccgcaggtgccgtgttctgccagcactgcccttcacctggcctgaactaaggagcagtggcagaaggtgggccccatgtgtttacagcatttccaggtccagagaggttggcagacaagtgccattttaataaaaatgtatttaaaaaaagaaaaaagacaatatactgacagtctaatcatcagatttgtcctataggactgtgacatttattttccaaagtttttaaagaatacgggtctgtggtgatgaatacagtacaatcctttttcactgttatgtctttaatgtaagagaaaattatatatatctggtttgcagtattaatgtgatagatagatgctgttttttcattttattgactgtggggtgcttctgtgatctgtttagcatatcaagagtgttttggagcctggagacgagaccgcctctcagttcttagtgcttaaggacaggaatatgcagttaacttaatgtgacagcaacctgcttccccccgtggagactgtgcagcgtgtacccacgggaggggcgggtatgctctccgtgccgctcgccgccctccctgccgcctcatccccctgtgtcactcactcagctgatgaagcacaagtggaaattatttattcttgcattgctgggaaacacattcgtgtgtcgggacgcactcctctccgtgtgcgcttttgtcagatgactttcatagatctatgcactgagatttgtagaaagctgtcggtggtggctctgctgggcgagaggctgtcagtcacagcgaaggaggctgcctggccctgggaggcccaaggatggcagggccagcagaaggcataggccattcttctggggtttgcatttggggccccaggcgtggggttgccagtctagaaactgttgcactaagactgacactgcggacaattttgaaggctaacaacagacaactctgtttgtgctgagtgcgctttttgtctctgtacacagttttagtaagactcaaatccgtgttccgtgtagaggcgtcaggaaggaggcgagcctcccctagtgctgctgtgcgctccttagatcccccttcctgctgctgttccctccctggccctgtgcgacacttacctcggcactgtggtggggtggggtgccaaaggagctgcctcctgctgcgcggcaccccctccgcctttgtgctcagctgcttcggaggcagcaggaggggcagcaggccgcgggtggggggtcgccggacacctcgcctggatgttggcggcaatgacaaagggatgactattatttgtgaagacgtgtactcagagtggtgtgtgtgtgtacgcacgcgtgtgtccctgtgtgtgtgtgagtgtcttattaatggcattagtctcttctggctgtattttttttttaaacctttttaaatgacagaagccccactctaagaaatcgcaattccctgttgttttattggcaagtggcactttctcctgttttcagaaggatacagacatgctcttagcttaaattaacagacgcattcaagctaaggagggaatcttgtgactagtaacttttcaaatcggaaattagtttccagccatttctagaatcatctggaactatgtgtctcgaaggtgtgtttcttgcacctgcatcaggctctctgtctgggggatggtggttcttgtttaaaatgcagatttgtgggcctgctgccacctcctgagtgcgtacttcagggctggcctgggcatctgtgtctaagcgatggcctgcagccctgggctccctggggtctgaggacccagctctggcagcacccggcagggaggaggtgcttcctgagcagatgcctgggacagactgggctg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