LOCUS       XM_017731264            6358 bp    mRNA    linear   VRT 03-AUG-2016
DEFINITION  PREDICTED: Corvus brachyrhynchos ATPase copper transporting beta
            (ATP7B), transcript variant X4, mRNA.
ACCESSION   XM_017731264
VERSION     XM_017731264.1
DBLINK      BioProject: PRJNA253849
KEYWORDS    RefSeq.
SOURCE      Corvus brachyrhynchos (American crow)
  ORGANISM  Corvus brachyrhynchos
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Passeriformes; Corvoidea;
            Corvidae; Corvus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_008237436.1) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Version          :: Corvus brachyrhynchos Annotation
                                           Release 101
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 7.1
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6358
                     /organism="Corvus brachyrhynchos"
                     /mol_type="mRNA"
                     /isolate="BGI_N302"
                     /db_xref="taxon:85066"
                     /chromosome="Unknown"
                     /sex="female"
                     /country="USA"
     gene            1..6358
                     /gene="ATP7B"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 3 ESTs, 15 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 2 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:103613590"
     CDS             191..4489
                     /gene="ATP7B"
                     /codon_start=1
                     /product="copper-transporting ATPase 2 isoform X4"
                     /protein_id="XP_017586753.1"
                     /db_xref="GeneID:103613590"
                     /translation="

MKHNFAFDNMGYEESSETMPSPPSPEHSVVVNIVGMTCQSCVQSIEGQISKVKGILRIKVSLEQNHAVIKYLQSEISPEQICQEILDMGFDANIAEDKLTTATVNLPSLKEAVVKLRVEGMTCQSCVTSIEGKIRKLHGVAKIKVSLDNQEAIVAYHPYIIQPDDLKRHISDLGYDCTIKSKSAPLKLGALDLQRLQNANPRETPASLKSDGLDPLVTEVGSTATVTLQIEGMHCKSCIRNIEGNISDLPGIKSIKVSLEHKCAVVQYTPDFITLSALQQAIESLPPGNFKVTLHNGSEAGKAASPSGAFTYDLIRQPPQGTTLTAVIKIDGMTCNSCVQSIEGAISQRQGVQHVAVSLAGSTGTIHYDPAVTSGEELRAAIEDMGFDASVLTVYCAFIQDTATGEHRCQPDASKAAVKPGAPEPPHQGCASDALPDSPHLDGSNRLSGATEEKCVLQITGMTCASCVSTIERNLQKEDGIVSVLVALMAGKAEIKYKPELIQPLEIAQLIQNLGFEATVMEDNAETEGQVELLITGMTCASCVHNIESKLMRTNGIFSASVALATSKAHIQFDPEIIGPRDIIKVIKEIGFHASVAKRAPNAHNLDHKKEIQQWRKSFLYSLVFGIPVVVIMIYMQIPNGGDRGSKVLERNLIPGLSILNLLFFILCTFVQFLGGWYFYVQAYKSLRHKTTNMDVLIVLATTIAYLYSCVILIVAIIEKAEKSPVTFFDTPPMLFVFIALGRWLEHIAKGKTSEALAKLMSLQATEATVVTLGPDHSIVREEQVPVELVQRGDVIKVVPGGKFPVDGKVIEGSSMADESLITGEPMPVIKKPGSTVIAGSINAHGSLLVNATHVGSDTTLAQIVKLVEEAQMSKAPIQQLADKFSGYFVPFIIIISTVTLIAWTTIGFVNFDIIKKYFPNQSKNISKAEIILRFAFQTSITVLSIACPCSLGLATPTAVMVGTGVAAQNGILIKGGKPLEMAHQIKTVMFDKTGTITCGVPKVMRVLLMGDTTMLPLKKVLAVVGTAEASSEHPLGMAVTKYCKEELGTESLGYCTDFQAVPGCGISCKVGGVEAILGSELDVNISGDSSAPLGDNAVITLLESQGPSASQKYSVLIGNREWMRRNGLNIRNDVNDAMTNHEMKGQTAILVAIDGMLCGMIAIADTVKQEAALAVHTLQSMGIDVVLITGDNRKTAKAIATQVGIKKVFAEVLPSHKVAKVQELQNGKKKVAMVGDGVNDSPALARADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRIRINLILALIYNMLGIPIAAGVFMPVGLVLQPWMGSAAMAASSVSVLLSSLQLKCYKKPDTERYEAQAQGRMKPLTPSQISVHIGMDDRRRDSSKASPWDQTSQVSLSSLASDRLPRGNGFIEEEGGKWSLLINGADEEQYI"

