LOCUS       XM_017660997            8644 bp    mRNA    linear   MAM 30-OCT-2020
DEFINITION  PREDICTED: Manis javanica argonaute RISC component 1 (AGO1),
            transcript variant X6, mRNA.
ACCESSION   XM_017660997
VERSION     XM_017660997.2
DBLINK      BioProject: PRJNA666704
KEYWORDS    RefSeq.
SOURCE      Manis javanica (Malayan pangolin)
  ORGANISM  Manis javanica
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Laurasiatheria; Pholidota; Manidae; Manis.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NW_023436065.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Oct 30, 2020 this sequence version replaced XM_017660997.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Manis javanica Annotation Release
                                           101
            Annotation Version          :: 101
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.5
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8644
                     /organism="Manis javanica"
                     /mol_type="mRNA"
                     /isolate="MJ74"
                     /db_xref="taxon:9974"
                     /chromosome="Unknown"
                     /sex="female"
                     /dev_stage="adult"
                     /collection_date="2017"
     gene            1..8644
                     /gene="AGO1"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 5 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 19 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:108397530"
     CDS             229..2811
                     /gene="AGO1"
                     /codon_start=1
                     /product="protein argonaute-1 isoform X6"
                     /protein_id="XP_017516486.1"
                     /db_xref="GeneID:108397530"
                     /translation="

MEAGPSGAAAGAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEVDIPKIDVYHYEVDIKPDKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALPIGNERVDFEVTIPGEGKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPLTDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLESGQTVECTVAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLMKNASYNLDPYIQEFGIKVKDDMTEVTGRVLPAPILQYGGRVSRNRAIATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTLSNLCLKINVKLGGINNILVPHQRSAVFQQPVIFLGADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRFKPTRIIFYRDGVPEGQLPQILHYELLAIRDACIKLEKDYQPGITYIVVQKRHHTRLFCADKNERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQLCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRDPQALAKAVQVHQDTLRTMYFA"

     misc_feature    328..720
                     /gene="AGO1"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:435368"
     misc_feature    748..900
                     /gene="AGO1"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    901..1263
                     /gene="AGO1"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(1057..1059,1102..1104,1144..1146,1156..1158,
                     1210..1212,1231..1233,1237..1239)
                     /gene="AGO1"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    1396..2682
