LOCUS       XM_017291877            6385 bp    mRNA    linear   INV 14-APR-2020
DEFINITION  PREDICTED: Drosophila miranda protein argonaute-2 (LOC108159004),
            transcript variant X5, mRNA.
ACCESSION   XM_017291877
VERSION     XM_017291877.2
DBLINK      BioProject: PRJNA623594
KEYWORDS    RefSeq.
SOURCE      Drosophila miranda
  ORGANISM  Drosophila miranda
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_046676.1) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 14, 2020 this sequence version replaced XM_017291877.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Drosophila miranda Annotation
                                           Release 102
            Annotation Version          :: 102
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 8.4
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6385
                     /organism="Drosophila miranda"
                     /mol_type="mRNA"
                     /strain="MSH22"
                     /db_xref="taxon:7229"
                     /chromosome="3"
                     /sex="male"
                     /tissue_type="Whole body"
     gene            1..6385
                     /gene="LOC108159004"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Gnomon. Supporting evidence
                     includes similarity to: 32 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 94 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:108159004"
     CDS             996..3851
                     /gene="LOC108159004"
                     /codon_start=1
                     /product="protein argonaute-2 isoform X3"
                     /protein_id="XP_017147366.1"
                     /db_xref="GeneID:108159004"
                     /translation="

MYPVGQQSQWTPSPTRAQSPSQAQTSFETLTSPPAPGSSVNPTAVTSPSAQNVAAGGATVGATASSAASQVASTLGTTTGTVTAAIATATPTTNPDMPVFTCPRRPNLGREGRPIVLRANHFQVTMPRGYVHHYDINIQPDKCPRKVNREIIETMVQAYSKIFGVLKPVFDGRNNLYTRDPLPIGNERLELEVTLPGEGKDRIFRVTIKWQAQVSLFNLEEALEGRTRQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPDGYYHPLGGGREVWFGFHQSVRPSQWKMMLNIDVSATAFYKAQPVIDFMCEVLDIRDIMEQRKPLTDSQRVKFTKEIKGLKIEITHCGQMRRKYRVCNVTRRPAQMQSFPLQLENGQTVECTVAKYFLDKYRMKLRYPHLPCLQVGQEHKHTYLPLEVCNIVAGQRCIKKLTDMQTSTMIKATARSAPDREREINNLVKRADFNNDSYVQEFGLAISNSMMEVRGRVLPPPKLQYGGRVSTGITGQQLFPPQNKVSLASPNQGVWDMRGKQFFTGVEIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAGMPIIGQPCFCKYATGPDQVEPMFRYLKITFPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQCVQAKNVNKTSPQTLSNLCLKINVKLGGINSILVPSIRPKVFNEPVIFLGADVTHPPAGDNKKPSIAAVVGSMDAHPSRYAATVRVQQHRQEIIQELSSMVRELLIMFYKSTGGYKPHRIILYRDGVSEGQFPHVLQHELTAIREACIKLEPEYRPGITFIVVQKRHHTRLFCAEKKEQSGKSGNIPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVEKEHDSGEGSHQSGCSEDRTPGAMARAITVHADTKKVMYFA"

     misc_feature    1332..1721
                     /gene="LOC108159004"
                     /note="N-terminal domain of argonaute; Region: ArgoN;