     misc_feature    278..466
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(296..304,311..313)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    533..724
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(551..559,566..568)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    869..1045
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(887..895,902..904)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1169..1360
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1187..1195,1202..1204)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1556..1747
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1574..1582,1589..1591)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    1784..1975
                     /gene="ATP7B"
                     /note="Heavy-metal-associated domain (HMA) is a conserved
                     domain of approximately 30 amino acid residues found in a
                     number of proteins that transport or detoxify heavy
                     metals, for example, the CPx-type heavy metal ATPases and
                     copper chaperones. HMA domain...; Region: HMA; cd00371"
                     /db_xref="CDD:238219"
     misc_feature    order(1802..1810,1817..1819)
                     /gene="ATP7B"
                     /note="metal-binding site [ion binding]"
                     /db_xref="CDD:238219"
     misc_feature    2039..4162
                     /gene="ATP7B"
                     /note="P-type heavy metal-transporting ATPase, similar to
                     human copper-transporting ATPases, ATP7A and ATP7B;
                     Region: P-type_ATPase_Cu-like; cd02094"
                     /db_xref="CDD:319783"
     misc_feature    order(3032..3034,3038..3040,4091..4093)
                     /gene="ATP7B"
                     /note="putative Cu binding site [ion binding]; other site"
                     /db_xref="CDD:319783"
     misc_feature    order(3164..3172,3374..3376,3542..3550,3638..3640,
                     3758..3766,3824..3826,3833..3835,3842..3844,3899..3901,
                     3908..3910)
                     /gene="ATP7B"
                     /note="putative ATP binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:319783"
ORIGIN      

agagtggtgattcttaggaaggaaacataatagtatttctccttttgaactgcaattgcttgagtagtttgacagaagctcatactagtttgttctccgaaataacagaaattgcagaaacattaaaaggtccttattgtaggctttgtccaacactgattctcctcctgattgtgagctgaagcctacaatgaaacataattttgcttttgacaacatgggctatgaggagagctctgaaaccatgccctctccaccttccccagagcacagtgtggtagtcaacattgtgggaatgacttgccaatcatgtgtgcagtcgatagaaggccaaatttccaaggtgaagggcattttgagaattaaagtctcccttgaacagaaccatgctgttatcaagtatctgcagtcggaaataagtcctgaacagatttgccaggaaattctggatatgggctttgatgccaacatagcagaagataagttgacaacagcgactgtaaatttgccaagcttgaaagaagcagtagttaagcttcgggtagaaggcatgacatgccagtcctgtgtcaccagcattgaaggaaagattaggaaactacacggtgtagcaaaaatcaaggtgtcacttgataaccaagaagcaattgttgcttaccatccttacatcattcagcctgatgacctcaagagacacatcagtgacctggggtatgactgcaccattaaaagcaaatcagcccctttgaagctgggtgcccttgatctccagcgcttgcagaatgcaaaccctagggagacacctgcaagtctcaagagtgatgggctggatccactggttaccgaggtgggtagcacagctacagtgactttacagatagaaggcatgcactgcaagtcctgtatcagaaacatcgaaggaaatatatcagatcttcctggcataaaaagtattaaagtgtctttggagcataaatgtgctgtggtacagtataccccagatttcatcaccctgtcagctttgcagcaagctattgaatcccttccacctggaaactttaaagtaaccctccataatggttcagaagcaggcaaagcagcatctccctcaggtgctttcacatacgatctcatcagacagccaccgcaaggcacgacacttacggctgttattaagattgatggcatgacctgcaattcttgtgtacagtccatagaaggggccatatcacagagacaaggagtgcagcatgtagcagtttctctagctggcagtactgggaccatacactatgatccagctgtcacgagtggagaagagttaagagctgccatagaagacatgggatttgatgcctctgtactgacagtgtattgtgcatttattcaagatactgctactggagaacacaggtgccagcctgatgccagcaaagctgccgtgaaacctggagctccagagcctcctcaccaaggctgtgcctcagatgctcttccagacagtcctcaccttgatgggtcaaacaggctcagtggagccacagaagaaaagtgtgttttacaaatcacaggcatgacctgtgcatcgtgtgtgtctaccattgaaagaaatttgcagaaagaagatggaattgtttcagtgttggtagcactgatggcaggtaaagcagagataaaatacaagccagaactcatacagcctcttgaaatagcacagctgatccagaatctgggttttgaagctactgtcatggaagataatgcagaaacagaagggcaggtggagcttcttattacagggatgacttgtgcttcttgtgttcacaatattgaatccaaactcatgagaacaaatggcatattctctgcctcagttgcacttgcgactagcaaagctcacatccagtttgatcctgaaattattggccctcgagatattataaaagtaatcaaggaaattggctttcatgcttctgtggctaaaagagctccaaatgcacataacctggatcacaaaaaggaaatacagcagtggaggaaatctttcttgtacagcctagtgtttggtattcctgttgtagtcataatgatttatatgcaaatacccaatggtggggaccgcgggtctaaggtgctggaacggaatctcattcctggattatctattttgaatcttctcttctttatcctctgcacttttgttcagttccttggtggatggtatttttacgtacaagcttacaagtcactgaggcacaagacgaccaatatggatgtgctcattgtactggccacgacgattgcttatctgtattcctgtgtgatcctgatagtagcaatcattgaaaaggcagagaaaagcccagtcactttcttcgacactcctccgatgttgtttgtgttcattgcacttggcagatggctggaacacatagccaagggtaagacctcagaagctcttgctaaacttatgtctcttcaagccacagaagccactgtggtgactcttggacctgaccactccattgtcagggaggagcaagtacctgttgaacttgttcaaaggggtgatgttataaaagttgttcctggtggaaagttcccagtggatggaaaggtcattgaaggcagttctatggcagatgagtctctcattactggggaacctatgccagtcattaaaaagcctgggagcacagtgattgctggttctataaatgcacatggctcacttcttgttaatgcaactcatgttggtagtgataccactctggcacagattgtgaaattggtggaagaagctcaaatgtcaaaggcacccatccagcaactggcagataaatttagtggctactttgttccatttatcatcatcatctcaactgtgacattgatagcatggaccacaattggttttgtaaattttgatattattaaaaaatattttcctaatcagagcaaaaacatttcaaaagctgaaataatactgaggtttgcatttcaaacctcgatcactgtgctgagcattgcatgcccttgctctttaggcctggctacccccacagctgtaatggtgggcacaggagtggctgcacagaatggtattctcatcaagggtggaaaacccctggaaatggcacatcagatcaagactgtgatgtttgataaaactgggaccatcacctgtggagttcctaaagtcatgagggtgcttttgatgggggacacaaccatgctccccctgaagaaggtactggcagttgttggtacagcagaagccagcagcgagcatcctttaggaatggctgtcactaaatactgcaaagaggagcttggcactgagagcctgggatactgcactgacttccaggcagtcccaggctgtggtatcagctgcaaggtcggaggagttgaggccattcttggcagtgagctggatgttaacatcagtggggatagcagtgctcctctgggagataatgcagtgatcacgctcttggaatcacaaggtccatcagcttctcagaaatactcggtgttgattggaaatcgtgagtggatgcgacgcaatggcttgaatattagaaatgatgtaaatgatgcaatgacaaaccatgaaatgaaaggacagactgccatactagtggctatagatggtatgttgtgtggaatgatcgcaatagcagacactgtcaagcaggaggcggcccttgctgtgcacacactgcaaagcatgggaatagacgtggtgctgataacaggagacaacaggaaaactgcaaaagccattgctactcaggttgggatcaaaaaagtctttgcggaggtgcttccttctcacaaggttgcaaaggtccaggaactccaaaatggaaagaagaaggttgcgatggttggtgatggagtcaacgattcccctgcactagccagggctgatgttggaattgcaattggaacgggcaccgatgttgccattgaagctgcagatgttgttcttatccgaaatgatttactggatgtagttgccagtattcacttatcgaagagaacagttcgaaggatacggataaatctgattcttgccttaatttataatatgcttggaatacccatagcagcaggtgtgttcatgcctgttggcctcgtgcttcagccttggatgggatcagctgcaatggcagcttcttctgtgtctgtcctgctgtcttccctgcagctgaaatgttacaagaagccagacacagaaaggtatgaagcacaagctcaaggccgcatgaagccactcactccttctcaaatcagtgttcacattggaatggacgataggaggagggattcttccaaagcatctccctgggatcagactagccaagtgtccctctcttccttggcttcagacaggctgccaagaggcaatggttttattgaggaggaagggggcaagtggtcattgctcataaatggagcagatgaagaacagtacatctgaagcactggactcttggtacagggggagatgttcctccccaccactgaggggaaggactgatacttcatcaacagcttcagtgttgtaagtgaagtatttcttcagctcataagacatttgcaactcagctcagagttgggttgtatggattgtggatttttttcaggtcaccagttatttctagttacggaaataatctgtggcactataatgaactggcttgtttgcacacagcattttgtgaaataatgtaaaattgtaattttcggagtttctgaaaaagaatttctttctctgtgactctttgctaggaaccaaatgtcatacttttcactcttttaaactttattacttcaagactacatgaagcaaaagtattttcagagctgccaaatataaatttctgtctaaatgaaattagcaatggcataaggaactctgtagtcggaagttgaatttttacacagaattgtaactagacatgtcactgtgagaacactttgtgtttaggattcatggcatctcctgagacaaaaagtgctttgttgtttcacctactataactctctgaaaggtctttttcaaagattttcacttgctttgaggtattgcatccttttgatgcacatttctattgctctcctagattttctcttttgctccttatgaggccttttcccctttttcttgcacaagaggtcttctatgagttatcattatgcttacagatattcctgtctgggacaaactccttgaagttaccaggaatctttacattcctattgaagtccataaaggcagaacaattcctggtcccagttatccaagataccttgcaggacccagggaagctcctaagagttgggcagttgtctgtctctttcctttgacagagtgaagaatttatgccagtgtgagcaaaggtggtatttaccttggtatgactgagcagaactagcactggtgtgactccagcatagctgcacagagtgagtttattgcatagcttaaccccaacttgctggttgcttaaaatggagctaaaagtttaaattataaaatggccttaaagggggcttctatttgctatcatataaataaatgccaggacttgaattaagaaaatttgtaatttaaatttgtatttatgttttgcattggttttagttcccctctttacttcggtgagaaatcaaagtgctggatgacccttttttgctttaacatctttaccaaagcttgcagtaatttcatccctgtggatgtcagcttcaccccttaatactttttacagtcaggacagtaggaatcaacagctttggtgcactggatccaggccctgagtgctgtgttgtccaggtgtgggactctgatgtaagcaaagttttatagtctaatttagaaagaagaggaaatactgtgctaaacaaaattcaataactacttcttttcattgactgaaatatagagctgtttccaacacaggttcaaatcctgcttctcctaatgtaaaaatgaaaaacaagtcagagaggaaaagaattgtgcttaaagcattggacaggtcttcctattttctcagcagtgtcttaaattacaaaccagttttaaaactctatgcaggtagagattgctttcacagcacacacacacttttcaaacatgccatagatgcatgtccctatgagaaagaaggtctgacgtttcactattctgtgttttcttaccagttcttacagtaaaaatatgttgggggtttttttgtttgtttttttctttttcaaatcaaacaaataactgtgtgtctttgtttttcttttttcttgaagggttcagaataaaaagagcataaacagaggttgttggatt

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