                     /gene="AGO1"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(1816..1818,1828..1830,1864..1875,1882..1884,
                     1906..1908,1915..1917,1927..1929,1939..1941)
                     /gene="AGO1"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(2020..2022,2026..2028,2236..2238,2650..2652)
                     /gene="AGO1"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

tcgcgcctgcgcactagcagctggccgggcgctcgctgggggagctgctgcaggctccgcggcggcggcggcaacggaggctgcgggggcagcggcgctggcggccgggcttggtggtggagccgagcccggcccgggagccctagcagctaaggtgcggggtacctaggcccctcacgctggactccacagtctccgggccgcctgacctctgcacgggtatatgggatggaagcgggaccctcgggagcagctgcgggcgcctacctgccccccctgcagcaggtgttccaggcacctcgccggcctggcattggcactgtggggaaaccaatcaagctcctggccaattactttgaggtggacatcccgaagattgacgtctaccactacgaggtggatatcaagccggataagtgtcctcgcagagtcaaccgggaagtggtggaatacatggtccagcatttcaagcctcagatctttggtgatcgcaagcccgtgtatgatggaaagaagaacatttacactgtcacagcactgcccattggcaacgaacgggttgactttgaggtgacaatccctggggaagggaaggatcgaatcttcaaggtctccatcaagtggctagccattgtgagctggcgcatgctgcatgaggccctggttagtggccagatccctgttcccttggagtctgtgcaagccctggatgtggccatgaggcacctggcatccatgaggtacacccctgtgggccgctccttcttctcaccgcctgagggctactaccacccgctggggggtgggcgcgaggtctggttcggctttcaccagtctgtgcgccctgccatgtggaagatgatgctcaacattgatgtctcagccactgccttctacaaggcacagccagtgattgagttcatgtgtgaggtgctggacatccggaacatagatgagcagcccaagcccctcactgactcccagcgcgttcgcttcaccaaggagatcaagggcctgaaggtggaagtgacccactgtgggcagatgaagaggaaataccgtgtatgtaatgttacccgccgccctgccagccatcagacgtttcccttgcagctggagagtggacagactgtagagtgcacagtggcacagtatttcaagcagaaatataaccttcagctcaagtatccccacctgccctgcctgcaagttggccaagaacaaaagcatacctacctgcccctggaggtctgcaacattgtggctgggcagcgctgcattaagaagctgactgacaaccagacttcaactatgataaaggctacagctaggtcggccccggacagacaggaggagatcagccgcctgatgaagaatgccagctacaacctagatccctacatccaggaatttgggatcaaagtgaaggatgacatgacggaagtgacggggcgagtgctgccggcgcccatcttgcagtacggcggccgggtgagcaggaaccgagccattgccacacccaatcagggtgtctgggacatgcgggggaaacagttctacaatgggattgagataaaagtctgggccatcgcctgcttcgcaccccaaaaacagtgtcgagaagaggtgctcaagaacttcacagaccagctgcggaagatttccaaggatgcagggatgcccatccagggccagccttgcttctgcaaatatgcgcagggggcggacagcgtggagcccatgttccggcatctcaagaacacctactcagggctgcagctcataattgtcatcctgccagggaagacgccagtatatgctgaggtgaaacgtgttggagatacactcttgggaatggctacgcagtgtgtgcaagtgaagaatgtggtcaagacctcgcctcagacgctgtccaacctctgcctgaagatcaatgtcaaacttggtggcattaacaacatcctagtcccacaccagcgctctgccgtctttcagcagccagtgatattcctgggagcagatgttacacaccccccagcaggggatgggaaaaaaccttctatcacagcagtggtcggcagtatggatgcccacccgagccgttactgtgctactgtgcgcgtacagcgaccacggcaggagatcattgaagacttatcctacatggtgcgtgagctgctaatccagttctacaagtccacccgcttcaagcctacccgcatcatcttctaccgagatggggttcctgaaggccaactcccccagatccttcactacgagctgctggccattcgtgatgcctgtatcaaactggaaaaggactaccagcctgggatcacttatattgtggtgcagaaacgccatcacacccgccttttttgtgctgacaagaatgagcgaattgggaagagtggtaacatcccagcggggaccactgtggataccaacatcacccacccatttgagtttgacttctatctgtgcagccacgcaggcatccagggcaccagccgaccatcccattactatgtcctttgggatgacaaccgtttcacagcggatgaactccagatcttgacgtaccagctgtgccacacttatgtacgatgcacacgctctgtctctatcccagcacctgcctactatgcccgcctggtggctttccgggcacgataccacctagtggacaaggagcatgacagtggagagggcagccacatatcggggcagagcaatgggcgggacccccaggccctggccaaagctgtgcaggttcaccaggatactctgcgcaccatgtacttcgcttgaaggcagaacgctgttacctcactggatagaagaaagctttccaagccccaagagctgtgccacccaaatccagaggacgagggaggaggaaggggggtagggaagaatacagaaggccttgtttccttctacaaagggggcaaaaggttggggaacagggccagtaagccagaccaccagccagaaatctctgatatccacctcatgcccctgacccctcacccatcttgtcacatctggccctgaccccactggaccaagaagggcagcatcagtgcccaccatacacacaggtgtctcatgtgactcacaatgctaaagactcatgcctgacagcttggtaaagtcagctctgcagccctatggacaaaagctggtagatttgggcttgatattttagatgggaaagtgagaggcttgagaaagtgggtgggaggagggaaggattctttaggagccttaatcagaaaaggtctagatttgtttaagaaaaaaaagtgaaacctgatccagatcaatattttagaatactagatgttttaatgggttgggaatccagtttgtaggaagatttttaatgctaatggtttcatttgctcctccccagctgccaccacccctttcctatattcctctttctccaccttttctaccccaccttacacctcctccctgacagacatccagcccctagtaagacttaaggcactatggcacttagctctgaaatgacacgaccctgtcttccttccgcctgctggtgggtaaccagtgccttccctgtaacggtaatgctgcagaactgcaaccttttgtacctttctttgggggatggggtgggggtgggaaaggaggtaggtagggaagaaatacccctaactcaacaagcctccagccagagcgccagcaattttgcatttgaaggaattgacttccatattcattgagcttttaaaaagatcacaacctcaaaatggttaaaatccattgacatttgcactttcagacatgacaagtctcggagctgctgagatgactggcccctggcctttccacttatgtctcctcttctccctgtctcccgtatcttcccacctgcctggatctggaggagttacttccctagcatttcttgctcttggcttttctcctgatggtcaagtctcttatgtttcaatatttcttaactggggtgtcttataacaaatgatccttaggtctaaaataagaaaaaagagcaaaaactaaatgttatttttataccataactcgagtctattgccaaaatctggaaatccctcccatgcccagtgagtttacatcccagaaacatggagccatcagaaggaactatgtacctgacttgttctttggcctggccaggcaggtgggtctagccccagggtggggctcagacactatccttcctcgtgcagataatacctttttcttgctacaggttccctctgcactgccttgcactctttcttgcaaatgcatcttccctttttctagactgtcctcctgacactttggctcattcccaattccagtgtgtcctgtggacagactggggattttgctgctccctattgcttctgtttacacaaatgaattttcctgatttccccactagggcatgtaagtgggtggcatgattctttttttttttttttgtcgtatccttggataaagatgggtttggctgtcttacagacctggaaaagtagggggttctagcttggtgcctgctggccttgaagcgaggcccccctttttcctgagctgttcattttttcctgtcccactcctgaggtgcagttagagcttcagtgtggaagtttctctttctgaggaacctgggctttggtttgccccaatctggtgataaagccatgatagtttagacctagctcaggcttggaggccagccagaggaaggccagtctgaatctgggcctttgtatttagagctaccatttcccctctccagcagcccttgtacaaacccagatttgctatgcaaaacagtctatcccaggttctgtttgggttggttcttggttcagtgacttcacaaaacatagcacaaacattgattatgaagaaggcatcaggactgttgagtaactcctcctttacttccttcctactggctatagcgtgtggtgccccatgggcacagcccagctgcagaacaaaatggagggttctcggaggaggcaactcactggagagcctacattccttacacaagtgcctaaagagagtgatgccaacactccatctgccctgttcatcgccttcatatactgtctacttcgtgttcagtcaccctttggggaggggagctctcttgggacagtgggctctgcatgttctcttcttgggtgcattttggggctaggatcagggcactattcctggagggtccagttattcaccagcatttgcaaatgtccacagggagctggtggtagccacctactctcaacacgtttgtgttctctctttctctctttgcctcactctctcacatgggttttgagctggggcttgaaatgcattttttagctctttggcattgcacatgccactcaagaaataaatgcaaaagcagcagcttggacattggcaagaaaacgacttcttgcttttaattttattttttttaatctttgagactgaaaaatacctttgaccttgaggattattcttgtttgaaaggtagtgcatgtagattgagaagtgctgttggcgacaagctttggttttctgggctttggtttaagtggtgcttcttaagctctgaggaagtgctggggtgaccccagcctcatcctcttagataggtcttttaccccctttgttctactctttgccttccttttcctcttctttctgttcctggcttcctgttccttctattcactcagcttatctactggcctgcctatgtaatgatgaattctctgcatggctacaatgctctcactgttatcttggcaaggtcaggcttagctctttggctttggaagaccaagaatctattccccaagtccagtgatgtcctttctgggctggactgccatcaagctcacacaagggtagagcagcaggcctgcccaactagcatgaaatcaggagggcttctggcaacttccacgcctgtctactccttggggtcagtatctctcgacttttcttgatctggttccatttctctctacctggggcctcccttttctaaggatatcctagggttgagctattgggtatccagggttgaagggttaagggatggacatgggggaggaaaagagtgatgggaagagaatggagaggatttggataaaaggtaggaaaggagagcactgctcactggtaatttttccaatccagcctgtcccactgggggttgaggtgctacttctggcctctggggataaacctgggctgtttttgctgggaacctaagcttagactaatgctgaaaggggtatctaaaagtgtgaaacctgcctataaagctcctggttcccacctacagatagctcctctgtggccgcctctttggctcaacaagttcctggataagtttttcttttttcgtgcccagaattctgtaaatgagtctggcactcaagatgggcagccaaggggacactttgatttcttagctggaccatggtatacagtgggacagtgttttagacctggtatcatatgtaacaaacaaggatggaagttccttccccttcaggatagaaagtcatcttaaacgagccaaaatgcagttttggaaactacatcaggggaagttatttttatttatatttacatttactgggcctaggccaacccaggatggtagctgggatgccttccttcttaaagtttgatcatggcagggatatgcagggcactctttcctttttggccttctgagcataatgggaagaagggattctctggttttcttcccccattccccaccctccattaattaggacttgccttctccctgggcagggagagaggctaggttggtgctctccccttactctattcctactgactcagaacctctggctgctgtttgggagcccaagaaagggagtggagggaatgggctcaaaacaaaacagaataaggtgaggaaggcagatttccttctttaaaaaggaaaataggaaaccctccaagaattgtgcaagacaatgtgtcaaatgcactgagtcccctggtgtagtagcaataaggaaaaatgaaatgactttcctgtgcacacagtccaacctgactggtgtgtgatgttgcacttagcagccatccggtgggcatgtgtgactactctgggtttcactttagtttctaaactttttgttcctctcaagtccagcatggatggggaaatgtccctagagccccacagctgtgtacttgtttgcattttgtttccctctgagacttgtgtttgtgtcatgctttgagctgtaccttgtccagtccattgtaaaattatcccagcagctgtaatgtacagttccttctaaagcaagcaagagcagcagcacaattctgtgttttataaagatgacagtggcttctatttctaaagtgcggtctctctctctttttttttcctattagcaaaacaaactattggaattaatcatatctctggtagattttagtttagagtaacagattattacaagagcagaaccatcacttctaaaggaagaaagtagataaaacaaattccagagtgttgaaactgcatattctatggaatcatacagggtctccacttattctttcaacaaatacacaaagcaccatgtctagcagtactgtgggggagaaggcaagcacaattcaaaattgagaaaaactgtttttttccttaaggaccttaaagtttgatgggggatatgaataaccaaatggttctggtataggagtgagatgggggcctggattgaggctgtaaagctatagcaatgaggatagagaagaaaggcaaatttgagacacactcaggaaatagaattaataggactcaatggatgatggaggaagaagagagtagaggctaatgcctgggtttctgcttagaagcagtgagtaaattgggactctgatcaagattggaggagaaggaagactcagaaggaaggtggtgaatttattgtaaagaaagacaattagccttttatagactgggttttgaggtttccatggggcaacgaggttaagggtgtcaataaacacttatgttttggtgctcaggaaagactataaaactgtagttatagatgtgagattcatactcataggtggtagttaaaagccacaggaatgaacaagatggcttaaagaaagagtaaagcaagagaaacatagcacacaactctaggaaaacacttaaactgtgggatgaggagaggaagcctacctaagatgactcaaatcactagtagataccatatatttgactgatttaatgagatgggagaaaaatcaagagagtggaataggatccaagaagggcatgattaacaacataagctgctgcattgaggaggggatgttattttccagtcactttatcattctccatcccatcttctctgggatcttataattttatggtcattctccagtatttcttgaaaatgagcactggaaaaaccaactttaagtaagtctaagactaggactttcaaggtgttcaccacaaccaccactgccatctccacctccagcttcctgtcctcaggagatacttgtaaaagaataaaataaacaaacctaattttgttcctca

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