                     pfam16486"
                     /db_xref="CDD:435368"
     misc_feature    1749..1901
                     /gene="LOC108159004"
                     /note="Argonaute linker 1 domain; Region: ArgoL1;
                     pfam08699"
                     /db_xref="CDD:430160"
     misc_feature    1902..2264
                     /gene="LOC108159004"
                     /note="PAZ domain, argonaute_like subfamily. Argonaute is
                     part of the RNA-induced silencing complex (RISC), and is
                     an endonuclease that plays a key role in the RNA
                     interference pathway. The PAZ domain has been named after
                     the proteins Piwi,Argonaut, and Zwille; Region:
                     PAZ_argonaute_like; cd02846"
                     /db_xref="CDD:239212"
     misc_feature    order(2058..2060,2103..2105,2145..2147,2157..2159,
                     2211..2213,2232..2234,2238..2240)
                     /gene="LOC108159004"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239212"
     misc_feature    2400..3722
                     /gene="LOC108159004"
                     /note="PIWI domain, Argonaute-like subfamily. Argonaute is
                     the central component of the RNA-induced silencing complex
                     (RISC) and related complexes. The PIWI domain is the
                     C-terminal portion of Argonaute and consists of two
                     subdomains, one of which provides the...; Region:
                     Piwi_ago-like; cd04657"
                     /db_xref="CDD:240015"
     misc_feature    order(2853..2855,2865..2867,2901..2912,2919..2921,
                     2943..2945,2952..2954,2964..2966,2976..2978)
                     /gene="LOC108159004"
                     /note="5' RNA guide strand anchoring site [active]"
                     /db_xref="CDD:240015"
     misc_feature    order(3057..3059,3063..3065,3276..3278,3690..3692)
                     /gene="LOC108159004"
                     /note="active site"
                     /db_xref="CDD:240015"
ORIGIN      

tggttaagagtgtacagcatgcgtcacgctcacacgtcgcgagtacgatttttgtgtggacggtgtggtgcctgctgggaaaatctgaagaaaattgcattttttgcataatgcgcgacgtgaaaagctaacaaaagttgtggaaaatcaaaattcgatagtctggccacagtttgtgcataatttcgggcagcgcgaacgtgtttggtgcacaaaaaccacgtctcgaaaatatcagatcagaattatacgtgcacacatttttgctgccatattaaacgcatacaacagcgttttattgctgtatagagcagagccagagcggagcggagcaccagggcagagcatagcccagagcccagagaccacacactaacactcacgagcgagatatgcgagaataaagaagaatttttcttagttgtattacaaaagcattaggatacacatatgtatataagtgtatatatacatgcatatgtgtgtacataggagtgtacatataaactaaacgaaagctgtgcctacatttgtgttcttttccaatactaaacttacaaaacaaacaacaacaaccacaataataatataaataaactaatgttaatgcaagcaaagagccaacagatcttcaaaaccagtctgtgctcattccaatacatatatacgtatatatataaataattatatatatatagatattatatataactacgcctacgccacgcccacgcgcaacaacaacaacatggagaatcaaccaaacgaataaaactttaaactaatttaaagtgtgataagcaaaaggctgaaatctaaaaacaaaacaaaaaaactatgaataattagtagaaaccaaaagcaacaagcaacatcaacaacaatcaattacatatacaccaaaacacaagacatccaaacacgagccaacaacaacctttttatacattaattaaactatttttcttaaataaaacttaacttagtgcaagaaaatgtatccagtcggtcaacagtcacagtggaccccctcgcccacgcgggctcagagtccctctcaggcgcagactagcttcgaaacgctcacatcaccaccagcgccgggttcttcggtcaatcccaccgctgtaaccagcccaagtgcccagaatgtggcagctgggggcgccactgtgggtgcgacggcctcatcagcagcctcccaggtggcgtccaccctgggaaccacaaccgggactgtgactgctgcgattgccaccgctactccgaccaccaatccggatatgcccgtcttcacatgtccgcgtcgccccaatctgggacgcgagggcaggccgatcgtacttcgagccaatcactttcaggtgacgatgcctcgcggctatgtgcatcattacgatatcaacatacagccggacaagtgtccgcgcaaggtgaatcgcgagattatcgagaccatggtgcaggcctacagcaagatctttggcgttctgaaaccggtattcgacggacgcaacaatctgtacacccgcgatcctctgccgatcggtaacgagcgcctcgagctggaggtgacactgcccggcgagggcaaggaccgcatctttcgcgtgacgatcaagtggcaggcccaggtctcgttattcaacctggaggaggctctggagggtcgcacgcgtcaaataccctacgacgccatccttgccctggacgtggtcatgcgtcatctgccgagcatgacctatacgccagtcggacggagctttttcagctcgccggatggctactatcatcctctgggtggtggacgtgaggtctggttcggtttccatcaaagcgtgaggccctcgcaatggaaaatgatgctgaacattgatgtctcggccactgctttctacaaggctcaacccgtgattgactttatgtgcgaggtgctggatatacgcgacatcatggagcagcgcaagccgctcacagactcgcagcgggtcaagttcaccaaggagatcaagggactcaagattgagatcacgcactgtggccagatgcggcgcaagtatcgtgtctgcaatgtaacccgccgaccggctcaaatgcaatcattcccactgcagttggagaatggtcaaactgtggagtgcactgtggccaagtatttcctggacaagtatcgaatgaagttgcgctacccccatctgccgtgcctgcaggtgggacaggagcacaagcacacctatctgccgctcgaggtgtgcaacattgtggctggccagcgatgcatcaaaaagctcaccgatatgcagacatcgacgatgatcaaggccactgcacgctcggcaccggatcgcgagcgtgagatcaacaatctggtgaagcgtgcggactttaacaacgactcgtatgtccaggagttcggtctggccatctccaattcgatgatggaggtgaggggacgagtgctaccgccgcccaagcttcagtatgggggacgtgtgtccactggcatcaccgggcagcagttgtttccgccccagaataaggtgagccttgcctcgcccaaccaaggtgtctgggacatgcgcggcaagcagttcttcacgggcgtggagatcaggatctgggccattgcctgctttgccccgcagcgaacagtgcgcgaggatgccttgaggaacttcacccagcagctgcagaagatctcaaacgacgccggtatgccgataataggccagccctgcttctgcaaatatgctacggggccggatcaagtggagccgatgttccgatacctgaaaatcaccttcccggggctgcagctcgtcgttgttgtgctgcccggcaagaccccggtctatgcggaggtcaagcgcgtgggcgacaccgtcttgggcatggccacccagtgtgtgcaggcgaagaacgtgaacaagacatcgccccagacgctgtccaatctgtgtctgaagataaacgtcaagctgggcggcatcaattcgattctggtgccctccatccggcccaaggtctttaacgagcccgttatcttcctgggagctgacgtcacacacccaccagccggcgataacaagaagccatcgattgccgctgttgttggttcaatggacgcccatccgtcacgatatgcggccactgtgcgagtacagcaacaccgccaggagatcatccaggagctgagcagcatggtgcgcgagctactgattatgttctacaagtcgacgggtggctacaagccccaccgaatcatcctgtaccgggacggcgtctccgagggacagttcccgcatgtgctgcagcacgagttgaccgccataagggaggcgtgcatcaagctagagcccgaatacaggccaggcatcacattcatcgttgtccagaagcgccatcatacgcgactcttctgcgccgagaagaaggagcagagcggcaagtctggcaatataccggccggcaccaccgtcgatgtgggcatcacgcatccaaccgaatttgatttctatctgtgcagtcatcagggcattcaaggcaccagccgtccctcgcactatcacgtgctctgggatgacaatcactttgactccgacgagcttcagtgcctcacgtatcagctgtgccacacctatgtgaggtgcacgcgctccgtcagtataccagctccagcctactatgcccacttggtggcttttcgtgcaaggtatcatctggtggagaaggagcacgactccggcgagggctcacaccagagcggatgctcagaggatcggacaccgggagccatggccagagccatcacggtccatgcagacacgaagaaggtcatgtactttgcctaaaaagtagccaaattaccaaaccacaaaccccaacaaagtaaccccaagaaaaccacaacaaaaatcaaaaattaaaaatcaacttcgaaattcaattcgaataagcaaagagagatggagatagagtacctccccacctccccagtaagcctcccaaatccctcctcaaatcagaaaagccaagcaaagagaaagttttacgtttaagtttagaaagtgagaaagtttaaggagtatataaggaatatcttgcatgcattagttttagggcaaaacgacacaacaaaaacccacagcaaacactcaaacacacacacacagagatcgactcaaggaggactacaaaaacgtgaaaatcgagacacgacaccgtgaagaattgattatagacatagggaataggggatcgggaaggaaatcgaatgttaatgcacaacaaaatgtgaaaattctcaacagaagcatagcaaacaaagcgaaaaggcgaaaggctaaaaaaaaaaatggaaaaccattttaacaaaaactaaacttaaagggaacaaaactacgaacgcaacaccaaaagccaagcagcagcattaattatctatcatcaaacttactacaagaacaccacgagagagagacacaacttttgtaaatgtgggggggaaaccaattaaaaatacaataaattgtataatatatttttacaaataacgaattgaagacaaaagggggggatggaacggatggaatgaacatttgaataagaatgaatgaacgcatacgaccaaaggtttttagtatacaaaaacgaatgaaaaacaaagcacacaaaaaacaattgaatatgtttgctgatcgacgactcacacaacatacaacacacaaaaaccgcaataaaacaccacaccacaccacacaacaacaaattaaaactctgattctctgtactgtgaacgaagaccaccaccaaaatgaaaataaagataaagatgaacatttaagggaaaactaaacaccaataagtggggcactcgactcgacaaaggcattaaagcgctgaaacacaacatagaaaatacgaaacgaaaatgaataaaatacttcaataactaaagtgcagattaaactgaaaacatttaatagtttgtaagatttggctctaccaaaaaaacaaaggaaagaagacggaccggacggatatgatatatatatatatatatatatatatatatggagagagagagagagagagagagagagagagagagagagagcggcataacgataaatccaatttctacaagggacaaaacgtatggtataaacaattgctattaatatttacatagatttatgaccatcaacaaatacactgtactaattataatttttttaaagaatcggggaaataaccaaccaatacgaatgcgataccggaaatacttaagcatatacatacatacgatacatcaattatacatacatatatgtgtatatatataatttgttcaaaagtgcaaataatatgctgatattttgtgttagtctttagttaatctttttttatgctcagcgagacactcccataccgccaacgcccgtaaaacacacacgaactctgagtcccacaggcatatcactcaaatgtccaatccaccctttatttatgtaccttaacccgtaagcttaacttaacgatatttaattgtatttaatattttaaattttttttaaagcaaaaccattatttgttatttcctcgcgtcgctggggcgagagcatcaatgtaatttcgtattaaaaattaactttagccaagtggtgtacgggtaatatagagcaaggaaaccaactccttcccactgcactgtgtgggtggcaacaacatttcaatattttacaaagtagttttaatttgccattaattaaatacaaaaaaagaaacaaaacacaacaaacaaacgacaagagaaaaatgaaatatggaaagatgaataatacatattctatatcgacgacacagttcaagttaacattataatgatttttcattaaaatgctatgcaggaggagagccatctctcgccgtccctcctgcaccagcaccttatttatacttatacttatacttatgtatgtatgctatgtacgagtacaacccacgcaaaccccaacacaatcatcaaattaggcttagttttgccagtcgcataaatgatgtgagaattgtaaaattcaaaagatacatatatatatattatatacattaatttgcatatatacatttataaaactcttacaaattagtctgtaatcttcagagcaaaatcacatttctgatctgatctgatttcttttaattcaattgtaatttgaccgccgtttctatttgttctttgtagtcacgtttcaacacaagggattaaaattttaaatttatttctaaatgtttacttaaagtagagtgtttattacccatcatgcccaagcggaatccaatcctatttttaagcaaaacataaacgaacacaatgcaaaaagaa

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